ALPHASUITEATLASTM

PDB 8VYS

Cryo-EM Structure of the BRAF V600E monomer bound to PLX8394

ELECTRON MICROSCOPY · 3.06 Å

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Protein descriptions

Descriptions refer to the mapped proteins, not necessarily the full deposited construct or assembly.

P15056 · Chains A

Serine/threonine-protein kinase B-raf

Homo sapiens

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway [1, 2]. Phosphorylates PFKFB2 [3].

May play a role in the postsynaptic responses of hippocampal neurons [4]

UniProt · P15056 · Snapshot 10/11/2026

Supporting publications · 4
  1. PubMed 21441910
  2. PubMed 29433126
  3. PubMed 36402789
  4. PubMed 1508179

Components and protein mappings

Mappings below identify source-linked proteins. They do not establish residue-level annotation coverage or direct binding.

  • Serine/threonine-protein kinase B-raf

    PROTEIN · Chains A

    Homo sapiens

    P15056

  • 14-3-3 protein zeta/delta

    PROTEIN · Chains B, C

    Homo sapiens

    P63104

  • (3S)-N-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide

    LIGAND · Chains D

    No UniProt mapping provided

Protein annotations are displayed in the viewer only where residue mappings are verified. Domain annotations do not apply to DNA or RNA.

Biological assemblies

  • Assembly 1

    author defined assembly

    Component membership checked · Chains A, B, C, D

    Open assembly 1 →

Primary publication

BRAF oncogenic mutants evade autoinhibition through a common mechanism.

Paper date: 29/05/2025

Sources and attribution

Snapshot updated 09/11/2026. Source descriptions are attributed below; Atlas combines and displays their annotations.

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