PROTEIN OVERVIEW

TP53Cellular tumor antigen p53

P04637Homo sapiensReviewed · UniProt

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence.

Sequence393 aa

Source mass43.65 kDa

Recorded PDB entries318

Isoforms listed9

UniProt locations Cytoplasm · Nucleus · Nucleus, PML body · Endoplasmic reticulum · Mitochondrion matrix · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence ^{[44, 66, 63, 69, 73, 101, 104, 122, 126, 139, 144, 149, 153, 171, 173, 174, 36]}. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type ^{[44, 66, 63, 69, 73, 88, 101, 104, 122, 126, 139, 144, 149, 153, 174, 36]}. Negatively regulates cell division by controlling expression of a set of genes required for this process ^{[44, 66, 63, 69, 73, 101, 104, 122, 126, 139, 144, 149, 153, 36]}.

One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression ^{[66, 88]}. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 ^[66].

However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP ^[66]. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.

LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.

Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 ^[149]

Experimental evidence 18 publications

Evidence & references

ECO:0000269 PubMed:11025664 ↗
ECO:0000269 PubMed:12524540 ↗
ECO:0000269 PubMed:12810724 ↗
ECO:0000269 PubMed:15186775 ↗
ECO:0000269 PubMed:15340061 ↗
ECO:0000269 PubMed:17189187 ↗
ECO:0000269 PubMed:17317671 ↗
ECO:0000269 PubMed:17349958 ↗
ECO:0000269 PubMed:19556538 ↗
ECO:0000269 PubMed:20673990 ↗
ECO:0000269 PubMed:20959462 ↗
ECO:0000269 PubMed:22726440 ↗
ECO:0000269 PubMed:24051492 ↗
ECO:0000269 PubMed:24652652 ↗
ECO:0000269 PubMed:35618207 ↗
ECO:0000269 PubMed:36634798 ↗
ECO:0000269 PubMed:38653238 ↗
ECO:0000269 PubMed:9840937 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11025664"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12524540"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12810724"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15186775"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15340061"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17189187"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17317671"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17349958"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19556538"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20673990"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20959462"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22726440"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "24051492"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "24652652"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "35618207"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "36634798"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "38653238"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "9840937"
        }
      ],
      "value": "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)"
    }
  ],
  "commentType": "FUNCTION"
}

Interpretation caution · UniProt

Interaction with BANP was reported to enhance phosphorylation on Ser-15 upon ultraviolet irradiation ^[79]. However, the publication has been retracted due to image duplication and manipulation. Interaction with BANP has been confirmed in mouse studies (By similarity).

Phosphorylation at Ser-15 has been confirmed by other studies ^{[40, 48, 83, 82, 101, 112, 139, 158]}. Its nuclear and cytoplasmic localization has been confirmed by other studies ^{[73, 95, 102, 111, 26, 138, 144]}

By similarityExperimental evidenceCurator inference 17 publications

Evidence & references

ECO:0000250 UniProtKB:P02340
ECO:0000269 PubMed:10570149 ↗
ECO:0000269 PubMed:11554766 ↗
ECO:0000269 PubMed:15340061 ↗
ECO:0000269 PubMed:15701641 ↗
ECO:0000269 PubMed:15866171 ↗
ECO:0000269 PubMed:16219768 ↗
ECO:0000269 PubMed:17170702 ↗
ECO:0000269 PubMed:17317671 ↗
ECO:0000269 PubMed:17591690 ↗
ECO:0000269 PubMed:17954561 ↗
ECO:0000269 PubMed:18206965 ↗
ECO:0000269 PubMed:19011621 ↗
ECO:0000269 PubMed:20959462 ↗
ECO:0000269 PubMed:21597459 ↗
ECO:0000269 PubMed:22726440 ↗
ECO:0000269 PubMed:25772236 ↗
ECO:0000305 PubMed:32144153 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000250",
          "source": "UniProtKB",
          "id": "P02340"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10570149"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11554766"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15340061"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15701641"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15866171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16219768"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17170702"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17317671"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17591690"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17954561"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18206965"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19011621"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20959462"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "21597459"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22726440"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25772236"
        },
        {
          "evidenceCode": "ECO:0000305",
          "source": "PubMed",
          "id": "32144153"
        }
      ],
      "value": "Interaction with BANP was reported to enhance phosphorylation on Ser-15 upon ultraviolet irradiation (PubMed:15701641). However, the publication has been retracted due to image duplication and manipulation. Interaction with BANP has been confirmed in mouse studies (By similarity). Phosphorylation at Ser-15 has been confirmed by other studies (PubMed:10570149, PubMed:11554766, PubMed:15866171, PubMed:16219768, PubMed:17317671, PubMed:17954561, PubMed:20959462, PubMed:25772236). Its nuclear and cytoplasmic localization has been confirmed by other studies (PubMed:15340061, PubMed:17170702, PubMed:17591690, PubMed:18206965, PubMed:19011621, PubMed:21597459, PubMed:22726440)"
    }
  ],
  "commentType": "CAUTION"
}

Additional functional context

Isoform 2

Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"
    }
  ],
  "commentType": "MISCELLANEOUS",
  "molecule": "Isoform 2"
}

Isoform 3

Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"
    }
  ],
  "commentType": "MISCELLANEOUS",
  "molecule": "Isoform 3"
}

Isoform 7

Produced by alternative promoter usage

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Produced by alternative promoter usage"
    }
  ],
  "commentType": "MISCELLANEOUS",
  "molecule": "Isoform 7"
}

Isoform 8

Produced by alternative promoter usage and alternative splicing

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Produced by alternative promoter usage and alternative splicing"
    }
  ],
  "commentType": "MISCELLANEOUS",
  "molecule": "Isoform 8"
}

Isoform 9

Produced by alternative promoter usage and alternative splicing

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Produced by alternative promoter usage and alternative splicing"
    }
  ],
  "commentType": "MISCELLANEOUS",
  "molecule": "Isoform 9"
}

Cofactors

Zn(2+) · CHEBI:29105

Evidence

ECO:0000269 PubMed:14534297 ↗
ECO:0000269 PubMed:16793544 ↗
ECO:0000269 PubMed:17015838 ↗
ECO:0000269 PubMed:18650397 ↗
ECO:0000269 PubMed:19515728 ↗
ECO:0000269 PubMed:20142040 ↗
ECO:0000269 PubMed:20364130 ↗

Binds 1 zinc ion per subunit.

Experimental evidence 7 publications

Evidence & references

ECO:0000269 PubMed:14534297 ↗
ECO:0000269 PubMed:16793544 ↗
ECO:0000269 PubMed:17015838 ↗
ECO:0000269 PubMed:18650397 ↗
ECO:0000269 PubMed:19515728 ↗
ECO:0000269 PubMed:20142040 ↗
ECO:0000269 PubMed:20364130 ↗

Complete source annotation

{
  "commentType": "COFACTOR",
  "cofactors": [
    {
      "name": "Zn(2+)",
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "14534297"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16793544"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17015838"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18650397"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19515728"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20142040"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20364130"
        }
      ],
      "cofactorCrossReference": {
        "database": "ChEBI",
        "id": "CHEBI:29105"
      }
    }
  ],
  "note": {
    "texts": [
      {
        "evidences": [
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "14534297"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "16793544"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "17015838"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "18650397"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "19515728"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "20142040"
          },
          {
            "evidenceCode": "ECO:0000269",
            "source": "PubMed",
            "id": "20364130"
          }
        ],
        "value": "Binds 1 zinc ion per subunit."
      }
    ]
  }
}

GO functions & biological processes

negative regulation of cell population proliferationacts upstream ofUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0008285 · evidence & context

ECO:0000250 PMID:30514107 ↗ ISS · ARUK-UCL · 20210810
qualifier: acts_upstream_of
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10361"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0002254", "relation": "occurs_in"}]}]

regulation of cell cycleacts upstream ofUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0051726 · evidence & context

ECO:0000250 PMID:30514107 ↗ ISS · ARUK-UCL · 20210810
qualifier: acts_upstream_of
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10361"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0002254", "relation": "occurs_in"}]}]

regulation of cell cycle G2/M phase transitionacts upstream of negative effectUniProtKB:P04637

GO:1902749 · evidence & context

ECO:0000315 PMID:10962037 ↗ IMP · UniProt · 20210802
qualifier: acts_upstream_of_negative_effect

DNA damage responseacts upstream of or withinUniProtKB:P04637

GO:0006974 · evidence & context

ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: acts_upstream_of_or_within

ER overload responseacts upstream of or withinUniProtKB:P04637

GO:0006983 · evidence & context

ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: acts_upstream_of_or_within

All recorded function and process assertions (156)

cellular response to glucose starvationacts upstream of or withinUniProtKB:P04637

GO:0042149 · evidence & context

ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20070314
qualifier: acts_upstream_of_or_within

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatoracts upstream of or withinUniProtKB:P04637

GO:0042771 · evidence & context

ECO:0000314 PMID:14654789 ↗ IDA · MGI · 20101117
qualifier: acts_upstream_of_or_within
ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: acts_upstream_of_or_within

regulation of apoptotic processacts upstream of or withinUniProtKB:P04637

GO:0042981 · evidence & context

ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: acts_upstream_of_or_within

positive regulation of transcription by RNA polymerase IIacts upstream of or withinUniProtKB:P04637

GO:0045944 · evidence & context

ECO:0000316 PMID:16061649 ↗ IGI · MGI · 20120113
qualifier: acts_upstream_of_or_within
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WWK9"}]}]
ECO:0000314 PMID:17599062 ↗ IDA · MGI · 20070906
qualifier: acts_upstream_of_or_within

positive regulation of miRNA transcriptionacts upstream of or withinUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000315 PMID:30089260 ↗ IMP · ARUK-UCL · 20231018
qualifier: acts_upstream_of_or_within
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS0000476BE1_9606", "relation": "has_input"}]}]

positive regulation of miRNA transcriptionacts upstream of or withinUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000315 PMID:30089260 ↗ IMP · ARUK-UCL · 20231018
qualifier: acts_upstream_of_or_within
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS00005743AE_9606", "relation": "has_input"}]}]

transcription cis-regulatory region bindingenablesUniProtKB:P04637

GO:0000976 · evidence & context

ECO:0000256 GO_REF:0000002 IEA · InterPro · 20260727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "InterPro", "id": "IPR011615"}]}]
ECO:0000314 PMID:15710329 ↗ IDA · BHF-UCL · 20111212
qualifier: enables
ECO:0000314 PMID:17996705 ↗ IDA · BHF-UCL · 20090617
qualifier: enables

RNA polymerase II transcription regulatory region sequence-specific DNA bindingenablesUniProtKB:P04637

GO:0000977 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

RNA polymerase II cis-regulatory region sequence-specific DNA bindingenablesUniProtKB:P04637

GO:0000978 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · UniProt · 20180429
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20200909
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000314 PMID:24289924 ↗ IDA · ParkinsonsUK-UCL · 20230704
qualifier: enables

RNA polymerase II cis-regulatory region sequence-specific DNA bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0000978 · evidence & context

ECO:0000314 PMID:22578566 ↗ IDA · ARUK-UCL · 20211122
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0045893", "relation": "part_of"}, {"db": "GO", "id": "0001216", "relation": "part_of"}, {"db": "RNAcentral", "id": "URS0000446722_9606", "relation": "has_input"}]}]

DNA-binding transcription factor activity, RNA polymerase II-specificenablesUniProtKB:P04637

GO:0000981 · evidence & context

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20260528
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0005556 GO_REF:0000113 ISA · NTNU_SB · 20190405
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "tfclass", "id": "6.3.1"}]}]
ECO:0000314 PMID:17310983 ↗ IDA · CAFA · 20170125
qualifier: enables
ECO:0000314 PMID:24652652 ↗ IDA · UniProt · 20141210
qualifier: enables
ECO:0000314 PMID:34381247 ↗ IDA · UniProt · 20240722
qualifier: enables
ECO:0000314 PMID:35618207 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:36634798 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:38653238 ↗ IDA · UniProt · 20240530
qualifier: enables

DNA-binding transcription factor activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0000981 · evidence & context

ECO:0000314 PMID:24289924 ↗ IDA · ParkinsonsUK-UCL · 20230704
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0051123", "relation": "part_of"}]}]

cis-regulatory region sequence-specific DNA bindingenablesUniProtKB:P04637

GO:0000987 · evidence & context

ECO:0000314 PMID:10329733 ↗ IDA · ARUK-UCL · 20210810
qualifier: enables

core promoter sequence-specific DNA bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001046 · evidence & context

ECO:0000314 PMID:23629966 ↗ IDA · CAFA · 20200214
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0060333", "relation": "part_of"}]}]

TFIID-class transcription factor complex bindingenablesUniProtKB:P04637

GO:0001094 · evidence & context

ECO:0000353 PMID:24289924 ↗ IPI · ParkinsonsUK-UCL · 20180108
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P21675"}]}]

transcription coactivator bindingenablesUniProtKB:P04637

GO:0001223 · evidence & context

ECO:0000353 PMID:11950834 ↗ IPI · BHF-UCL · 20250111
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P51532"}]}]
ECO:0000353 PMID:11950834 ↗ IPI · BHF-UCL · 20250111
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12824"}]}]

DNA-binding transcription repressor activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001227 · evidence & context

ECO:0000314 PMID:10329733 ↗ IDA · ARUK-UCL · 20210810
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415", "relation": "has_input"}]}]

DNA-binding transcription activator activity, RNA polymerase II-specificenablesUniProtKB:P04637

GO:0001228 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

DNA-binding transcription activator activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001228 · evidence & context

ECO:0000314 PMID:12609999 ↗ IDA · GO_Central · 20201201
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936", "relation": "has_input"}]}, {"connectedXrefs": [{"db": "GO", "id": "0000785", "relation": "occurs_in"}]}]

DNA-binding transcription activator activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001228 · evidence & context

ECO:0000314 PMID:17145718 ↗ IDA · ARUK-UCL · 20211119
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07812", "relation": "has_input"}]}]

DNA-binding transcription activator activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001228 · evidence & context

ECO:0000314 PMID:17146433 ↗ IDA · BHF-UCL · 20181011
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H4X1", "relation": "has_input"}]}]

DNA-binding transcription activator activity, RNA polymerase II-specificenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0001228 · evidence & context

ECO:0000314 PMID:22578566 ↗ IDA · ARUK-UCL · 20211206
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS0000446722_9606", "relation": "has_input"}, {"db": "GO", "id": "1902895", "relation": "part_of"}]}]

protease bindingenablesUniProtKB:P04637

GO:0002020 · evidence & context

ECO:0000353 PMID:11923872 ↗ IPI · UniProt · 20100727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]

p53 bindingenablesUniProtKB:P04637

GO:0002039 · evidence & context

ECO:0000353 PMID:25417702 ↗ IPI · CAFA · 20161216
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}]
ECO:0000353 PMID:25417702 ↗ IPI · CAFA · 20161216
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}]

DNA bindingenablesUniProtKB:P04637

GO:0003677 · evidence & context

ECO:0000256 GO_REF:0000002 IEA · InterPro · 20260727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "InterPro", "id": "IPR002117"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR012346"}]}]
ECO:0000314 PMID:15358771 ↗ IDA · UniProt · 20170213
qualifier: enables
ECO:0000315 PMID:15629713 ↗ IMP · CAFA · 20161209
qualifier: enables
ECO:0000315 PMID:2144364 ↗ IMP · UniProt · 20040608
qualifier: enables

chromatin bindingenablesUniProtKB:P04637

GO:0003682 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000314 PMID:16322561 ↗ IDA · UniProt · 20111107
qualifier: enables
ECO:0000314 PMID:17599062 ↗ IDA · MGI · 20070906
qualifier: enables
ECO:0000314 PMID:26334721 ↗ IDA · MGI · 20230912
qualifier: enables

DNA-binding transcription factor activityenablesUniProtKB:P04637

GO:0003700 · evidence & context

ECO:0000501 GO_REF:0000120 IEA · UniProt · 20260727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR002117"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR008967"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR012346"}]}]
ECO:0000315 PMID:16479015 ↗ IMP · UniProt · 20170718
qualifier: enables
ECO:0000314 PMID:18549481 ↗ IDA · BHF-UCL · 20110428
qualifier: enables
ECO:0000314 PMID:26334721 ↗ IDA · MGI · 20230912
qualifier: enables
ECO:0000314 PMID:7587074 ↗ IDA · UniProt · 20040608
qualifier: enables

mRNA 3'-UTR bindingenablesUniProtKB:P04637

GO:0003730 · evidence & context

ECO:0000314 PMID:16213212 ↗ IDA · CAFA · 20170125
qualifier: enables

copper ion bindingenablesUniProtKB:P04637

GO:0005507 · evidence & context

ECO:0000314 PMID:7824276 ↗ IDA · UniProt · 20040610
qualifier: enables

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:10196247 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:11146555 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q16666-2"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:11178989 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:11672523 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:12006491 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:12080348 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06748-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:12915590 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:14557665 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15144954 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06748-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15144954 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15205477 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15364927 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15542844 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99986"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15660129 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17844"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:16227626 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17676"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:16432196 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:16845383 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:16845383 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17080083 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17098746 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q86XK2"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17139261 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17159902 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17268548 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17310983 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17347673 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17438265 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17470788 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17568776 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17875722 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17906639 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WUF5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:17964266 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18172499 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18235501 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18235502 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18275817 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WUF5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18309296 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18316739 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18485870 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:18504427 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15672"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19043414 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19098711 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19166840 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19255450 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19411066 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19433796 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UBL3"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19626115 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRR4"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19656744 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19740107 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26447"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20173098 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20227041 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P11473"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20228809 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NPI1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20452352 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26447"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20660729 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NPI1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20708156 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21132010 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21170087 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21245319 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21317932 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60285"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21397192 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q16666-2"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21513714 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WUF5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21726810 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21857681 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21988832 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:21988832 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22085928 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22265415 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12772"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22510990 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22575647 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22659184 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22819825 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22975381 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22975381 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15672"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:23623661 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WUF5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:23752197 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26447"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:23776060 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:23870121 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9P0U4"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:23870121 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UBL3"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24207125 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24219989 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17844"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24219989 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRR4"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24492002 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99986"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24667498 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:25402006 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15672"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:27519799 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:29187402 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06587"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:29340707 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99986"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:29997244 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26447"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:32606738 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92569"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UBL3"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:34591612 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:35044719 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:36897777 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:40205054 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:8875929 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637

GO:0005515 · evidence & context

ECO:0000353 PMID:10196247 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:10226625 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:10415337 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NS56"}]}]
ECO:0000353 PMID:10518217 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:10518217 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:10518217 ↗ IPI · UniProt · 20060224
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N9B5"}]}]
ECO:0000353 PMID:10597287 ↗ IPI · BHF-UCL · 20151222
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99973"}]}]
ECO:0000353 PMID:10608892 ↗ IPI · UniProt · 20050701
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:10666337 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P11388"}]}]
ECO:0000353 PMID:10666337 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q02880"}]}]
ECO:0000353 PMID:10823891 ↗ IPI · UniProt · 20110112
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P42858"}]}]
ECO:0000353 PMID:10823891 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P42858"}]}]
ECO:0000353 PMID:10823891 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:10823891 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96ST3"}]}]
ECO:0000353 PMID:11080164 ↗ IPI · UniProt · 20060112
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29590-5"}]}]
ECO:0000353 PMID:11359905 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96ST3"}]}]
ECO:0000353 PMID:11388671 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N2W9"}]}]
ECO:0000353 PMID:11546806 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96S44"}]}]
ECO:0000353 PMID:11672523 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q923E4"}]}]
ECO:0000353 PMID:11672523 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EB6"}]}]
ECO:0000353 PMID:11684014 ↗ IPI · UniProt · 20051122
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:11684014 ↗ IPI · UniProt · 20051122
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96KQ4"}]}]
ECO:0000353 PMID:11706030 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9ESJ1"}]}]
ECO:0000353 PMID:11781842 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P54132"}]}]
ECO:0000353 PMID:11861836 ↗ IPI · UniProt · 20060113
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03406"}]}]
ECO:0000353 PMID:11877378 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:12080348 ↗ IPI · UniProt · 20040608
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06748"}]}]
ECO:0000353 PMID:12615712 ↗ IPI · UniProt · 20260625
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q7LG56"}]}]
ECO:0000353 PMID:12620801 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03126"}]}]
ECO:0000353 PMID:12620801 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05086"}]}]
ECO:0000353 PMID:12667443 ↗ IPI · UniProt · 20070305
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415"}]}]
ECO:0000353 PMID:12667443 ↗ IPI · UniProt · 20040614
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07817"}]}]
ECO:0000353 PMID:12692135 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:12702766 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q86Z02"}]}]
ECO:0000353 PMID:12730672 ↗ IPI · AgBase · 20150504
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P27958-PRO_0000037566"}]}]
ECO:0000353 PMID:12750254 ↗ IPI · UniProt · 20050216
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WYH8"}]}]
ECO:0000353 PMID:12750254 ↗ IPI · UniProt · 20050216
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UNL4"}]}]
ECO:0000353 PMID:12915590 ↗ IPI · UniProt · 20060112
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29590"}]}]
ECO:0000353 PMID:12915590 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29590"}]}]
ECO:0000353 PMID:14627987 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09874"}]}]
ECO:0000353 PMID:1465435 ↗ IPI · UniProt · 20040614
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P20226"}]}]
ECO:0000353 PMID:14744935 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P49841"}]}]
ECO:0000353 PMID:14759370 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P45481"}]}]
ECO:0000353 PMID:14759370 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:14759370 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:14985081 ↗ IPI · AgBase · 20150310
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:14985081 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888-1"}]}]
ECO:0000353 PMID:14985081 ↗ IPI · AgBase · 20150310
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:14985081 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:15044383 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09874"}]}]
ECO:0000353 PMID:15044383 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q7Z2E3"}]}]
ECO:0000353 PMID:15068796 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:15133049 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O75925"}]}]
ECO:0000353 PMID:15144954 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06748"}]}]
ECO:0000353 PMID:15310821 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:15525938 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:15542844 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:15577914 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15392"}]}]
ECO:0000353 PMID:15580310 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NZC7"}]}]
ECO:0000353 PMID:15604276 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:15660129 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92841"}]}]
ECO:0000353 PMID:15687255 ↗ IPI · UniProt · 20211220
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15559"}]}]
ECO:0000353 PMID:15710329 ↗ IPI · BHF-UCL · 20111212
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15941"}]}]
ECO:0000353 PMID:15735003 ↗ IPI · UniProt · 20060503
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O43715"}]}]
ECO:0000353 PMID:15782130 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P12956"}]}]
ECO:0000353 PMID:15916963 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:15916963 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:15960975 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H7Z6"}]}]
ECO:0000353 PMID:15989956 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q7Z6Z7"}]}]
ECO:0000353 PMID:16003391 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:16169070 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O95376"}]}]
ECO:0000353 PMID:16169070 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04792"}]}]
ECO:0000353 PMID:16169070 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P48643"}]}]
ECO:0000353 PMID:16169070 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BWC9"}]}]
ECO:0000353 PMID:16169070 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BX70"}]}]
ECO:0000353 PMID:16189514 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14641"}]}]
ECO:0000353 PMID:16189514 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96M61"}]}]
ECO:0000353 PMID:16322561 ↗ IPI · UniProt · 20111107
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y3T9"}]}]
ECO:0000353 PMID:16322561 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y3T9"}]}]
ECO:0000353 PMID:16376338 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63104"}]}]
ECO:0000353 PMID:16376884 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06748"}]}]
ECO:0000353 PMID:16377624 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05655"}]}]
ECO:0000353 PMID:16402859 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:16415881 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:16442532 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04731"}]}]
ECO:0000353 PMID:16443602 ↗ IPI · ARUK-UCL · 20190715
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415"}]}]
ECO:0000353 PMID:16474402 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:16493710 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05086"}]}]
ECO:0000353 PMID:16511572 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14757"}]}]
ECO:0000353 PMID:16601686 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H7Z6"}]}]
ECO:0000353 PMID:16611888 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:16611888 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:16713569 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14641"}]}]
ECO:0000353 PMID:16713569 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96M61"}]}]
ECO:0000353 PMID:16732283 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63165"}]}]
ECO:0000353 PMID:16753148 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P53350"}]}]
ECO:0000353 PMID:16793543 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P32776"}]}]
ECO:0000353 PMID:16793543 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P32780"}]}]
ECO:0000353 PMID:16845383 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:16845383 ↗ IPI · UniProt · 20100713
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UER7"}]}]
ECO:0000353 PMID:16847267 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P43356"}]}]
ECO:0000353 PMID:16951253 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:16959611 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P23511"}]}]
ECO:0000353 PMID:16959611 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P25208"}]}]
ECO:0000353 PMID:16959611 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13547"}]}]
ECO:0000353 PMID:17080083 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:17108971 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8R5A0"}]}]
ECO:0000353 PMID:17108971 ↗ IPI · UniProt · 20110121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:17108971 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:17108971 ↗ IPI · UniProt · 20110121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRG4"}]}]
ECO:0000353 PMID:17121812 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WZ73"}]}]
ECO:0000353 PMID:17121812 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q969K3"}]}]
ECO:0000353 PMID:17139261 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17139261 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P22736"}]}]
ECO:0000353 PMID:17145718 ↗ IPI · UniProt · 20170201
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q63934-2"}]}]
ECO:0000353 PMID:17159902 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17170702 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17170702 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q86TM6"}]}]
ECO:0000353 PMID:17184779 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04792"}]}]
ECO:0000353 PMID:17184779 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38646"}]}]
ECO:0000353 PMID:17237821 ↗ IPI · ParkinsonsUK-UCL · 20161005
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · UniProt · 20091202
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P30153"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P30153"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · UniProt · 20091202
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P67775"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13362"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · UniProt · 20091201
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13362-1"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · UniProt · 20091201
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13362-2"}]}]
ECO:0000353 PMID:17245430 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q7L7W2"}]}]
ECO:0000353 PMID:17254968 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15759"}]}]
ECO:0000353 PMID:17254968 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IW41"}]}]
ECO:0000353 PMID:17268548 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14980"}]}]
ECO:0000353 PMID:17268548 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17268548 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:17274640 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P36873-1"}]}]
ECO:0000353 PMID:17290220 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17298945 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:17317671 ↗ IPI · UniProt · 20091012
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92585"}]}]
ECO:0000353 PMID:17347673 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14503"}]}]
ECO:0000353 PMID:17438265 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:17482142 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96KB5"}]}]
ECO:0000353 PMID:17568776 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:17612295 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:17662718 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:17707234 ↗ IPI · UniProt · 20110121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NQR1"}]}]
ECO:0000353 PMID:17719541 ↗ IPI · UniProt · 20130522
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM9"}]}]
ECO:0000353 PMID:17719542 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P55060"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60341-1"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · BHF-UCL · 20110427
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888-1"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:17805299 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRG4"}]}]
ECO:0000353 PMID:17875722 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:17904127 ↗ IPI · UniProt · 20170623
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N2F6-2"}]}]
ECO:0000353 PMID:17906639 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:17906639 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13526"}]}]
ECO:0000353 PMID:18087040 ↗ IPI · UniProt · 20130515
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60936"}]}]
ECO:0000353 PMID:18087040 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60936"}]}]
ECO:0000353 PMID:18172499 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P49757"}]}]
ECO:0000353 PMID:18230339 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:18275817 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:18309296 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:18309296 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61289"}]}]
ECO:0000353 PMID:18354501 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P32780"}]}]
ECO:0000353 PMID:18382127 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WZ73"}]}]
ECO:0000353 PMID:18382127 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q969K3"}]}]
ECO:0000353 PMID:18388957 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:18391200 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:18485870 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P45481"}]}]
ECO:0000353 PMID:18485870 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:18485870 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92993"}]}]
ECO:0000353 PMID:18510931 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9PST7"}]}]
ECO:0000353 PMID:18566590 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:18624398 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63279"}]}]
ECO:0000353 PMID:18656471 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P46821"}]}]
ECO:0000353 PMID:18690848 ↗ IPI · UniProt · 20190124
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60356"}]}]
ECO:0000353 PMID:18690848 ↗ IPI · UniProt · 20190124
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60356"}, {"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:18695251 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13155"}]}]
ECO:0000353 PMID:18812399 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61981"}]}]
ECO:0000353 PMID:18952844 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14980"}]}]
ECO:0000353 PMID:18977328 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03126"}]}]
ECO:0000353 PMID:18977328 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06463"}]}]
ECO:0000353 PMID:19008854 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:19011621 ↗ IPI · UniProt · 20190221
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14744"}]}]
ECO:0000353 PMID:19043414 ↗ IPI · UniProt · 20091104
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
ECO:0000353 PMID:19098711 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:19098711 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N488"}]}]
ECO:0000353 PMID:19151705 ↗ IPI · UniProt · 20090424
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09XV5"}]}]
ECO:0000353 PMID:19196987 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14920"}]}]
ECO:0000353 PMID:19196987 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y297"}]}]
ECO:0000353 PMID:19217391 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · UniProt · 20110616
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06945"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06945"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · UniProt · 20110616
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · UniProt · 20110616
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:19234109 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:19255450 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:19339993 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:19345189 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O88898"}]}]
ECO:0000353 PMID:19345189 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15796"}]}]
ECO:0000353 PMID:19345189 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}]
ECO:0000353 PMID:19433796 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:19483087 ↗ IPI · UniProt · 20091009
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5"}]}]
ECO:0000353 PMID:19483087 ↗ IPI · UniProt · 20120708
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PM5-1"}]}]
ECO:0000353 PMID:19508870 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96GM8"}]}]
ECO:0000353 PMID:19521340 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:19536131 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:19536131 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UHC7"}]}]
ECO:0000353 PMID:19556538 ↗ IPI · UniProt · 20101221
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15164"}]}]
ECO:0000353 PMID:19556538 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15164"}]}]
ECO:0000353 PMID:19619542 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:19651603 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P45481"}]}]
ECO:0000353 PMID:19680552 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q923E4"}]}]
ECO:0000353 PMID:19684601 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63165"}]}]
ECO:0000353 PMID:19798103 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P0CG48"}]}]
ECO:0000353 PMID:19805293 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:19833129 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P53350"}]}]
ECO:0000353 PMID:19933256 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61981"}]}]
ECO:0000353 PMID:20075864 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13547"}]}]
ECO:0000353 PMID:20075864 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N9N5"}]}]
ECO:0000353 PMID:20096447 ↗ IPI · UniProt · 20120708
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14694"}]}]
ECO:0000353 PMID:20118233 ↗ IPI · UniProt · 20110121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96KQ7"}]}]
ECO:0000353 PMID:20118233 ↗ IPI · UniProt · 20110121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H9B1"}]}]
ECO:0000353 PMID:20123734 ↗ IPI · UniProt · 20111116
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y3T9"}]}]
ECO:0000353 PMID:20124405 ↗ IPI · UniProt · 20110912
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P34947"}]}]
ECO:0000353 PMID:20153329 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38646"}]}]
ECO:0000353 PMID:20159018 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BWC9"}]}]
ECO:0000353 PMID:20167603 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q923E4"}]}]
ECO:0000353 PMID:20173098 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q6PCD5"}]}]
ECO:0000353 PMID:20173098 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q6PCD5"}]}]
ECO:0000353 PMID:20206173 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31947"}]}]
ECO:0000353 PMID:20228809 ↗ IPI · UniProt · 20110103
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NPI1"}]}]
ECO:0000353 PMID:20385133 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O95863"}]}]
ECO:0000353 PMID:20421506 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P51587"}]}]
ECO:0000353 PMID:20515689 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:20534433 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63165"}]}]
ECO:0000353 PMID:20562916 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BV47"}]}]
ECO:0000353 PMID:20562916 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BV47"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04271"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06703"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P23297"}]}]
ECO:0000353 PMID:20591429 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29034"}]}]
ECO:0000353 PMID:20622899 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96KB5"}]}]
ECO:0000353 PMID:20705607 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:20713054 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8TAQ5"}]}]
ECO:0000353 PMID:20864041 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P43356"}]}]
ECO:0000353 PMID:20864041 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UBF1"}]}]
ECO:0000353 PMID:20959462 ↗ IPI · UniProt · 20111116
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96GD4"}]}]
ECO:0000353 PMID:20959462 ↗ IPI · UniProt · 20111116
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y3T9"}]}]
ECO:0000353 PMID:21057547 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15169"}]}]
ECO:0000353 PMID:21057547 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29590"}]}]
ECO:0000353 PMID:21078964 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9UHH9"}]}]
ECO:0000353 PMID:21081126 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P13693"}]}]
ECO:0000353 PMID:21130767 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15424"}]}]
ECO:0000353 PMID:21130767 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96SB4"}]}]
ECO:0000353 PMID:21170034 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:21245319 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:21317932 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60285"}]}]
ECO:0000353 PMID:21390126 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P45481"}]}]
ECO:0000353 PMID:21423215 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IZD2"}]}]
ECO:0000353 PMID:21460856 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13362"}]}]
ECO:0000353 PMID:21471221 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:21513714 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:21597459 ↗ IPI · UniProt · 20200922
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q969V5"}]}]
ECO:0000353 PMID:21625211 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31947"}]}]
ECO:0000353 PMID:21653829 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P51114"}]}]
ECO:0000353 PMID:21670263 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P32776"}]}]
ECO:0000353 PMID:21741598 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13526"}]}]
ECO:0000353 PMID:21741598 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}]
ECO:0000353 PMID:21782458 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRG4"}]}]
ECO:0000353 PMID:21821029 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61978"}]}]
ECO:0000353 PMID:21821029 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61978-2"}]}]
ECO:0000353 PMID:21831840 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P08047"}]}]
ECO:0000353 PMID:21857681 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29066"}]}]
ECO:0000353 PMID:21857681 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P49407"}]}]
ECO:0000353 PMID:21892170 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02829"}]}]
ECO:0000353 PMID:21900206 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936"}]}]
ECO:0000353 PMID:21900206 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P49841"}]}]
ECO:0000353 PMID:21900206 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13526"}]}]
ECO:0000353 PMID:21952639 ↗ IPI · UniProt · 20120708
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PU4"}]}]
ECO:0000353 PMID:21952639 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96PU4"}]}]
ECO:0000353 PMID:21988832 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WTS6"}]}]
ECO:0000353 PMID:22056774 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:22085928 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H9J4"}]}]
ECO:0000353 PMID:22085928 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H9J4-2"}]}]
ECO:0000353 PMID:22103682 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P19338"}]}]
ECO:0000353 PMID:22124327 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96FW1"}]}]
ECO:0000353 PMID:22340593 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38646"}]}]
ECO:0000353 PMID:22451927 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P13693"}]}]
ECO:0000353 PMID:22499945 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O95352-2"}]}]
ECO:0000353 PMID:22522597 ↗ IPI · UniProt · 20170511
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NZM5"}]}]
ECO:0000353 PMID:22575647 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15466"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O43847"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O75970"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P48643"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P53350"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61981"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63104"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8TEW0"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:22723347 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14503"}]}]
ECO:0000353 PMID:22726440 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38646"}]}]
ECO:0000353 PMID:22810585 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:22810586 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:22810586 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06463"}]}]
ECO:0000353 PMID:22819825 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O95376"}]}]
ECO:0000353 PMID:22945289 ↗ IPI · UniProt · 20130418
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q569K4"}]}]
ECO:0000353 PMID:22975381 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26687"}]}]
ECO:0000353 PMID:23010591 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:23063560 ↗ IPI · DisProt · 20220214
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09429"}]}]
ECO:0000353 PMID:23063560 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09429"}]}]
ECO:0000353 PMID:23092970 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P61978"}]}]
ECO:0000353 PMID:23320542 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:23431171 ↗ IPI · UniProt · 20130314
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92794"}]}]
ECO:0000353 PMID:23576507 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P89055"}]}]
ECO:0000353 PMID:23734815 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P25208"}]}]
ECO:0000353 PMID:24449765 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y618"}]}]
ECO:0000353 PMID:24625977 ↗ IPI · UniProt · 20230927
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38646"}]}]
ECO:0000353 PMID:24667498 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:24667498 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q6NYC1"}]}]
ECO:0000353 PMID:24722188 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99608"}]}]
ECO:0000353 PMID:25168243 ↗ IPI · UniProt · 20210716
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99LG4"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O75925"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04792"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29590"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P30153"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13362"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13547"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15796"}]}]
ECO:0000353 PMID:25314079 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:25402006 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15884"}]}]
ECO:0000353 PMID:25422469 ↗ IPI · UniProt · 20170620
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15205"}]}]
ECO:0000353 PMID:25502805 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:25579814 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888-1"}]}]
ECO:0000353 PMID:25591766 ↗ IPI · UniProt · 20170110
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96EQ8"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15884"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9NRG4"}]}]
ECO:0000353 PMID:25651062 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:25651062 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888-1"}]}]
ECO:0000353 PMID:25670079 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15796"}]}]
ECO:0000353 PMID:25837623 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:25857266 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9Y265"}]}]
ECO:0000353 PMID:26302407 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06330"}]}]
ECO:0000353 PMID:26302407 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:26331536 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15036"}]}]
ECO:0000353 PMID:26789255 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03126"}]}]
ECO:0000353 PMID:26789255 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05086"}]}]
ECO:0000353 PMID:27107012 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14641"}]}]
ECO:0000353 PMID:27107012 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O43741"}]}]
ECO:0000353 PMID:27323408 ↗ IPI · UniProt · 20170522
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8WV93"}]}]
ECO:0000353 PMID:27605672 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:28842590 ↗ IPI · UniProt · 20191121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O00571"}]}]
ECO:0000353 PMID:29628311 ↗ IPI · ARUK-UCL · 20200627
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O43189"}]}]
ECO:0000353 PMID:31467278 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63279"}]}]
ECO:0000353 PMID:31511497 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9HBM6"}]}]
ECO:0000353 PMID:31515488 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14641"}]}]
ECO:0000353 PMID:31515488 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:31515488 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96M61"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04271"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06703"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P23297"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P25815"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P29034"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31949"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P33763"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P33764"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "A0A6Q8PF08"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09936"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P13473-2"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P21333-2"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31948"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P42858"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P55212"}]}]
ECO:0000353 PMID:32814053 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q7Z412"}]}]
ECO:0000353 PMID:33591310 ↗ IPI · UniProt · 20220620
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q15038"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P41235"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:33961781 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:34316702 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N488"}]}]
ECO:0000353 PMID:34404770 ↗ IPI · UniProt · 20220715
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H5H4"}]}]
ECO:0000353 PMID:34591612 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936"}]}]
ECO:0000353 PMID:34591612 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:34591612 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:34591612 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q93009"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12888"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:34591642 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q99608"}]}]
ECO:0000353 PMID:35122041 ↗ IPI · UniProt · 20230425
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P05062"}]}]
ECO:0000353 PMID:35122041 ↗ IPI · UniProt · 20230425
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P11413"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31948"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P41235"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P48643"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:35140242 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:35271311 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63104"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14757"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O14920"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O43741"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P15056"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13547"}]}]
ECO:0000353 PMID:36897777 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:36931259 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P31947"}]}]
ECO:0000353 PMID:39009827 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P00519"}]}]
ECO:0000353 PMID:40205054 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O15151"}]}]
ECO:0000353 PMID:40205054 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14999"}]}]
ECO:0000353 PMID:40205054 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8IWT3"}]}]
ECO:0000353 PMID:7663514 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P18074"}]}]
ECO:0000353 PMID:7663514 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P19447"}]}]
ECO:0000353 PMID:7663514 ↗ IPI · UniProt · 20040706
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q03468"}]}]
ECO:0000353 PMID:7799929 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P20226"}]}]
ECO:0000353 PMID:8207801 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03126"}]}]
ECO:0000353 PMID:8207801 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P06463"}]}]
ECO:0000353 PMID:8344494 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:8675009 ↗ IPI · UniProt · 20050707
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06609"}]}]
ECO:0000353 PMID:8875926 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13625"}]}]
ECO:0000353 PMID:9050995 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]
ECO:0000353 PMID:9194564 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:9194564 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:9194565 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q09472"}]}]
ECO:0000353 PMID:9194565 ↗ IPI · UniProt · 20040610
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q92793"}]}]
ECO:0000353 PMID:9380510 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q06609"}]}]
ECO:0000353 PMID:9472015 ↗ IPI · UniProt · 20040719
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09429"}]}]
ECO:0000353 PMID:9472015 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P09429"}]}]
ECO:0000353 PMID:9529249 ↗ IPI · UniProt · 20221219
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]
ECO:0000353 PMID:9529249 ↗ IPI · BHF-UCL · 20100113
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q8N726-1"}]}]
ECO:0000353 PMID:9807817 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P03070"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:11427532 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14191"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005657", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]
ECO:0000353 PMID:15735006 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q14191"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005657", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:12667443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:12667443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07817-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:14963330 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07817-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:16151013 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07817-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19521340 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:22726440 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P30405"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24814347 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07817-1"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005739", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:15855171 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05397"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0048471", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]
ECO:0000353 PMID:19857493 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05397"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0048471", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]
ECO:0000353 PMID:25241761 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q05397"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0048471", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:16319068 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P35232"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0031965", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]
ECO:0000353 PMID:20134482 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P35232"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0031965", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]
ECO:0000353 PMID:24380853 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P35232"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0031965", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005737", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:19656744 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P23396"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0005634", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0005829", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:26334721 ↗ IPI · MGI · 20230912
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "PR", "id": "Q9CXT6"}]}]
extensions: [{"connectedXrefs": [{"db": "PR", "id": "Q9CXT6", "relation": "has_input"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:26334721 ↗ IPI · MGI · 20230912
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60341"}]}]
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60341", "relation": "has_input"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:9188558 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26663-PRO_0000037536"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0030430", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0042025", "relation": "occurs_in"}]}]
ECO:0000353 PMID:9827557 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P26663-PRO_0000037536"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0030430", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "GO", "id": "0042025", "relation": "occurs_in"}]}]

protein bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0005515 · evidence & context

