ALPHASUITEATLASTM

PDB 7ROV

KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903

X-RAY DIFFRACTION · 1.32 Å

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Protein descriptions

Descriptions refer to the mapped proteins, not necessarily the full deposited construct or assembly.

P01116 · Chains A, B

GTPase KRas

Homo sapiens

Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival [1, 2]. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity [3, 4]. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity).

Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner [5]. Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex [6]

UniProt · P01116 · Snapshot 10/11/2026

Supporting publications · 6
  1. PubMed 22711838
  2. PubMed 23698361
  3. PubMed 20949621
  4. PubMed 39809765
  5. PubMed 24623306
  6. PubMed 40934300

Components and protein mappings

Mappings below identify source-linked proteins. They do not establish residue-level annotation coverage or direct binding.

  • Isoform 2B of GTPase KRas

    PROTEIN · Chains A, B

    Homo sapiens

    P01116

  • Cyclic peptide MP-9903

    PROTEIN · Chains C, D

    synthetic construct

    No UniProt mapping provided

  • PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER

    LIGAND · Chains E, G

    No UniProt mapping provided

  • MAGNESIUM ION

    LIGAND · Chains F, I

    No UniProt mapping provided

  • GLYCEROL

    LIGAND · Chains H

    No UniProt mapping provided

Protein annotations are displayed in the viewer only where residue mappings are verified. Domain annotations do not apply to DNA or RNA.

Biological assemblies

  • Assembly 1

    author and software defined assembly

    Component membership checked · Chains A, C, E, F

    Open assembly 1 →

  • Assembly 2

    author and software defined assembly

    Component membership checked · Chains B, D, G, H, I

    Open assembly 2 →

Primary publication

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.

Paper date: 25/11/2021

Sources and attribution

Snapshot updated 09/11/2026. Source descriptions are attributed below; Atlas combines and displays their annotations.

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