ECO:0000353 PMID:9733515 ↗ IPI · ARUK-UCL · 20190819
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13315"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0006974", "relation": "part_of"}]}]
ECO:0000353 PMID:9733515 ↗ IPI · ARUK-UCL · 20190819
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13535"}]}]
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0006974", "relation": "part_of"}]}]

zinc ion bindingenablesUniProtKB:P04637

GO:0008270 · evidence & context

ECO:0000304 PMID:10065153 ↗ TAS · UniProt · 20090325
qualifier: enables

enzyme bindingenablesUniProtKB:P04637

GO:0019899 · evidence & context

ECO:0000353 PMID:17805299 ↗ IPI · BHF-UCL · 20110427
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O60341"}]}]

receptor tyrosine kinase bindingenablesUniProtKB:P04637

GO:0030971 · evidence & context

ECO:0000353 PMID:23027130 ↗ IPI · BHF-UCL · 20121126
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q16288"}]}]

ubiquitin protein ligase bindingenablesUniProtKB:P04637

GO:0031625 · evidence & context

ECO:0000501 GO_REF:0000120 IEA · UniProt · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00028807"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000353 PMID:8875929 ↗ IPI · UniProt · 20100727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987"}]}]

ubiquitin protein ligase bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0031625 · evidence & context

ECO:0000269 PMID:8875929 ↗ EXP · DisProt · 20220808
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q00987", "relation": "has_input"}]}]

histone deacetylase regulator activityenablesUniProtKB:P04637

GO:0035033 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

ATP-dependent DNA/DNA annealing activityenablesUniProtKB:P04637

GO:0036310 · evidence & context

ECO:0000314 PMID:8183576 ↗ IDA · UniProt · 20210519
qualifier: enables

identical protein bindingenablesUniProtKB:P04637

GO:0042802 · evidence & context

ECO:0000353 PMID:10876243 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:14759370 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:14985081 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:15629713 ↗ IPI · CAFA · 20191126
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:16291740 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:16461914 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:17612295 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:17620598 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:18087040 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:19011621 ↗ IPI · UniProt · 20191121
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:19339993 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:19667193 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:20004160 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:20159469 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:20364130 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:21178074 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:21522129 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:21988832 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:22653443 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:22972749 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:25402006 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:25609649 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:31837246 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]
ECO:0000353 PMID:35512704 ↗ IPI · IntAct · 20260725
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}]

histone deacetylase bindingenablesUniProtKB:P04637

GO:0042826 · evidence & context

ECO:0000353 PMID:23629966 ↗ IPI · CAFA · 20161108
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q13547"}]}]

protein heterodimerization activityenablesUniProtKB:P04637

GO:0046982 · evidence & context

ECO:0000353 PMID:10837489 ↗ IPI · UniProt · 20061013
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07820"}]}]

protein-folding chaperone bindingenablesUniProtKB:P04637

GO:0051087 · evidence & context

ECO:0000353 PMID:15358771 ↗ IPI · UniProt · 20170213
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P08238"}]}]
ECO:0000353 PMID:18086682 ↗ IPI · UniProt · 20080718
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10809"}]}]

protein phosphatase 2A bindingenablesUniProtKB:P04637

GO:0051721 · evidence & context

ECO:0000353 PMID:17245430 ↗ IPI · UniProt · 20100727
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P63151"}]}]

RNA polymerase II-specific DNA-binding transcription factor bindingenablesUniProtKB:P04637

GO:0061629 · evidence & context

ECO:0000353 PMID:15705871 ↗ IPI · BHF-UCL · 20210910
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P28360"}]}]
ECO:0000353 PMID:18549481 ↗ IPI · BHF-UCL · 20110428
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q5HZG4"}]}]
ECO:0000353 PMID:19505873 ↗ IPI · UniProt · 20210708
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q01664"}]}]
ECO:0000353 PMID:23329847 ↗ IPI · ARUK-UCL · 20210917
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q96BR9"}]}]

14-3-3 protein bindingenablesUniProtKB:P04637

GO:0071889 · evidence & context

ECO:0000269 PMID:20206173 ↗ EXP · DisProt · 20220614
qualifier: enables

MDM2/MDM4 family protein bindingenablesUniProtKB:P04637

GO:0097371 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

disordered domain specific bindingenablesUniProtKB:P04637

GO:0097718 · evidence & context

ECO:0000353 PMID:15629713 ↗ IPI · CAFA · 20161209
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q16665"}]}]

general transcription initiation factor bindingenablesUniProtKB:P04637

GO:0140296 · evidence & context

ECO:0000353 PMID:15053879 ↗ IPI · BHF-UCL · 20210429
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P21675"}]}]

molecular function activator activityenablesUniProtKB:P04637

GO:0140677 · evidence & context

ECO:0000269 PMID:14759370 ↗ EXP · DisProt · 20220214
qualifier: enables
ECO:0000269 PMID:16793543 ↗ EXP · DisProt · 20220214
qualifier: enables
ECO:0000353 PMID:7559631 ↗ IPI · DisProt · 20220308
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P20226"}]}]

molecular condensate scaffold activityenablesUniProtKB:P04637

GO:0140693 · evidence & context

ECO:0000314 PMID:31953488 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:35618207 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:36108750 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:36634798 ↗ IDA · UniProt · 20240530
qualifier: enables
ECO:0000314 PMID:38653238 ↗ IDA · UniProt · 20240530
qualifier: enables

promoter-specific chromatin bindingenablesUniProtKB:P04637

GO:1990841 · evidence & context

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20260528
qualifier: enables
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P07193"}]}]
ECO:0000314 PMID:24356969 ↗ IDA · UniProt · 20180305
qualifier: enables
ECO:0000314 PMID:24652652 ↗ IDA · UniProt · 20250519
qualifier: enables

promoter-specific chromatin bindingenablesUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1990841 · evidence & context

ECO:0000314 PMID:20725088 ↗ IDA · UniProt · 20181008
qualifier: enables
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "O75677", "relation": "has_input"}, {"db": "CL", "id": "0000066", "relation": "occurs_in"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P38936", "relation": "has_input"}, {"db": "CL", "id": "0000066", "relation": "occurs_in"}]}]

negative regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0000122 · evidence & context

ECO:0000314 PMID:10329733 ↗ IDA · ARUK-UCL · 20210810
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10415", "relation": "has_input"}]}]

negative regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637

GO:0000122 · evidence & context

ECO:0000250 PMID:19749791 ↗ ISS · BHF-UCL · 20101001
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]

hematopoietic progenitor cell differentiationinvolved inUniProtKB:P04637

GO:0002244 · evidence & context

ECO:0000315 PMID:30146126 ↗ IMP · UniProt · 20190403
qualifier: involved_in

nucleotide-excision repairinvolved inUniProtKB:P04637

GO:0006289 · evidence & context

ECO:0000315 PMID:7663514 ↗ IMP · UniProt · 20040706
qualifier: involved_in

regulation of DNA-templated transcriptioninvolved inUniProtKB:P04637

GO:0006355 · evidence & context

ECO:0000256 GO_REF:0000002 IEA · InterPro · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "InterPro", "id": "IPR002117"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR008967"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR012346"}]}]
ECO:0000315 PMID:25417702 ↗ IMP · CAFA · 20161216
qualifier: involved_in
ECO:0000314 PMID:7587074 ↗ IDA · UniProt · 20040608
qualifier: involved_in

regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0006357 · evidence & context

ECO:0000314 PMID:30089260 ↗ IDA · ARUK-UCL · 20230714
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07954", "relation": "has_input"}, {"db": "GO", "id": "0006974", "relation": "part_of"}]}]

autophagyinvolved inUniProtKB:P04637

GO:0006914 · evidence & context

ECO:0000315 PMID:23629966 ↗ IMP · CAFA · 20161108
qualifier: involved_in

apoptotic processinvolved inUniProtKB:P04637

GO:0006915 · evidence & context

ECO:0000256 GO_REF:0000002 IEA · InterPro · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "InterPro", "id": "IPR002117"}]}]

DNA damage responseinvolved inUniProtKB:P04637

GO:0006974 · evidence & context

ECO:0000314 PMID:15710329 ↗ IDA · BHF-UCL · 20111212
qualifier: involved_in
ECO:0000314 PMID:17938203 ↗ IDA · UniProt · 20140815
qualifier: involved_in
ECO:0000315 PMID:24356969 ↗ IMP · UniProt · 20180305
qualifier: involved_in
ECO:0000314 PMID:30089260 ↗ IDA · ARUK-UCL · 20230714
qualifier: involved_in

response to oxidative stressinvolved inUniProtKB:P04637

GO:0006979 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00026273"}]}]

Ras protein signal transductioninvolved inUniProtKB:P04637

GO:0007265 · evidence & context

ECO:0000270 PMID:9054499 ↗ IEP · BHF-UCL · 20091126
qualifier: involved_in

circadian rhythminvolved inUniProtKB:P04637

GO:0007623 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

intracellular protein localizationinvolved inUniProtKB:P04637

GO:0008104 · evidence & context

ECO:0000314 PMID:16507995 ↗ IDA · UniProt · 20061013
qualifier: involved_in

negative regulation of cell population proliferationinvolved inUniProtKB:P04637

GO:0008285 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · BHF-UCL · 20110204
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000315 PMID:12730672 ↗ IMP · AgBase · 20150504
qualifier: involved_in
ECO:0000314 PMID:22783376 ↗ IDA · CACAO · 20130411
qualifier: involved_in

determination of adult lifespaninvolved inUniProtKB:P04637

GO:0008340 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · BHF-UCL · 20110204
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

mRNA transcriptioninvolved inUniProtKB:P04637

GO:0009299 · evidence & context

ECO:0000315 PMID:16479015 ↗ IMP · UniProt · 20170718
qualifier: involved_in

response to xenobiotic stimulusinvolved inUniProtKB:P04637

GO:0009410 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00092608"}]}]

response to UVinvolved inUniProtKB:P04637

GO:0009411 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00028103"}]}]

response to ionizing radiationinvolved inUniProtKB:P04637

GO:0010212 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00090590"}]}]

response to gamma radiationinvolved inUniProtKB:P04637

GO:0010332 · evidence & context

ECO:0000315 PMID:7958916 ↗ IMP · BHF-UCL · 20091118
qualifier: involved_in

positive regulation of gene expressioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0010628 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · ARUK-UCL · 20250119
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10361"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0010012", "relation": "occurs_in"}, {"db": "UniProtKB", "id": "P01100", "relation": "has_input"}]}, {"connectedXrefs": [{"db": "CL", "id": "0010012", "relation": "occurs_in"}, {"db": "UniProtKB", "id": "P18146", "relation": "has_input"}]}, {"connectedXrefs": [{"db": "CL", "id": "0010012", "relation": "occurs_in"}, {"db": "UniProtKB", "id": "O94907", "relation": "has_input"}]}]

positive regulation of gene expressioninvolved inUniProtKB:P04637

GO:0010628 · evidence & context

ECO:0000314 PMID:15314173 ↗ IDA · CAFA · 20170125
qualifier: involved_in
ECO:0000315 PMID:19160485 ↗ IMP · CAFA · 20170125
qualifier: involved_in

positive regulation of gene expressioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0010628 · evidence & context

ECO:0000314 PMID:20332243 ↗ IDA · BHF-UCL · 20210108
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS00004F4657_9606", "relation": "has_input"}]}]

positive regulation of gene expressioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0010628 · evidence & context

ECO:0000314 PMID:26100857 ↗ IDA · BHF-UCL · 20220905
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS000033F823_9606", "relation": "has_input"}]}]

viral processinvolved inUniProtKB:P04637

GO:0016032 · evidence & context

ECO:0000315 PMID:22574148 ↗ IMP · CACAO · 20130222
qualifier: involved_in

negative regulation of cell growthinvolved inUniProtKB:P04637

GO:0030308 · evidence & context

ECO:0000315 PMID:8986812 ↗ IMP · UniProt · 20040610
qualifier: involved_in

DNA damage response, signal transduction by p53 class mediatorinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0030330 · evidence & context

ECO:0000314 PMID:15149599 ↗ IDA · BHF-UCL · 20241126
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0031571", "relation": "causally_upstream_of"}]}]

DNA damage response, signal transduction by p53 class mediatorinvolved inUniProtKB:P04637

GO:0030330 · evidence & context

ECO:0000314 PMID:16213212 ↗ IDA · CAFA · 20170125
qualifier: involved_in
ECO:0000315 PMID:16213212 ↗ IMP · CAFA · 20170125
qualifier: involved_in
ECO:0000315 PMID:16479015 ↗ IMP · UniProt · 20170718
qualifier: involved_in
ECO:0000315 PMID:20160708 ↗ IMP · BHF-UCL · 20101021
qualifier: involved_in
ECO:0000314 PMID:29681526 ↗ IDA · UniProt · 20250211
qualifier: involved_in
ECO:0000315 PMID:7958916 ↗ IMP · BHF-UCL · 20231018
qualifier: involved_in

mitotic G1 DNA damage checkpoint signalinginvolved inUniProtKB:P04637

GO:0031571 · evidence & context

ECO:0000315 PMID:7958916 ↗ IMP · BHF-UCL · 20091118
qualifier: involved_in

negative regulation of telomere maintenance via telomeraseinvolved inUniProtKB:P04637

GO:0032211 · evidence & context

ECO:0000314 PMID:10597287 ↗ IDA · BHF-UCL · 20231018
qualifier: involved_in

tumor necrosis factor-mediated signaling pathwayinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0033209 · evidence & context

ECO:0000316 PMID:22499991 ↗ IGI · BHF-UCL · 20200221
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P01375"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "2000008", "relation": "occurs_in"}, {"db": "UBERON", "id": "0002067", "relation": "occurs_in"}]}]

cellular response to UVinvolved inUniProtKB:P04637

GO:0034644 · evidence & context

ECO:0000314 PMID:16213212 ↗ IDA · CAFA · 20170125
qualifier: involved_in

cellular response to glucose starvationinvolved inUniProtKB:P04637

GO:0042149 · evidence & context

ECO:0000314 PMID:21471221 ↗ IDA · UniProt · 20110830
qualifier: involved_in

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorinvolved inUniProtKB:P04637

GO:0042771 · evidence & context

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20260528
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000154790"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "ZFIN", "id": "ZDB-GENE-990415-270"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000315 PMID:16213212 ↗ IMP · CAFA · 20170125
qualifier: involved_in
ECO:0000314 PMID:17403783 ↗ IDA · UniProt · 20101105
qualifier: involved_in

regulation of apoptotic processinvolved inUniProtKB:P04637

GO:0042981 · evidence & context

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20260528
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1336991"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "RGD", "id": "1307083"}]}, {"connectedXrefs": [{"db": "RGD", "id": "3889"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P10360"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}, {"connectedXrefs": [{"db": "ZFIN", "id": "ZDB-GENE-990415-270"}]}]

positive regulation of apoptotic processinvolved inUniProtKB:P04637

GO:0043065 · evidence & context

ECO:0000314 PMID:12667443 ↗ IDA · UniProt · 20191112
qualifier: involved_in
ECO:0000314 PMID:15565177 ↗ IDA · UniProt · 20170714
qualifier: involved_in
ECO:0000314 PMID:20959462 ↗ IDA · UniProt · 20111116
qualifier: involved_in

negative regulation of apoptotic processinvolved inUniProtKB:P04637

GO:0043066 · evidence & context

ECO:0000316 PMID:12203124 ↗ IGI · BHF-UCL · 20200923
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17208"}]}]
ECO:0000316 PMID:12433990 ↗ IGI · BHF-UCL · 20200923
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17208"}]}]
ECO:0000315 PMID:20124405 ↗ IMP · CACAO · 20130313
qualifier: involved_in

entrainment of circadian clock by photoperiodinvolved inUniProtKB:P04637

GO:0043153 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · UniProt · 20141216
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

transcription initiation-coupled chromatin remodelinginvolved inUniProtKB:P04637

GO:0045815 · evidence & context

ECO:0000314 PMID:16322561 ↗ IDA · GO_Central · 20220623
qualifier: involved_in

negative regulation of DNA-templated transcriptioninvolved inUniProtKB:P04637

GO:0045892 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0005547 PMID:16492744 ↗ NAS · ComplexPortal · 20251229
qualifier: involved_in
ECO:0000315 PMID:23629966 ↗ IMP · CAFA · 20161108
qualifier: involved_in
ECO:0000314 PMID:24051492 ↗ IDA · UniProt · 20141216
qualifier: involved_in
ECO:0000314 PMID:9271120 ↗ IDA · ComplexPortal · 20251229
qualifier: involved_in

positive regulation of DNA-templated transcriptioninvolved inUniProtKB:P04637

GO:0045893 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00029082"}]}]
ECO:0000314 PMID:16322561 ↗ IDA · UniProt · 20111107
qualifier: involved_in
ECO:0000314 PMID:17403783 ↗ IDA · UniProt · 20101105
qualifier: involved_in
ECO:0000315 PMID:20096447 ↗ IMP · UniProt · 20100219
qualifier: involved_in
ECO:0000314 PMID:20378837 ↗ IDA · CACAO · 20130414
qualifier: involved_in

positive regulation of RNA polymerase II transcription preinitiation complex assemblyinvolved inUniProtKB:P04637

GO:0045899 · evidence & context

ECO:0000314 PMID:24289924 ↗ IDA · BHF-UCL · 20200504
qualifier: involved_in

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0045944 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · ParkinsonsUK-UCL · 20231018
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9BXH1", "relation": "has_input"}, {"db": "GO", "id": "0070059", "relation": "part_of"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q13794", "relation": "has_input"}, {"db": "GO", "id": "0070059", "relation": "part_of"}]}]

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637

GO:0045944 · evidence & context

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20250902
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "RGD", "id": "3889"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P07193"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q29537"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}]
ECO:0000314 PMID:11672523 ↗ IDA · BHF-UCL · 20200504
qualifier: involved_in
ECO:0000314 PMID:17310983 ↗ IDA · CAFA · 20170125
qualifier: involved_in
ECO:0000314 PMID:18549481 ↗ IDA · BHF-UCL · 20200504
qualifier: involved_in
ECO:0000314 PMID:20959462 ↗ IDA · UniProt · 20111116
qualifier: involved_in
ECO:0000315 PMID:24356969 ↗ IMP · UniProt · 20180305
qualifier: involved_in
ECO:0000314 PMID:24652652 ↗ IDA · UniProt · 20141210
qualifier: involved_in

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0045944 · evidence & context

ECO:0000314 PMID:17145718 ↗ IDA · ARUK-UCL · 20200504
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07812", "relation": "has_input"}]}]

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0045944 · evidence & context

ECO:0000315 PMID:17146433 ↗ IMP · BHF-UCL · 20200504
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H4X1", "relation": "has_input"}]}]

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0045944 · evidence & context

ECO:0000314 PMID:30089260 ↗ IDA · ARUK-UCL · 20231018
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07954", "relation": "has_input"}, {"db": "GO", "id": "0006974", "relation": "part_of"}]}]

positive regulation of transcription by RNA polymerase IIinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0045944 · evidence & context

ECO:0000315 PMID:7958916 ↗ IMP · BHF-UCL · 20231018
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P38936", "relation": "has_input"}]}]

response to antibioticinvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0046677 · evidence & context

ECO:0000270 PMID:20810912 ↗ IEP · UniProt · 20140815
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "occurs_in"}]}]

negative regulation of fibroblast proliferationinvolved inUniProtKB:P04637

GO:0048147 · evidence & context

ECO:0000315 PMID:10962037 ↗ IMP · UniProt · 20111117
qualifier: involved_in

circadian behaviorinvolved inUniProtKB:P04637

GO:0048512 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · UniProt · 20141216
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

bone marrow developmentinvolved inUniProtKB:P04637

GO:0048539 · evidence & context

ECO:0000315 PMID:30146126 ↗ IMP · UniProt · 20190314
qualifier: involved_in

negative regulation of DNA metabolic processinvolved inUniProtKB:P04637

GO:0051053 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00088036"}]}]

negative regulation of helicase activityinvolved inUniProtKB:P04637

GO:0051097 · evidence & context

ECO:0000304 PMID:7663514 ↗ TAS · UniProt · 20040805
qualifier: involved_in

protein tetramerizationinvolved inUniProtKB:P04637

GO:0051262 · evidence & context

ECO:0000256 GO_REF:0000002 IEA · InterPro · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "InterPro", "id": "IPR010991"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR036674"}]}]

regulation of cell cycleinvolved inUniProtKB:P04637

GO:0051726 · evidence & context

ECO:0000316 PMID:12203124 ↗ IGI · BHF-UCL · 20210812
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17208"}]}]
ECO:0000316 PMID:12433990 ↗ IGI · BHF-UCL · 20210812
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P17208"}]}]
ECO:0000314 PMID:15149599 ↗ IDA · BHF-UCL · 20210812
qualifier: involved_in
ECO:0000315 PMID:7958916 ↗ IMP · BHF-UCL · 20210812
qualifier: involved_in

hematopoietic stem cell differentiationinvolved inUniProtKB:P04637

GO:0060218 · evidence & context

ECO:0000315 PMID:30146126 ↗ IMP · UniProt · 20190403
qualifier: involved_in

type II interferon-mediated signaling pathwayinvolved inUniProtKB:P04637

GO:0060333 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

positive regulation of programmed necrotic cell deathinvolved inUniProtKB:P04637

GO:0062100 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

protein-containing complex assemblyinvolved inUniProtKB:P04637

GO:0065003 · evidence & context

ECO:0000314 PMID:12915590 ↗ IDA · UniProt · 20060110
qualifier: involved_in

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressinvolved inUniProtKB:P04637

GO:0070059 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

positive regulation of thymocyte apoptotic processinvolved inUniProtKB:P04637

GO:0070245 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · BHF-UCL · 20110204
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

cellular response to hypoxiainvolved inUniProtKB:P04637

GO:0071456 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00092776"}]}]

cellular response to hypoxiainvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:0071456 · evidence & context

ECO:0000270 PMID:20810912 ↗ IEP · UniProt · 20140815
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "occurs_in"}]}]

cellular response to xenobiotic stimulusinvolved inUniProtKB:P04637

GO:0071466 · evidence & context

ECO:0000270 PMID:20810912 ↗ IEP · UniProt · 20110323
qualifier: involved_in

cellular response to ionizing radiationinvolved inUniProtKB:P04637

GO:0071479 · evidence & context

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000315 PMID:20160708 ↗ IMP · BHF-UCL · 20101021
qualifier: involved_in

cellular response to gamma radiationinvolved inUniProtKB:P04637

GO:0071480 · evidence & context

ECO:0000314 PMID:16213212 ↗ IDA · CAFA · 20170125
qualifier: involved_in

signal transduction by p53 class mediatorinvolved inUniProtKB:P04637

GO:0072331 · evidence & context

ECO:0000314 PMID:15314173 ↗ IDA · CAFA · 20170125
qualifier: involved_in
ECO:0000314 PMID:18549481 ↗ IDA · BHF-UCL · 20250216
qualifier: involved_in
ECO:0000314 PMID:25384516 ↗ IDA · UniProt · 20250519
qualifier: involved_in
ECO:0000314 PMID:29681526 ↗ IDA · UniProt · 20230530
qualifier: involved_in

intrinsic apoptotic signaling pathway by p53 class mediatorinvolved inUniProtKB:P04637

GO:0072332 · evidence & context

ECO:0000315 PMID:12172011 ↗ IMP · BHF-UCL · 20110428
qualifier: involved_in
ECO:0000315 PMID:16322561 ↗ IMP · UniProt · 20130617
qualifier: involved_in
ECO:0000315 PMID:17310983 ↗ IMP · CAFA · 20170125
qualifier: involved_in

cellular response to actinomycin Dinvolved inUniProtKB:P04637

GO:0072717 · evidence & context

ECO:0000314 PMID:15314173 ↗ IDA · CAFA · 20170125
qualifier: involved_in

positive regulation of release of cytochrome c from mitochondriainvolved inUniProtKB:P04637

GO:0090200 · evidence & context

ECO:0000314 PMID:14963330 ↗ IDA · UniProt · 20140815
qualifier: involved_in

cellular senescenceinvolved inUniProtKB:P04637

GO:0090398 · evidence & context

ECO:0000315 PMID:12080348 ↗ IMP · GO_Central · 20220201
qualifier: involved_in

replicative senescenceinvolved inUniProtKB:P04637

GO:0090399 · evidence & context

ECO:0000315 PMID:19951988 ↗ IMP · BHF-UCL · 20110110
qualifier: involved_in

oxidative stress-induced premature senescenceinvolved inUniProtKB:P04637

GO:0090403 · evidence & context

ECO:0000315 PMID:19951988 ↗ IMP · BHF-UCL · 20110110
qualifier: involved_in

apoptotic signaling pathwayinvolved inUniProtKB:P04637

GO:0097190 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00028296"}]}]

intrinsic apoptotic signaling pathwayinvolved inUniProtKB:P04637

GO:0097193 · evidence & context

ECO:0000304 PMID:16462759 ↗ TAS · HGNC-UCL · 20070316
qualifier: involved_in

oligodendrocyte apoptotic processinvolved inUniProtKB:P04637

GO:0097252 · evidence & context

ECO:0000314 PMID:7720704 ↗ IDA · UniProt · 20130503
qualifier: involved_in

positive regulation of execution phase of apoptosisinvolved inUniProtKB:P04637

GO:1900119 · evidence & context

ECO:0000315 PMID:14985081 ↗ IMP · AgBase · 20150310
qualifier: involved_in

positive regulation of miRNA transcriptioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000314 PMID:20546595 ↗ IDA · BHF-UCL · 20210108
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0002548", "relation": "occurs_in"}, {"db": "RNAcentral", "id": "URS00000AF93C_9606", "relation": "has_input"}]}]

positive regulation of miRNA transcriptioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000316 PMID:22499991 ↗ IGI · BHF-UCL · 20210107
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P01375"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "2000008", "relation": "occurs_in"}, {"db": "UBERON", "id": "0002067", "relation": "occurs_in"}, {"db": "GO", "id": "0033209", "relation": "part_of"}, {"db": "RNAcentral", "id": "URS000014D9C1_9606", "relation": "has_output"}, {"db": "RNAcentral", "id": "URS000075C8DF_9606", "relation": "has_input"}]}]

positive regulation of miRNA transcriptioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000316 PMID:22499991 ↗ IGI · BHF-UCL · 20210107
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P01375"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "2000008", "relation": "occurs_in"}, {"db": "UBERON", "id": "0002067", "relation": "occurs_in"}, {"db": "GO", "id": "0033209", "relation": "part_of"}, {"db": "RNAcentral", "id": "URS000075A884_9606", "relation": "has_output"}]}]

positive regulation of miRNA transcriptioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000316 PMID:22499991 ↗ IGI · BHF-UCL · 20210107
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P01375"}]}]
extensions: [{"connectedXrefs": [{"db": "CL", "id": "2000008", "relation": "occurs_in"}, {"db": "UBERON", "id": "0002067", "relation": "occurs_in"}, {"db": "GO", "id": "0033209", "relation": "part_of"}, {"db": "RNAcentral", "id": "URS000075B715_9606", "relation": "has_output"}]}]

positive regulation of miRNA transcriptioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1902895 · evidence & context

ECO:0000315 PMID:22578566 ↗ IMP · ARUK-UCL · 20211122
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "RNAcentral", "id": "URS0000446722_9606", "relation": "has_input"}]}]

negative regulation of G1 to G0 transitioninvolved inUniProtKB:P04637

GO:1903451 · evidence & context

ECO:0000314 PMID:15314173 ↗ IDA · CAFA · 20210803
qualifier: involved_in

negative regulation of G1 to G0 transitioninvolved inUniProtKB:P04637 · Context-qualified assertion; see evidence

GO:1903451 · evidence & context

ECO:0000315 PMID:21471221 ↗ IMP · UniProt · 20210803
qualifier: involved_in
extensions: [{"connectedXrefs": [{"db": "GO", "id": "0042149", "relation": "part_of"}]}]

negative regulation of pentose-phosphate shuntinvolved inUniProtKB:P04637

GO:1905856 · evidence & context

ECO:0000315 PMID:21336310 ↗ IMP · CACAO · 20180417
qualifier: involved_in

positive regulation of reactive oxygen species metabolic processinvolved inUniProtKB:P04637

GO:2000379 · evidence & context

ECO:0000315 PMID:20160708 ↗ IMP · BHF-UCL · 20110323
qualifier: involved_in

positive regulation of cellular senescenceinvolved inUniProtKB:P04637

GO:2000774 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · BHF-UCL · 20220223
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}]
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000314 PMID:29474172 ↗ IDA · UniProt · 20220301
qualifier: involved_in

regulation of intrinsic apoptotic signaling pathwayinvolved inUniProtKB:P04637

GO:2001242 · evidence & context

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00087888"}]}]

positive regulation of intrinsic apoptotic signaling pathwayinvolved inUniProtKB:P04637

GO:2001244 · evidence & context

ECO:0000250 GO_REF:0000024 ISS · UniProt · 20190131
qualifier: involved_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P10361"}]}]
ECO:0000315 PMID:14963330 ↗ IMP · UniProt · 20140815
qualifier: involved_in
ECO:0000315 PMID:27031958 ↗ IMP · UniProt · 20190117
qualifier: involved_in

Names & Taxonomy

Recommended name: Cellular tumor antigen p53
Gene: TP53
Accession / entry: P04637 · P53_HUMAN
Species: Homo sapiens · NCBI 9606
Recorded aliases: Antigen NY-CO-13 · P53 · Phosphoprotein p53 · Tumor suppressor p53

Full taxonomy & recorded names

Eukaryota → Metazoa → Chordata → Craniata → Vertebrata → Euteleostomi → Mammalia → Eutheria → Euarchontoglires → Primates → Haplorrhini → Catarrhini → Hominidae → Homo

{
  "names": {
    "recommendedName": {
      "fullName": {
        "value": "Cellular tumor antigen p53"
      }
    },
    "alternativeNames": [
      {
        "fullName": {
          "value": "Antigen NY-CO-13"
        }
      },
      {
        "fullName": {
          "value": "Phosphoprotein p53"
        }
      },
      {
        "fullName": {
          "value": "Tumor suppressor p53"
        }
      }
    ]
  },
  "genes": [
    {
      "geneName": {
        "value": "TP53"
      },
      "synonyms": [
        {
          "value": "P53"
        }
      ]
    }
  ]
}

Subcellular Location

UniProt locations and GO cellular-component assertions. Relations and contexts remain distinct; “part of” is not automatically a residence claim.

CytoplasmReported location

Recruited into PML bodies together with CHEK2 ^[63]. Translocates to mitochondria upon oxidative stress ^[144]. Translocates to mitochondria in response to mitomycin C treatment ^[160]. Competitive inhibition of TP53 interaction with HSPA9/MOT-2 by UBXN2A results in increased protein abundance and subsequent translocation of TP53 to the nucleus ^[151]

UniProt

Experimental evidence 9 publications

Evidence & references

ECO:0000269 PubMed:15340061 ↗
ECO:0000269 PubMed:17170702 ↗
ECO:0000269 PubMed:19011621 ↗
ECO:0000269 PubMed:19033443 ↗
ECO:0000269 PubMed:21597459 ↗
ECO:0000269 PubMed:22726440 ↗
ECO:0000269 PubMed:22914926 ↗
ECO:0000269 PubMed:24625977 ↗
ECO:0000269 PubMed:26634371 ↗

NucleusReported location

UniProt

Experimental evidence 9 publications

Evidence & references

ECO:0000269 PubMed:15340061 ↗
ECO:0000269 PubMed:17170702 ↗
ECO:0000269 PubMed:17591690 ↗
ECO:0000269 PubMed:18206965 ↗
ECO:0000269 PubMed:19011621 ↗
ECO:0000269 PubMed:21597459 ↗
ECO:0000269 PubMed:22914926 ↗
ECO:0000269 PubMed:24625977 ↗
ECO:0000269 PubMed:26634371 ↗

Nucleus, PML bodyReported location

UniProt

Experimental evidence 3 publications

Evidence & references

ECO:0000269 PubMed:11025664 ↗
ECO:0000269 PubMed:12810724 ↗
ECO:0000269 PubMed:36108750 ↗

Endoplasmic reticulumReported location

UniProt

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:17170702 ↗

Mitochondrion matrixReported location

UniProt

Experimental evidence 3 publications

Evidence & references

ECO:0000269 PubMed:22726440 ↗
ECO:0000269 PubMed:25168243 ↗
ECO:0000269 PubMed:27323408 ↗

Cytoplasm, cytoskeleton, microtubule organizing center, centrosomeReported location

UniProt

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:28842590 ↗

NucleusReported location

Isoform 1

Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4

UniProt

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:23752197 ↗

CytoplasmReported location

Isoform 1

Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

All recorded location assertions (44)

NucleusReported location

Isoform 2

Localized mainly in the nucleus with minor staining in the cytoplasm

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 2

Localized mainly in the nucleus with minor staining in the cytoplasm

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

NucleusReported location

Isoform 3

Localized in the nucleus in most cells but found in the cytoplasm in some cells

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 3

Localized in the nucleus in most cells but found in the cytoplasm in some cells

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

NucleusReported location

Isoform 4

Predominantly nuclear but translocates to the cytoplasm following cell stress

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 4

Predominantly nuclear but translocates to the cytoplasm following cell stress

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

NucleusReported location

Isoform 7

Localized mainly in the nucleus with minor staining in the cytoplasm

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 7

Localized mainly in the nucleus with minor staining in the cytoplasm

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

NucleusReported location

Isoform 8

Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 8

Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

CytoplasmReported location

Isoform 9

UniProt

Evidence & references

No separate evidence record is supplied for this statement.

nuclear bodycolocalizes with

1 publication

Evidence & references

ECO:0000314 PMID:10360174 ↗ IDA · BHF-UCL · 20091211
qualifier: colocalizes_with

chromatinis active in

Evidence & references

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20250408
qualifier: is_active_in
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "RGD", "id": "1307083"}]}, {"connectedXrefs": [{"db": "RGD", "id": "3889"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}, {"connectedXrefs": [{"db": "ZFIN", "id": "ZDB-GENE-990415-270"}]}]

nucleusis active in

1 publication

Evidence & references

ECO:0000318 GO_REF:0000033 IBA · GO_Central · 20250902
qualifier: is_active_in
withFrom: [{"connectedXrefs": [{"db": "FB", "id": "FBgn0039044"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1330810"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:1336991"}]}, {"connectedXrefs": [{"db": "MGI", "id": "MGI:98834"}]}, {"connectedXrefs": [{"db": "PANTHER", "id": "PTN000893833"}]}, {"connectedXrefs": [{"db": "RGD", "id": "3889"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "O15350"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P04637"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "P10360"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q9H3D4"}]}, {"connectedXrefs": [{"db": "UniProtKB", "id": "Q9TUB2"}]}]
ECO:0000314 PMID:36108750 ↗ IDA · UniProt · 20240530
qualifier: is_active_in

chromatinlocated in

4 publications

Evidence & references

ECO:0005556 GO_REF:0000113 ISA · NTNU_SB · 20190405
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "tfclass", "id": "6.3.1"}]}]
ECO:0000314 PMID:15710329 ↗ IDA · BHF-UCL · 20111212
qualifier: located_in
ECO:0000314 PMID:17805299 ↗ IDA · BHF-UCL · 20110427
qualifier: located_in
ECO:0000314 PMID:22521434 ↗ IDA · BHF-UCL · 20121127
qualifier: located_in
ECO:0000314 PMID:23629966 ↗ IDA · CAFA · 20161108
qualifier: located_in

chromatinlocated in

UniProtKB:P04637 · [{"connectedXrefs": [{"db": "SO", "id": "0001668", "relation": "coincident_with"}, {"db": "GO", "id": "0034644", "relation": "existence_overlaps"}]}]

1 publication

Evidence & references

ECO:0000314 PMID:24289924 ↗ IDA · ARUK-UCL · 20210107
qualifier: located_in
extensions: [{"connectedXrefs": [{"db": "SO", "id": "0001668", "relation": "coincident_with"}, {"db": "GO", "id": "0034644", "relation": "existence_overlaps"}]}]

chromatinlocated in

UniProtKB:P04637 · [{"connectedXrefs": [{"db": "SO", "id": "0000167", "relation": "coincident_with"}]}]

1 publication

Evidence & references

ECO:0000315 PMID:30089260 ↗ IMP · ARUK-UCL · 20210107
qualifier: located_in
extensions: [{"connectedXrefs": [{"db": "SO", "id": "0000167", "relation": "coincident_with"}]}]

nucleuslocated in

Experimental evidence 22 publications

Evidence & references

ECO:0000501 GO_REF:0000120 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR002117"}]}, {"connectedXrefs": [{"db": "InterPro", "id": "IPR012346"}]}, {"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0191"}]}]
ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: located_in
ECO:0000314 PMID:14963330 ↗ IDA · UniProt · 20120213
qualifier: located_in
ECO:0000269 PMID:15340061 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:16322561 ↗ IDA · UniProt · 20111107
qualifier: located_in
ECO:0000315 PMID:16479015 ↗ IMP · UniProt · 20170719
qualifier: located_in
ECO:0000314 PMID:16507995 ↗ IDA · UniProt · 20061013
qualifier: located_in
ECO:0000269 PMID:17170702 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:17403783 ↗ IDA · UniProt · 20101105
qualifier: located_in
ECO:0000269 PMID:17591690 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000269 PMID:18206965 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:18756595 ↗ IDA · BHF-UCL · 20091118
qualifier: located_in
ECO:0000314 PMID:19011621 ↗ IDA · UniProt · 20190221
qualifier: located_in
ECO:0000314 PMID:19234109 ↗ IDA · UniProt · 20110616
qualifier: located_in
ECO:0000314 PMID:20096447 ↗ IDA · UniProt · 20100219
qualifier: located_in
ECO:0000314 PMID:21597459 ↗ IDA · UniProt · 20200922
qualifier: located_in
ECO:0000314 PMID:22914926 ↗ IDA · UniProt · 20260102
qualifier: located_in
ECO:0000269 PMID:23752197 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:24101517 ↗ IDA · MGI · 20140915
qualifier: located_in
ECO:0000314 PMID:24289924 ↗ IDA · ParkinsonsUK-UCL · 20160928
qualifier: located_in
ECO:0000314 PMID:24625977 ↗ IDA · UniProt · 20230927
qualifier: located_in
ECO:0000314 PMID:26634371 ↗ IDA · UniProt · 20230927
qualifier: located_in
ECO:0000314 PMID:7720704 ↗ IDA · UniProt · 20040609
qualifier: located_in

nucleuslocated in

UniProtKB:P04637 · [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "part_of"}]}]

1 publication

Evidence & references

ECO:0000314 PMID:20810912 ↗ IDA · UniProt · 20140815
qualifier: located_in
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "part_of"}]}]

nucleoplasmlocated in

2 publications

Evidence & references

ECO:0000314 GO_REF:0000052 IDA · HPA · 20251115
qualifier: located_in
ECO:0000314 PMID:11080164 ↗ IDA · UniProt · 20060112
qualifier: located_in
ECO:0000314 PMID:12915590 ↗ IDA · UniProt · 20060109
qualifier: located_in
ECO:0000304 Reactome:R-HSA-264435 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-2997706 TAS · Reactome · 20220118
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3215152 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3215251 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3215310 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3221982 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222006 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222020 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222093 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222116 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222128 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222237 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3222259 TAS · Reactome · 20130528
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3239014 TAS · Reactome · 20130528
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3700981 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3700997 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-3786258 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-4331331 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-4331340 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-4395236 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-4647593 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5628871 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5628899 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5629187 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5632759 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5632887 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5632914 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5632939 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5633295 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5633414 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5633460 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5689950 TAS · Reactome · 20160519
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5689973 TAS · Reactome · 20160519
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5693609 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6789960 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791285 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791302 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791327 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791349 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791387 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6791409 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6793685 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6796649 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6797766 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6797993 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798020 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798082 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798129 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798138 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798282 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798304 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798374 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6798615 TAS · Reactome · 20150919
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799246 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799332 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799409 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799418 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799431 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799462 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799761 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799777 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6799815 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6800042 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6800253 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6800279 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6800836 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6801087 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6801166 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6801209 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6801355 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6801641 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6802165 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803391 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803425 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803719 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803801 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803858 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803914 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6803935 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804188 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804191 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804242 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804379 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804383 TAS · Reactome · 20151009
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804402 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804425 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804441 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804762 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804879 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804996 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6804998 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805035 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805059 TAS · Reactome · 20151017
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805103 TAS · Reactome · 20151017
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805109 TAS · Reactome · 20151017
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805122 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805126 TAS · Reactome · 20151018
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805276 TAS · Reactome · 20151019
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805285 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805399 TAS · Reactome · 20151019
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805470 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805479 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805620 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805638 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805730 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805740 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6805755 TAS · Reactome · 20151021
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6806408 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6806412 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6806413 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6806417 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6806419 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6811479 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6811508 TAS · Reactome · 20151020
qualifier: located_in
ECO:0000304 Reactome:R-HSA-69685 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8852337 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8852351 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8853911 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8952128 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9710323 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9723906 TAS · Reactome · 20210512
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9749464 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9836362 TAS · Reactome · 20230526
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9851076 TAS · Reactome · 20150929
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9851077 TAS · Reactome · 20151016
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9959857 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9959860 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-HSA-9959863 TAS · Reactome · 20130503
qualifier: located_in
ECO:0000304 Reactome:R-NUL-992753 TAS · Reactome · 20130503
qualifier: located_in

replication forklocated in

Evidence & references

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

nucleoluslocated in

1 publication

Evidence & references

ECO:0000314 PMID:12080348 ↗ IDA · UniProt · 20040608
qualifier: located_in

cytoplasmlocated in

Experimental evidence 14 publications

Evidence & references

ECO:0000501 GO_REF:0000120 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}, {"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0086"}]}]
ECO:0000314 PMID:14744935 ↗ IDA · MGI · 20101109
qualifier: located_in
ECO:0000269 PMID:15340061 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:16131611 ↗ IDA · UniProt · 20110228
qualifier: located_in
ECO:0000315 PMID:16479015 ↗ IMP · UniProt · 20170719
qualifier: located_in
ECO:0000269 PMID:17170702 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:19011621 ↗ IDA · UniProt · 20190221
qualifier: located_in
ECO:0000269 PMID:19033443 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:20096447 ↗ IDA · UniProt · 20100219
qualifier: located_in
ECO:0000314 PMID:21597459 ↗ IDA · UniProt · 20200922
qualifier: located_in
ECO:0000269 PMID:22726440 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000314 PMID:23629966 ↗ IDA · CAFA · 20161108
qualifier: located_in
ECO:0000314 PMID:24625977 ↗ IDA · UniProt · 20230927
qualifier: located_in
ECO:0000314 PMID:26634371 ↗ IDA · UniProt · 20230927
qualifier: located_in
ECO:0000314 PMID:7720704 ↗ IDA · UniProt · 20040609
qualifier: located_in

cytoplasmlocated in

UniProtKB:P04637 · [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "part_of"}]}]

1 publication

Evidence & references

ECO:0000314 PMID:20810912 ↗ IDA · UniProt · 20140815
qualifier: located_in
extensions: [{"connectedXrefs": [{"db": "CL", "id": "0000525", "relation": "part_of"}]}]

mitochondrionlocated in

3 publications

Evidence & references

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000314 PMID:12667443 ↗ IDA · UniProt · 20040614
qualifier: located_in
ECO:0000314 PMID:24101517 ↗ IDA · MGI · 20140915
qualifier: located_in
ECO:0000314 PMID:25168243 ↗ IDA · UniProt · 20210716
qualifier: located_in

mitochondrial matrixlocated in

Experimental evidence 3 publications

Evidence & references

ECO:0000501 GO_REF:0000120 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}, {"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0170"}]}]
ECO:0000269 PMID:22726440 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000269 PMID:25168243 ↗ EXP · UniProt · 20251027
qualifier: located_in
ECO:0000269 PMID:27323408 ↗ EXP · UniProt · 20251027
qualifier: located_in

endoplasmic reticulumlocated in

Experimental evidence 1 publication

Evidence & references

ECO:0007322 GO_REF:0000044 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0095"}]}]
ECO:0000269 PMID:17170702 ↗ EXP · UniProt · 20251027
qualifier: located_in

centrosomelocated in

1 publication

Evidence & references

ECO:0007322 GO_REF:0000044 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0048"}]}]
ECO:0000314 PMID:28842590 ↗ IDA · UniProt · 20191121
qualifier: located_in

cytosollocated in

2 publications

Evidence & references

ECO:0000314 GO_REF:0000052 IDA · HPA · 20251115
qualifier: located_in
ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]
ECO:0000314 PMID:14963330 ↗ IDA · UniProt · 20120213
qualifier: located_in
ECO:0000314 PMID:24101517 ↗ IDA · MGI · 20140915
qualifier: located_in
ECO:0000304 Reactome:R-HSA-5690843 TAS · Reactome · 20160519
qualifier: located_in
ECO:0000304 Reactome:R-HSA-6793685 TAS · Reactome · 20251218
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8852351 TAS · Reactome · 20251218
qualifier: located_in
ECO:0000304 Reactome:R-HSA-8852354 TAS · Reactome · 20251218
qualifier: located_in

nuclear matrixlocated in

1 publication

Evidence & references

ECO:0000314 PMID:11080164 ↗ IDA · UniProt · 20060112
qualifier: located_in

PML bodylocated in

2 publications

Evidence & references

ECO:0007322 GO_REF:0000044 IEA · UniProt · 20260727
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB-SubCell", "id": "SL-0465"}]}]
ECO:0000314 PMID:12006491 ↗ IDA · BHF-UCL · 20080911
qualifier: located_in
ECO:0000314 PMID:22869143 ↗ IDA · UniProt · 20130314
qualifier: located_in

site of double-strand breaklocated in

Evidence & references

ECO:0000265 GO_REF:0000107 IEA · Ensembl · 20260724
qualifier: located_in
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "P02340"}]}, {"connectedXrefs": [{"db": "ensembl", "id": "ENSMUSP00000104298"}]}]

transcription regulator complexpart of

Evidence & references

ECO:0000256 GO_REF:0000117 IEA · UniProt · 20260727
qualifier: part_of
withFrom: [{"connectedXrefs": [{"db": "ARBA", "id": "ARBA00026399"}]}]

transcription regulator complexpart of

UniProtKB:P04637 · [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07812", "relation": "has_input"}]}]

1 publication

Evidence & references

ECO:0000316 PMID:17145718 ↗ IGI · ARUK-UCL · 20180921
qualifier: part_of
withFrom: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q12837"}]}]
extensions: [{"connectedXrefs": [{"db": "UniProtKB", "id": "Q07812", "relation": "has_input"}]}]

transcription repressor complexpart of

2 publications

Evidence & references

ECO:0000353 PMID:18677113 ↗ IPI · ComplexPortal · 20251229
qualifier: part_of
ECO:0000353 PMID:8875929 ↗ IPI · ComplexPortal · 20251229
qualifier: part_of

protein-containing complexpart of

3 publications

Evidence & references

ECO:0000315 PMID:15629713 ↗ IMP · CAFA · 20161209
qualifier: part_of
ECO:0000314 PMID:17310983 ↗ IDA · CAFA · 20170125
qualifier: part_of
ECO:0000314 PMID:9529249 ↗ IDA · BHF-UCL · 20100113
qualifier: part_of

Membrane topology 0

Filter

No annotation is recorded in this UniProt entry.

Disease & Variants

Source annotations; a recorded variant is not automatically a clinical classification.

TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "note": {
    "texts": [
      {
        "value": "TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. TP53 defects are found in Barrett metaplasia a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma"
      }
    ]
  }
}

Esophageal cancer ESCR

A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.

Evidence & references

No separate evidence record is supplied for this statement.

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Esophageal cancer",
    "diseaseAccession": "DI-01537",
    "acronym": "ESCR",
    "description": "A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "133239"
    }
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Li-Fraumeni syndrome LFS

An autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.

Experimental evidence 10 publications

Evidence & references

ECO:0000269 PubMed:10484981 ↗
ECO:0000269 PubMed:1565144 ↗
ECO:0000269 PubMed:1737852 ↗
ECO:0000269 PubMed:1933902 ↗
ECO:0000269 PubMed:1978757 ↗
ECO:0000269 PubMed:2259385 ↗
ECO:0000269 PubMed:36108750 ↗
ECO:0000269 PubMed:7887414 ↗
ECO:0000269 PubMed:8825920 ↗
ECO:0000269 PubMed:9452042 ↗

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Li-Fraumeni syndrome",
    "diseaseAccession": "DI-01904",
    "acronym": "LFS",
    "description": "An autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "151623"
    },
    "evidences": [
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "10484981"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "1565144"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "1737852"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "1933902"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "1978757"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "2259385"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "36108750"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "7887414"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "8825920"
      },
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "9452042"
      }
    ]
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Squamous cell carcinoma of the head and neck HNSCC

A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Evidence & references

No separate evidence record is supplied for this statement.

The gene represented in this entry is involved in disease pathogenesis

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Squamous cell carcinoma of the head and neck",
    "diseaseAccession": "DI-01696",
    "acronym": "HNSCC",
    "description": "A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "275355"
    }
  },
  "note": {
    "texts": [
      {
        "value": "The gene represented in this entry is involved in disease pathogenesis"
      }
    ]
  }
}

Lung cancer LNCR

A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.

Evidence & references

No separate evidence record is supplied for this statement.

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Lung cancer",
    "diseaseAccession": "DI-02205",
    "acronym": "LNCR",
    "description": "A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "211980"
    }
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Papilloma of choroid plexus CPP

A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures.

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:12085209 ↗

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Papilloma of choroid plexus",
    "diseaseAccession": "DI-01346",
    "acronym": "CPP",
    "description": "A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "260500"
    },
    "evidences": [
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "12085209"
      }
    ]
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Adrenocortical carcinoma ADCC

A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome.

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:11481490 ↗

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Adrenocortical carcinoma",
    "diseaseAccession": "DI-02740",
    "acronym": "ADCC",
    "description": "A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "202300"
    },
    "evidences": [
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "11481490"
      }
    ]
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Basal cell carcinoma 7 BCC7

A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:21946351 ↗

Disease susceptibility is associated with variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Basal cell carcinoma 7",
    "diseaseAccession": "DI-03503",
    "acronym": "BCC7",
    "description": "A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. It is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "614740"
    },
    "evidences": [
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "21946351"
      }
    ]
  },
  "note": {
    "texts": [
      {
        "value": "Disease susceptibility is associated with variants affecting the gene represented in this entry"
      }
    ]
  }
}

Bone marrow failure syndrome 5 BMFS5

A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. BMFS5 is an autosomal dominant form characterized by infantile onset of severe red cell anemia requiring transfusion. Additional features include hypogammaglobulinemia, poor growth with microcephaly, developmental delay, and seizures.

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:30146126 ↗

The disease is caused by variants affecting the gene represented in this entry

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "commentType": "DISEASE",
  "disease": {
    "diseaseId": "Bone marrow failure syndrome 5",
    "diseaseAccession": "DI-05371",
    "acronym": "BMFS5",
    "description": "A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. BMFS5 is an autosomal dominant form characterized by infantile onset of severe red cell anemia requiring transfusion. Additional features include hypogammaglobulinemia, poor growth with microcephaly, developmental delay, and seizures.",
    "diseaseCrossReference": {
      "database": "MIM",
      "id": "618165"
    },
    "evidences": [
      {
        "evidenceCode": "ECO:0000269",
        "source": "PubMed",
        "id": "30146126"
      }
    ]
  },
  "note": {
    "texts": [
      {
        "value": "The disease is caused by variants affecting the gene represented in this entry"
      }
    ]
  }
}

Natural variants 1,363

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Scroll across the table for evidence and actions.

1,363 recorded rows

Feature	Position	Description	Evidence	Inspect
Q5HVAR_044543	5	in a sporadic cancer; somatic mutation; abolishes strongly phosphorylation Q → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S6LVAR_044544	6	in a sporadic cancer; somatic mutation; reduces interaction with ZNF385A S → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D7HVAR_005851	7	in a sporadic cancer; somatic mutation; dbSNP:rs587782646 D → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P8SVAR_044545	8	in a sporadic cancer; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
V10IVAR_044546	10	in a sporadic cancer; somatic mutation; dbSNP:rs535274413 V → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E11KVAR_044547	11	in sporadic cancers; somatic mutation; dbSNP:rs201382018 E → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E11QVAR_044548	11	in sporadic cancers; somatic mutation; dbSNP:rs201382018 E → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S15RVAR_044549	15	in a sporadic cancer; somatic mutation S → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q16LVAR_044550	16	in a sporadic cancer; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E17DVAR_044551	17	in a sporadic cancer; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K24NVAR_044552	24	in a sporadic cancer; somatic mutation K → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E28AVAR_044553	28	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
NN29KDVAR_047158	29–30	in a sporadic cancer; somatic mutation NN → KD	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
V31IVAR_044554	31	in sporadic cancers; somatic mutation; dbSNP:rs201753350 V → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S33TVAR_044555	33	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P34LVAR_044556	34	in a sporadic cancer; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L35FVAR_005852	35	in sporadic cancers; somatic mutation; dbSNP:rs121912661 L → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P36LVAR_044557	36	in a sporadic cancer; somatic mutation; dbSNP:rs587781866 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S37PVAR_044558	37	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S37TVAR_044559	37	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A39PVAR_044560	39	in a sporadic cancer; somatic mutation A → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A39VVAR_044561	39	in a sporadic cancer; somatic mutation; dbSNP:rs1353016807 A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D42YVAR_044562	42	in a sporadic cancer; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L43SVAR_005853	43	in a sporadic cancer; somatic mutation L → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
M44IVAR_044563	44	in a sporadic cancer; somatic mutation; dbSNP:rs1060501190 M → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
M44TVAR_044564	44	in a sporadic cancer; somatic mutation M → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
M44VVAR_044565	44	in a sporadic cancer; somatic mutation M → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L45MVAR_044566	45	in a sporadic cancer; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S46FVAR_044567	46	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S46PVAR_044568	46	in sporadic cancers; somatic mutation; dbSNP:rs876659630 S → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P47LVAR_044569	47	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P47SVAR_014632	47	in dbSNP:rs1800371 P → S	Experimental evidence Evidence & references ECO:0000269 Reference:Ref.12	No verified residues in this structure
D48GVAR_044570	48	in a sporadic cancer; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D49HVAR_044571	49	in sporadic cancers; somatic mutation; dbSNP:rs587780728 D → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D49NVAR_044572	49	in a sporadic cancer; somatic mutation; dbSNP:rs587780728 D → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D49YVAR_044573	49	in sporadic cancers; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q52HVAR_044574	52	in a sporadic cancer; somatic mutation Q → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
W53CVAR_005854	53	in sporadic cancers; somatic mutation W → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
W53GVAR_044575	53	in a sporadic cancer; somatic mutation W → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F54LVAR_044576	54	in a sporadic cancer; somatic mutation; dbSNP:rs1555526742 F → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F54YVAR_044577	54	in a sporadic cancer; somatic mutation F → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E56KVAR_044578	56	in sporadic cancers; somatic mutation E → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E56VVAR_044579	56	in a sporadic cancer; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P58QVAR_044580	58	in a sporadic cancer; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P58TVAR_044581	58	in a sporadic cancer; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G59CVAR_044582	59	in sporadic cancers; somatic mutation; dbSNP:rs1237722021 G → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G59DVAR_044583	59	in sporadic cancers; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G59NVAR_045783	59	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions G → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P60LVAR_044584	60	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P60QVAR_044585	60	in a sporadic cancer; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P60SVAR_005855	60	in a sporadic cancer; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D61GVAR_044586	61	in sporadic cancers; somatic mutation; dbSNP:rs1460793472 D → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D61NVAR_044587	61	in sporadic cancers; somatic mutation D → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E62DVAR_044588	62	in a sporadic cancer; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A63TVAR_044589	63	in a sporadic cancer; somatic mutation; dbSNP:rs876658902 A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A63VVAR_044590	63	in a sporadic cancer; somatic mutation; dbSNP:rs372201428 A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R65TVAR_044591	65	in a sporadic cancer; somatic mutation; dbSNP:rs1060501210 R → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
M66IVAR_044592	66	in a sporadic cancer; somatic mutation; dbSNP:rs1555526711 M → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
M66RVAR_044593	66	in a sporadic cancer; somatic mutation M → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P67LVAR_044594	67	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P67RVAR_044595	67	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P67SVAR_044596	67	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E68GVAR_044597	68	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E68QVAR_044598	68	in a sporadic cancer; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A69DVAR_044599	69	in a sporadic cancer; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A69GVAR_044600	69	in sporadic cancers; somatic mutation; dbSNP:rs756233241 A → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A69TVAR_044601	69	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A69VVAR_044602	69	in a sporadic cancer; somatic mutation; dbSNP:rs756233241 A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A70TVAR_044603	70	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P71TVAR_044604	71	in a sporadic cancer; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P72CVAR_045784	72	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions; dbSNP:rs730882014 P → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P72GVAR_045785	72	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P72HVAR_045786	72	in sporadic cancers; somatic mutation; dbSNP:rs1042522 P → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P72LVAR_045787	72	in a sporadic cancer; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P72RVAR_005856	72	in dbSNP:rs1042522 P → R	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:14702039 ↗ ECO:0000269 PubMed:16131611 ↗ ECO:0000269 PubMed:1999338 ↗ ECO:0000269 Reference:Ref.17	No verified residues in this structure
V73EVAR_044605	73	in a sporadic cancer; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
V73LVAR_044606	73	in sporadic cancers; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
V73MVAR_044607	73	in sporadic cancers; somatic mutation; dbSNP:rs587782423 V → M	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A74TVAR_044608	74	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P75LVAR_044609	75	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P75RVAR_044610	75	in sporadic cancers; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P75SVAR_044611	75	in a sporadic cancer; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A76GVAR_044612	76	in a sporadic cancer; somatic mutation A → G	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2946935 ↗	No verified residues in this structure
A76TVAR_044613	76	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P77AVAR_044614	77	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A78VVAR_044615	78	in sporadic cancers; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A79GVAR_044616	79	in a sporadic cancer; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A79TVAR_005857	79	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A79VVAR_044617	79	in sporadic cancers; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P80LVAR_044618	80	in a sporadic cancer; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P80SVAR_044619	80	in a sporadic cancer; somatic mutation; dbSNP:rs1060501204 P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T81IVAR_044620	81	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P82LVAR_044621	82	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs534447939 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P82SVAR_044622	82	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A83EVAR_044623	83	in a sporadic cancer; somatic mutation; dbSNP:rs201717599 A → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A83VVAR_044624	83	in sporadic cancers; somatic mutation; dbSNP:rs201717599 A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A84GVAR_044625	84	in sporadic cancers; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A84VVAR_044626	84	in sporadic cancers; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P85LVAR_044627	85	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P85SVAR_044628	85	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A86VVAR_044629	86	in a sporadic cancer; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P87QVAR_005858	87	in sporadic cancers; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A88TVAR_044630	88	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A88VVAR_044631	88	in sporadic cancers; somatic mutation; dbSNP:rs1555526631 A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P89LVAR_044632	89	in sporadic cancers; somatic mutation; dbSNP:rs730881994 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P89SVAR_044633	89	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S90FVAR_044634	90	in sporadic cancers; somatic mutation; dbSNP:rs1555526625 S → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S90YVAR_044635	90	in a sporadic cancer; somatic mutation S → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
W91CVAR_044636	91	in a sporadic cancer; somatic mutation W → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P92AVAR_044637	92	in a sporadic cancer; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P92LVAR_044638	92	in a sporadic cancer; somatic mutation; dbSNP:rs1210700121 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P92SVAR_044639	92	in a sporadic cancer; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L93MVAR_044640	93	in a sporadic cancer; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L93PVAR_044641	93	in a sporadic cancer; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S94LVAR_044642	94	in sporadic cancers; somatic mutation S → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S94TVAR_005859	94	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S95FVAR_044643	95	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S95TVAR_044644	95	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S96CVAR_044645	96	in a sporadic cancer; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S96FVAR_044646	96	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S96PVAR_044647	96	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V97AVAR_044648	97	in a sporadic cancer; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V97FVAR_044649	97	in a sporadic cancer; somatic mutation V → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V97IVAR_044650	97	in familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs730882023 V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P98LVAR_044651	98	in sporadic cancers; somatic mutation; dbSNP:rs1245723119 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P98SVAR_044652	98	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S99FVAR_044653	99	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S99PVAR_044654	99	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q100RVAR_044655	100	in a sporadic cancer; somatic mutation Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K101NVAR_044656	101	in a sporadic cancer; somatic mutation; dbSNP:rs878854069 K → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K101RVAR_044657	101	in sporadic cancers; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T102IVAR_044658	102	in sporadic cancers; somatic mutation; dbSNP:rs786202717 T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q104HVAR_044659	104	in sporadic cancers; somatic mutation Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q104LVAR_044660	104	in a sporadic cancer; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G105CVAR_044661	105	in LFS; germline mutation and in sporadic cancers; somatic mutation G → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G105DVAR_044662	105	in sporadic cancers; somatic mutation; dbSNP:rs587781504 G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G105RVAR_044663	105	in sporadic cancers; somatic mutation; dbSNP:rs1060501195 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G105SVAR_044664	105	in a sporadic cancer; somatic mutation; dbSNP:rs1060501195 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G105VVAR_044665	105	in sporadic cancers; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S106GVAR_044666	106	in a sporadic cancer; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S106RVAR_044667	106	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555526581 S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y107CVAR_044668	107	in a sporadic cancer; somatic mutation; dbSNP:rs587782447 Y → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y107DVAR_044669	107	in sporadic cancers; somatic mutation Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y107HVAR_044670	107	in a sporadic cancer; somatic mutation; dbSNP:rs368771578 Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G108DVAR_044671	108	in a sporadic cancer; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G108SVAR_044672	108	in sporadic cancers; somatic mutation; dbSNP:rs587782461 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F109CVAR_044673	109	in sporadic cancers; somatic mutation F → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F109LVAR_044674	109	in a sporadic cancer; somatic mutation F → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F109SVAR_044675	109	in sporadic cancers; somatic mutation; dbSNP:rs1064796722 F → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R110CVAR_005860	110	in sporadic cancers; somatic mutation; dbSNP:rs587781371 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R110GVAR_044676	110	in a sporadic cancer; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R110HVAR_044677	110	in sporadic cancers; somatic mutation; dbSNP:rs11540654 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R110LVAR_005861	110	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs11540654 R → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20385133 ↗	1/1 residues mapped to 9R2Q
R110PVAR_005862	110	in sporadic cancers; somatic mutation; dbSNP:rs11540654 R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
R110SVAR_044678	110	in a sporadic cancer; somatic mutation; dbSNP:rs587781371 R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L111MVAR_044679	111	in a sporadic cancer; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L111PVAR_044680	111	in sporadic cancers; somatic mutation; dbSNP:rs1057519997 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L111QVAR_044681	111	in sporadic cancers; somatic mutation; dbSNP:rs1057519997 L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L111RVAR_044682	111	in sporadic cancers; somatic mutation; dbSNP:rs1057519997 L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G112DVAR_044683	112	in sporadic cancers; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G112SVAR_044684	112	in sporadic cancers; somatic mutation; dbSNP:rs1423803759 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113CVAR_005863	113	in sporadic cancers; somatic mutation F → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113GVAR_045788	113	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions F → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113IVAR_044685	113	in a sporadic cancer; somatic mutation F → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113LVAR_044686	113	in sporadic cancers; somatic mutation F → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113SVAR_044687	113	in sporadic cancers; somatic mutation F → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F113VVAR_033033	113	in sporadic cancers; somatic mutation; dbSNP:rs587781642 F → V	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
H115YVAR_044688	115	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S116CVAR_044689	116	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S116FVAR_044690	116	in a sporadic cancer; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S116PVAR_044691	116	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G117EVAR_044692	117	in sporadic cancers; somatic mutation; dbSNP:rs755238756 G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G117RVAR_044693	117	in sporadic cancers; somatic mutation; dbSNP:rs1555526518 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T118AVAR_044694	118	in a sporadic cancer; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T118IVAR_044695	118	in sporadic cancers; somatic mutation; dbSNP:rs1064794141 T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T118RVAR_044696	118	in a sporadic cancer; somatic mutation T → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A119DVAR_044697	119	in a sporadic cancer; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A119TVAR_044698	119	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K120EVAR_044699	120	in sporadic cancers; somatic mutation; abolished acetylation; impaired ability to induce pro-apoptotic program; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs121912658 K → E	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17189187 ↗ ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
K120MVAR_044700	120	in sporadic cancers; somatic mutation K → M	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17189187 ↗	1/1 residues mapped to 9R2Q
K120QVAR_044701	120	in a sporadic cancer; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs121912658 K → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
K120RVAR_044702	120	in sporadic cancers; somatic mutation K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17189187 ↗	1/1 residues mapped to 9R2Q
S121FVAR_044703	121	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V122LVAR_044704	122	in a sporadic cancer; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T123IVAR_044705	123	in a sporadic cancer; somatic mutation; dbSNP:rs1555526486 T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T123NVAR_044706	123	in a sporadic cancer; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C124GVAR_044707	124	in a sporadic cancer; somatic mutation; dbSNP:rs730881997 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C124RVAR_044708	124	in sporadic cancers; somatic mutation C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C124SVAR_044709	124	in sporadic cancers; somatic mutation; dbSNP:rs730881997 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C124WVAR_044710	124	in a sporadic cancer; somatic mutation C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C124YVAR_044711	124	in a sporadic cancer; somatic mutation C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T125AVAR_044712	125	in a sporadic cancer; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T125KVAR_044713	125	in sporadic cancers; somatic mutation; dbSNP:rs786201057 T → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T125MVAR_005864	125	in sporadic cancers; somatic mutation; dbSNP:rs786201057 T → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T125PVAR_044714	125	in a sporadic cancer; somatic mutation; dbSNP:rs1057520003 T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T125RVAR_044715	125	in sporadic cancers; somatic mutation; dbSNP:rs786201057 T → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126CVAR_044716	126	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555526335 Y → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126DVAR_005865	126	in sporadic cancers; somatic mutation; dbSNP:rs886039483 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126FVAR_044717	126	in a sporadic cancer; somatic mutation Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126GVAR_045789	126	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions Y → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126HVAR_044718	126	in sporadic cancers; somatic mutation Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126NVAR_005866	126	in sporadic cancers; somatic mutation; dbSNP:rs886039483 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y126SVAR_044719	126	in sporadic cancers; somatic mutation Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S127CVAR_044720	127	in a sporadic cancer; somatic mutation; dbSNP:rs730881999 S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S127FVAR_005867	127	in sporadic cancers; somatic mutation; dbSNP:rs730881999 S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S127PVAR_044721	127	in sporadic cancers; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S127TVAR_044722	127	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S127YVAR_044723	127	in sporadic cancers; somatic mutation S → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P128AVAR_044724	128	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P128LVAR_044725	128	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P128RVAR_044726	128	in sporadic cancers; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P128SVAR_005868	128	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A129DVAR_005869	129	in sporadic cancers; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A129GVAR_044727	129	in a sporadic cancer; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A129TVAR_044728	129	in sporadic cancers; somatic mutation; dbSNP:rs1438095083 A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A129VVAR_044729	129	in sporadic cancers; somatic mutation; dbSNP:rs137852792 A → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130FVAR_044730	130	in sporadic cancers; somatic mutation; dbSNP:rs863224683 L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130HVAR_044731	130	in sporadic cancers; somatic mutation L → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130IVAR_044732	130	in a sporadic cancer; somatic mutation L → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130PVAR_044733	130	in sporadic cancers; somatic mutation; dbSNP:rs1131691013 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130RVAR_005870	130	in sporadic cancers; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L130VVAR_044734	130	in sporadic cancers; somatic mutation; dbSNP:rs863224683 L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131DVAR_044735	131	in a sporadic cancer; somatic mutation N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131HVAR_044736	131	in sporadic cancers; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131IVAR_044737	131	in sporadic cancers; somatic mutation; dbSNP:rs1131691037 N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131KVAR_005872	131	in sporadic cancers; somatic mutation; dbSNP:rs769270327 N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131SVAR_005871	131	in sporadic cancers; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131TVAR_044738	131	in a sporadic cancer; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N131YVAR_044739	131	in sporadic cancers; somatic mutation; dbSNP:rs587782160 N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
KM132NLVAR_047159	132–133	in a sporadic cancer; somatic mutation KM → NL	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
K132EVAR_044740	132	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs747342068 K → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132LVAR_045790	132	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions K → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132MVAR_005873	132	in sporadic cancers; somatic mutation; dbSNP:rs1057519996 K → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132NVAR_044741	132	in sporadic cancers; somatic mutation; dbSNP:rs866775781 K → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132QVAR_005874	132	in sporadic cancers; somatic mutation; dbSNP:rs747342068 K → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1694291 ↗	1/1 residues mapped to 9R2Q
K132RVAR_044742	132	in sporadic cancers; somatic mutation; dbSNP:rs1057519996 K → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132TVAR_044743	132	in sporadic cancers; somatic mutation; dbSNP:rs1057519996 K → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K132WVAR_045791	132	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions K → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M133IVAR_044744	133	in sporadic cancers; somatic mutation; dbSNP:rs1064795139 M → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M133KVAR_044745	133	in sporadic cancers; somatic mutation M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M133LVAR_044746	133	in sporadic cancers; somatic mutation M → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M133RVAR_044747	133	in LFS; germline mutation and in sporadic cancers; somatic mutation M → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M133TVAR_005875	133	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934873 M → T	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1933902 ↗	1/1 residues mapped to 9R2Q
M133VVAR_044748	133	in sporadic cancers; somatic mutation; dbSNP:rs1057280220 M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F134CVAR_044749	134	in sporadic cancers; somatic mutation; dbSNP:rs780442292 F → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F134IVAR_044750	134	in sporadic cancers; somatic mutation F → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F134LVAR_036504	134	in sporadic cancers; somatic mutation; dbSNP:rs267605077 F → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
F134SVAR_044751	134	in sporadic cancers; somatic mutation F → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F134VVAR_044752	134	in sporadic cancers; somatic mutation F → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135FVAR_005877	135	in sporadic cancers; somatic mutation; dbSNP:rs587781991 C → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135GVAR_044753	135	in sporadic cancers; somatic mutation; dbSNP:rs1057519975 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135RVAR_044754	135	in sporadic cancers; somatic mutation; dbSNP:rs1057519975 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135SVAR_005876	135	in sporadic cancers; somatic mutation; dbSNP:rs1057519975 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135TVAR_045792	135	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions C → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135WVAR_044755	135	in sporadic cancers; somatic mutation; dbSNP:rs1057519976 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C135YVAR_044756	135	in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP; dbSNP:rs587781991 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q136EVAR_005878	136	in sporadic cancers; somatic mutation; dbSNP:rs1555526268 Q → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q136HVAR_044757	136	in sporadic cancers; somatic mutation; dbSNP:rs758781593 Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q136KVAR_005879	136	in a sporadic cancer; somatic mutation Q → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q136PVAR_044758	136	in sporadic cancers; somatic mutation Q → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q136RVAR_044759	136	in sporadic cancers; somatic mutation Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L137MVAR_044760	137	in sporadic cancers; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L137PVAR_044761	137	in sporadic cancers; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L137QVAR_005880	137	in sporadic cancers; somatic mutation L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L137VVAR_044762	137	in sporadic cancers; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A138DVAR_044763	138	in sporadic cancers; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A138PVAR_005881	138	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934875 A → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A138SVAR_044764	138	in LFS; germline mutation A → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A138TVAR_044765	138	in sporadic cancers; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A138VVAR_033034	138	in sporadic cancers; somatic mutation; dbSNP:rs750600586 A → V	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17224074 ↗ ECO:0000269 PubMed:27657329 ↗	1/1 residues mapped to 9R2Q
K139EVAR_044766	139	in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity; dbSNP:rs1212996409 K → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
K139NVAR_005882	139	in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity K → N	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:14660794 ↗ ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
K139QVAR_044767	139	in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity K → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
K139RVAR_044768	139	in sporadic cancers; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K139TVAR_044769	139	in sporadic cancers; somatic mutation; mimics lactylation, leading to decreased ability to undergo liquid-liquid phase separation and activate the transcription factor activity K → T	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
T140AVAR_044770	140	in sporadic cancers; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T140IVAR_044771	140	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T140NVAR_044772	140	in a sporadic cancer; somatic mutation; dbSNP:rs786202561 T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T140PVAR_044773	140	in a sporadic cancer; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T140SVAR_044774	140	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141AVAR_045793	141	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions C → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141FVAR_005885	141	in sporadic cancers; somatic mutation; dbSNP:rs587781288 C → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141GVAR_005884	141	in sporadic cancers; somatic mutation; dbSNP:rs1057519978 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141RVAR_044775	141	in sporadic cancers; somatic mutation; dbSNP:rs1057519978 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141SVAR_044776	141	in sporadic cancers; somatic mutation; dbSNP:rs1057519978 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141WVAR_044777	141	in sporadic cancers; somatic mutation; dbSNP:rs1057519977 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C141YVAR_005886	141	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781288 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142AVAR_044778	142	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142FVAR_045794	142	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142HVAR_044779	142	in sporadic cancers; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142LVAR_044780	142	in sporadic cancers; somatic mutation; dbSNP:rs779196500 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142RVAR_044781	142	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142SVAR_044782	142	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P142TVAR_044783	142	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V143AVAR_005887	143	in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius; severely represses interaction with ZNF385A V → A	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17719541 ↗ ECO:0000269 PubMed:8013454 ↗	1/1 residues mapped to 9R2Q
V143EVAR_044784	143	in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V143GVAR_044785	143	in sporadic cancers; somatic mutation; dbSNP:rs1555526241 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V143LVAR_044786	143	in sporadic cancers; somatic mutation; dbSNP:rs587782620 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V143MVAR_044787	143	in sporadic cancers; somatic mutation; dbSNP:rs587782620 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q144HVAR_044788	144	in sporadic cancers; somatic mutation; dbSNP:rs786201419 Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q144KVAR_044789	144	in sporadic cancers; somatic mutation Q → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q144LVAR_044790	144	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786203071 Q → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q144PVAR_005888	144	in sporadic cancers; somatic mutation; dbSNP:rs786203071 Q → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q144RVAR_044791	144	in sporadic cancers; somatic mutation Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L145MVAR_044792	145	in sporadic cancers; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L145PVAR_005889	145	in sporadic cancers; somatic mutation; dbSNP:rs587782197 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L145QVAR_005890	145	in sporadic cancers; somatic mutation L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L145RVAR_044793	145	in sporadic cancers; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L145VVAR_044794	145	in sporadic cancers; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
W146CVAR_044795	146	in a sporadic cancer; somatic mutation W → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
W146GVAR_044796	146	in sporadic cancers; somatic mutation; dbSNP:rs786203064 W → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
W146LVAR_044797	146	in sporadic cancers; somatic mutation W → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
W146RVAR_044798	146	in sporadic cancers; somatic mutation W → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
W146SVAR_044799	146	in sporadic cancers; somatic mutation W → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147AVAR_044800	147	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147DVAR_005891	147	in sporadic cancers; somatic mutation V → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147EVAR_044801	147	in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147FVAR_044802	147	in a sporadic cancer; somatic mutation V → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147GVAR_005892	147	in sporadic cancers; somatic mutation; dbSNP:rs1453167097 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V147IVAR_044803	147	in sporadic cancers; somatic mutation; dbSNP:rs1555526226 V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148AVAR_044804	148	in a sporadic cancer; somatic mutation; dbSNP:rs1046611742 D → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148EVAR_044805	148	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148GVAR_044806	148	in a sporadic cancer; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148NVAR_044807	148	in sporadic cancers; somatic mutation D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148VVAR_044808	148	in sporadic cancers; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D148YVAR_044809	148	in sporadic cancers; somatic mutation; dbSNP:rs1131691007 D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S149FVAR_044810	149	in sporadic cancers; somatic mutation; dbSNP:rs1555526214 S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S149PVAR_005893	149	in sporadic cancers; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S149TVAR_044811	149	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150AVAR_044812	150	in a sporadic cancer; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150IVAR_044813	150	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150KVAR_044814	150	in sporadic cancers; somatic mutation T → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150NVAR_044815	150	in a sporadic cancer; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150PVAR_044816	150	in a sporadic cancer; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T150RVAR_044817	150	in a sporadic cancer; somatic mutation T → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P151AVAR_005894	151	in sporadic cancers; somatic mutation; dbSNP:rs28934874 P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P151HVAR_044818	151	in sporadic cancers; somatic mutation; dbSNP:rs1057520000 P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P151LVAR_044819	151	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P151RVAR_044820	151	in sporadic cancers; somatic mutation; dbSNP:rs1057520000 P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P151SVAR_005895	151	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874 P → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:7682763 ↗	1/1 residues mapped to 9R2Q
P151TVAR_005896	151	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934874 P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P152AVAR_044821	152	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P152LVAR_005897	152	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782705 P → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1868473 ↗	1/1 residues mapped to 9R2Q
P152QVAR_044822	152	in sporadic cancers; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P152RVAR_044823	152	in sporadic cancers; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P152SVAR_005898	152	in sporadic cancers; somatic mutation; dbSNP:rs767328513 P → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
P152TVAR_044824	152	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153AVAR_044825	153	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153FVAR_045795	153	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions P → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153HVAR_044826	153	in a sporadic cancer; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153LVAR_044827	153	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153RVAR_044828	153	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153SVAR_044829	153	in sporadic cancers; somatic mutation; dbSNP:rs1064795860 P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P153TVAR_005899	153	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154AVAR_044830	154	in sporadic cancers; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154CVAR_044831	154	in a sporadic cancer; somatic mutation G → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154DVAR_044832	154	in sporadic cancers; somatic mutation; dbSNP:rs762846821 G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154IVAR_045796	154	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions G → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154SVAR_044833	154	in sporadic cancers; somatic mutation; dbSNP:rs137852789 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G154VVAR_005900	154	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs762846821 G → V	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2263646 ↗	1/1 residues mapped to 9R2Q
T155AVAR_005901	155	in sporadic cancers; somatic mutation; dbSNP:rs772683278 T → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1868473 ↗	1/1 residues mapped to 9R2Q
T155IVAR_044834	155	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T155MVAR_044835	155	in a sporadic cancer; somatic mutation T → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T155NVAR_044836	155	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786202752 T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T155PVAR_044837	155	in sporadic cancers; somatic mutation; does not induce SNAI1 degradation T → P	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:14660794 ↗ ECO:0000269 PubMed:20385133 ↗	1/1 residues mapped to 9R2Q
T155SVAR_044838	155	in sporadic cancers; somatic mutation; dbSNP:rs786202752 T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R156CVAR_044839	156	in sporadic cancers; somatic mutation; dbSNP:rs563378859 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R156GVAR_044840	156	in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R156HVAR_044841	156	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs371524413 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R156LVAR_044842	156	in sporadic cancers; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R156PVAR_005902	156	in sporadic cancers; somatic mutation R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:7682763 ↗	1/1 residues mapped to 9R2Q
R156SVAR_044843	156	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V157AVAR_044844	157	in sporadic cancers; somatic mutation; dbSNP:rs1131691023 V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V157DVAR_005903	157	in sporadic cancers; somatic mutation V → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V157FVAR_005904	157	in sporadic cancers; somatic mutation; dbSNP:rs121912654 V → F	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
V157GVAR_044845	157	in sporadic cancers; somatic mutation V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V157IVAR_012977	157	in sporadic cancers; somatic mutation; dbSNP:rs121912654 V → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:9419979 ↗	1/1 residues mapped to 9R2Q
V157LVAR_044846	157	in sporadic cancers; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158CVAR_005905	158	in sporadic cancers; somatic mutation; dbSNP:rs587780068 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158FVAR_045797	158	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions R → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158GVAR_005906	158	in LFS; germline mutation and in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158HVAR_005907	158	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782144 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158LVAR_044847	158	in sporadic cancers; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158PVAR_044848	158	in sporadic cancers; somatic mutation; dbSNP:rs587782144 R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158QVAR_044849	158	in a sporadic cancer; somatic mutation R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158SVAR_044850	158	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R158YVAR_045798	158	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions R → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159DVAR_044851	159	in sporadic cancers; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159FVAR_045799	159	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions; dbSNP:rs730882022 A → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159GVAR_044852	159	in sporadic cancers; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159PVAR_044853	159	in sporadic cancers; somatic mutation; dbSNP:rs730882000 A → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159SVAR_044854	159	in sporadic cancers; somatic mutation A → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159TVAR_044855	159	in sporadic cancers; somatic mutation; dbSNP:rs730882000 A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A159VVAR_044856	159	in sporadic cancers; somatic mutation; dbSNP:rs1555526131 A → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
MA160IPVAR_047160	160–161	in a sporadic cancer; somatic mutation MA → IP	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
MA160ISVAR_047161	160–161	in sporadic cancers; somatic mutation MA → IS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
MA160ITVAR_047162	160–161	in a sporadic cancer; somatic mutation MA → IT	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
M160IVAR_005908	160	in sporadic cancers; somatic mutation; dbSNP:rs772354334 M → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M160KVAR_044857	160	in sporadic cancers; somatic mutation M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M160TVAR_044858	160	in a sporadic cancer; somatic mutation M → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M160VVAR_044859	160	in sporadic cancers; somatic mutation; dbSNP:rs377274728 M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161DVAR_044860	161	in sporadic cancers; somatic mutation; dbSNP:rs1064795691 A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161FVAR_045800	161	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions A → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161GVAR_044861	161	in sporadic cancers; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161PVAR_044862	161	in sporadic cancers; somatic mutation A → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161SVAR_005909	161	in sporadic cancers; somatic mutation A → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161TVAR_044863	161	in sporadic cancers; somatic mutation; dbSNP:rs193920817 A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A161VVAR_044864	161	in sporadic cancers; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162FVAR_044865	162	in sporadic cancers; somatic mutation I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162MVAR_044866	162	in sporadic cancers; somatic mutation I → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162NVAR_044867	162	in a breast cancer with no family history; germline mutation and in sporadic cancers; somatic mutation I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162SVAR_005910	162	in sporadic cancers; somatic mutation; dbSNP:rs587780069 I → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162TVAR_044868	162	in sporadic cancers; somatic mutation I → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I162VVAR_005911	162	in sporadic cancers; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y163CVAR_033035	163	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs148924904 Y → C	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
Y163DVAR_044869	163	in sporadic cancers; somatic mutation; dbSNP:rs786203436 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y163FVAR_044870	163	in a sporadic cancer; somatic mutation Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y163HVAR_005912	163	in sporadic cancers; somatic mutation; dbSNP:rs786203436 Y → H	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
Y163NVAR_044871	163	in sporadic cancers; somatic mutation; dbSNP:rs786203436 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y163SVAR_044872	163	in sporadic cancers; somatic mutation Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164EVAR_044873	164	in sporadic cancers; somatic mutation; dbSNP:rs879254249 K → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164MVAR_044874	164	in sporadic cancers; somatic mutation K → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164NVAR_005913	164	in sporadic cancers; somatic mutation; dbSNP:rs1131691034 K → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164QVAR_005914	164	in sporadic cancers; somatic mutation K → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164RVAR_044875	164	in sporadic cancers; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K164TVAR_044876	164	in sporadic cancers; somatic mutation K → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q165EVAR_044877	165	in sporadic cancers; somatic mutation Q → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q165HVAR_044878	165	in a sporadic cancer; somatic mutation Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q165LVAR_005915	165	in sporadic cancers; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q165PVAR_044879	165	in sporadic cancers; somatic mutation Q → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q165RVAR_005916	165	in sporadic cancers; somatic mutation Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S166AVAR_044880	166	in sporadic cancers; somatic mutation S → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S166GVAR_044881	166	in a sporadic cancer; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S166LVAR_005917	166	in sporadic cancers; somatic mutation; dbSNP:rs1555526101 S → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S166PVAR_044882	166	in sporadic cancers; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S166TVAR_044883	166	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
QH167HDVAR_047163	167–168	in a sporadic cancer; somatic mutation QH → HD	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
QH167YLVAR_047164	167–168	in a sporadic cancer; somatic mutation QH → YL	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
Q167HVAR_044884	167	in sporadic cancers; somatic mutation Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q167KVAR_044885	167	in LFS; germline mutation and in a sporadic cancer; somatic mutation Q → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q167LVAR_044886	167	in sporadic cancers; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q167RVAR_044887	167	in sporadic cancers; somatic mutation Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
HM168LIVAR_047165	168–169	in a sporadic cancer; somatic mutation HM → LI	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
H168DVAR_044888	168	in sporadic cancers; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168LVAR_044889	168	in sporadic cancers; somatic mutation H → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168NVAR_044890	168	in sporadic cancers; somatic mutation H → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168PVAR_044891	168	in sporadic cancers; somatic mutation H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168QVAR_044892	168	in sporadic cancers; somatic mutation H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168RVAR_005918	168	in sporadic cancers; somatic mutation; dbSNP:rs867114783 H → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168VVAR_045801	168	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions H → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H168YVAR_044893	168	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
MT169ISVAR_047166	169–170	in a sporadic cancer; somatic mutation MT → IS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
M169IVAR_005919	169	in sporadic cancers; somatic mutation M → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
M169KVAR_044894	169	in sporadic cancers; somatic mutation M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M169TVAR_005920	169	in sporadic cancers; somatic mutation M → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M169VVAR_044895	169	in sporadic cancers; somatic mutation M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T170AVAR_044896	170	in sporadic cancers; somatic mutation; dbSNP:rs587780729 T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T170KVAR_044897	170	in a sporadic cancer; somatic mutation T → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T170MVAR_005921	170	in sporadic cancers; somatic mutation; dbSNP:rs779000871 T → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T170PVAR_044898	170	in a sporadic cancer; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T170SVAR_005922	170	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171AVAR_044899	171	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171DVAR_044900	171	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171GVAR_044901	171	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171KVAR_044902	171	in sporadic cancers; somatic mutation; dbSNP:rs587781845 E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171QVAR_044903	171	in a sporadic cancer; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E171VVAR_044904	171	in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V172AVAR_005923	172	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V172DVAR_044905	172	in sporadic cancers; somatic mutation V → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V172FVAR_044906	172	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1131691043 V → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V172GVAR_044907	172	in sporadic cancers; somatic mutation; dbSNP:rs1131691021 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V172IVAR_044908	172	in sporadic cancers; somatic mutation V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173AVAR_044909	173	in sporadic cancers; somatic mutation; dbSNP:rs1057519747 V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173EVAR_005924	173	in sporadic cancers; somatic mutation; dbSNP:rs1057519747 V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173GVAR_044910	173	in sporadic cancers; somatic mutation; dbSNP:rs1057519747 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173LVAR_005925	173	in sporadic cancers; somatic mutation; dbSNP:rs876660754 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173MVAR_005926	173	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs876660754 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V173WVAR_045802	173	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions V → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R174GVAR_044911	174	in LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs864622115 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R174KVAR_005927	174	in sporadic cancers; somatic mutation; dbSNP:rs1064796681 R → K	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:7682763 ↗	1/1 residues mapped to 9R2Q
R174MVAR_044912	174	in sporadic cancers; somatic mutation R → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R174SVAR_044913	174	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R174TVAR_044914	174	in a sporadic cancer; somatic mutation R → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R174WVAR_044915	174	in sporadic cancers; somatic mutation R → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R175CVAR_005928	175	in sporadic cancers; somatic mutation; dbSNP:rs138729528 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R175GVAR_005929	175	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs138729528 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R175HVAR_005932	175	in LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; reduces interaction with ZNF385A; dbSNP:rs28934578 R → H	Experimental evidence 7 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:17719541 ↗ ECO:0000269 PubMed:1868473 ↗ ECO:0000269 PubMed:20385133 ↗ ECO:0000269 PubMed:27657329 ↗ ECO:0000269 PubMed:7887414 ↗ ECO:0000269 PubMed:8825920 ↗	1/1 residues mapped to 9R2Q
R175LVAR_005930	175	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934578 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R175PVAR_005931	175	in sporadic cancers; somatic mutation R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17719541 ↗	1/1 residues mapped to 9R2Q
R175QVAR_044916	175	in a sporadic cancer; somatic mutation R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R175SVAR_044917	175	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
CP176FSVAR_047167	176–177	in a sporadic cancer; somatic mutation CP → FS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
C176FVAR_005933	176	in sporadic cancers; somatic mutation; dbSNP:rs786202962 C → F	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:1394225 ↗ ECO:0000269 PubMed:1868473 ↗ ECO:0000269 PubMed:8829627 ↗ ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
C176GVAR_044918	176	in sporadic cancers; somatic mutation C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C176RVAR_044919	176	in sporadic cancers; somatic mutation C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C176SVAR_044920	176	in sporadic cancers; somatic mutation; dbSNP:rs967461896 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C176WVAR_005934	176	in sporadic cancers; somatic mutation; dbSNP:rs1057519980 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C176YVAR_044921	176	in sporadic cancers; somatic mutation; dbSNP:rs786202962 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177AVAR_044922	177	in a sporadic cancer; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177FVAR_045803	177	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177HVAR_044923	177	in sporadic cancers; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177IVAR_045804	177	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions P → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177LVAR_005935	177	in sporadic cancers; somatic mutation; dbSNP:rs751477326 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177RVAR_036505	177	in sporadic cancers; somatic mutation; dbSNP:rs751477326 P → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
P177SVAR_044924	177	in sporadic cancers; somatic mutation; dbSNP:rs147002414 P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P177TVAR_044925	177	in a sporadic cancer; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
HH178QSVAR_047168	178–179	in a sporadic cancer; somatic mutation HH → QS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
H178DVAR_044926	178	in sporadic cancers; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178HPHPVAR_005936	178	in a Burkitt lymphoma H → HPHP	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1303181 ↗	1/1 residues mapped to 9R2Q
H178LVAR_044927	178	in a sporadic cancer; somatic mutation H → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178NVAR_044928	178	in sporadic cancers; somatic mutation; dbSNP:rs1064795203 H → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178PVAR_044929	178	in sporadic cancers; somatic mutation; dbSNP:rs1555526004 H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178QVAR_044930	178	in sporadic cancers; somatic mutation H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178RVAR_044931	178	in sporadic cancers; somatic mutation H → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H178YVAR_044932	178	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179DVAR_044933	179	in sporadic cancers; somatic mutation; dbSNP:rs587780070 H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179LVAR_044934	179	in sporadic cancers; somatic mutation; dbSNP:rs1057519991 H → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179NVAR_044935	179	in sporadic cancers; somatic mutation; dbSNP:rs587780070 H → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179PVAR_044936	179	in sporadic cancers; somatic mutation; dbSNP:rs1057519991 H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179QVAR_044937	179	in sporadic cancers; somatic mutation; dbSNP:rs876660821 H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179RVAR_044938	179	in sporadic cancers; somatic mutation; dbSNP:rs1057519991 H → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H179YVAR_044939	179	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780070 H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180AVAR_044940	180	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180DVAR_044941	180	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180GVAR_044942	180	in a sporadic cancer; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180KVAR_044943	180	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253911 E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180QVAR_044944	180	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E180VVAR_044945	180	in a sporadic cancer; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181CVAR_044946	181	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782596 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181GVAR_044947	181	in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181HVAR_044948	181	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs397514495 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181LVAR_005937	181	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs397514495 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181PVAR_044949	181	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R181SVAR_044950	181	in sporadic cancers; somatic mutation; dbSNP:rs587782596 R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C182RVAR_044951	182	in sporadic cancers; somatic mutation C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C182SVAR_005938	182	in sporadic cancers; somatic mutation C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C182YVAR_044952	182	in sporadic cancers; somatic mutation C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S183LVAR_044953	183	in sporadic cancers; somatic mutation; dbSNP:rs1555525970 S → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S183PVAR_044954	183	in sporadic cancers; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D184GVAR_044955	184	in sporadic cancers; somatic mutation; dbSNP:rs1060501209 D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D184HVAR_044956	184	in sporadic cancers; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D184NVAR_047169	184	in sporadic cancers; somatic mutation; dbSNP:rs72661117 D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D184VVAR_044957	184	in sporadic cancers; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D184YVAR_005939	184	in sporadic cancers; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185CVAR_044958	185	in a sporadic cancer; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185GVAR_044959	185	in sporadic cancers; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185IVAR_044960	185	in sporadic cancers; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185NVAR_044961	185	in a sporadic cancer; somatic mutation; dbSNP:rs150607408 S → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185RVAR_044962	185	in sporadic cancers; somatic mutation S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S185TVAR_044963	185	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186EVAR_044964	186	in a sporadic cancer; somatic mutation; dbSNP:rs375275361 D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186GVAR_044965	186	in sporadic cancers; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186HVAR_044966	186	in sporadic cancers; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186NVAR_044967	186	in sporadic cancers; somatic mutation; dbSNP:rs1060501206 D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186VVAR_044968	186	in sporadic cancers; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D186YVAR_005940	186	in a sporadic cancer; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187CVAR_005941	187	in sporadic cancers; somatic mutation G → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187DVAR_044969	187	in sporadic cancers; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187NVAR_045805	187	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions G → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187RVAR_044970	187	in sporadic cancers; somatic mutation G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187SVAR_005942	187	in sporadic cancers; somatic mutation; dbSNP:rs776167460 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G187VVAR_044971	187	in sporadic cancers; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L188PVAR_044972	188	in a sporadic cancer; somatic mutation; dbSNP:rs1199893366 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L188VVAR_044973	188	in sporadic cancers; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189DVAR_044974	189	in a sporadic cancer; somatic mutation A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189GVAR_044975	189	in sporadic cancers; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189PVAR_005943	189	in sporadic cancers; somatic mutation A → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189SVAR_044976	189	in a sporadic cancer; somatic mutation; dbSNP:rs1555525921 A → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189TVAR_044977	189	in sporadic cancers; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A189VVAR_044978	189	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912665 A → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190AVAR_044979	190	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190HVAR_044980	190	in a sporadic cancer; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190LVAR_005944	190	in sporadic cancers; somatic mutation; dbSNP:rs876660825 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190RVAR_044981	190	in sporadic cancers; somatic mutation; dbSNP:rs876660825 P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190SVAR_044982	190	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P190TVAR_044983	190	in sporadic cancers; somatic mutation; dbSNP:rs876660254 P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P191HVAR_044984	191	in sporadic cancers; somatic mutation; dbSNP:rs587778718 P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P191LVAR_044985	191	in sporadic cancers; somatic mutation; dbSNP:rs587778718 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P191RVAR_044986	191	in sporadic cancers; somatic mutation; dbSNP:rs587778718 P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P191SVAR_044987	191	in sporadic cancers; somatic mutation; dbSNP:rs868590738 P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P191TVAR_005945	191	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
QH192HNVAR_047170	192–193	in a sporadic cancer; somatic mutation QH → HN	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
QH192HYVAR_047171	192–193	in a sporadic cancer; somatic mutation QH → HY	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
Q192HVAR_044988	192	in sporadic cancers; somatic mutation Q → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q192KVAR_044989	192	in a sporadic cancer; somatic mutation Q → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q192LVAR_044990	192	in sporadic cancers; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q192PVAR_044991	192	in sporadic cancers; somatic mutation Q → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Q192RVAR_005946	192	in sporadic cancers; somatic mutation; dbSNP:rs730882002 Q → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193DVAR_005947	193	in sporadic cancers; somatic mutation; dbSNP:rs876658468 H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193LVAR_044992	193	in sporadic cancers; somatic mutation; dbSNP:rs786201838 H → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193NVAR_044993	193	in sporadic cancers; somatic mutation; dbSNP:rs876658468 H → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193PVAR_044994	193	in sporadic cancers; somatic mutation; dbSNP:rs786201838 H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193QVAR_044995	193	in sporadic cancers; somatic mutation H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H193RVAR_005948	193	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786201838 H → R	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:7887414 ↗	1/1 residues mapped to 9R2Q
H193YVAR_044996	193	in sporadic cancers; somatic mutation; dbSNP:rs876658468 H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L194FVAR_044997	194	in sporadic cancers; somatic mutation; dbSNP:rs587780071 L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L194HVAR_044998	194	in sporadic cancers; somatic mutation; dbSNP:rs1057519998 L → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L194IVAR_044999	194	in sporadic cancers; somatic mutation L → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L194PVAR_005949	194	in sporadic cancers; somatic mutation; dbSNP:rs1057519998 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L194RVAR_005950	194	in sporadic cancers; somatic mutation; dbSNP:rs1057519998 L → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:7682763 ↗	1/1 residues mapped to 9R2Q
L194VVAR_045000	194	in sporadic cancers; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195FVAR_045001	195	in sporadic cancers; somatic mutation; dbSNP:rs942158624 I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195LVAR_047172	195	in a sporadic cancer; somatic mutation I → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195NVAR_045002	195	in sporadic cancers; somatic mutation; dbSNP:rs760043106 I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195SVAR_045003	195	in sporadic cancers; somatic mutation; dbSNP:rs760043106 I → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195TVAR_005951	195	in sporadic cancers; somatic mutation; dbSNP:rs760043106 I → T	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17224074 ↗ ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
I195VVAR_045004	195	in a sporadic cancer; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I195YVAR_045806	195	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions I → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R196GVAR_045005	196	in sporadic cancers; somatic mutation; dbSNP:rs397516435 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R196LVAR_045006	196	in sporadic cancers; somatic mutation; dbSNP:rs483352697 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R196PVAR_045007	196	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs483352697 R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R196QVAR_045008	196	in sporadic cancers; somatic mutation; dbSNP:rs483352697 R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R196SVAR_045009	196	in a sporadic cancer; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V197EVAR_045010	197	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V197GVAR_045011	197	in sporadic cancers; somatic mutation V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V197LVAR_045012	197	in sporadic cancers; somatic mutation; dbSNP:rs786204041 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V197MVAR_045013	197	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs786204041 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E198DVAR_045014	198	in a sporadic cancer; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E198GVAR_045015	198	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E198KVAR_005952	198	in sporadic cancers; somatic mutation E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E198QVAR_045016	198	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E198VVAR_045017	198	in a sporadic cancer; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G199AVAR_045018	199	in a sporadic cancer; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G199EVAR_045019	199	in sporadic cancers; somatic mutation G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G199RVAR_045020	199	in sporadic cancers; somatic mutation G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G199VVAR_045021	199	in sporadic cancers; somatic mutation; dbSNP:rs1555525857 G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200DVAR_045022	200	in sporadic cancers; somatic mutation N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200IVAR_045023	200	in sporadic cancers; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200KVAR_045024	200	in a sporadic cancer; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200PVAR_045807	200	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions N → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200SVAR_045025	200	in sporadic cancers; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N200TVAR_045026	200	in a sporadic cancer; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
LR201FCVAR_047173	201–202	in a sporadic cancer; somatic mutation LR → FC	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
L201FVAR_045027	201	in sporadic cancers; somatic mutation; dbSNP:rs730882024 L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L201PVAR_045028	201	in a sporadic cancer; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L201SVAR_045029	201	in a sporadic cancer; somatic mutation L → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202CVAR_045030	202	in sporadic cancers; somatic mutation; dbSNP:rs587780072 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202GVAR_045031	202	in sporadic cancers; somatic mutation; dbSNP:rs587780072 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202HVAR_045032	202	in sporadic cancers; somatic mutation; dbSNP:rs587778719 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202LVAR_045033	202	in sporadic cancers; somatic mutation; dbSNP:rs587778719 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202PVAR_045034	202	in sporadic cancers; somatic mutation R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R202SVAR_045035	202	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
VE203LVVAR_047174	203–204	in a sporadic cancer; somatic mutation VE → LV	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
V203AVAR_045036	203	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V203EVAR_045037	203	in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V203LVAR_045038	203	in sporadic cancers; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V203MVAR_045039	203	in sporadic cancers; somatic mutation; dbSNP:rs730882003 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V203WVAR_045808	203	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions V → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204AVAR_045040	204	in sporadic cancers; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204DVAR_045041	204	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204GVAR_045042	204	in sporadic cancers; somatic mutation; dbSNP:rs1260903787 E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204KVAR_045043	204	in sporadic cancers; somatic mutation E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204QVAR_045044	204	in a sporadic cancer; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E204VVAR_045045	204	in a sporadic cancer; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y205CVAR_005953	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520007 Y → C	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1459726 ↗	1/1 residues mapped to 9R2Q
Y205DVAR_005954	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520008 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y205FVAR_047175	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520007 Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y205HVAR_045046	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520008 Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y205NVAR_045047	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520008 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y205SVAR_045048	205	in sporadic cancers; somatic mutation; dbSNP:rs1057520007 Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L206FVAR_045049	206	in a sporadic cancer; somatic mutation L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L206MVAR_045050	206	in a sporadic cancer; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
DD207EYVAR_047176	207–208	in a sporadic cancer; somatic mutation DD → EY	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
D207EVAR_045051	207	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D207GVAR_045052	207	in sporadic cancers; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D207HVAR_045053	207	in sporadic cancers; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D207NVAR_045054	207	in sporadic cancers; somatic mutation; dbSNP:rs923100890 D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D207VVAR_045055	207	in a sporadic cancer; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D207YVAR_045056	207	in a sporadic cancer; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208EVAR_045057	208	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208GVAR_045058	208	in sporadic cancers; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208HVAR_045059	208	in a sporadic cancer; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208IVAR_045809	208	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208NVAR_045060	208	in sporadic cancers; somatic mutation D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208VVAR_045061	208	in sporadic cancers; somatic mutation; dbSNP:rs1464727668 D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D208YVAR_045062	208	in a sporadic cancer; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R209IVAR_045063	209	in sporadic cancers; somatic mutation R → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R209KVAR_045064	209	in sporadic cancers; somatic mutation R → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R209SVAR_045065	209	in a sporadic cancer; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R209TVAR_045066	209	in sporadic cancers; somatic mutation R → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210DVAR_045067	210	in sporadic cancers; somatic mutation N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210HVAR_045068	210	in sporadic cancers; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210IVAR_045069	210	in a sporadic cancer; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210KVAR_045070	210	in a sporadic cancer; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210SVAR_045071	210	in sporadic cancers; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210TVAR_045072	210	in a sporadic cancer; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N210YVAR_045073	210	in a familial cancer not matching LFS; germline mutation; dbSNP:rs1060501200 N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T211AVAR_045074	211	in sporadic cancers; somatic mutation; dbSNP:rs1060501198 T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T211IVAR_045075	211	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T211NVAR_045076	211	in sporadic cancers; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T211PVAR_045077	211	in a sporadic cancer; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T211SVAR_045078	211	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F212IVAR_045079	212	in sporadic cancers; somatic mutation; dbSNP:rs1064795766 F → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F212LVAR_045080	212	in sporadic cancers; somatic mutation F → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F212SVAR_045081	212	in sporadic cancers; somatic mutation F → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F212VVAR_045082	212	in a sporadic cancer; somatic mutation F → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F212YVAR_045083	212	in sporadic cancers; somatic mutation F → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R213GVAR_045084	213	in sporadic cancers; somatic mutation; dbSNP:rs397516436 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R213LVAR_045085	213	in sporadic cancers; somatic mutation; dbSNP:rs587778720 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R213PVAR_036506	213	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587778720 R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
R213QVAR_005955	213	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587778720 R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R213WVAR_045086	213	in sporadic cancers; somatic mutation R → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H214DVAR_045087	214	in sporadic cancers; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H214PVAR_045088	214	in a sporadic cancer; somatic mutation; dbSNP:rs1057519992 H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H214QVAR_047177	214	in sporadic cancers; somatic mutation; dbSNP:rs587781386 H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H214RVAR_045089	214	in sporadic cancers; somatic mutation; dbSNP:rs1057519992 H → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H214YVAR_045090	214	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215CVAR_045091	215	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215GVAR_045092	215	in sporadic cancers; somatic mutation; dbSNP:rs886039484 S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215IVAR_045093	215	in sporadic cancers; somatic mutation; dbSNP:rs587782177 S → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215KVAR_045810	215	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions S → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215NVAR_045094	215	in sporadic cancers; somatic mutation; dbSNP:rs587782177 S → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215RVAR_045095	215	in sporadic cancers; somatic mutation; dbSNP:rs1057520001 S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S215TVAR_045096	215	in sporadic cancers; somatic mutation; dbSNP:rs587782177 S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V216AVAR_045097	216	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V216EVAR_045098	216	in sporadic cancers; somatic mutation; dbSNP:rs1057520004 V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V216GVAR_045099	216	in sporadic cancers; somatic mutation; dbSNP:rs1057520004 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V216LVAR_045100	216	in sporadic cancers; somatic mutation; dbSNP:rs730882025 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V216MVAR_005956	216	in sporadic cancers; somatic mutation; dbSNP:rs730882025 V → M	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
V216WVAR_045811	216	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions V → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217AVAR_045101	217	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217EVAR_045102	217	in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217GVAR_045103	217	in sporadic cancers; somatic mutation V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217IVAR_045104	217	in a sporadic cancer; somatic mutation V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217LVAR_045105	217	in sporadic cancers; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V217MVAR_047178	217	in dbSNP:rs35163653 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V218AVAR_045106	218	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V218EVAR_045107	218	in sporadic cancers; somatic mutation V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V218GVAR_045108	218	in sporadic cancers; somatic mutation; dbSNP:rs1555525743 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V218LVAR_045109	218	in sporadic cancers; somatic mutation V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V218MVAR_045110	218	in sporadic cancers; somatic mutation; dbSNP:rs878854072 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219CVAR_045812	219	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions P → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219HVAR_045111	219	in a sporadic cancer; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219LVAR_045112	219	in sporadic cancers; somatic mutation; dbSNP:rs1420675064 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219RVAR_045113	219	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219SVAR_045114	219	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253894 P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P219TVAR_045115	219	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y220CVAR_005957	220	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912666 Y → C	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:7682763 ↗ ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
Y220DVAR_045116	220	in sporadic cancers; somatic mutation; dbSNP:rs530941076 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y220FVAR_045117	220	in a sporadic cancer; somatic mutation Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y220HVAR_005958	220	in sporadic cancers; somatic mutation; dbSNP:rs530941076 Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y220NVAR_045118	220	in sporadic cancers; somatic mutation; dbSNP:rs530941076 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y220SVAR_005959	220	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912666 Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E221AVAR_045119	221	in sporadic cancers; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E221DVAR_045120	221	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E221GVAR_045121	221	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E221KVAR_045122	221	in sporadic cancers; somatic mutation; dbSNP:rs786201592 E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E221QVAR_045123	221	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222AVAR_045124	222	in a sporadic cancer; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222LVAR_045125	222	in sporadic cancers; somatic mutation; dbSNP:rs146340390 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222QVAR_045126	222	in sporadic cancers; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222RVAR_045127	222	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222SVAR_045128	222	in sporadic cancers; somatic mutation; dbSNP:rs1060501203 P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P222TVAR_045129	222	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223AVAR_047179	223	in a sporadic cancer; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223HVAR_045130	223	in sporadic cancers; somatic mutation; dbSNP:rs138983188 P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223LVAR_045131	223	in sporadic cancers; somatic mutation; dbSNP:rs138983188 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223RVAR_045132	223	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223SVAR_045133	223	in a sporadic cancer; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P223TVAR_045134	223	in a sporadic cancer; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E224DVAR_045135	224	in sporadic cancers; somatic mutation; dbSNP:rs267605076 E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E224GVAR_045136	224	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E224KVAR_045137	224	in sporadic cancers; somatic mutation; dbSNP:rs1555525707 E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E224VVAR_045138	224	in a sporadic cancer; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225AVAR_045139	225	in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225DVAR_045140	225	in a sporadic cancer; somatic mutation V → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225FVAR_045141	225	in sporadic cancers; somatic mutation V → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225GVAR_045142	225	in a sporadic cancer; somatic mutation V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225IVAR_045143	225	in sporadic cancers; somatic mutation V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V225LVAR_045144	225	in a sporadic cancer; somatic mutation; dbSNP:rs746504075 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G226AVAR_045145	226	in sporadic cancers; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G226DVAR_047180	226	in sporadic cancers; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G226NVAR_045844	226	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions G → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G226SVAR_045146	226	in sporadic cancers; somatic mutation G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G226VVAR_045147	226	in sporadic cancers; somatic mutation; dbSNP:rs970212462 G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S227CVAR_045148	227	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S227FVAR_045149	227	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S227PVAR_045150	227	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S227TVAR_045151	227	in LFS; germline mutation and in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228AVAR_045152	228	in sporadic cancers; somatic mutation D → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228EVAR_005960	228	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228GVAR_045153	228	in sporadic cancers; somatic mutation D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228HVAR_045154	228	in sporadic cancers; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228NVAR_045155	228	in sporadic cancers; somatic mutation D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228PVAR_045845	228	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228VVAR_045156	228	in sporadic cancers; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D228YVAR_045157	228	in sporadic cancers; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C229GVAR_045158	229	in a sporadic cancer; somatic mutation C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C229NVAR_045846	229	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions C → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C229RVAR_045159	229	in sporadic cancers; somatic mutation; dbSNP:rs1064794312 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C229SVAR_045160	229	in sporadic cancers; somatic mutation C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C229YVAR_045161	229	in sporadic cancers; somatic mutation; dbSNP:rs1064793603 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T230AVAR_045162	230	in sporadic cancers; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T230IVAR_005961	230	in sporadic cancers; somatic mutation T → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
T230NVAR_045163	230	in sporadic cancers; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T230PVAR_045164	230	in sporadic cancers; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T230SVAR_045165	230	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T231AVAR_045166	231	in sporadic cancers; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T231IVAR_045167	231	in sporadic cancers; somatic mutation; dbSNP:rs1555525564 T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T231NVAR_045168	231	in sporadic cancers; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T231SVAR_045169	231	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I232FVAR_045170	232	in sporadic cancers; somatic mutation I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I232LVAR_045171	232	in sporadic cancers; somatic mutation; dbSNP:rs1555525562 I → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I232NVAR_045172	232	in sporadic cancers; somatic mutation I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I232SVAR_045173	232	in sporadic cancers; somatic mutation; does not induce SNAI1 degradation I → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20385133 ↗	1/1 residues mapped to 9R2Q
I232TVAR_005962	232	in sporadic cancers; somatic mutation; dbSNP:rs587781589 I → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I232VVAR_045174	232	in sporadic cancers; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233DVAR_045175	233	in LFS; germline mutation and in a sporadic cancer; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233LVAR_045176	233	in sporadic cancers; somatic mutation H → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233PVAR_045177	233	in a sporadic cancer; somatic mutation H → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233QVAR_045178	233	in sporadic cancers; somatic mutation H → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233RVAR_047181	233	in sporadic cancers; somatic mutation; dbSNP:rs879254233 H → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
H233YVAR_045179	233	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234CVAR_005963	234	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780073 Y → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234DVAR_045180	234	in sporadic cancers; somatic mutation; dbSNP:rs864622237 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234FVAR_045181	234	in a sporadic cancer; somatic mutation Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234HVAR_005964	234	in sporadic cancers; somatic mutation; dbSNP:rs864622237 Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234KVAR_045847	234	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions Y → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234NVAR_045182	234	in sporadic cancers; somatic mutation; dbSNP:rs864622237 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234QVAR_045848	234	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions Y → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y234SVAR_045183	234	in sporadic cancers; somatic mutation; dbSNP:rs587780073 Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235DVAR_047182	235	in an adrenocortical carcinoma with no family history; germline mutation and in sporadic cancers; somatic mutation N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235HVAR_045184	235	in a sporadic cancer; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235IVAR_045185	235	in sporadic cancers; somatic mutation; dbSNP:rs144340710 N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235MVAR_045849	235	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions N → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235SVAR_045186	235	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs144340710 N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235TVAR_045187	235	in sporadic cancers; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N235YVAR_045188	235	in sporadic cancers; somatic mutation; dbSNP:rs786204145 N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236CVAR_045189	236	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882026 Y → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236DVAR_045190	236	in sporadic cancers; somatic mutation; dbSNP:rs587782289 Y → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236FVAR_045191	236	in a sporadic cancer; somatic mutation Y → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236HVAR_045192	236	in sporadic cancers; somatic mutation; dbSNP:rs587782289 Y → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236NVAR_045193	236	in sporadic cancers; somatic mutation; dbSNP:rs587782289 Y → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
Y236SVAR_045194	236	in sporadic cancers; somatic mutation; dbSNP:rs730882026 Y → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M237IVAR_005965	237	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587782664 M → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:27657329 ↗	1/1 residues mapped to 9R2Q
M237KVAR_045195	237	in sporadic cancers; somatic mutation; dbSNP:rs765848205 M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M237LVAR_045196	237	in sporadic cancers; somatic mutation M → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M237RVAR_045197	237	in sporadic cancers; somatic mutation; dbSNP:rs765848205 M → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M237TVAR_045198	237	in sporadic cancers; somatic mutation M → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M237VVAR_045199	237	in sporadic cancers; somatic mutation; dbSNP:rs730882004 M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238FVAR_005966	238	in sporadic cancers; somatic mutation; dbSNP:rs730882005 C → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238GVAR_045200	238	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057519981 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238HVAR_045850	238	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions C → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238RVAR_045201	238	in sporadic cancers; somatic mutation; dbSNP:rs1057519981 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238SVAR_045202	238	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882005 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238WVAR_045203	238	in sporadic cancers; somatic mutation; dbSNP:rs193920789 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C238YVAR_005967	238	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882005 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239DVAR_045204	239	in sporadic cancers; somatic mutation; dbSNP:rs876660807 N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239HVAR_045205	239	in a sporadic cancer; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239IVAR_045206	239	in a sporadic cancer; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239KVAR_045207	239	in sporadic cancers; somatic mutation; dbSNP:rs1057522275 N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239SVAR_045208	239	in sporadic cancers; somatic mutation; dbSNP:rs1057519999 N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239TVAR_045209	239	in sporadic cancers; somatic mutation; dbSNP:rs1057519999 N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N239YVAR_045210	239	in sporadic cancers; somatic mutation N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240CVAR_045211	240	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240GVAR_045212	240	in sporadic cancers; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240IVAR_005968	240	in sporadic cancers; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240NVAR_045213	240	in sporadic cancers; somatic mutation S → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240PVAR_045214	240	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240RVAR_045215	240	in sporadic cancers; somatic mutation S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S240TVAR_045216	240	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S241AVAR_033036	241	in sporadic cancers; somatic mutation; dbSNP:rs1057520002 S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
S241CVAR_045217	241	in sporadic cancers; somatic mutation; dbSNP:rs28934573 S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S241FVAR_005969	241	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573 S → F	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:1699228 ↗	1/1 residues mapped to 9R2Q
S241PVAR_045218	241	in sporadic cancers; somatic mutation; dbSNP:rs1057520002 S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S241TVAR_047183	241	in LFS; germline mutation and in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S241YVAR_045219	241	in sporadic cancers; somatic mutation; dbSNP:rs28934573 S → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C242FVAR_005970	242	in sporadic cancers; somatic mutation; dbSNP:rs121912655 C → F	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:1394225 ↗ ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
C242GVAR_045220	242	in sporadic cancers; somatic mutation; dbSNP:rs1057519982 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C242RVAR_045221	242	in sporadic cancers; somatic mutation C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C242SVAR_045222	242	in sporadic cancers; somatic mutation; dbSNP:rs121912655 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C242WVAR_045223	242	in sporadic cancers; somatic mutation; dbSNP:rs375874539 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C242YVAR_045224	242	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912655 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
MG243ICVAR_047184	243–244	in a sporadic cancer; somatic mutation MG → IC	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
MG243ISVAR_047185	243–244	in a sporadic cancer; somatic mutation MG → IS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
M243IVAR_045225	243	in sporadic cancers; somatic mutation M → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M243KVAR_045226	243	in sporadic cancers; somatic mutation M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M243LVAR_045227	243	in sporadic cancers; somatic mutation; dbSNP:rs786203117 M → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M243RVAR_045228	243	in sporadic cancers; somatic mutation M → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M243TVAR_045229	243	in sporadic cancers; somatic mutation; dbSNP:rs730882006 M → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M243VVAR_045230	243	in sporadic cancers; somatic mutation; dbSNP:rs786203117 M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244AVAR_047186	244	in sporadic cancers; somatic mutation; dbSNP:rs985033810 G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244CVAR_045231	244	in sporadic cancers; somatic mutation; dbSNP:rs1057519989 G → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244DVAR_045232	244	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057517983 G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244EVAR_045233	244	in a sporadic cancer; somatic mutation G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244RVAR_045234	244	in sporadic cancers; somatic mutation; dbSNP:rs1057519989 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244SVAR_045235	244	in sporadic cancers; somatic mutation; dbSNP:rs1057519989 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G244VVAR_045236	244	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs985033810 G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245AVAR_005971	245	in sporadic cancers; somatic mutation; dbSNP:rs121912656 G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245CVAR_005972	245	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575 G → C	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:1394225 ↗ ECO:0000269 PubMed:1978757 ↗	1/1 residues mapped to 9R2Q
G245DVAR_005973	245	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656 G → D	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2259385 ↗	1/1 residues mapped to 9R2Q
G245EVAR_045237	245	in a sporadic cancer; somatic mutation G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245FVAR_045851	245	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions G → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245HVAR_045852	245	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions G → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245LVAR_045853	245	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions G → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245NVAR_045854	245	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions G → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245RVAR_045238	245	in sporadic cancers; somatic mutation; dbSNP:rs28934575 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G245SVAR_005974	245	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575 G → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:8829627 ↗	1/1 residues mapped to 9R2Q
G245VVAR_005975	245	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912656 G → V	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2263646 ↗	1/1 residues mapped to 9R2Q
M246IVAR_045239	246	in sporadic cancers; somatic mutation; dbSNP:rs1019340046 M → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M246KVAR_045240	246	in sporadic cancers; somatic mutation M → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M246LVAR_044020	246	in sporadic cancers; somatic mutation; dbSNP:rs483352695 M → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M246RVAR_005976	246	in sporadic cancers; somatic mutation; dbSNP:rs587780074 M → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M246TVAR_005977	246	in sporadic cancers; somatic mutation; dbSNP:rs587780074 M → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
M246VVAR_005978	246	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs483352695 M → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
NR247IPVAR_047187	247–248	in a sporadic cancer; somatic mutation NR → IP	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
NR247KWVAR_047188	247–248	in sporadic cancers; somatic mutation NR → KW	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
N247DVAR_045241	247	in sporadic cancers; somatic mutation; dbSNP:rs1452189221 N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247FVAR_045855	247	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions N → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247IVAR_005980	247	in sporadic cancers; somatic mutation; dbSNP:rs786201762 N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247KVAR_045242	247	in sporadic cancers; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247SVAR_045243	247	in sporadic cancers; somatic mutation; dbSNP:rs786201762 N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247TVAR_047189	247	in sporadic cancers; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N247YVAR_045244	247	in sporadic cancers; somatic mutation N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R248CVAR_045245	248	in a sporadic cancer; somatic mutation R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R248GVAR_005981	248	in sporadic cancers; somatic mutation; dbSNP:rs121912651 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R248LVAR_005982	248	in sporadic cancers; somatic mutation; dbSNP:rs11540652 R → L	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:1394225 ↗ ECO:0000269 PubMed:7682763 ↗	1/1 residues mapped to 9R2Q
R248PVAR_045246	248	in sporadic cancers; somatic mutation; dbSNP:rs11540652 R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R248QVAR_005983	248	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652 R → Q	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:2263646 ↗ ECO:0000269 PubMed:7682763 ↗ ECO:0000269 PubMed:7887414 ↗	1/1 residues mapped to 9R2Q
R248WVAR_005984	248	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912651 R → W	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:1978757 ↗ ECO:0000269 PubMed:27657329 ↗ ECO:0000269 PubMed:8829627 ↗	1/1 residues mapped to 9R2Q
RP249SAVAR_047190	249–250	in a sporadic cancer; somatic mutation RP → SA	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
RP249SSVAR_047191	249–250	in sporadic cancers; somatic mutation RP → SS	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
R249GVAR_005985	249	in sporadic cancers; somatic mutation; dbSNP:rs587782082 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R249IVAR_045247	249	in a sporadic cancer; somatic mutation R → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R249KVAR_045248	249	in sporadic cancers; somatic mutation; dbSNP:rs587782329 R → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R249MVAR_033037	249	in sporadic cancers; somatic mutation; dbSNP:rs587782329 R → M	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
R249NVAR_045856	249	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions R → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R249SVAR_005986	249	in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs28934571 R → S	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:1694291 ↗ ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:20385133 ↗	1/1 residues mapped to 9R2Q
R249TVAR_045249	249	in sporadic cancers; somatic mutation; dbSNP:rs587782329 R → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R249WVAR_045250	249	in sporadic cancers; somatic mutation; dbSNP:rs587782082 R → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250AVAR_045251	250	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250FVAR_045857	250	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250HVAR_045252	250	in sporadic cancers; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250LVAR_047192	250	in sporadic cancers; somatic mutation; dbSNP:rs1064794311 P → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250NVAR_045858	250	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250QVAR_045253	250	in sporadic cancers; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250SVAR_045254	250	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P250TVAR_045255	250	in sporadic cancers; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251FVAR_045256	251	in sporadic cancers; somatic mutation I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251LVAR_045257	251	in sporadic cancers; somatic mutation; dbSNP:rs730882007 I → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251MVAR_045258	251	in LFS; germline mutation; dbSNP:rs878854074 I → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251NVAR_005987	251	in sporadic cancers; somatic mutation I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251SVAR_033038	251	in sporadic cancers; somatic mutation; dbSNP:rs730882027 I → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
I251TVAR_045259	251	in sporadic cancers; somatic mutation I → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I251VVAR_045260	251	in sporadic cancers; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L252FVAR_045261	252	in sporadic cancers; somatic mutation L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L252HVAR_045262	252	in a sporadic cancer; somatic mutation L → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L252IVAR_045263	252	in sporadic cancers; somatic mutation L → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L252PVAR_005988	252	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912653 L → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1978757 ↗	1/1 residues mapped to 9R2Q
L252VVAR_045264	252	in a sporadic cancer; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T253AVAR_045265	253	in sporadic cancers; somatic mutation T → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T253IVAR_045266	253	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T253NVAR_045267	253	in sporadic cancers; somatic mutation; dbSNP:rs1555525465 T → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T253PVAR_047193	253	in sporadic cancers; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T253SVAR_045268	253	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254DVAR_045859	254	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions I → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254FVAR_045269	254	in a sporadic cancer; somatic mutation I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254LVAR_045270	254	in a sporadic cancer; somatic mutation I → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254MVAR_045271	254	in a sporadic cancer; somatic mutation I → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254NVAR_017908	254	in sporadic cancers; somatic mutation I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254SVAR_045272	254	in sporadic cancers; somatic mutation; dbSNP:rs1330865474 I → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254TVAR_017909	254	in sporadic cancers; somatic mutation I → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I254VVAR_045273	254	in sporadic cancers; somatic mutation; dbSNP:rs746601313 I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255FVAR_045274	255	in sporadic cancers; somatic mutation; dbSNP:rs1057519995 I → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255MVAR_045275	255	in sporadic cancers; somatic mutation I → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255NVAR_045276	255	in sporadic cancers; somatic mutation; dbSNP:rs876659675 I → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255SVAR_045277	255	in sporadic cancers; somatic mutation; dbSNP:rs876659675 I → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255TVAR_045278	255	in sporadic cancers; somatic mutation; dbSNP:rs876659675 I → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
I255VVAR_045279	255	in sporadic cancers; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T256IVAR_045280	256	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T256KVAR_045281	256	in sporadic cancers; somatic mutation T → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T256PVAR_045282	256	in sporadic cancers; somatic mutation T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T256SVAR_045283	256	in sporadic cancers; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L257PVAR_005989	257	in sporadic cancers; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L257QVAR_045284	257	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934577 L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L257RVAR_045285	257	in sporadic cancers; somatic mutation; dbSNP:rs28934577 L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L257VVAR_045286	257	in sporadic cancers; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258AVAR_045287	258	in sporadic cancers; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258DVAR_005990	258	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258GVAR_045288	258	in sporadic cancers; somatic mutation; dbSNP:rs1060501201 E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258KVAR_005991	258	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912652 E → K	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1978757 ↗	1/1 residues mapped to 9R2Q
E258LVAR_045860	258	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions E → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258QVAR_045289	258	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E258VVAR_045290	258	in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259AVAR_047194	259	in a sporadic cancer; somatic mutation D → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259EVAR_045291	259	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259GVAR_045292	259	in sporadic cancers; somatic mutation; dbSNP:rs745425759 D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259HVAR_045293	259	in sporadic cancers; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259NVAR_045294	259	in sporadic cancers; somatic mutation D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259PVAR_045861	259	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259SVAR_045862	259	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259VVAR_045295	259	in sporadic cancers; somatic mutation D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D259YVAR_033039	259	in sporadic cancers; somatic mutation D → Y	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17224074 ↗	1/1 residues mapped to 9R2Q
S260AVAR_045296	260	in sporadic cancers; somatic mutation S → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S260CVAR_045297	260	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S260FVAR_045298	260	in sporadic cancers; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S260PVAR_045299	260	in sporadic cancers; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S260TVAR_045300	260	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S260YVAR_045301	260	in sporadic cancers; somatic mutation; dbSNP:rs876658916 S → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S261CVAR_045302	261	in a sporadic cancer; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S261GVAR_045303	261	in sporadic cancers; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S261IVAR_045304	261	in sporadic cancers; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S261NVAR_045305	261	in a sporadic cancer; somatic mutation S → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S261RVAR_045306	261	in sporadic cancers; somatic mutation S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
GN262PDVAR_047195	262–263	in a sporadic cancer; somatic mutation GN → PD	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
G262CVAR_045307	262	in a sporadic cancer; somatic mutation; dbSNP:rs200579969 G → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G262DVAR_047196	262	in sporadic cancers; somatic mutation G → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G262HVAR_045863	262	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions G → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G262SVAR_045308	262	in sporadic cancers; somatic mutation; dbSNP:rs200579969 G → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G262VVAR_045309	262	in sporadic cancers; somatic mutation; dbSNP:rs1131691025 G → V	Experimental evidence Evidence & references ECO:0000269 Reference:Ref.23	1/1 residues mapped to 9R2Q
N263DVAR_045310	263	in sporadic cancers; somatic mutation; dbSNP:rs72661119 N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N263HVAR_045311	263	in sporadic cancers; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N263IVAR_045312	263	in sporadic cancers; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N263KVAR_045313	263	in a sporadic cancer; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N263SVAR_045314	263	in a sporadic cancer; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L264IVAR_045315	264	in sporadic cancers; somatic mutation L → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L264PVAR_045316	264	in a sporadic cancer; somatic mutation; dbSNP:rs1555525353 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L264QVAR_045317	264	in a sporadic cancer; somatic mutation L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L264RVAR_045318	264	in sporadic cancers; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L264VVAR_045319	264	in a sporadic cancer; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L265MVAR_045320	265	in sporadic cancers; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L265PVAR_045321	265	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs879253942 L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L265QVAR_045322	265	in sporadic cancers; somatic mutation L → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L265RVAR_047197	265	in sporadic cancers; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G266AVAR_045323	266	in sporadic cancers; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G266EVAR_045324	266	in sporadic cancers; somatic mutation; dbSNP:rs193920774 G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G266RVAR_045325	266	in sporadic cancers; somatic mutation; dbSNP:rs1057519990 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G266VVAR_045326	266	in sporadic cancers; somatic mutation; dbSNP:rs193920774 G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R267GVAR_045327	267	in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R267HVAR_045328	267	in a sporadic cancer; somatic mutation R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R267PVAR_045329	267	in sporadic cancers; somatic mutation; dbSNP:rs587780075 R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R267QVAR_045330	267	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780075 R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R267WVAR_036507	267	in sporadic cancers; somatic mutation; dbSNP:rs55832599 R → W	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
N268FVAR_045864	268	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions N → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N268HVAR_045331	268	in sporadic cancers; somatic mutation N → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N268IVAR_045332	268	in sporadic cancers; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N268KVAR_045333	268	in a sporadic cancer; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N268SVAR_045334	268	in sporadic cancers; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N268YVAR_045335	268	in a sporadic cancer; somatic mutation N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269CVAR_045336	269	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269GVAR_045337	269	in sporadic cancers; somatic mutation S → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269IVAR_047198	269	in a sporadic cancer; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269NVAR_045338	269	in sporadic cancers; somatic mutation S → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269RVAR_045339	269	in sporadic cancers; somatic mutation S → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
S269TVAR_045340	269	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270CVAR_045341	270	in sporadic cancers; somatic mutation; dbSNP:rs1057519986 F → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270IVAR_045342	270	in sporadic cancers; somatic mutation; dbSNP:rs1057519988 F → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270LVAR_045343	270	in sporadic cancers; somatic mutation; dbSNP:rs1057519987 F → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270SVAR_045344	270	in sporadic cancers; somatic mutation; dbSNP:rs1057519986 F → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270VVAR_045345	270	in sporadic cancers; somatic mutation; dbSNP:rs1057519988 F → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
F270YVAR_045346	270	in sporadic cancers; somatic mutation F → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271AVAR_045347	271	in sporadic cancers; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271DVAR_045348	271	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271GVAR_045349	271	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271KVAR_036508	271	in sporadic cancers; somatic mutation; dbSNP:rs1060501191 E → K	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
E271PVAR_045865	271	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions E → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271QVAR_045350	271	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271RVAR_045866	271	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions E → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E271VVAR_047199	271	in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V272AVAR_045351	272	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V272EVAR_045352	272	in sporadic cancers; somatic mutation; dbSNP:rs876660333 V → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V272GVAR_045353	272	in sporadic cancers; somatic mutation; dbSNP:rs876660333 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V272LVAR_005992	272	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121912657 V → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1737852 ↗	1/1 residues mapped to 9R2Q
V272MVAR_045354	272	in sporadic cancers; somatic mutation; dbSNP:rs121912657 V → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R273CVAR_005993	273	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121913343 R → C	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:17224074 ↗ ECO:0000269 PubMed:7887414 ↗ ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
R273GVAR_005994	273	in LFS; germline mutation and in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R273HVAR_005995	273	in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; does not induce SNAI1 degradation; dbSNP:rs28934576 R → H	Experimental evidence 8 publications Evidence & references ECO:0000269 PubMed:10570149 ↗ ECO:0000269 PubMed:1394225 ↗ ECO:0000269 PubMed:1565144 ↗ ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:1699228 ↗ ECO:0000269 PubMed:1868473 ↗ ECO:0000269 PubMed:20385133 ↗ ECO:0000269 PubMed:7682763 ↗ ECO:0000269 Reference:Ref.14	1/1 residues mapped to 9R2Q
R273LVAR_036509	273	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934576 R → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
R273NVAR_045867	273	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions R → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R273PVAR_045355	273	in sporadic cancers; somatic mutation; dbSNP:rs28934576 R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:27657329 ↗	1/1 residues mapped to 9R2Q
R273QVAR_045356	273	in sporadic cancers; somatic mutation R → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R273SVAR_045357	273	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs121913343 R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R273YVAR_045868	273	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions R → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274AVAR_045358	274	in sporadic cancers; somatic mutation; dbSNP:rs1057520006 V → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274DVAR_045359	274	in sporadic cancers; somatic mutation; dbSNP:rs1057520006 V → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274FVAR_005997	274	in sporadic cancers; somatic mutation; dbSNP:rs1057520005 V → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274GVAR_047200	274	in sporadic cancers; somatic mutation; dbSNP:rs1057520006 V → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274IVAR_045360	274	in sporadic cancers; somatic mutation V → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
V274LVAR_045361	274	in sporadic cancers; somatic mutation; dbSNP:rs1057520005 V → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275FVAR_045362	275	in sporadic cancers; somatic mutation; dbSNP:rs863224451 C → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275GVAR_045363	275	in sporadic cancers; somatic mutation C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275RVAR_045364	275	in sporadic cancers; somatic mutation; dbSNP:rs1057519983 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275SVAR_045365	275	in sporadic cancers; somatic mutation; dbSNP:rs863224451 C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275WVAR_005999	275	in sporadic cancers; somatic mutation; dbSNP:rs1555525279 C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C275YVAR_005998	275	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs863224451 C → Y	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:7887414 ↗	1/1 residues mapped to 9R2Q
A276DVAR_045366	276	in sporadic cancers; somatic mutation; dbSNP:rs786202082 A → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A276GVAR_045367	276	in sporadic cancers; somatic mutation; dbSNP:rs786202082 A → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A276PVAR_045368	276	in sporadic cancers; somatic mutation; dbSNP:rs1131691029 A → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A276SVAR_045369	276	in sporadic cancers; somatic mutation A → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A276TVAR_045370	276	in sporadic cancers; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
A276VVAR_045371	276	in sporadic cancers; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277FVAR_045372	277	in sporadic cancers; somatic mutation; dbSNP:rs763098116 C → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277GVAR_006000	277	in sporadic cancers; somatic mutation; dbSNP:rs1064795369 C → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277RVAR_045373	277	in sporadic cancers; somatic mutation; dbSNP:rs1064795369 C → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277SVAR_045374	277	in sporadic cancers; somatic mutation C → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277WVAR_047201	277	in sporadic cancers; somatic mutation C → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
C277YVAR_045375	277	in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs763098116 C → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P278AVAR_006001	278	in sporadic cancers; somatic mutation; dbSNP:rs17849781 P → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:15489334 ↗	1/1 residues mapped to 9R2Q
P278FVAR_045869	278	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions P → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P278HVAR_006002	278	in sporadic cancers; somatic mutation; dbSNP:rs876659802 P → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P278LVAR_006003	278	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs876659802 P → L	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2263646 ↗	1/1 residues mapped to 9R2Q
P278RVAR_045376	278	in sporadic cancers; somatic mutation; dbSNP:rs876659802 P → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
P278SVAR_006004	278	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17849781 P → S	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:16959974 ↗ ECO:0000269 PubMed:2263646 ↗ ECO:0000269 PubMed:9450901 ↗	1/1 residues mapped to 9R2Q
P278TVAR_006005	278	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17849781 P → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G279EVAR_006006	279	in sporadic cancers; somatic mutation; dbSNP:rs1064793881 G → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G279RVAR_045377	279	in sporadic cancers; somatic mutation; dbSNP:rs1555525248 G → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G279VVAR_045378	279	in sporadic cancers; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
G279WVAR_045379	279	in sporadic cancers; somatic mutation G → W	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R280GVAR_045380	280	in sporadic cancers; somatic mutation; dbSNP:rs753660142 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R280IVAR_006008	280	in sporadic cancers; somatic mutation; dbSNP:rs121912660 R → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
R280KVAR_006007	280	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; no effect on interaction with CCAR2; dbSNP:rs121912660 R → K	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:1694291 ↗ ECO:0000269 PubMed:25732823 ↗	1/1 residues mapped to 9R2Q
R280PVAR_045381	280	in a sporadic cancer; somatic mutation R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R280SVAR_045382	280	in sporadic cancers; somatic mutation R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R280TVAR_006009	280	in sporadic cancers; somatic mutation; dbSNP:rs121912660 R → T	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1631151 ↗	1/1 residues mapped to 9R2Q
DR281EWVAR_047203	281–282	in sporadic cancers; somatic mutation DR → EW	Evidence & references No separate evidence record is supplied for this statement.	2/2 residues mapped to 9R2Q
D281AVAR_006010	281	in sporadic cancers; somatic mutation; dbSNP:rs587781525 D → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D281EVAR_006011	281	in sporadic cancers; somatic mutation; dbSNP:rs1057519984 D → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1459726 ↗	1/1 residues mapped to 9R2Q
D281GVAR_006012	281	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781525 D → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D281HVAR_006013	281	in sporadic cancers; somatic mutation; dbSNP:rs764146326 D → H	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16959974 ↗	1/1 residues mapped to 9R2Q
D281NVAR_047202	281	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs764146326 D → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D281RVAR_045870	281	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D281VVAR_006014	281	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587781525 D → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
D281YVAR_045383	281	in sporadic cancers; somatic mutation; dbSNP:rs764146326 D → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R282GVAR_045384	282	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934574 R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R282HVAR_045385	282	in a sporadic cancer; somatic mutation R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R282LVAR_006015	282	in sporadic cancers; somatic mutation; dbSNP:rs730882008 R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R282PVAR_045386	282	in sporadic cancers; somatic mutation; dbSNP:rs730882008 R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R282QVAR_045387	282	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs730882008 R → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:18453682 ↗ ECO:0000269 Reference:Ref.22	1/1 residues mapped to 9R2Q
R282WVAR_006016	282	in LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation; dbSNP:rs28934574 R → W	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:20385133 ↗ ECO:0000269 PubMed:8829627 ↗	1/1 residues mapped to 9R2Q
R283CVAR_006017	283	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs149633775 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R283GVAR_006018	283	in sporadic cancers; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R283HVAR_006019	283	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs371409680 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R283LVAR_045388	283	in sporadic cancers; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R283PVAR_006020	283	in sporadic cancers; somatic mutation R → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R283SVAR_045389	283	in a sporadic cancer; somatic mutation; dbSNP:rs149633775 R → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T284AVAR_006021	284	in sporadic cancers; somatic mutation T → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
T284IVAR_045390	284	in sporadic cancers; somatic mutation; dbSNP:rs863224685 T → I	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T284KVAR_045391	284	in sporadic cancers; somatic mutation T → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
T284PVAR_006022	284	in sporadic cancers; somatic mutation; dbSNP:rs1204379654 T → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E285AVAR_045392	285	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E285DVAR_045393	285	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E285GVAR_045394	285	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E285KVAR_006023	285	in sporadic cancers; somatic mutation; dbSNP:rs112431538 E → K	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:1459726 ↗ ECO:0000269 PubMed:1694291 ↗	1/1 residues mapped to 9R2Q
E285QVAR_006024	285	in LFS; germline mutation and in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E285VVAR_006025	285	in sporadic cancers; somatic mutation; dbSNP:rs121912667 E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E286AVAR_006026	286	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1057519985 E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E286DVAR_006027	286	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E286GVAR_006028	286	in sporadic cancers; somatic mutation; dbSNP:rs1057519985 E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E286KVAR_006029	286	in sporadic cancers; somatic mutation; dbSNP:rs786201059 E → K	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:11023613 ↗ ECO:0000269 PubMed:8316628 ↗	1/1 residues mapped to 9R2Q
E286LVAR_045871	286	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions E → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E286QVAR_006030	286	in sporadic cancers; somatic mutation; dbSNP:rs786201059 E → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:8829627 ↗	1/1 residues mapped to 9R2Q
E286VVAR_045395	286	in sporadic cancers; somatic mutation; dbSNP:rs1057519985 E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E287AVAR_047204	287	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E287DVAR_045396	287	in sporadic cancers; somatic mutation; dbSNP:rs748891343 E → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E287GVAR_045397	287	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E287KVAR_045398	287	in sporadic cancers; somatic mutation; dbSNP:rs587782006 E → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
E287VVAR_045399	287	in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N288DVAR_045400	288	in a sporadic cancer; somatic mutation N → D	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N288KVAR_045401	288	in sporadic cancers; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N288SVAR_045402	288	in sporadic cancers; somatic mutation N → S	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N288TVAR_045403	288	in sporadic cancers; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
N288YVAR_045404	288	in sporadic cancers; somatic mutation N → Y	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L289FVAR_045405	289	in sporadic cancers; somatic mutation L → F	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L289HVAR_045406	289	in sporadic cancers; somatic mutation L → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L289PVAR_045407	289	in sporadic cancers; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L289RVAR_045408	289	in a sporadic cancer; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
L289VVAR_045409	289	in sporadic cancers; somatic mutation; dbSNP:rs1555525154 L → V	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R290CVAR_045410	290	in sporadic cancers; somatic mutation; dbSNP:rs770374782 R → C	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R290HVAR_045411	290	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs55819519 R → H	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
R290LVAR_045412	290	in LFS; germline mutation and in sporadic cancers; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291EVAR_045413	291	in sporadic cancers; somatic mutation; dbSNP:rs1555525126 K → E	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291MVAR_045414	291	in sporadic cancers; somatic mutation K → M	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291NVAR_045415	291	in sporadic cancers; somatic mutation; dbSNP:rs372613518 K → N	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291QVAR_047205	291	in sporadic cancers; somatic mutation K → Q	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291RVAR_045416	291	in sporadic cancers; somatic mutation; dbSNP:rs781490101 K → R	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K291TVAR_045417	291	in sporadic cancers; somatic mutation K → T	Evidence & references No separate evidence record is supplied for this statement.	1/1 residues mapped to 9R2Q
K292EVAR_045418	292	in sporadic cancers; somatic mutation K → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K292GVAR_045872	292	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions K → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K292IVAR_015819	292	in LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs121912663 K → I	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10484981 ↗	No verified residues in this structure
K292NVAR_045419	292	in sporadic cancers; somatic mutation K → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K292QVAR_045420	292	in a sporadic cancer; somatic mutation K → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K292RVAR_045421	292	in sporadic cancers; somatic mutation; dbSNP:rs121912663 K → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K292TVAR_045422	292	in sporadic cancers; somatic mutation K → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G293AVAR_045423	293	in a sporadic cancer; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G293RVAR_045424	293	in sporadic cancers; somatic mutation; dbSNP:rs587780076 G → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G293VVAR_045425	293	in sporadic cancers; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G293WVAR_045426	293	in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs587780076 G → W	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294AVAR_045427	294	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294DVAR_045428	294	in sporadic cancers; somatic mutation; dbSNP:rs1305324490 E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294GVAR_045429	294	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294KVAR_047206	294	in sporadic cancers; somatic mutation E → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294QVAR_045430	294	in sporadic cancers; somatic mutation E → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E294VVAR_045431	294	in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P295HVAR_045432	295	in a sporadic cancer; somatic mutation P → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P295LVAR_045433	295	in sporadic cancers; somatic mutation; dbSNP:rs751713111 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P295RVAR_045434	295	in a sporadic cancer; somatic mutation; dbSNP:rs751713111 P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P295SVAR_045435	295	in sporadic cancers; somatic mutation; dbSNP:rs1131691006 P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296CVAR_045873	296	in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions H → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296DVAR_045436	296	in sporadic cancers; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296LVAR_047207	296	in sporadic cancers; somatic mutation H → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296NVAR_045437	296	in sporadic cancers; somatic mutation H → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296PVAR_006031	296	in a sporadic cancer; somatic mutation H → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296QVAR_045438	296	in sporadic cancers; somatic mutation H → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296RVAR_045439	296	in a sporadic cancer; somatic mutation; dbSNP:rs483352696 H → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H296YVAR_045440	296	in sporadic cancers; somatic mutation; dbSNP:rs672601296 H → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H297DVAR_045441	297	in a sporadic cancer; somatic mutation H → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H297NVAR_045442	297	in a sporadic cancer; somatic mutation H → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H297PVAR_045443	297	in sporadic cancers; somatic mutation H → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H297RVAR_045444	297	in sporadic cancers; somatic mutation; dbSNP:rs876659477 H → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H297YVAR_045445	297	in sporadic cancers; somatic mutation H → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E298AVAR_045446	298	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E298DVAR_045447	298	in sporadic cancers; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E298KVAR_045448	298	in sporadic cancers; somatic mutation; dbSNP:rs201744589 E → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E298QVAR_045449	298	in sporadic cancers; somatic mutation; dbSNP:rs201744589 E → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E298VVAR_045450	298	in sporadic cancers; somatic mutation E → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L299PVAR_045451	299	in sporadic cancers; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L299QVAR_045452	299	in sporadic cancers; somatic mutation L → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L299RVAR_045453	299	in a sporadic cancer; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L299VVAR_045454	299	in a sporadic cancer; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P300AVAR_045455	300	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P300LVAR_045456	300	in sporadic cancers; somatic mutation; dbSNP:rs909643864 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P300RVAR_006032	300	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P300SVAR_045457	300	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P301AVAR_045458	301	in sporadic cancers; somatic mutation P → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P301LVAR_006033	301	in sporadic cancers; somatic mutation; dbSNP:rs1555525067 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P301QVAR_045459	301	in sporadic cancers; somatic mutation P → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P301SVAR_045460	301	in sporadic cancers; somatic mutation P → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P301TVAR_047208	301	in a sporadic cancer; somatic mutation P → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G302AVAR_045461	302	in a sporadic cancer; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G302EVAR_006034	302	in sporadic cancers; somatic mutation; dbSNP:rs1060501202 G → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G302RVAR_045462	302	in a sporadic cancer; somatic mutation; dbSNP:rs863224686 G → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G302VVAR_006035	302	in a sporadic cancer; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S303CVAR_045463	303	in sporadic cancers; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S303IVAR_045464	303	in sporadic cancers; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S303NVAR_045465	303	in sporadic cancers; somatic mutation; dbSNP:rs876658714 S → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S303TVAR_045466	303	in sporadic cancers; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T304AVAR_045467	304	in sporadic cancers; somatic mutation; dbSNP:rs587782654 T → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T304IVAR_045468	304	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T304NVAR_045469	304	in a sporadic cancer; somatic mutation T → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T304SVAR_047209	304	in a sporadic cancer; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K305EVAR_045470	305	in a sporadic cancer; somatic mutation K → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K305MVAR_045471	305	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation K → M	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K305NVAR_045472	305	in sporadic cancers; somatic mutation; loss of nuclear localization K → N	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10551826 ↗	No verified residues in this structure
K305RVAR_045473	305	in sporadic cancers; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K305TVAR_045474	305	in a sporadic cancer; somatic mutation K → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R306PVAR_045475	306	in LFS; germline mutation and in a sporadic cancer; somatic mutation R → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R306QVAR_006036	306	in sporadic cancers; somatic mutation; dbSNP:rs1048095040 R → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A307PVAR_045476	307	in a sporadic cancer; somatic mutation A → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A307SVAR_045477	307	in sporadic cancers; somatic mutation A → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A307TVAR_006037	307	in sporadic cancers; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L308MVAR_045478	308	in sporadic cancers; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L308VVAR_045479	308	in a sporadic cancer; somatic mutation L → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P309RVAR_045480	309	in a sporadic cancer; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P309SVAR_006038	309	in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs1555525012 P → S	Experimental evidence Evidence & references ECO:0000269 Reference:Ref.14	No verified residues in this structure
N310IVAR_045481	310	in a sporadic cancer; somatic mutation N → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
N310TVAR_045482	310	in sporadic cancers; somatic mutation N → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
N311HVAR_045483	311	in sporadic cancers; somatic mutation; dbSNP:rs1555525007 N → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
N311KVAR_045484	311	in a sporadic cancer; somatic mutation N → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
N311SVAR_045485	311	in a sporadic cancer; somatic mutation; dbSNP:rs56184981 N → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
N311TVAR_045486	311	in sporadic cancers; somatic mutation; dbSNP:rs56184981 N → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T312IVAR_045487	312	in sporadic cancers; somatic mutation T → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T312SVAR_045488	312	in sporadic cancers; somatic mutation; dbSNP:rs145151284 T → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S313CVAR_045489	313	in a sporadic cancer; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S313IVAR_045490	313	in a sporadic cancer; somatic mutation S → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S313NVAR_045491	313	in a sporadic cancer; somatic mutation S → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S313RVAR_045492	313	in a sporadic cancer; somatic mutation; dbSNP:rs1367492395 S → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S314FVAR_045493	314	in a sporadic cancer; somatic mutation; dbSNP:rs751440465 S → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S315CVAR_045494	315	in a sporadic cancer; somatic mutation S → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S315FVAR_045495	315	in a sporadic cancer; somatic mutation S → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S315PVAR_045496	315	in a sporadic cancer; somatic mutation S → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P316LVAR_045497	316	in a sporadic cancer; somatic mutation; dbSNP:rs1555524979 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P316TVAR_045498	316	in a sporadic cancer; somatic mutation; dbSNP:rs772773208 P → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q317HVAR_045499	317	in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs1060501199 Q → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q317KVAR_045500	317	in sporadic cancers; somatic mutation; dbSNP:rs764735889 Q → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q317LVAR_047210	317	in a sporadic cancer; somatic mutation Q → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q317PVAR_045501	317	in a sporadic cancer; somatic mutation Q → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q317RVAR_045502	317	in sporadic cancers; somatic mutation; dbSNP:rs1159579789 Q → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P318LVAR_045503	318	in sporadic cancers; somatic mutation; dbSNP:rs1555524975 P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K319EVAR_045504	319	in sporadic cancers; somatic mutation K → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K319NVAR_045505	319	in a sporadic cancer; somatic mutation K → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K319RVAR_045506	319	in a sporadic cancer; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K320NVAR_045507	320	in sporadic cancers; somatic mutation K → N	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K321EVAR_045508	321	in kidney cancer; germline mutation K → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
K321RVAR_045509	321	in a sporadic cancer; somatic mutation K → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P322LVAR_045510	322	in sporadic cancers; somatic mutation P → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
P322RVAR_045511	322	in sporadic cancers; somatic mutation P → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L323GVAR_045874	323	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions L → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L323MVAR_045512	323	in a sporadic cancer; somatic mutation L → M	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L323PVAR_045513	323	in a sporadic cancer; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L323RVAR_045514	323	in a sporadic cancer; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L323VVAR_047211	323	in a sporadic cancer; somatic mutation; dbSNP:rs1432281680 L → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D324EVAR_045515	324	in sporadic cancers; somatic mutation D → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D324SVAR_045875	324	in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions D → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D324YVAR_045516	324	in a sporadic cancer; somatic mutation D → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G325AVAR_045517	325	in a sporadic cancer; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G325EVAR_045518	325	in sporadic cancers; somatic mutation G → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G325VVAR_006039	325	in LFS; germline mutation; dbSNP:rs121912659 G → V	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:1565144 ↗	No verified residues in this structure
E326GVAR_045519	326	in a sporadic cancer; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Y327HVAR_045520	327	in a sporadic cancer; somatic mutation Y → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Y327SVAR_045521	327	in a sporadic cancer; somatic mutation Y → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F328LVAR_045522	328	in a sporadic cancer; somatic mutation F → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F328SVAR_045523	328	in sporadic cancers; somatic mutation F → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F328VVAR_045524	328	in a sporadic cancer; somatic mutation F → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T329IVAR_045525	329	in a sporadic cancer; somatic mutation; dbSNP:rs969930693 T → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
T329SVAR_045526	329	in a sporadic cancer; somatic mutation T → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L330HVAR_045527	330	in sporadic cancers; somatic mutation L → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L330PVAR_047212	330	in a sporadic cancer; somatic mutation L → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L330RVAR_045528	330	in sporadic cancers; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q331HVAR_045529	331	in sporadic cancers; somatic mutation; dbSNP:rs11575996 Q → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q331PVAR_045530	331	in sporadic cancers; somatic mutation Q → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q331RVAR_045531	331	in sporadic cancers; somatic mutation; dbSNP:rs1064795056 Q → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
I332VVAR_045532	332	in a sporadic cancer; somatic mutation I → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G334VVAR_006040	334	in sporadic cancers; somatic mutation G → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G334WVAR_045533	334	in a sporadic cancer; somatic mutation; dbSNP:rs730882028 G → W	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R335GVAR_045534	335	in a sporadic cancer; somatic mutation R → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R335HVAR_045535	335	in a sporadic cancer; somatic mutation; dbSNP:rs771939956 R → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R335LVAR_045536	335	in a sporadic cancer; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R337CVAR_006041	337	in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs587782529 R → C	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:36108750 ↗ ECO:0000269 PubMed:9452042 ↗	No verified residues in this structure
R337HVAR_035016	337	in LFS; germline mutation and in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664 R → H	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:11481490 ↗ ECO:0000269 PubMed:36108750 ↗	No verified residues in this structure
R337LVAR_045537	337	in sporadic cancers; somatic mutation; dbSNP:rs121912664 R → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R337PVAR_045538	337	in sporadic cancers; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912664 R → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:36108750 ↗	No verified residues in this structure
F338IVAR_045539	338	in a sporadic cancer; somatic mutation F → I	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F338LVAR_045540	338	in a sporadic cancer; somatic mutation; dbSNP:rs150293825 F → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E339KVAR_022316	339	in a sporadic cancer; somatic mutation; dbSNP:rs17882252 E → K	Experimental evidence Evidence & references ECO:0000269 Reference:Ref.12	No verified residues in this structure
E339QVAR_045541	339	in a sporadic cancer; somatic mutation; dbSNP:rs17882252 E → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F341CVAR_045542	341	in sporadic cancers; somatic mutation F → C	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R342LVAR_045543	342	in a sporadic cancer; somatic mutation R → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R342PVAR_045544	342	in sporadic cancers; somatic mutation; dbSNP:rs375338359 R → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R342QVAR_047213	342	in sporadic cancers; somatic mutation; dbSNP:rs375338359 R → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E343GVAR_045545	343	in sporadic cancers; somatic mutation E → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L344PVAR_045546	344	in LFS; germline mutation and in a sporadic cancer; somatic mutation; impaired ability to tetramerize and undergo liquid-liquid phase separation; dbSNP:rs121912662 L → P	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:36108750 ↗	No verified residues in this structure
L344RVAR_045547	344	in a sporadic cancer; somatic mutation L → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E346AVAR_045548	346	in a sporadic cancer; somatic mutation E → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A347GVAR_045549	347	in a sporadic cancer; somatic mutation A → G	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A347TVAR_045550	347	in sporadic cancers; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L348FVAR_045551	348	in a sporadic cancer; somatic mutation L → F	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
L348SVAR_045552	348	in a sporadic cancer; somatic mutation L → S	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E349DVAR_045553	349	in a sporadic cancer; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
D352HVAR_045554	352	in a sporadic cancer; somatic mutation D → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A353TVAR_045555	353	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q354EVAR_045556	354	in a sporadic cancer; somatic mutation Q → E	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q354KVAR_045557	354	in a sporadic cancer; somatic mutation; dbSNP:rs755394212 Q → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Q354RVAR_047214	354	in sporadic cancers; somatic mutation; dbSNP:rs752142489 Q → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G356AVAR_045558	356	in a sporadic cancer; somatic mutation G → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G356WVAR_045559	356	in a sporadic cancer; somatic mutation G → W	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E358DVAR_045560	358	in a sporadic cancer; somatic mutation E → D	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
E358KVAR_045561	358	in a sporadic cancer; somatic mutation; dbSNP:rs587782237 E → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G360AVAR_045562	360	in dbSNP:rs35993958 G → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G360VVAR_045563	360	in a sporadic cancer; somatic mutation; dbSNP:rs35993958 G → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R363KVAR_045564	363	in a sporadic cancer; somatic mutation; dbSNP:rs876660285 R → K	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A364PVAR_045565	364	in a sporadic cancer; somatic mutation A → P	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A364TVAR_045566	364	in a sporadic cancer; somatic mutation A → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
A364VVAR_045567	364	in a sporadic cancer; somatic mutation A → V	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H365RVAR_047215	365	in a sporadic cancer; somatic mutation H → R	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
H365YVAR_045568	365	in a familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation; dbSNP:rs267605075 H → Y	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S366AVAR_022317	366	in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs17881470 S → A	Experimental evidence Evidence & references ECO:0000269 Reference:Ref.12	No verified residues in this structure
K370QVAR_045569	370	in a sporadic cancer; somatic mutation K → Q	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S376AVAR_045570	376	in a sporadic cancer; somatic mutation S → A	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S376TVAR_045571	376	in a sporadic cancer; somatic mutation S → T	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
R379HVAR_045572	379	in sporadic cancers; somatic mutation; dbSNP:rs863224682 R → H	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
F385LVAR_045573	385	in a sporadic cancer; somatic mutation; dbSNP:rs1555524094 F → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
G389WVAR_045574	389	in a sporadic cancer; somatic mutation; dbSNP:rs587783064 G → W	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
S392LVAR_045575	392	in a sporadic cancer; somatic mutation S → L	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure

Laboratory mutagenesis 38

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38 recorded rows

Feature	Position	Description	Evidence	Inspect
S15A	15	Loss of interaction with PPP2R5C, PPP2CAANDPPP2R1A. S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17967874 ↗	No verified residues in this structure
T18A	18	No effect on interaction with MDM2 and increase in protein levels after DNA damage. T → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10570149 ↗	No verified residues in this structure
S20A	20	Abolishes phosphorylation site. Abolishes increase in protein levels after DNA damage. S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10570149 ↗	No verified residues in this structure
S20D	20	Constitutively increased TP53 protein levels. S → D	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10570149 ↗	No verified residues in this structure
LW22QS	22–23	Loss of interaction with MDM2, leading to constitutively increased TP53 protein levels. LW → QS	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10570149 ↗	No verified residues in this structure
K24R	24	Abolishes ubiquitination by MUL1. K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:21597459 ↗	No verified residues in this structure
S37D	37	Abolishes phosphorylation by MAPKAPK5. S → D	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17254968 ↗	No verified residues in this structure
S46A	46	Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP. S → A	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:11740489 ↗ ECO:0000269 PubMed:16219768 ↗ ECO:0000269 PubMed:17349958 ↗	No verified residues in this structure
Mutagenesis	46	Alters interaction with WWOX.	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:11740489 ↗ ECO:0000269 PubMed:16219768 ↗ ECO:0000269 PubMed:17349958 ↗	No verified residues in this structure
T55A	55	Blocks phosphorylation by TAF1. T → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:15053879 ↗	No verified residues in this structure
S183A	183	Abolishes strongly phosphorylation. S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
S183E	183	Inhibits slightly its transcriptional activity. S → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
R248S	248	Does not induce SNAI1 degradation. R → S	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20385133 ↗	1/1 residues mapped to 9R2Q
S269A	269	Abolishes phosphorylation. S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
S269E	269	Inhibits strongly its transcriptional activity. S → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
T284E	284	Inhibits strongly its transcriptional activity. T → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
KK291RR	291–292	Abolishes polyubiquitination by MKRN1. KK → RR	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19536131 ↗	1/2 residues mapped to 9R2Q
K319A	319	Loss of nuclear localization; when associated with A-320 and A-321. K → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2156209 ↗	No verified residues in this structure
K320A	320	Loss of nuclear localization; when associated with A-319 and A-321. K → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2156209 ↗	No verified residues in this structure
K321A	321	Loss of nuclear localization; when associated with A-319 and A-320. K → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:2156209 ↗	No verified residues in this structure
RGRER333KGKEK	333–337	Reduced methylation by PRMT5. Reduced nuclear localization. Decreased binding to promoters of target genes. Reduced transcriptional activity. Decrease in cell cycle arrest. RGRER → KGKEK	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19011621 ↗	No verified residues in this structure
P359D	359	Abolishes binding to USP7. P → D	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16402859 ↗	No verified residues in this structure
G361E	361	Abolishes binding to USP7. G → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16402859 ↗	No verified residues in this structure
S362A	362	Abolishes binding to USP7. S → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:16402859 ↗	No verified residues in this structure
K370R	370	Induces a decrease in methylation by SMYD2. K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17108971 ↗	No verified residues in this structure
K372R	372	Induces a decrease in protein stabilization. K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:15525938 ↗	No verified residues in this structure
K373R	373	Abolishes dimethylation by EHMT1 and EHMT2. K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20118233 ↗	No verified residues in this structure
K381Q	381	Mimics acetylation, leading to increased stability. K → Q	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:29474172 ↗	No verified residues in this structure
K381R	381	Decreased acetylation. K → R	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:29474172 ↗	No verified residues in this structure
K382A	382	Abolishes acetylation by CREBBP. K → A	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:10884347 ↗ ECO:0000269 PubMed:11740489 ↗ ECO:0000269 PubMed:17707234 ↗ ECO:0000269 PubMed:20870725 ↗	No verified residues in this structure
K382R	382	Abolishes monomethylation by KMT5A. K → R	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:10884347 ↗ ECO:0000269 PubMed:11740489 ↗ ECO:0000269 PubMed:17707234 ↗ ECO:0000269 PubMed:20870725 ↗	No verified residues in this structure
L383A	383	Abolishes S-315 phosphorylation by CDK2/cyclin A. L → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10884347 ↗	No verified residues in this structure
F385A	385	Reduced SUMO1 conjugation. F → A	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:10884347 ↗ ECO:0000269 PubMed:11124955 ↗	No verified residues in this structure
K386A	386	Abolishes SUMO1 conjugation, in vitro and in vivo. K → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:11124955 ↗ ECO:0000269 Reference:Ref.37	No verified residues in this structure
T387A	387	No effect SUMO1 conjugation. T → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:11124955 ↗	No verified residues in this structure
E388A	388	Abolishes SUMO1 conjugation. E → A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:11124955 ↗	No verified residues in this structure
S392D	392	Mimics phosphorylation; promotes ability to undergo liquid-liquid phase separation. S → D	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:35618207 ↗	No verified residues in this structure
S392E	392	Abolished ability to undergo liquid-liquid phase separation. S → E	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:31953488 ↗	No verified residues in this structure

PTM/Processing

Acetylation of Lys-382 by CREBBP enhances transcriptional activity ^{[42, 75, 133, 150]}. Acetylation of Lys-382 by EP300 ^{[42, 75, 133, 150]}. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce pro-apoptotic program and modulate cell senescence ^{[42, 75, 133, 150]}.

Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner ^{[42, 75, 133, 150, 165]}. Acetylation at Lys-381 increases stability ^[166]. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence ^[166].

Acetylated at Lys-120 by KAT5, KAT6A and KAT8; regulating its ability to induce pro-apoptotic program ^{[88, 120, 150]}

Experimental evidence 8 publications

Evidence & references

ECO:0000269 PubMed:10656795 ↗
ECO:0000269 PubMed:15448695 ↗
ECO:0000269 PubMed:17189187 ↗
ECO:0000269 PubMed:19854137 ↗
ECO:0000269 PubMed:20228809 ↗
ECO:0000269 PubMed:23431171 ↗
ECO:0000269 PubMed:29474172 ↗
ECO:0000269 PubMed:29681526 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10656795"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15448695"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17189187"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19854137"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20228809"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "23431171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "29474172"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "29681526"
        }
      ],
      "value": "Acetylation of Lys-382 by CREBBP enhances transcriptional activity (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Acetylation of Lys-382 by EP300 (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation of Lys-382 by SIRT1 impairs its ability to induce pro-apoptotic program and modulate cell senescence (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171). Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner (PubMed:10656795, PubMed:15448695, PubMed:20228809, PubMed:23431171, PubMed:29681526). Acetylation at Lys-381 increases stability (PubMed:29474172). Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence (PubMed:29474172). Acetylated at Lys-120 by KAT5, KAT6A and KAT8; regulating its ability to induce pro-apoptotic program (PubMed:17189187, PubMed:19854137, PubMed:23431171)"
    }
  ],
  "commentType": "PTM"
}

Lactylation by AARS1 prevents ability to undergo liquid-liquid phase separation (LLPS), thereby inhibiting transcription factor activity

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:38653238 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "38653238"
        }
      ],
      "value": "Lactylation by AARS1 prevents ability to undergo liquid-liquid phase separation (LLPS), thereby inhibiting transcription factor activity"
    }
  ],
  "commentType": "PTM"
}

Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter.

Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2 ^{[46, 167]}. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis.

Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation.

Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 ^[143].

It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300.

Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage.

Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin ^[161]. Phosphorylation at Ser-392 regulates its ability to undergo liquid-liquid phase separation by increasing fluidity of TP53/p53 condensates ^[171]

By similarityExperimental evidence 33 publications

Evidence & references

ECO:0000250
ECO:0000269 PubMed:10570149 ↗
ECO:0000269 PubMed:10606744 ↗
ECO:0000269 PubMed:10884347 ↗
ECO:0000269 PubMed:10951572 ↗
ECO:0000269 PubMed:11239457 ↗
ECO:0000269 PubMed:11447225 ↗
ECO:0000269 PubMed:11546806 ↗
ECO:0000269 PubMed:11551930 ↗
ECO:0000269 PubMed:11554766 ↗
ECO:0000269 PubMed:11740489 ↗
ECO:0000269 PubMed:11780126 ↗
ECO:0000269 PubMed:12810724 ↗
ECO:0000269 PubMed:14702041 ↗
ECO:0000269 PubMed:15053879 ↗
ECO:0000269 PubMed:15866171 ↗
ECO:0000269 PubMed:16377624 ↗
ECO:0000269 PubMed:16704422 ↗
ECO:0000269 PubMed:1705009 ↗
ECO:0000269 PubMed:17108107 ↗
ECO:0000269 PubMed:17254968 ↗
ECO:0000269 PubMed:17349958 ↗
ECO:0000269 PubMed:17591690 ↗
ECO:0000269 PubMed:17967874 ↗
ECO:0000269 PubMed:18022393 ↗
ECO:0000269 PubMed:20041275 ↗
ECO:0000269 PubMed:20124405 ↗
ECO:0000269 PubMed:20959462 ↗
ECO:0000269 PubMed:21317932 ↗
ECO:0000269 PubMed:2141171 ↗
ECO:0000269 PubMed:22214662 ↗
ECO:0000269 PubMed:28842590 ↗
ECO:0000269 PubMed:31527692 ↗
ECO:0000269 PubMed:9372954 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000250"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10570149"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10606744"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10884347"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10951572"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11239457"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11447225"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11546806"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11551930"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11554766"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11740489"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11780126"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12810724"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "14702041"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15053879"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15866171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16377624"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16704422"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "1705009"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17108107"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17254968"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17349958"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17591690"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17967874"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18022393"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20041275"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20124405"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20959462"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "21317932"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "2141171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22214662"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "28842590"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "31527692"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "9372954"
        }
      ],
      "value": "Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity). Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1 (PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage. Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (PubMed:28842590). Phosphorylation at Ser-392 regulates its ability to undergo liquid-liquid phase separation by increasing fluidity of TP53/p53 condensates (PubMed:35618207)"
    }
  ],
  "commentType": "PTM"
}

Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A

Evidence & references

No separate evidence record is supplied for this statement.

Complete source annotation

{
  "texts": [
    {
      "value": "Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A"
    }
  ],
  "commentType": "PTM"
}

May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:8632915 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "8632915"
        }
      ],
      "value": "May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line"
    }
  ],
  "commentType": "PTM"
}

Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation ^{[41, 63, 73, 95, 129, 165]}. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome ^{[41, 63, 134]}. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation ^[115].

Deubiquitinated by USP10, leading to its stabilization ^[125]. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation ^[122]. Ubiquitination by TOPORS induces degradation ^[116].

Deubiquitination by USP7, leading to stabilization ^[72]. Isoform 4 is monoubiquitinated in an MDM2-independent manner ^[73]. Ubiquitinated by COP1, which leads to proteasomal degradation ^[118].

Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 ^[237]. Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation ^[138].

Deubiquitinated by USP3, leading to stabilization ^[162]. Ubiquitinated by MSL2, promoting its cytoplasmic localization ^[117]. Also ubiquitinated by the SCF(FBXO22)-KDMA4A complex; leading to proteasomal degradation ^[159]

By similarityExperimental evidence 20 publications

Evidence & references

ECO:0000250 UniProtKB:P02340
ECO:0000269 PubMed:10722742 ↗
ECO:0000269 PubMed:12810724 ↗
ECO:0000269 PubMed:15053880 ↗
ECO:0000269 PubMed:15340061 ↗
ECO:0000269 PubMed:17170702 ↗
ECO:0000269 PubMed:18206965 ↗
ECO:0000269 PubMed:19033443 ↗
ECO:0000269 PubMed:19473992 ↗
ECO:0000269 PubMed:19536131 ↗
ECO:0000269 PubMed:19556538 ↗
ECO:0000269 PubMed:19837670 ↗
ECO:0000269 PubMed:19880522 ↗
ECO:0000269 PubMed:20096447 ↗
ECO:0000269 PubMed:20173098 ↗
ECO:0000269 PubMed:21597459 ↗
ECO:0000269 PubMed:25591766 ↗
ECO:0000269 PubMed:25732823 ↗
ECO:0000269 PubMed:26868148 ↗
ECO:0000269 PubMed:28807825 ↗
ECO:0000269 PubMed:29681526 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000250",
          "source": "UniProtKB",
          "id": "P02340"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10722742"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12810724"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15053880"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15340061"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17170702"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18206965"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19033443"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19473992"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19536131"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19556538"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19837670"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19880522"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20096447"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20173098"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "21597459"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25591766"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25732823"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "26868148"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "28807825"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "29681526"
        }
      ],
      "value": "Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation (PubMed:10722742, PubMed:12810724, PubMed:15340061, PubMed:17170702, PubMed:19880522, PubMed:29681526). Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:10722742, PubMed:12810724, PubMed:20173098). Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation (PubMed:19536131). Deubiquitinated by USP10, leading to its stabilization (PubMed:20096447). Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation (PubMed:19556538). Ubiquitination by TOPORS induces degradation (PubMed:19473992). Deubiquitination by USP7, leading to stabilization (PubMed:15053880). Isoform 4 is monoubiquitinated in an MDM2-independent manner (PubMed:15340061). Ubiquitinated by COP1, which leads to proteasomal degradation (PubMed:19837670). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (PubMed:25732823). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (PubMed:21597459). Deubiquitinated by USP3, leading to stabilization (PubMed:28807825). Ubiquitinated by MSL2, promoting its cytoplasmic localization (PubMed:19033443). Also ubiquitinated by the SCF(FBXO22)-KDMA4A complex; leading to proteasomal degradation (PubMed:26868148)"
    }
  ],
  "commentType": "PTM"
}

Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation ^{[74, 91]}. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity ^[89]. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370 ^[89].

Dimethylated at Lys-373 by EHMT1 and EHMT2 ^[130]. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity ^[106]. Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20 ^[148].

Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation ^[105]. Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity ^[26]

Experimental evidence 8 publications

Evidence & references

ECO:0000269 PubMed:15525938 ↗
ECO:0000269 PubMed:16415881 ↗
ECO:0000269 PubMed:17108971 ↗
ECO:0000269 PubMed:17707234 ↗
ECO:0000269 PubMed:17805299 ↗
ECO:0000269 PubMed:19011621 ↗
ECO:0000269 PubMed:20118233 ↗
ECO:0000269 PubMed:22864287 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15525938"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16415881"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17108971"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17707234"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17805299"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19011621"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20118233"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22864287"
        }
      ],
      "value": "Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation (PubMed:15525938, PubMed:16415881). Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity (PubMed:17108971). Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370 (PubMed:17108971). Dimethylated at Lys-373 by EHMT1 and EHMT2 (PubMed:20118233). Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity (PubMed:17707234). Dimethylation at Lys-370 and Lys-382 diminishes p53 ubiquitination, through stabilizing association with the methyl reader PHF20 (PubMed:22864287). Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (PubMed:17805299). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (PubMed:19011621)"
    }
  ],
  "commentType": "PTM"
}

Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9

Experimental evidence 2 publications

Evidence & references

ECO:0000269 PubMed:11124955 ↗
ECO:0000269 PubMed:22214662 ↗
ECO:0000269 Reference:Ref.37

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "11124955"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22214662"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "Reference",
          "id": "Ref.37"
        }
      ],
      "value": "Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9"
    }
  ],
  "commentType": "PTM"
}

Processed chains & precursor regions 1

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1 recorded rows

Feature	Position	Description	Evidence	Inspect
ChainPRO_0000185703	1–393	Cellular tumor antigen p53	Evidence & references No separate evidence record is supplied for this statement.	200/393 residues mapped to 9R2Q

Modifications 36

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Scroll across the table for evidence and actions.

36 recorded rows

Feature	Position	Description	Evidence	Inspect
Modified residue	9	Phosphoserine; by HIPK4	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:18022393 ↗	No verified residues in this structure
Modified residue	15	Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM	Experimental evidence 8 publications Evidence & references ECO:0000269 PubMed:10570149 ↗ ECO:0000269 PubMed:11554766 ↗ ECO:0000269 PubMed:15866171 ↗ ECO:0000269 PubMed:17108107 ↗ ECO:0000269 PubMed:17591690 ↗ ECO:0000269 PubMed:17967874 ↗ ECO:0000269 PubMed:21317932 ↗ ECO:0000269 PubMed:28842590 ↗	No verified residues in this structure
Modified residue	18	Phosphothreonine; by CK1, VRK1 and VRK2	Experimental evidence 4 publications Evidence & references ECO:0000269 PubMed:10606744 ↗ ECO:0000269 PubMed:10951572 ↗ ECO:0000269 PubMed:16704422 ↗ ECO:0000269 PubMed:31527692 ↗	No verified residues in this structure
Modified residue	20	Phosphoserine; by CHEK2, CK1 and PLK3	Experimental evidence 5 publications Evidence & references ECO:0000269 PubMed:10570149 ↗ ECO:0000269 PubMed:11447225 ↗ ECO:0000269 PubMed:11551930 ↗ ECO:0000269 PubMed:12810724 ↗ ECO:0000269 PubMed:20041275 ↗	No verified residues in this structure
Modified residue	33	Phosphoserine; by CDK5 and CDK7	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17591690 ↗ ECO:0000269 PubMed:9372954 ↗	No verified residues in this structure
Modified residue	37	Phosphoserine; by MAPKAPK5	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17254968 ↗	No verified residues in this structure
Modified residue	46	Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG	Experimental evidence 5 publications Evidence & references ECO:0000269 PubMed:11740489 ↗ ECO:0000269 PubMed:11780126 ↗ ECO:0000269 PubMed:16377624 ↗ ECO:0000269 PubMed:17349958 ↗ ECO:0000269 PubMed:17591690 ↗	No verified residues in this structure
Modified residue	55	Phosphothreonine; by TAF1 and GRK5	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:15053879 ↗ ECO:0000269 PubMed:20124405 ↗	No verified residues in this structure
Modified residue	120	N6-acetyllysine	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:17189187 ↗ ECO:0000269 PubMed:19854137 ↗ ECO:0000269 PubMed:23431171 ↗	1/1 residues mapped to 9R2Q
Modified residue	120	N6-lactoyllysine	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
Modified residue	139	N6-lactoyllysine	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:38653238 ↗	1/1 residues mapped to 9R2Q
Modified residue	183	Phosphoserine; by AURKB	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
Modified residue	269	Phosphoserine; by AURKB	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
Modified residue	284	Phosphothreonine; by AURKB	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20959462 ↗	1/1 residues mapped to 9R2Q
Modified residue	305	N6-acetyllysine	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:12724314 ↗	No verified residues in this structure
Modified residue	315	Phosphoserine; by AURKA, CDK1 and CDK2	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:10884347 ↗ ECO:0000269 PubMed:14702041 ↗	No verified residues in this structure
Modified residue	321	N6-acetyllysine	By similarity Evidence & references ECO:0000250 UniProtKB:P02340	No verified residues in this structure
Modified residue	333	Omega-N-methylarginine; by PRMT5	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19011621 ↗	No verified residues in this structure
Modified residue	335	Symmetric dimethylarginine; by PRMT5	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19011621 ↗	No verified residues in this structure
Modified residue	337	Symmetric dimethylarginine; by PRMT5	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19011621 ↗	No verified residues in this structure
Modified residue	370	N6,N6-dimethyllysine; alternate	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17108971 ↗ ECO:0000269 PubMed:22864287 ↗	No verified residues in this structure
Modified residue	370	N6-methyllysine; by SMYD2; alternate	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:17108971 ↗ ECO:0000269 PubMed:22864287 ↗	No verified residues in this structure
Modified residue	372	N6-methyllysine; by SETD7	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:15525938 ↗ ECO:0000269 PubMed:16415881 ↗	No verified residues in this structure
Modified residue	373	N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:20118233 ↗	No verified residues in this structure
Modified residue	373	N6-acetyllysine; alternate	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10656795 ↗	No verified residues in this structure
Modified residue	381	N6-acetyllysine	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:29474172 ↗ ECO:0007744 PubMed:19608861 ↗	No verified residues in this structure
Modified residue	382	N6,N6-dimethyllysine; alternate	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:17707234 ↗ ECO:0000269 PubMed:20870725 ↗ ECO:0000269 PubMed:22864287 ↗	No verified residues in this structure
Modified residue	382	N6-acetyllysine; alternate	Experimental evidence 6 publications Evidence & references ECO:0000269 PubMed:10656795 ↗ ECO:0000269 PubMed:15448695 ↗ ECO:0000269 PubMed:20228809 ↗ ECO:0000269 PubMed:23431171 ↗ ECO:0000269 PubMed:29681526 ↗ ECO:0007744 PubMed:19608861 ↗	No verified residues in this structure
Modified residue	382	N6-methyllysine; by KMT5A; alternate	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:17707234 ↗ ECO:0000269 PubMed:20870725 ↗ ECO:0000269 PubMed:22864287 ↗	No verified residues in this structure
Modified residue	392	Phosphoserine; by CK2, CDK2 and NUAK1	Experimental evidence 6 publications Evidence & references ECO:0000269 PubMed:10884347 ↗ ECO:0000269 PubMed:11239457 ↗ ECO:0000269 PubMed:17108107 ↗ ECO:0000269 PubMed:21317932 ↗ ECO:0000269 PubMed:22214662 ↗ ECO:0000269 PubMed:35618207 ↗	No verified residues in this structure
Cross-link	24	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:21597459 ↗	No verified residues in this structure
Cross-link	291	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19536131 ↗	1/1 residues mapped to 9R2Q
Cross-link	292	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19536131 ↗	No verified residues in this structure
Cross-link	351	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19033443 ↗	No verified residues in this structure
Cross-link	357	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19033443 ↗	No verified residues in this structure
Cross-link	386	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:11124955 ↗ ECO:0000269 PubMed:22214662 ↗ ECO:0000269 Reference:Ref.37	No verified residues in this structure

Expression

Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver.

Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine.

Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:16131611 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16131611"
        }
      ],
      "value": "Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine"
    }
  ],
  "commentType": "TISSUE SPECIFICITY"
}

Induction

Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress

Experimental evidence 2 publications

Evidence & references

ECO:0000269 PubMed:10570149 ↗
ECO:0000269 PubMed:16131611 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "10570149"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16131611"
        }
      ],
      "value": "Up-regulated in response to DNA damage. Isoform 2 is not induced in tumor cells in response to stress"
    }
  ],
  "commentType": "INDUCTION"
}

Interaction

Documented interaction partners

UniProt’s filtered IntAct records. Experiment counts describe reported experiments, not binding strength or independent publications. Separate products remain separate rows.

Find a partner187 records

Partner / product	Species	Experiments	Evidence & actions
ABL1P00519With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P00519. Reported experiment count: 2. Open protein ↗
AIMP2Q13155With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q13155. Reported experiment count: 6. Open protein ↗
ARIH2O95376With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O95376. Reported experiment count: 5. Open protein ↗
ARRB1P49407With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P49407. Reported experiment count: 5. Open protein ↗
ASH2LQ9UBL3With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9UBL3. Reported experiment count: 8. Open protein ↗
ATG7O95352-2With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O95352-2. Reported experiment count: 4. Open protein ↗
AXIN1O15169With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O15169. Reported experiment count: 4. Open protein ↗
BANPQ8N9N5With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8N9N5. Reported experiment count: 3. Open protein ↗
BCL2P10415With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P10415. Reported experiment count: 5. Open protein ↗
BCL2L1Q07817-1With P04637	Homo sapiens	26	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q07817-1. Reported experiment count: 26. Open protein ↗
BHLHE40O14503With P04637	Homo sapiens	11	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O14503. Reported experiment count: 11. Open protein ↗
BRAFP15056With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P15056. Reported experiment count: 4. Open protein ↗
BRCA2P51587With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P51587. Reported experiment count: 7. Open protein ↗
BRD7Q9NPI1With P04637	Homo sapiens	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9NPI1. Reported experiment count: 9. Open protein ↗
BTBD2Q9BX70With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9BX70. Reported experiment count: 2. Open protein ↗
BTRCQ9Y297With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9Y297. Reported experiment count: 2. Open protein ↗
CASP6P55212With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P55212. Reported experiment count: 3. Open protein ↗
CCDC106Q9BWC9With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9BWC9. Reported experiment count: 3. Open protein ↗
CCT5P48643With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P48643. Reported experiment count: 3. Open protein ↗
CDKN1AP38936With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P38936. Reported experiment count: 6. Open protein ↗
CEBPBP17676With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P17676. Reported experiment count: 4. Open protein ↗
CHEK1O14757With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O14757. Reported experiment count: 2. Open protein ↗
CREBBPQ92793With P04637	Homo sapiens	17	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q92793. Reported experiment count: 17. Open protein ↗
CSE1LP55060With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P55060. Reported experiment count: 5. Open protein ↗
CUL7Q14999With P04637	Homo sapiens	19	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q14999. Reported experiment count: 19. Open protein ↗
CUL9Q8IWT3With P04637	Homo sapiens	16	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8IWT3. Reported experiment count: 16. Open protein ↗
CXXC1Q9P0U4With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9P0U4. Reported experiment count: 7. Open protein ↗
DAXXQ9UER7With P04637	Homo sapiens	13	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9UER7. Reported experiment count: 13. Open protein ↗
DDX17Q92841With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q92841. Reported experiment count: 3. Open protein ↗
DDX5P17844With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P17844. Reported experiment count: 6. Open protein ↗
DROSHAQ9NRR4With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9NRR4. Reported experiment count: 5. Open protein ↗
DUSP26Q9BV47With P04637	Homo sapiens	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9BV47. Reported experiment count: 9. Open protein ↗
DVL2O14641With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O14641. Reported experiment count: 6. Open protein ↗
EP300Q09472With P04637	Homo sapiens	21	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q09472. Reported experiment count: 21. Open protein ↗
ETS2P15036With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P15036. Reported experiment count: 4. Open protein ↗
FBXO11Q86XK2With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q86XK2. Reported experiment count: 4. Open protein ↗
FLNAP21333-2With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P21333-2. Reported experiment count: 3. Open protein ↗
FXR1P51114With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P51114. Reported experiment count: 2. Open protein ↗
GSK3BP49841With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P49841. Reported experiment count: 3. Open protein ↗
GTF2H1P32780With P04637	Homo sapiens	12	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P32780. Reported experiment count: 12. Open protein ↗
HDAC1Q13547With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q13547. Reported experiment count: 8. Open protein ↗
HIPK1Q86Z02With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q86Z02. Reported experiment count: 2. Open protein ↗
HMGB1P09429With P04637	Homo sapiens	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P09429. Reported experiment count: 9. Open protein ↗
HNF4AP41235With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P41235. Reported experiment count: 3. Open protein ↗
HNRNPKP61978With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P61978. Reported experiment count: 2. Open protein ↗
HNRNPKP61978-2With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P61978-2. Reported experiment count: 2. Open protein ↗
HSPA9P38646With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P38646. Reported experiment count: 6. Open protein ↗
HSPB1P04792With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P04792. Reported experiment count: 3. Open protein ↗
HTTP42858With P04637	Homo sapiens	19	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P42858. Reported experiment count: 19. Open protein ↗
HUWE1Q7Z6Z7With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q7Z6Z7. Reported experiment count: 3. Open protein ↗
IFI16Q16666-2With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q16666-2. Reported experiment count: 6. Open protein ↗
IKBKBO14920With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O14920. Reported experiment count: 3. Open protein ↗
IP6K2Q9UHH9With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9UHH9. Reported experiment count: 4. Open protein ↗
JMJD6Q6NYC1With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q6NYC1. Reported experiment count: 7. Open protein ↗
KAT5Q92993With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q92993. Reported experiment count: 3. Open protein ↗
KAT8Q9H7Z6With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9H7Z6. Reported experiment count: 2. Open protein ↗
KDM1AO60341-1With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O60341-1. Reported experiment count: 6. Open protein ↗
KMT2EQ8IZD2With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8IZD2. Reported experiment count: 4. Open protein ↗
LAMP2P13473-2With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P13473-2. Reported experiment count: 3. Open protein ↗
MAGEA2BP43356With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P43356. Reported experiment count: 7. Open protein ↗
MAGEB18Q96M61With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96M61. Reported experiment count: 3. Open protein ↗
MAGEC2Q9UBF1With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9UBF1. Reported experiment count: 3. Open protein ↗
MAP1BP46821With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P46821. Reported experiment count: 6. Open protein ↗
MAPK11Q15759With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q15759. Reported experiment count: 2. Open protein ↗
MAPKAPK5Q8IW41With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8IW41. Reported experiment count: 2. Open protein ↗
MDM2Q00987With P04637	Homo sapiens	117	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q00987. Reported experiment count: 117. Open protein ↗
MDM4O15151With P04637	Homo sapiens	27	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O15151. Reported experiment count: 27. Open protein ↗
MKRN1Q9UHC7With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9UHC7. Reported experiment count: 8. Open protein ↗
MPDZO75970With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O75970. Reported experiment count: 3. Open protein ↗
MT1AP04731With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P04731. Reported experiment count: 3. Open protein ↗
NCLP19338With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P19338. Reported experiment count: 2. Open protein ↗
NCOR2Q9Y618With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9Y618. Reported experiment count: 7. Open protein ↗
NDNQ99608With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q99608. Reported experiment count: 4. Open protein ↗
NFYAP23511With P04637	Homo sapiens	11	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P23511. Reported experiment count: 11. Open protein ↗
NFYBP25208With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P25208. Reported experiment count: 6. Open protein ↗
NOC2LQ9Y3T9With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9Y3T9. Reported experiment count: 8. Open protein ↗
NOL3O60936With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O60936. Reported experiment count: 3. Open protein ↗
NPM1P06748With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P06748. Reported experiment count: 6. Open protein ↗
NPM1P06748-1With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P06748-1. Reported experiment count: 3. Open protein ↗
NR0B2Q15466With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q15466. Reported experiment count: 3. Open protein ↗
NR4A1P22736With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P22736. Reported experiment count: 6. Open protein ↗
NRDCO43847With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O43847. Reported experiment count: 6. Open protein ↗
NUAK1O60285With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O60285. Reported experiment count: 5. Open protein ↗
NUMBP49757With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P49757. Reported experiment count: 5. Open protein ↗
OTUB1Q96FW1With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96FW1. Reported experiment count: 8. Open protein ↗
PARD3Q8TEW0With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8TEW0. Reported experiment count: 3. Open protein ↗
PARP1P09874With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P09874. Reported experiment count: 3. Open protein ↗
PBKQ96KB5With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96KB5. Reported experiment count: 7. Open protein ↗
PEX26Q7Z412With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q7Z412. Reported experiment count: 3. Open protein ↗
PHB1P35232With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P35232. Reported experiment count: 6. Open protein ↗
PIAS1O75925With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O75925. Reported experiment count: 4. Open protein ↗
PIAS4Q8N2W9With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8N2W9. Reported experiment count: 2. Open protein ↗
PIK3R3Q92569With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q92569. Reported experiment count: 5. Open protein ↗
PIN1Q13526With P04637	Homo sapiens	12	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q13526. Reported experiment count: 12. Open protein ↗
PLK1P53350With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P53350. Reported experiment count: 6. Open protein ↗
PMLP29590With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P29590. Reported experiment count: 4. Open protein ↗
PMP22A0A6Q8PF08With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: A0A6Q8PF08. Reported experiment count: 3. Open protein ↗
PPIFP30405With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P30405. Reported experiment count: 4. Open protein ↗
PPP1CCP36873-1With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P36873-1. Reported experiment count: 2. Open protein ↗
PPP1R13LQ8WUF5With P04637	Homo sapiens	12	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8WUF5. Reported experiment count: 12. Open protein ↗
PPP2R1AP30153With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P30153. Reported experiment count: 3. Open protein ↗
PPP2R5CQ13362With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q13362. Reported experiment count: 4. Open protein ↗
PRKAB2O43741With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O43741. Reported experiment count: 3. Open protein ↗
PRKCDQ05655With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q05655. Reported experiment count: 4. Open protein ↗
PSME3P61289With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P61289. Reported experiment count: 7. Open protein ↗
PTK2Q05397With P04637	Homo sapiens	13	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q05397. Reported experiment count: 13. Open protein ↗
RAD51Q06609With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q06609. Reported experiment count: 2. Open protein ↗
RBPJQ06330With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q06330. Reported experiment count: 5. Open protein ↗
RCHY1Q96PM5With P04637	Homo sapiens	13	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96PM5. Reported experiment count: 13. Open protein ↗
RFWD3Q6PCD5With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q6PCD5. Reported experiment count: 5. Open protein ↗
RING1Q06587With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q06587. Reported experiment count: 7. Open protein ↗
RPS3P23396With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P23396. Reported experiment count: 4. Open protein ↗
RUVBL1Q9Y265With P04637	Homo sapiens	10	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9Y265. Reported experiment count: 10. Open protein ↗
RYBPQ8N488With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8N488. Reported experiment count: 4. Open protein ↗
S100A1P23297With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P23297. Reported experiment count: 3. Open protein ↗
S100A11P31949With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P31949. Reported experiment count: 2. Open protein ↗
S100A2P29034With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P29034. Reported experiment count: 4. Open protein ↗
S100A3P33764With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P33764. Reported experiment count: 2. Open protein ↗
S100A4P26447With P04637	Homo sapiens	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P26447. Reported experiment count: 9. Open protein ↗
S100A5P33763With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P33763. Reported experiment count: 2. Open protein ↗
S100A6P06703With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P06703. Reported experiment count: 3. Open protein ↗
S100BP04271With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P04271. Reported experiment count: 3. Open protein ↗
S100PP25815With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P25815. Reported experiment count: 2. Open protein ↗
SAFBQ15424With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q15424. Reported experiment count: 5. Open protein ↗
SETD7Q8WTS6With P04637	Homo sapiens	11	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8WTS6. Reported experiment count: 11. Open protein ↗
SFNP31947With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P31947. Reported experiment count: 5. Open protein ↗
SIN3AQ96ST3With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96ST3. Reported experiment count: 2. Open protein ↗
SIRT1Q96EB6With P04637	Homo sapiens	18	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96EB6. Reported experiment count: 18. Open protein ↗
SMAD2Q15796With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q15796. Reported experiment count: 7. Open protein ↗
SMYD2Q9NRG4With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9NRG4. Reported experiment count: 6. Open protein ↗
SNAI1O95863With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O95863. Reported experiment count: 2. Open protein ↗
SOX4Q06945With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q06945. Reported experiment count: 4. Open protein ↗
SP1P08047With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P08047. Reported experiment count: 3. Open protein ↗
SREBF2Q12772With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q12772. Reported experiment count: 3. Open protein ↗
SRPK1Q96SB4With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96SB4. Reported experiment count: 3. Open protein ↗
STIP1P31948With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P31948. Reported experiment count: 4. Open protein ↗
SUMO1P63165With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P63165. Reported experiment count: 3. Open protein ↗
SYVN1Q86TM6With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q86TM6. Reported experiment count: 5. Open protein ↗
TAF9BQ9HBM6With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9HBM6. Reported experiment count: 2. Open protein ↗
TBPP20226With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P20226. Reported experiment count: 2. Open protein ↗
TCF4P15884With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P15884. Reported experiment count: 2. Open protein ↗
TOE1Q96GM8With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96GM8. Reported experiment count: 3. Open protein ↗
TP53P04637With P04637	Homo sapiens	34	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P04637. Reported experiment count: 34. Open protein ↗
TP53BP1Q12888With P04637	Homo sapiens	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q12888. Reported experiment count: 8. Open protein ↗
TP53BP1Q12888-1With P04637	Homo sapiens	17	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q12888-1. Reported experiment count: 17. Open protein ↗
TP53BP2Q13625With P04637	Homo sapiens	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q13625. Reported experiment count: 9. Open protein ↗
TP63Q9H3D4With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9H3D4. Reported experiment count: 5. Open protein ↗
TPT1P13693With P04637	Homo sapiens	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P13693. Reported experiment count: 7. Open protein ↗
TRIM24O15164With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O15164. Reported experiment count: 3. Open protein ↗
TWIST1Q15672With P04637	Homo sapiens	10	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q15672. Reported experiment count: 10. Open protein ↗
UBCP0CG48With P04637	Homo sapiens	15	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P0CG48. Reported experiment count: 15. Open protein ↗
UBE2IP63279With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P63279. Reported experiment count: 3. Open protein ↗
UBE3AQ05086With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q05086. Reported experiment count: 6. Open protein ↗
UCHL1P09936With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P09936. Reported experiment count: 3. Open protein ↗
UHRF2Q96PU4With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q96PU4. Reported experiment count: 3. Open protein ↗
USP42Q9H9J4With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9H9J4. Reported experiment count: 2. Open protein ↗
USP42Q9H9J4-2With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9H9J4-2. Reported experiment count: 2. Open protein ↗
USP7Q93009With P04637	Homo sapiens	19	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q93009. Reported experiment count: 19. Open protein ↗
VDRP11473With P04637	Homo sapiens	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P11473. Reported experiment count: 6. Open protein ↗
VRK1Q99986With P04637	Homo sapiens	11	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q99986. Reported experiment count: 11. Open protein ↗
WRNQ14191With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q14191. Reported experiment count: 5. Open protein ↗
WWOXQ9NZC7With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9NZC7. Reported experiment count: 2. Open protein ↗
XPO1O14980With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O14980. Reported experiment count: 3. Open protein ↗
XRCC6P12956With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P12956. Reported experiment count: 2. Open protein ↗
YWHAGP61981With P04637	Homo sapiens	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P61981. Reported experiment count: 5. Open protein ↗
YWHAZP63104With P04637	Homo sapiens	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P63104. Reported experiment count: 3. Open protein ↗
ZNF420Q8TAQ5With P04637	Homo sapiens	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8TAQ5. Reported experiment count: 4. Open protein ↗
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunitQ7L7W2With P04637	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q7L7W2. Reported experiment count: 2. Open protein ↗
Arrb1P29066With P04637	Rattus norvegicusCross-species	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P29066. Reported experiment count: 3. Open protein ↗
Cables1Q9ESJ1With P04637	Mus musculusCross-species	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9ESJ1. Reported experiment count: 3. Open protein ↗
CrebbpP45481With P04637	Mus musculusCross-species	10	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P45481. Reported experiment count: 10. Open protein ↗
E6P03126With P04637	Human papillomavirus type 16Cross-species	5	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P03126. Reported experiment count: 5. Open protein ↗
E6P06463With P04637	Human papillomavirus type 18Cross-species	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P06463. Reported experiment count: 3. Open protein ↗
HSP82P02829With P04637	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)Cross-species	8	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P02829. Reported experiment count: 8. Open protein ↗
Ifi205bQ08619With P04637	Species not verifiedCross-species	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q08619. Reported experiment count: 2. Open protein ↗
NSP1P89055With P04637	Rotavirus spCross-species	6	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P89055. Reported experiment count: 6. Open protein ↗
Sirt1Q923E4With P04637	Mus musculusCross-species	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q923E4. Reported experiment count: 4. Open protein ↗
Smyd2Q8R5A0With P04637	Mus musculusCross-species	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8R5A0. Reported experiment count: 3. Open protein ↗
TFB1P32776With P04637	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)Cross-species	7	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P32776. Reported experiment count: 7. Open protein ↗
Tp63O88898With P04637	Mus musculusCross-species	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: O88898. Reported experiment count: 2. Open protein ↗
Twist1P26687With P04637	Mus musculusCross-species	4	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P26687. Reported experiment count: 4. Open protein ↗
znf585b.SQ9PST7With P04637	Xenopus laevisCross-species	3	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q9PST7. Reported experiment count: 3. Open protein ↗
Large T antigenP03070With P04637	Simian virus 40Cross-species	22	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: P03070. Reported experiment count: 22. Open protein ↗
Genome polyproteinPRO_0000037536With P04637	Hepatitis C virus genotype 1b (isolate BK)Cross-species	9	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: PRO_0000037536. Reported experiment count: 9. Product record ↗
Q8QW27Q8QW27With P04637	Species not verifiedCross-species	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637. Partner: Q8QW27. Reported experiment count: 2. Open protein ↗
DDX5P17844With P04637-1	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637-1. Partner: P17844. Reported experiment count: 2. Open protein ↗
DDX5P17844With P04637-7	Homo sapiens	2	IntAct evidence Pair evidence in IntAct ↗ Source product: P04637-7. Partner: P17844. Reported experiment count: 2. Open protein ↗

Complex membership & assembly descriptions

Co-membership does not by itself prove direct binding between every pair.

TP53-MDM2-MDM4 transcription regulation complex CPX-6093 Complex Portal

Homo sapiens; 9606 ·

Evidence: inferred by curator

TP53 · P04637 ·
MDM2 · Q00987 ·
MDM4 · O15151 ·

Transcriptional repressor complex, formation of which inhibits the ability of TP53/p53 to induce cell cycle arrest. The mechanism of action is primarily through the ubiquitinylation of p53, a critical step in mediating its degradation by nuclear and cytoplasmic proteasomes, and by directly inhibiting p53 transactivation capacity and by promoting the nuclear export of p53.

Source & references ↗

TP53-MDM4 transcription regulation complex CPX-663 Complex Portal

Homo sapiens; 9606 · Heterodimer

Evidence: physical interaction evidence

TP53 · P04637 ·
MDM4 · O15151 ·

Transcriptional repressor complex, formation of which inhibits the ability of TP53/p53 to induce cell cycle arrest. The mechanism of action is primarily through the binding of MDM4 binds to the p53 transactivation domain.

Source & references ↗

TP53-MDM2 transcription regulation complex CPX-759 Complex Portal

Homo sapiens; 9606 ·

Evidence: physical interaction evidence

TP53 · P04637 ·
MDM2 · Q00987 ·

Source & references ↗

UniProt subunit description

Forms homodimers and homotetramers ^[26]. Binds DNA as a homotetramer ^[172]. Interacts with AXIN1.

Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex.

Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1.

Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1.

Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1.

Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus).

Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53 ^{[40, 129, 140, 180]}.

Interacts with PDCD5; the interaction is direct and prevents the interaction between TP53 and MDM2, thereby stabilizing TP53 ^[140]. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation.

Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1.

Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage.

Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2.

Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA).

Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct.

Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination.

Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3 ^[103].

Interacts (via C-terminus) with POU4F2 isoform 1 (via C-terminus) ^[92]. Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53 ^[146]. Interacts with AFG1L; mediates mitochondrial translocation of TP53 ^[160].

Interacts with UBD ^[154]. Interacts with TAF6 isoform 1 and isoform 4 ^[124]. Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity).

Interacts with NUPR1; interaction is stress-dependent ^[110]. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A ^[110]. Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent ^[26].

Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 ^[66]. Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity ^[66]. When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin ^[161].

Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 ^[112]. Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation ^[138]. Interacts with S100A4; this interaction promotes TP53 degradation ^{[152, 197]}.

Interacts with BANP (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis ^[155]. Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome ^[77].

Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes ^[163]. Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state ^[170]. Forms a ternary complex with ALDOB and G6PD; this interaction is direct.

ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 ^[165]. Interacts with HSPA9/MOT-2; the interaction promotes the degradation of TP53 ^[151].

Interacts with FBXO22; this interaction promotes TP53 proteasomal degradation ^[159]

By similarityExperimental evidence 77 publications

Evidence & references

ECO:0000250 UniProtKB:P02340
ECO:0000250 UniProtKB:P10361
ECO:0000269 PubMed:12524540 ↗
ECO:0000269 PubMed:12750254 ↗
ECO:0000269 PubMed:12810724 ↗
ECO:0000269 PubMed:12851404 ↗
ECO:0000269 PubMed:14534297 ↗
ECO:0000269 PubMed:14702041 ↗
ECO:0000269 PubMed:15053879 ↗
ECO:0000269 PubMed:15109303 ↗
ECO:0000269 PubMed:15136035 ↗
ECO:0000269 PubMed:15186775 ↗
ECO:0000269 PubMed:15687255 ↗
ECO:0000269 PubMed:15855171 ↗
ECO:0000269 PubMed:16219768 ↗
ECO:0000269 PubMed:16322561 ↗
ECO:0000269 PubMed:16376338 ↗
ECO:0000269 PubMed:16377624 ↗
ECO:0000269 PubMed:16402859 ↗
ECO:0000269 PubMed:16474402 ↗
ECO:0000269 PubMed:16793544 ↗
ECO:0000269 PubMed:16845383 ↗
ECO:0000269 PubMed:17015838 ↗
ECO:0000269 PubMed:17108107 ↗
ECO:0000269 PubMed:17121812 ↗
ECO:0000269 PubMed:17145718 ↗
ECO:0000269 PubMed:17170702 ↗
ECO:0000269 PubMed:17245430 ↗
ECO:0000269 PubMed:17317671 ↗
ECO:0000269 PubMed:17332504 ↗
ECO:0000269 PubMed:17591690 ↗
ECO:0000269 PubMed:17719541 ↗
ECO:0000269 PubMed:17904127 ↗
ECO:0000269 PubMed:17954561 ↗
ECO:0000269 PubMed:17967874 ↗
ECO:0000269 PubMed:18585004 ↗
ECO:0000269 PubMed:18650397 ↗
ECO:0000269 PubMed:18690848 ↗
ECO:0000269 PubMed:18996393 ↗
ECO:0000269 PubMed:19011621 ↗
ECO:0000269 PubMed:19509332 ↗
ECO:0000269 PubMed:19515728 ↗
ECO:0000269 PubMed:19536131 ↗
ECO:0000269 PubMed:19556538 ↗
ECO:0000269 PubMed:19837670 ↗
ECO:0000269 PubMed:19880522 ↗
ECO:0000269 PubMed:20096117 ↗
ECO:0000269 PubMed:20124405 ↗
ECO:0000269 PubMed:20142040 ↗
ECO:0000269 PubMed:20228809 ↗
ECO:0000269 PubMed:20364130 ↗
ECO:0000269 PubMed:20385133 ↗
ECO:0000269 PubMed:20660729 ↗
ECO:0000269 PubMed:20870725 ↗
ECO:0000269 PubMed:20959462 ↗
ECO:0000269 PubMed:21317932 ↗
ECO:0000269 PubMed:21952639 ↗
ECO:0000269 PubMed:22214662 ↗
ECO:0000269 PubMed:22522597 ↗
ECO:0000269 PubMed:22726440 ↗
ECO:0000269 PubMed:22914926 ↗
ECO:0000269 PubMed:22945289 ↗
ECO:0000269 PubMed:23431171 ↗
ECO:0000269 PubMed:23752197 ↗
ECO:0000269 PubMed:24625977 ↗
ECO:0000269 PubMed:25168243 ↗
ECO:0000269 PubMed:25422469 ↗
ECO:0000269 PubMed:25732823 ↗
ECO:0000269 PubMed:26868148 ↗
ECO:0000269 PubMed:27323408 ↗
ECO:0000269 PubMed:28842590 ↗
ECO:0000269 PubMed:29681526 ↗
ECO:0000269 PubMed:32442400 ↗
ECO:0000269 PubMed:33591310 ↗
ECO:0000269 PubMed:34404770 ↗
ECO:0000269 PubMed:35122041 ↗
ECO:0000269 PubMed:8875926 ↗
ECO:0000269 PubMed:8875929 ↗
ECO:0000269 PubMed:9840937 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000250",
          "source": "UniProtKB",
          "id": "P02340"
        },
        {
          "evidenceCode": "ECO:0000250",
          "source": "UniProtKB",
          "id": "P10361"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12524540"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12750254"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12810724"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "12851404"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "14534297"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "14702041"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15053879"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15109303"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15136035"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15186775"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15687255"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "15855171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16219768"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16322561"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16376338"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16377624"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16402859"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16474402"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16793544"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "16845383"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17015838"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17108107"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17121812"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17145718"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17170702"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17245430"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17317671"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17332504"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17591690"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17719541"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17904127"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17954561"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17967874"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18585004"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18650397"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18690848"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "18996393"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19011621"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19509332"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19515728"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19536131"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19556538"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19837670"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19880522"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20096117"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20124405"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20142040"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20228809"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20364130"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20385133"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20660729"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20870725"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "20959462"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "21317932"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "21952639"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22214662"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22522597"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22726440"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22914926"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "22945289"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "23431171"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "23752197"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "24625977"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25168243"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25422469"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25732823"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "26868148"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "27323408"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "28842590"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "29681526"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "32442400"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "33591310"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "34404770"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "35122041"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "8875926"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "8875929"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "9840937"
        }
      ],
      "value": "Forms homodimers and homotetramers (PubMed:19011621). Binds DNA as a homotetramer (PubMed:36108750). Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53 (PubMed:10570149, PubMed:19880522, PubMed:22914926, PubMed:8875929). Interacts with PDCD5; the interaction is direct and prevents the interaction between TP53 and MDM2, thereby stabilizing TP53 (PubMed:22914926). Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Isoform 1 interacts with isoform 2 and with isoform 4. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest. Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3 (PubMed:17332504). Interacts (via C-terminus) with POU4F2 isoform 1 (via C-terminus) (PubMed:17145718). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53 (PubMed:22522597). Interacts with AFG1L; mediates mitochondrial translocation of TP53 (PubMed:27323408). Interacts with UBD (PubMed:25422469). Interacts with TAF6 isoform 1 and isoform 4 (PubMed:20096117). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent (PubMed:18690848). Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (PubMed:19011621). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (PubMed:12524540). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (PubMed:12524540). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (PubMed:28842590). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (PubMed:17954561). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (PubMed:21597459). Interacts with S100A4; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with BANP (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (PubMed:25168243). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (PubMed:33591310). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (PubMed:34404770). Forms a ternary complex with ALDOB and G6PD; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (PubMed:29681526). Interacts with HSPA9/MOT-2; the interaction promotes the degradation of TP53 (PubMed:24625977). Interacts with FBXO22; this interaction promotes TP53 proteasomal degradation (PubMed:26868148)"
    }
  ],
  "commentType": "SUBUNIT"
}

(Microbial infection) Interacts with cancer-associated/HPV E6 viral proteins leading to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:2175676 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "2175676"
        }
      ],
      "value": "(Microbial infection) Interacts with cancer-associated/HPV E6 viral proteins leading to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6"
    }
  ],
  "commentType": "SUBUNIT"
}

(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:19776115 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "19776115"
        }
      ],
      "value": "(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL123"
    }
  ],
  "commentType": "SUBUNIT"
}

(Microbial infection) Interacts (via N-terminus) with human adenovirus 5 E1B-55K protein; this interaction leads to the inhibition of TP53 function and/or its degradation

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:25772236 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "25772236"
        }
      ],
      "value": "(Microbial infection) Interacts (via N-terminus) with human adenovirus 5 E1B-55K protein; this interaction leads to the inhibition of TP53 function and/or its degradation"
    }
  ],
  "commentType": "SUBUNIT"
}

(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction results in the cytoplasmic localization of TP53 thereby decreasing its transcriptional activity

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:34523970 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "34523970"
        }
      ],
      "value": "(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF45; this interaction results in the cytoplasmic localization of TP53 thereby decreasing its transcriptional activity"
    }
  ],
  "commentType": "SUBUNIT"
}

Other association resources

Resource links only; their association networks and counts are not added to the partner table.

BioGRID · 113010 ↗IntAct · P04637 ↗STRING · 9606.ENSP00000269305 ↗

Structure

SELECTED EXPERIMENTAL STRUCTURE

9R2Q · p53 bound to nucleosome at position SHL-5.7 (non-crosslinked sample)

Method: Electron microscopy
Resolution: 3.2 Å
Assembly 1: Hetero 12-mer · A4B2C2D2E2
Symmetry: C1
Deposited / released: 30/04/2025 / 02/07/2025
Entry version: 1.0 · 02/07/2025

393aa · full canonical protein

417aa · deposited protein construct(s)

200canonical residues verified in coordinates

Verified residue selection uses chain(s) K. Deposited construct lengths are per protein entity, not the full precursor or a total across assembly copies.

200/200 residues mapped to 9R2Q

Components & chains

Chain labels below are mmCIF identifiers used by the viewer. Assembly membership does not establish direct binding.

Component	Identity / length	Chains	Inspect
Histone H3.1Protein / polymer · Entity 1Homo sapiens	P68431139 aa	A, E	Visible
Histone H4Protein / polymer · Entity 2Homo sapiens	P62805106 aa	B, F	Visible
Histone H2A type 1-B/EProtein / polymer · Entity 3Homo sapiens	P04908133 aa	C, G	Visible
Histone H2B type 1-JProtein / polymer · Entity 4Homo sapiens	P06899128 aa	D, H	Visible
DNA-forProtein / polymer · Entity 5synthetic construct	153 aa	I	Visible
DNA-revProtein / polymer · Entity 6synthetic construct	153 aa	J	Visible
Cellular tumor antigen p53Protein / polymer · Entity 7Homo sapiens	P04637417 aa	K, L, M, N	Visible

Chemical diagrams are recorded RCSB component depictions. Glycan names and source identifiers retain the recorded linkage information.

Structure validation

Recorded PDBe metrics describe model geometry. Percentiles compare with the archive; they are not probabilities of correctness. Missing metrics are not zero.

Clashscore1.1

Serious atomic overlaps per 1,000 atoms; lower is better.

Archive percentile: 94.1

Ramachandran outliers0.0%

Backbone conformations outside preferred regions; lower is better.

Archive percentile: 100.0

Side-chain outliers0.44%

Unusual side-chain conformations; lower is better.

Archive percentile: 87.6

Full validation report ↗

Publication

p53 bound to nucleosome at position SHL-5.7 (non-crosslinked sample)

Paper date: Not supplied · Read publication

Structure references are from the dated source record. Opening another structure follows your existing Atlas account permissions.

Available structures 319

Filter

Scroll across the table for evidence and actions.

319 recorded rows

Record	Evidence type	Method	Resolution	Open
9R2Q	experimental	EM	3.20 A	Open in Atlas ↗
9R2M	experimental	EM	3.50 A	Open in Atlas ↗
8R1F	experimental	EM	3.67 A	Open in Atlas ↗
8R1G	experimental	EM	3.99 A	Open in Atlas ↗
7XZZ	experimental	EM	4.07 A	Open in Atlas ↗
9R2P	experimental	EM	4.18 A	Open in Atlas ↗
9R04	experimental	EM	4.20 A	Open in Atlas ↗
6XRE	experimental	EM	4.60 A	Open in Atlas ↗
9CHT	experimental	EM	3.54 A	Open in Atlas ↗
3Q01	experimental	X-ray	2.10 A	Open in Atlas ↗
3Q05	experimental	X-ray	2.40 A	Open in Atlas ↗
4MZR	experimental	X-ray	2.90 A	Open in Atlas ↗
3TS8	experimental	X-ray	2.80 A	Open in Atlas ↗
6GGC	experimental	X-ray	1.24 A	Open in Atlas ↗
6GGE	experimental	X-ray	1.25 A	Open in Atlas ↗
8E7A	experimental	X-ray	1.30 A	Open in Atlas ↗
6SHZ	experimental	X-ray	1.24 A	Open in Atlas ↗
5O1E	experimental	X-ray	1.30 A	Open in Atlas ↗
5O1C	experimental	X-ray	1.32 A	Open in Atlas ↗
5O1H	experimental	X-ray	1.32 A	Open in Atlas ↗
6GGB	experimental	X-ray	1.32 A	Open in Atlas ↗
6GGF	experimental	X-ray	1.32 A	Open in Atlas ↗
3ZME	experimental	X-ray	1.35 A	Open in Atlas ↗
5AOK	experimental	X-ray	1.35 A	Open in Atlas ↗
5G4N	experimental	X-ray	1.35 A	Open in Atlas ↗
5O1G	experimental	X-ray	1.35 A	Open in Atlas ↗
5AB9	experimental	X-ray	1.36 A	Open in Atlas ↗
5O1D	experimental	X-ray	1.36 A	Open in Atlas ↗
8A92	experimental	X-ray	1.37 A	Open in Atlas ↗
5G4M	experimental	X-ray	1.38 A	Open in Atlas ↗
5O1F	experimental	X-ray	1.38 A	Open in Atlas ↗
8QWO	experimental	X-ray	1.38 A	Open in Atlas ↗
9S9L	experimental	X-ray	1.38 A	Open in Atlas ↗
5A7B	experimental	X-ray	1.40 A	Open in Atlas ↗
5O1I	experimental	X-ray	1.40 A	Open in Atlas ↗
6GGD	experimental	X-ray	1.40 A	Open in Atlas ↗
6SI3	experimental	X-ray	1.40 A	Open in Atlas ↗
9S9P	experimental	X-ray	1.40 A	Open in Atlas ↗
4AGQ	experimental	X-ray	1.42 A	Open in Atlas ↗
5LAP	experimental	X-ray	1.42 A	Open in Atlas ↗
5O1B	experimental	X-ray	1.43 A	Open in Atlas ↗
5O1A	experimental	X-ray	1.44 A	Open in Atlas ↗
6SI1	experimental	X-ray	1.44 A	Open in Atlas ↗
8QWN	experimental	X-ray	1.44 A	Open in Atlas ↗
4AGO	experimental	X-ray	1.45 A	Open in Atlas ↗
8A31	experimental	X-ray	1.46 A	Open in Atlas ↗
5AOJ	experimental	X-ray	1.47 A	Open in Atlas ↗
8A32	experimental	X-ray	1.47 A	Open in Atlas ↗
5G4O	experimental	X-ray	1.48 A	Open in Atlas ↗
9S9O	experimental	X-ray	1.49 A	Open in Atlas ↗
2VUK	experimental	X-ray	1.50 A	Open in Atlas ↗
4AGP	experimental	X-ray	1.50 A	Open in Atlas ↗
4KVP	experimental	X-ray	1.50 A	Open in Atlas ↗
5AOL	experimental	X-ray	1.50 A	Open in Atlas ↗
6SI2	experimental	X-ray	1.50 A	Open in Atlas ↗
6SL6	experimental	X-ray	1.67 A	Open in Atlas ↗
4AGM	experimental	X-ray	1.52 A	Open in Atlas ↗
6SI0	experimental	X-ray	1.53 A	Open in Atlas ↗
8CG7	experimental	X-ray	1.53 A	Open in Atlas ↗
8QWM	experimental	X-ray	1.54 A	Open in Atlas ↗
6GGA	experimental	X-ray	1.55 A	Open in Atlas ↗
9G6T	experimental	X-ray	1.56 A	Open in Atlas ↗
9SUK	experimental	X-ray	1.56 A	Open in Atlas ↗
8RBA	experimental	X-ray	1.57 A	Open in Atlas ↗
3Q06	experimental	X-ray	3.20 A	Open in Atlas ↗
2J21	experimental	X-ray	1.60 A	Open in Atlas ↗
2X0U	experimental	X-ray	1.60 A	Open in Atlas ↗
4AGN	experimental	X-ray	1.60 A	Open in Atlas ↗
8DC6	experimental	X-ray	1.60 A	Open in Atlas ↗
5ABA	experimental	X-ray	1.62 A	Open in Atlas ↗
9G6U	experimental	X-ray	1.64 A	Open in Atlas ↗
2J1X	experimental	X-ray	1.65 A	Open in Atlas ↗
8QWL	experimental	X-ray	1.65 A	Open in Atlas ↗
9G5H	experimental	X-ray	1.65 A	Open in Atlas ↗
8QWK	experimental	X-ray	1.69 A	Open in Atlas ↗
8RBB	experimental	X-ray	1.69 A	Open in Atlas ↗
4AGL	experimental	X-ray	1.70 A	Open in Atlas ↗
9BR4	experimental	X-ray	1.70 A	Open in Atlas ↗
9S9R	experimental	X-ray	1.70 A	Open in Atlas ↗
9SZZ	experimental	X-ray	1.70 A	Open in Atlas ↗
8DC8	experimental	X-ray	1.72 A	Open in Atlas ↗
9S9N	experimental	X-ray	1.72 A	Open in Atlas ↗
5AOM	experimental	X-ray	1.74 A	Open in Atlas ↗
2WGX	experimental	X-ray	1.75 A	Open in Atlas ↗
5AOI	experimental	X-ray	1.78 A	Open in Atlas ↗
2BIP	experimental	X-ray	1.80 A	Open in Atlas ↗
2BIQ	experimental	X-ray	1.80 A	Open in Atlas ↗
2J1W	experimental	X-ray	1.80 A	Open in Atlas ↗
2J1Z	experimental	X-ray	1.80 A	Open in Atlas ↗
2J20	experimental	X-ray	1.80 A	Open in Atlas ↗
2X0V	experimental	X-ray	1.80 A	Open in Atlas ↗
6SI4	experimental	X-ray	1.80 A	Open in Atlas ↗
9S9M	experimental	X-ray	1.83 A	Open in Atlas ↗
4QO1	experimental	X-ray	1.92 A	Open in Atlas ↗
4LOE	experimental	X-ray	1.85 A	Open in Atlas ↗
8WD2	experimental	X-ray	1.85 A	Open in Atlas ↗
9S9Q	experimental	X-ray	1.87 A	Open in Atlas ↗
1UOL	experimental	X-ray	1.90 A	Open in Atlas ↗
2BIN	experimental	X-ray	1.90 A	Open in Atlas ↗
2BIO	experimental	X-ray	1.90 A	Open in Atlas ↗
9BR3	experimental	X-ray	1.90 A	Open in Atlas ↗
3D06	experimental	X-ray	1.20 A	Open in Atlas ↗
2BIM	experimental	X-ray	1.98 A	Open in Atlas ↗
8DC7	experimental	X-ray	1.99 A	Open in Atlas ↗
4LOF	experimental	X-ray	2.00 A	Open in Atlas ↗
4MZI	experimental	X-ray	1.25 A	Open in Atlas ↗
2OCJ	experimental	X-ray	2.05 A	Open in Atlas ↗
8RBC	experimental	X-ray	2.06 A	Open in Atlas ↗
7B4N	experimental	X-ray	1.32 A	Open in Atlas ↗
2X0W	experimental	X-ray	2.10 A	Open in Atlas ↗
8QWP	experimental	X-ray	2.10 A	Open in Atlas ↗
5XZC	experimental	EM	10.70 A	Open in Atlas ↗
9SPS	experimental	X-ray	1.42 A	Open in Atlas ↗
7B4H	experimental	X-ray	1.39 A	Open in Atlas ↗
9FZB	experimental	X-ray	1.44 A	Open in Atlas ↗
3D08	experimental	X-ray	1.40 A	Open in Atlas ↗
7B49	experimental	X-ray	1.42 A	Open in Atlas ↗
1TSR	experimental	X-ray	2.20 A	Open in Atlas ↗
1TUP	experimental	X-ray	2.20 A	Open in Atlas ↗
9SPP	experimental	X-ray	1.47 A	Open in Atlas ↗
9SPO	experimental	X-ray	1.48 A	Open in Atlas ↗
4IBY	experimental	X-ray	1.45 A	Open in Atlas ↗
5MCT	experimental	X-ray	1.45 A	Open in Atlas ↗
5MG7	experimental	X-ray	1.45 A	Open in Atlas ↗
8RCI	experimental	X-ray	1.50 A	Open in Atlas ↗
2XWR	experimental	X-ray	1.68 A	Open in Atlas ↗
7B4E	experimental	X-ray	1.58 A	Open in Atlas ↗
2PCX	experimental	X-ray	1.54 A	Open in Atlas ↗
5MF7	experimental	X-ray	1.59 A	Open in Atlas ↗
5MCV	experimental	X-ray	1.60 A	Open in Atlas ↗
9SPR	experimental	X-ray	1.66 A	Open in Atlas ↗
8DC4	experimental	X-ray	2.40 A	Open in Atlas ↗
6ZNC	experimental	X-ray	1.64 A	Open in Atlas ↗
9SPM	experimental	X-ray	1.71 A	Open in Atlas ↗
8E7B	experimental	X-ray	2.50 A	Open in Atlas ↗
2J1Y	experimental	X-ray	1.69 A	Open in Atlas ↗
3D05	experimental	X-ray	1.70 A	Open in Atlas ↗
3IGK	experimental	X-ray	1.70 A	Open in Atlas ↗
4IBT	experimental	X-ray	1.70 A	Open in Atlas ↗
4IBU	experimental	X-ray	1.70 A	Open in Atlas ↗
5MCU	experimental	X-ray	1.70 A	Open in Atlas ↗
7B4C	experimental	X-ray	1.71 A	Open in Atlas ↗
4LO9	experimental	X-ray	2.50 A	Open in Atlas ↗
7DHZ	experimental	X-ray	1.74 A	Open in Atlas ↗
7B4B	experimental	X-ray	1.76 A	Open in Atlas ↗
7EDS	experimental	X-ray	1.77 A	Open in Atlas ↗
4IBS	experimental	X-ray	1.78 A	Open in Atlas ↗
4IJT	experimental	X-ray	1.78 A	Open in Atlas ↗
7B4F	experimental	X-ray	1.78 A	Open in Atlas ↗
4IBW	experimental	X-ray	1.79 A	Open in Atlas ↗
2AC0	experimental	X-ray	1.80 A	Open in Atlas ↗
3D0A	experimental	X-ray	1.80 A	Open in Atlas ↗
3IGL	experimental	X-ray	1.80 A	Open in Atlas ↗
4IBQ	experimental	X-ray	1.80 A	Open in Atlas ↗
7B47	experimental	X-ray	1.80 A	Open in Atlas ↗
5BUA	experimental	X-ray	1.81 A	Open in Atlas ↗
8XCB	experimental	X-ray	1.83 A	Open in Atlas ↗
2AHI	experimental	X-ray	1.85 A	Open in Atlas ↗
7B4D	experimental	X-ray	1.85 A	Open in Atlas ↗
7B4G	experimental	X-ray	1.86 A	Open in Atlas ↗
9SPN	experimental	X-ray	1.93 A	Open in Atlas ↗
2YBG	experimental	X-ray	1.90 A	Open in Atlas ↗
3D09	experimental	X-ray	1.90 A	Open in Atlas ↗
5MCW	experimental	X-ray	1.90 A	Open in Atlas ↗
7B4A	experimental	X-ray	1.90 A	Open in Atlas ↗
3KZ8	experimental	X-ray	1.91 A	Open in Atlas ↗
4HJE	experimental	X-ray	1.91 A	Open in Atlas ↗
4IBZ	experimental	X-ray	1.92 A	Open in Atlas ↗
8XCE	experimental	X-ray	2.00 A	Open in Atlas ↗
7B46	experimental	X-ray	2.02 A	Open in Atlas ↗
7V97	experimental	X-ray	2.02 A	Open in Atlas ↗
6FJ5	experimental	X-ray	2.05 A	Open in Atlas ↗
7B48	experimental	X-ray	2.05 A	Open in Atlas ↗
4IBV	experimental	X-ray	2.10 A	Open in Atlas ↗
3KMD	experimental	X-ray	2.15 A	Open in Atlas ↗
7DHY	experimental	X-ray	2.15 A	Open in Atlas ↗
9SPQ	experimental	X-ray	2.20 A	Open in Atlas ↗
7YGI	experimental	X-ray	2.10 A	Open in Atlas ↗
2ATA	experimental	X-ray	2.20 A	Open in Atlas ↗
3D07	experimental	X-ray	2.20 A	Open in Atlas ↗
1YCS	experimental	X-ray	2.20 A	Open in Atlas ↗
5ECG	experimental	X-ray	3.00 A	Open in Atlas ↗
6FF9	experimental	X-ray	2.00 A	Open in Atlas ↗
4XR8	experimental	X-ray	2.25 A	Open in Atlas ↗
2ADY	experimental	X-ray	2.50 A	Open in Atlas ↗
8HLN	experimental	X-ray	2.35 A	Open in Atlas ↗
8GCR	experimental	EM	3.38 A	Open in Atlas ↗
6LHD	experimental	X-ray	2.50 A	Open in Atlas ↗
7DVD	experimental	X-ray	2.59 A	Open in Atlas ↗
8XP5	experimental	X-ray	2.55 A	Open in Atlas ↗
1GZH	experimental	X-ray	2.60 A	Open in Atlas ↗
8HLM	experimental	X-ray	2.52 A	Open in Atlas ↗
1KZY	experimental	X-ray	2.50 A	Open in Atlas ↗
6RZ3	experimental	X-ray	4.23 A	Open in Atlas ↗
8HLL	experimental	X-ray	2.62 A	Open in Atlas ↗
7EAX	experimental	X-ray	2.55 A	Open in Atlas ↗
7EEU	experimental	X-ray	2.90 A	Open in Atlas ↗
5LGY	experimental	X-ray	2.92 A	Open in Atlas ↗
2H1L	experimental	X-ray	3.16 A	Open in Atlas ↗
2MEJ	experimental	NMR	-	Open in Atlas ↗
2FEJ	experimental	NMR	-	Open in Atlas ↗
8J8N	experimental	EM	9.02 A	Open in Atlas ↗
7XZX	experimental	EM	4.53 A	Open in Atlas ↗
8UQR	experimental	X-ray	1.22 A	Open in Atlas ↗
2LY4	experimental	NMR	-	Open in Atlas ↗
1AIE	experimental	X-ray	1.50 A	Open in Atlas ↗
1C26	experimental	X-ray	1.70 A	Open in Atlas ↗
9C5S	experimental	X-ray	1.01 A	Open in Atlas ↗
2B3G	experimental	X-ray	1.60 A	Open in Atlas ↗
7NMI	experimental	X-ray	2.10 A	Open in Atlas ↗
1YC5	experimental	X-ray	1.40 A	Open in Atlas ↗
6V4F	experimental	X-ray	1.35 A	Open in Atlas ↗
5MHC	experimental	X-ray	1.20 A	Open in Atlas ↗
6RL3	experimental	X-ray	1.30 A	Open in Atlas ↗
6V4H	experimental	X-ray	1.53 A	Open in Atlas ↗
3LW1	experimental	X-ray	1.28 A	Open in Atlas ↗
3DAC	experimental	X-ray	1.80 A	Open in Atlas ↗
2H2D	experimental	X-ray	1.70 A	Open in Atlas ↗
6RWU	experimental	X-ray	1.46 A	Open in Atlas ↗
6RWS	experimental	X-ray	1.53 A	Open in Atlas ↗
3PDH	experimental	X-ray	1.80 A	Open in Atlas ↗
6RJZ	experimental	X-ray	1.58 A	Open in Atlas ↗
6RK8	experimental	X-ray	1.60 A	Open in Atlas ↗
6RL4	experimental	X-ray	1.60 A	Open in Atlas ↗
6RL6	experimental	X-ray	1.60 A	Open in Atlas ↗
6RM7	experimental	X-ray	1.60 A	Open in Atlas ↗
6SIO	experimental	X-ray	1.60 A	Open in Atlas ↗
6SIP	experimental	X-ray	1.60 A	Open in Atlas ↗
6SIQ	experimental	X-ray	1.60 A	Open in Atlas ↗
7BWN	experimental	X-ray	2.40 A	Open in Atlas ↗
6SIN	experimental	X-ray	1.64 A	Open in Atlas ↗
6RWI	experimental	X-ray	1.65 A	Open in Atlas ↗
2H59	experimental	X-ray	1.90 A	Open in Atlas ↗
6RWH	experimental	X-ray	1.68 A	Open in Atlas ↗
6S9Q	experimental	X-ray	1.69 A	Open in Atlas ↗
2H4H	experimental	X-ray	1.99 A	Open in Atlas ↗
5OL0	experimental	X-ray	1.99 A	Open in Atlas ↗
1MA3	experimental	X-ray	2.00 A	Open in Atlas ↗
2H4F	experimental	X-ray	2.00 A	Open in Atlas ↗
3DAB	experimental	X-ray	1.90 A	Open in Atlas ↗
5MOC	experimental	X-ray	1.80 A	Open in Atlas ↗
2FOJ	experimental	X-ray	1.60 A	Open in Atlas ↗
6RX2	experimental	X-ray	1.82 A	Open in Atlas ↗
4RP7	experimental	X-ray	1.58 A	Open in Atlas ↗
2H4J	experimental	X-ray	2.10 A	Open in Atlas ↗
1XQH	experimental	X-ray	1.75 A	Open in Atlas ↗
6R5L	experimental	X-ray	1.88 A	Open in Atlas ↗
6RKI	experimental	X-ray	1.88 A	Open in Atlas ↗
6RKK	experimental	X-ray	1.88 A	Open in Atlas ↗
6RKM	experimental	X-ray	1.88 A	Open in Atlas ↗
6RM5	experimental	X-ray	1.88 A	Open in Atlas ↗
6S39	experimental	X-ray	1.88 A	Open in Atlas ↗
4X34	experimental	X-ray	1.80 A	Open in Atlas ↗
6S40	experimental	X-ray	1.90 A	Open in Atlas ↗
6SLV	experimental	X-ray	1.90 A	Open in Atlas ↗
4RP6	experimental	X-ray	1.70 A	Open in Atlas ↗
2H2F	experimental	X-ray	2.20 A	Open in Atlas ↗
6T58	experimental	X-ray	3.10 A	Open in Atlas ↗
6S3C	experimental	X-ray	2.00 A	Open in Atlas ↗
5HOU	experimental	NMR	-	Open in Atlas ↗
5HPD	experimental	NMR	-	Open in Atlas ↗
4BUZ	experimental	X-ray	1.90 A	Open in Atlas ↗
1YCQ	experimental	X-ray	2.30 A	Open in Atlas ↗
5UN8	experimental	X-ray	2.13 A	Open in Atlas ↗
9EK4	experimental	X-ray	2.05 A	Open in Atlas ↗
2Z5S	experimental	X-ray	2.30 A	Open in Atlas ↗
2Z5T	experimental	X-ray	2.30 A	Open in Atlas ↗
1H26	experimental	X-ray	2.24 A	Open in Atlas ↗
2GS0	experimental	NMR	-	Open in Atlas ↗
9EJD	experimental	X-ray	2.15 A	Open in Atlas ↗
7EL4	experimental	X-ray	2.11 A	Open in Atlas ↗
2V5W	experimental	X-ray	2.00 A	Open in Atlas ↗
9EIQ	experimental	X-ray	2.21 A	Open in Atlas ↗
3TG5	experimental	X-ray	2.30 A	Open in Atlas ↗
2F1X	experimental	X-ray	2.30 A	Open in Atlas ↗
4FZ3	experimental	X-ray	2.10 A	Open in Atlas ↗
2FOO	experimental	X-ray	2.20 A	Open in Atlas ↗
1YCR	experimental	X-ray	2.60 A	Open in Atlas ↗
6VR1	experimental	X-ray	2.37 A	Open in Atlas ↗
2L14	experimental	NMR	-	Open in Atlas ↗
6VR5	experimental	X-ray	2.38 A	Open in Atlas ↗
4HFZ	experimental	X-ray	2.69 A	Open in Atlas ↗
3OQ5	experimental	X-ray	2.50 A	Open in Atlas ↗
6VRN	experimental	X-ray	2.46 A	Open in Atlas ↗
6VRM	experimental	X-ray	2.61 A	Open in Atlas ↗
1OLG	experimental	NMR	-	Open in Atlas ↗
1OLH	experimental	NMR	-	Open in Atlas ↗
1SAE	experimental	NMR	-	Open in Atlas ↗
1SAF	experimental	NMR	-	Open in Atlas ↗
1SAK	experimental	NMR	-	Open in Atlas ↗
1SAL	experimental	NMR	-	Open in Atlas ↗
3SAK	experimental	NMR	-	Open in Atlas ↗
2YDR	experimental	X-ray	2.75 A	Open in Atlas ↗
2K8F	experimental	NMR	-	Open in Atlas ↗
4ZZJ	experimental	X-ray	2.74 A	Open in Atlas ↗
8OXO	experimental	EM	3.00 A	Open in Atlas ↗
1A1U	experimental	NMR	-	Open in Atlas ↗
1HS5	experimental	NMR	-	Open in Atlas ↗
6VQO	experimental	X-ray	3.00 A	Open in Atlas ↗
1PES	experimental	NMR	-	Open in Atlas ↗
1PET	experimental	NMR	-	Open in Atlas ↗
2J0Z	experimental	NMR	-	Open in Atlas ↗
2J10	experimental	NMR	-	Open in Atlas ↗
2J11	experimental	NMR	-	Open in Atlas ↗
4BV2	experimental	X-ray	3.30 A	Open in Atlas ↗
9OBF	experimental	X-ray	3.25 A	Open in Atlas ↗
9YZH	experimental	X-ray	3.25 A	Open in Atlas ↗
8OXM	experimental	EM	3.30 A	Open in Atlas ↗
7RM4	experimental	X-ray	3.33 A	Open in Atlas ↗
2MZD	experimental	NMR	-	Open in Atlas ↗
5HP0	experimental	NMR	-	Open in Atlas ↗
1DT7	experimental	NMR	-	Open in Atlas ↗
2RUK	experimental	NMR	-	Open in Atlas ↗
6W51	experimental	X-ray	3.53 A	Open in Atlas ↗
1JSP	experimental	NMR	-	Open in Atlas ↗
2MWO	experimental	NMR	-	Open in Atlas ↗
2MWY	experimental	NMR	-	Open in Atlas ↗
2MWP	experimental	NMR	-	Open in Atlas ↗
AF-P04637-F1	predicted	AlphaFold	Not applicable	Open in Atlas ↗

Family & Domains

The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation ^{[168, 171, 172, 173, 174]}. Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS ^{[168, 171, 173, 174]}

Experimental evidence 5 publications

Evidence & references

ECO:0000269 PubMed:31953488 ↗
ECO:0000269 PubMed:35618207 ↗
ECO:0000269 PubMed:36108750 ↗
ECO:0000269 PubMed:36634798 ↗
ECO:0000269 PubMed:38653238 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "31953488"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "35618207"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "36108750"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "36634798"
        },
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "38653238"
        }
      ],
      "value": "The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation (PubMed:31953488, PubMed:35618207, PubMed:36108750, PubMed:36634798, PubMed:38653238). Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS (PubMed:31953488, PubMed:35618207, PubMed:36634798, PubMed:38653238)"
    }
  ],
  "commentType": "DOMAIN"
}

The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors

Experimental evidence 1 publication

Evidence & references

ECO:0000269 PubMed:17467953 ↗

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000269",
          "source": "PubMed",
          "id": "17467953"
        }
      ],
      "value": "The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors"
    }
  ],
  "commentType": "DOMAIN"
}

Belongs to the p53 family

Curator inference

Evidence & references

ECO:0000305

Complete source annotation

{
  "texts": [
    {
      "evidences": [
        {
          "evidenceCode": "ECO:0000305"
        }
      ],
      "value": "Belongs to the p53 family"
    }
  ],
  "commentType": "SIMILARITY"
}

Domain architecture

Canonical sequence1393 aa

Canonical coordinates. Overlapping marks share a lane; individual records and evidence are in the tables below. Gaps in coverage are not selectable in 3D. Use the track links and tables for keyboard inspection.

Atlas domains, motifs & repeats 4

Filter

Scroll across the table for evidence and actions.

4 recorded rows

Annotation	Position	Source & interpretation	Inspect
p53, transactivation domainIPR013872	6–30	INTERPROdomain The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This entry is comprised of a single amphipathic α helix and contains a highly conserved motif. Full source description The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation. This entry is comprised of a single amphipathic α helix and contains a highly conserved motif. The p53 tumour suppressor is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating non-transformed cells, but it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 seems to act as a tumour suppressor in some, but probably not all, tumour types. p53 has been implicated in cell cycle regulation, particularly in the monitoring of genomic DNA integrity prior to replication; for this reason it has been dubbed 'guardian of the genome'. p53 can be divided into different functional domains: an N-terminal transactivation domain ([interpro:IPR013872]), a proline-rich domain, a DNA-binding domain ([interpro:IPR008967]) which contains a conserved site ([interpro:IPR057064]), a tetramerisation domain ([interpro:IPR010991]) and a C-terminal regulatory region. Source entry ↗	No verified residues in this structure
Cellular tumor antigen p53, transactivation domain 2IPR040926	35–59	INTERPROdomain This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. Full source description This is a N-terminal transactivation domain (TAD) domain 2 found in p53 proteins. In p53 two TAD domains are found termed TAD1 (residues 1-39) and TAD2 (residues 40-61), both of which have been shown to be able to independently activate gene transcription and are intrinsically disordered protein domains that adopt a helical conformation for at least part of their length when bound. This inherent flexibility allows the TADs to adapt to and bind a broad range of proteins. This entry describes TAD2 which can independently interact with Taz2 domain of the histone acetyltransferase p300. It has also been shown to bind to OB-fold domain of replication protein 70 A (RPA) as well as the pleckstrin homology (PH) domain of the p62 and Tfb1 subunits of human and yeast TFIIH. Source entry ↗	No verified residues in this structure
p53, DNA-binding domainIPR011615	100–288	INTERPROdomain This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex. Full source description This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability. The DNA-binding domain consists of a β-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain. The p53 tumour suppressor is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating non-transformed cells, but it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 seems to act as a tumour suppressor in some, but probably not all, tumour types. p53 has been implicated in cell cycle regulation, particularly in the monitoring of genomic DNA integrity prior to replication; for this reason it has been dubbed 'guardian of the genome'. p53 can be divided into different functional domains: an N-terminal transactivation domain ([interpro:IPR013872]), a proline-rich domain, a DNA-binding domain ([interpro:IPR008967]) which contains a conserved site ([interpro:IPR057064]), a tetramerisation domain ([interpro:IPR010991]) and a C-terminal regulatory region. Source entry ↗	189/189 residues mapped to 9R2Q
p53, tetramerisation domainIPR010991	319–357	INTERPROdomain This entry represents the tetramerisation domain of p53. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. Full source description This entry represents the tetramerisation domain of p53. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation. The p53 tumour suppressor is a protein found in increased amounts in a wide variety of transformed cells. It is also detectable in many proliferating non-transformed cells, but it is undetectable or present at low levels in resting cells. It is frequently mutated or inactivated in many types of cancer. p53 seems to act as a tumour suppressor in some, but probably not all, tumour types. p53 has been implicated in cell cycle regulation, particularly in the monitoring of genomic DNA integrity prior to replication; for this reason it has been dubbed 'guardian of the genome'. p53 can be divided into different functional domains: an N-terminal transactivation domain ([interpro:IPR013872]), a proline-rich domain, a DNA-binding domain ([interpro:IPR008967]) which contains a conserved site ([interpro:IPR057064]), a tetramerisation domain ([interpro:IPR010991]) and a C-terminal regulatory region. Source entry ↗	No verified residues in this structure

UniProt domains, repeats & motifs 5

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5 recorded rows

Feature	Position	Description	Evidence	Inspect
Motif	17–25	TADI	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Motif	48–56	TADII	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Motif	305–321	Bipartite nuclear localization signal	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Motif	339–350	Nuclear export signal	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Motif	370–372	[KR]-[STA]-K motif	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure

Functional sites 6

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6 recorded rows

Feature	Position	Description	Evidence	Inspect
DNA binding	102–292	DNA binding	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:18996393 ↗ ECO:0000269 PubMed:20364130 ↗	190/191 residues mapped to 9R2Q
Binding site	176	Binding site	Experimental evidence 7 publications Evidence & references ECO:0000269 PubMed:14534297 ↗ ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:17015838 ↗ ECO:0000269 PubMed:18650397 ↗ ECO:0000269 PubMed:19515728 ↗ ECO:0000269 PubMed:20142040 ↗ ECO:0000269 PubMed:20364130 ↗	1/1 residues mapped to 9R2Q
Binding site	179	Binding site	Experimental evidence 7 publications Evidence & references ECO:0000269 PubMed:14534297 ↗ ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:17015838 ↗ ECO:0000269 PubMed:18650397 ↗ ECO:0000269 PubMed:19515728 ↗ ECO:0000269 PubMed:20142040 ↗ ECO:0000269 PubMed:20364130 ↗	1/1 residues mapped to 9R2Q
Binding site	238	Binding site	Experimental evidence 7 publications Evidence & references ECO:0000269 PubMed:14534297 ↗ ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:17015838 ↗ ECO:0000269 PubMed:18650397 ↗ ECO:0000269 PubMed:19515728 ↗ ECO:0000269 PubMed:20142040 ↗ ECO:0000269 PubMed:20364130 ↗	1/1 residues mapped to 9R2Q
Binding site	242	Binding site	Experimental evidence 7 publications Evidence & references ECO:0000269 PubMed:14534297 ↗ ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:17015838 ↗ ECO:0000269 PubMed:18650397 ↗ ECO:0000269 PubMed:19515728 ↗ ECO:0000269 PubMed:20142040 ↗ ECO:0000269 PubMed:20364130 ↗	1/1 residues mapped to 9R2Q
Site	120	Interaction with DNA	Experimental evidence 3 publications Evidence & references ECO:0000269 PubMed:16793544 ↗ ECO:0000269 PubMed:18996393 ↗ ECO:0000269 PubMed:20364130 ↗	1/1 residues mapped to 9R2Q

Sequence regions 23

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23 recorded rows

Feature	Position	Description	Evidence	Inspect
Region	1–320	Interaction with CCAR2	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:25732823 ↗	200/320 residues mapped to 9R2Q
Region	1–83	Interaction with HRMT1L2	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:15186775 ↗	No verified residues in this structure
Region	1–44	Transcription activation (acidic)	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Region	50–96	Disordered	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:31953488 ↗	5/47 residues mapped to 9R2Q
Region	66–110	Interaction with WWOX	Evidence & references No separate evidence record is supplied for this statement.	19/45 residues mapped to 9R2Q
Region	100–370	Interaction with HIPK1	By similarity Evidence & references ECO:0000250	192/271 residues mapped to 9R2Q
Region	100–300	Required for interaction with ZNF385A	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:17719541 ↗	192/201 residues mapped to 9R2Q
Region	113–236	Required for interaction with FBXO42	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:19509332 ↗	124/124 residues mapped to 9R2Q
Region	116–292	Interaction with AXIN1	By similarity Evidence & references ECO:0000250	176/177 residues mapped to 9R2Q
Region	241–248	Interaction with the 53BP2 SH3 domain	Evidence & references No separate evidence record is supplied for this statement.	8/8 residues mapped to 9R2Q
Region	256–294	Interaction with E4F1	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:10644996 ↗	36/39 residues mapped to 9R2Q
Region	273–280	Interaction with DNA	Evidence & references No separate evidence record is supplied for this statement.	8/8 residues mapped to 9R2Q
Region	282–325	Disordered	Evidence & references ECO:0000256 SAM:MobiDB-lite	10/44 residues mapped to 9R2Q
Region	300–393	Interaction with CARM1	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:15186775 ↗	No verified residues in this structure
Region	319–360	Interaction with HIPK2	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Region	325–356	Oligomerization	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Region	351–393	Disordered	Experimental evidence 2 publications Evidence & references ECO:0000269 PubMed:31953488 ↗ ECO:0000269 PubMed:36108750 ↗	No verified residues in this structure
Region	359–363	Interaction with USP7	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Region	368–387	Basic (repression of DNA-binding)	Evidence & references No separate evidence record is supplied for this statement.	No verified residues in this structure
Region	374–393	Interaction with MORN3	Experimental evidence 1 publication Evidence & references ECO:0000269 PubMed:29681526 ↗	No verified residues in this structure
Compositional bias	69–90	Pro residues	Evidence & references ECO:0000256 SAM:MobiDB-lite	No verified residues in this structure
Compositional bias	282–299	Basic and acidic residues	Evidence & references ECO:0000256 SAM:MobiDB-lite	10/18 residues mapped to 9R2Q
Compositional bias	365–384	Basic residues	Evidence & references ECO:0000256 SAM:MobiDB-lite	No verified residues in this structure

Sequence & Isoforms

Sequence & isoforms

UniProt’s canonical sequence is its selected representative. It is not necessarily the dominant isoform in every tissue.

Displayed sequence

UniProt’s canonical sequence · P04637-1393 aa43,653 Da · source sequence mass

The mass describes this unmodified source sequence, not every mature or modified product.

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Other recorded isoform sequences

P04637-2

341 aa · mass unavailable

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKENC

P04637-3

346 aa · mass unavailable

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWCYFLINSS

P04637-4

354 aa · mass unavailable

MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

P04637-5

302 aa · mass unavailable

MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKENC

P04637-6

307 aa · mass unavailable

MDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWCYFLINSS

P04637-7

261 aa · mass unavailable

MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

P04637-8

209 aa · mass unavailable

MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQDQTSFQKENC

P04637-9

214 aa · mass unavailable

MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQMLLDLRWCYFLINSS

Source isoform notes & selection

Alternative promoter usage · Alternative splicing

Complete source annotation

{
  "commentType": "ALTERNATIVE PRODUCTS",
  "events": [
    "Alternative promoter usage",
    "Alternative splicing"
  ],
  "isoforms": [
    {
      "name": {
        "value": "1"
      },
      "synonyms": [
        {
          "value": "p53"
        },
        {
          "value": "p53alpha"
        }
      ],
      "isoformIds": [
        "P04637-1"
      ],
      "isoformSequenceStatus": "Displayed"
    },
    {
      "name": {
        "value": "2"
      },
      "synonyms": [
        {
          "value": "I9RET"
        },
        {
          "value": "p53beta"
        }
      ],
      "isoformIds": [
        "P04637-2"
      ],
      "sequenceIds": [
        "VSP_006535",
        "VSP_006536"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "3"
      },
      "synonyms": [
        {
          "value": "p53gamma"
        }
      ],
      "isoformIds": [
        "P04637-3"
      ],
      "sequenceIds": [
        "VSP_040560",
        "VSP_040561"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "4"
      },
      "synonyms": [
        {
          "value": "Del40-p53"
        },
        {
          "value": "Del40-p53alpha"
        },
        {
          "value": "p47"
        }
      ],
      "isoformIds": [
        "P04637-4"
      ],
      "sequenceIds": [
        "VSP_040832"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "5"
      },
      "synonyms": [
        {
          "value": "Del40-p53beta"
        }
      ],
      "isoformIds": [
        "P04637-5"
      ],
      "sequenceIds": [
        "VSP_040832",
        "VSP_006535",
        "VSP_006536"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "6"
      },
      "synonyms": [
        {
          "value": "Del40-p53gamma"
        }
      ],
      "isoformIds": [
        "P04637-6"
      ],
      "sequenceIds": [
        "VSP_040832",
        "VSP_040560",
        "VSP_040561"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "7"
      },
      "synonyms": [
        {
          "value": "Del133-p53"
        },
        {
          "value": "Del133-p53alpha"
        }
      ],
      "isoformIds": [
        "P04637-7"
      ],
      "sequenceIds": [
        "VSP_040833"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "8"
      },
      "synonyms": [
        {
          "value": "Del133-p53beta"
        }
      ],
      "isoformIds": [
        "P04637-8"
      ],
      "sequenceIds": [
        "VSP_040833",
        "VSP_006535",
        "VSP_006536"
      ],
      "isoformSequenceStatus": "Described"
    },
    {
      "name": {
        "value": "9"
      },
      "synonyms": [
        {
          "value": "Del133-p53gamma"
        }
      ],
      "isoformIds": [
        "P04637-9"
      ],
      "sequenceIds": [
        "VSP_040833",
        "VSP_040560",
        "VSP_040561"
      ],
      "isoformSequenceStatus": "Described"
    }
  ]
}

P04637-1 · 1 · Displayed · p53, p53alpha

Complete source annotation

{
  "name": {
    "value": "1"
  },
  "synonyms": [
    {
      "value": "p53"
    },
    {
      "value": "p53alpha"
    }
  ],
  "isoformIds": [
    "P04637-1"
  ],
  "isoformSequenceStatus": "Displayed"
}

P04637-2 · 2 · Described · I9RET, p53beta · VSP_006535, VSP_006536

Complete source annotation

{
  "name": {
    "value": "2"
  },
  "synonyms": [
    {
      "value": "I9RET"
    },
    {
      "value": "p53beta"
    }
  ],
  "isoformIds": [
    "P04637-2"
  ],
  "sequenceIds": [
    "VSP_006535",
    "VSP_006536"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-3 · 3 · Described · p53gamma · VSP_040560, VSP_040561

Complete source annotation

{
  "name": {
    "value": "3"
  },
  "synonyms": [
    {
      "value": "p53gamma"
    }
  ],
  "isoformIds": [
    "P04637-3"
  ],
  "sequenceIds": [
    "VSP_040560",
    "VSP_040561"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-4 · 4 · Described · Del40-p53, Del40-p53alpha, p47 · VSP_040832

Complete source annotation

{
  "name": {
    "value": "4"
  },
  "synonyms": [
    {
      "value": "Del40-p53"
    },
    {
      "value": "Del40-p53alpha"
    },
    {
      "value": "p47"
    }
  ],
  "isoformIds": [
    "P04637-4"
  ],
  "sequenceIds": [
    "VSP_040832"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-5 · 5 · Described · Del40-p53beta · VSP_040832, VSP_006535, VSP_006536

Complete source annotation

{
  "name": {
    "value": "5"
  },
  "synonyms": [
    {
      "value": "Del40-p53beta"
    }
  ],
  "isoformIds": [
    "P04637-5"
  ],
  "sequenceIds": [
    "VSP_040832",
    "VSP_006535",
    "VSP_006536"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-6 · 6 · Described · Del40-p53gamma · VSP_040832, VSP_040560, VSP_040561

Complete source annotation

{
  "name": {
    "value": "6"
  },
  "synonyms": [
    {
      "value": "Del40-p53gamma"
    }
  ],
  "isoformIds": [
    "P04637-6"
  ],
  "sequenceIds": [
    "VSP_040832",
    "VSP_040560",
    "VSP_040561"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-7 · 7 · Described · Del133-p53, Del133-p53alpha · VSP_040833

Complete source annotation

{
  "name": {
    "value": "7"
  },
  "synonyms": [
    {
      "value": "Del133-p53"
    },
    {
      "value": "Del133-p53alpha"
    }
  ],
  "isoformIds": [
    "P04637-7"
  ],
  "sequenceIds": [
    "VSP_040833"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-8 · 8 · Described · Del133-p53beta · VSP_040833, VSP_006535, VSP_006536

Complete source annotation

{
  "name": {
    "value": "8"
  },
  "synonyms": [
    {
      "value": "Del133-p53beta"
    }
  ],
  "isoformIds": [
    "P04637-8"
  ],
  "sequenceIds": [
    "VSP_040833",
    "VSP_006535",
    "VSP_006536"
  ],
  "isoformSequenceStatus": "Described"
}

P04637-9 · 9 · Described · Del133-p53gamma · VSP_040833, VSP_040560, VSP_040561

Complete source annotation

{
  "name": {
    "value": "9"
  },
  "synonyms": [
    {
      "value": "Del133-p53gamma"
    }
  ],
  "isoformIds": [
    "P04637-9"
  ],
  "sequenceIds": [
    "VSP_040833",
    "VSP_040560",
    "VSP_040561"
  ],
  "isoformSequenceStatus": "Described"
}

Isoform sequence differences 6

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6 recorded rows

Feature	Position	Description	Evidence	Inspect
Alternative sequenceVSP_040833	1–132	in isoform 7, isoform 8 and isoform 9	Published statement 1 publication Evidence & references ECO:0000303 PubMed:16131611 ↗	41/132 residues mapped to 9R2Q
Alternative sequenceVSP_040832	1–39	in isoform 4, isoform 5 and isoform 6	Curator inference Evidence & references ECO:0000305	No verified residues in this structure
Alternative sequenceVSP_040560	332–346	in isoform 3, isoform 6 and isoform 9 IRGRERFEMFRELNE → MLLDLRWCYFLINSS	Published statement 1 publication Evidence & references ECO:0000303 PubMed:16131611 ↗	No verified residues in this structure
Alternative sequenceVSP_006535	332–341	in isoform 2, isoform 5 and isoform 8 IRGRERFEMF → DQTSFQKENC	Published statement 1 publication Evidence & references ECO:0000303 PubMed:16131611 ↗	No verified residues in this structure
Alternative sequenceVSP_006536	342–393	in isoform 2, isoform 5 and isoform 8	Published statement 1 publication Evidence & references ECO:0000303 PubMed:16131611 ↗	No verified residues in this structure
Alternative sequenceVSP_040561	347–393	in isoform 3, isoform 6 and isoform 9	Published statement 1 publication Evidence & references ECO:0000303 PubMed:16131611 ↗	No verified residues in this structure

Sequence conflicts & cautions 0

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No annotation is recorded in this UniProt entry.

Recorded secondary structure 42

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Scroll across the table for evidence and actions.

42 recorded rows

Feature	Position	Description	Evidence	Inspect
Helix	3–6	Helix	Evidence & references ECO:0007829 PDB:5HOU	No verified residues in this structure
Turn	8–10	Turn	Evidence & references ECO:0007829 PDB:5HOU	No verified residues in this structure
Helix	19–29	Helix	Evidence & references ECO:0007829 PDB:9C5S	No verified residues in this structure
Helix	30–32	Helix	Evidence & references ECO:0007829 PDB:5HPD	No verified residues in this structure
Beta strand	33–35	Beta strand	Evidence & references ECO:0007829 PDB:2L14	No verified residues in this structure
Helix	36–38	Helix	Evidence & references ECO:0007829 PDB:2B3G	No verified residues in this structure
Helix	41–44	Helix	Evidence & references ECO:0007829 PDB:2B3G	No verified residues in this structure
Helix	47–55	Helix	Evidence & references ECO:0007829 PDB:2B3G	No verified residues in this structure
Helix	96–99	Helix	Evidence & references ECO:0007829 PDB:8A92	4/4 residues mapped to 9R2Q
Turn	105–108	Turn	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Beta strand	110–112	Beta strand	Evidence & references ECO:0007829 PDB:3D06	3/3 residues mapped to 9R2Q
Beta strand	119–121	Beta strand	Evidence & references ECO:0007829 PDB:5BUA	3/3 residues mapped to 9R2Q
Beta strand	124–127	Beta strand	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Turn	128–131	Turn	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Beta strand	132–135	Beta strand	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Beta strand	141–146	Beta strand	Evidence & references ECO:0007829 PDB:3D06	6/6 residues mapped to 9R2Q
Beta strand	148–150	Beta strand	Evidence & references ECO:0007829 PDB:5UN8	3/3 residues mapped to 9R2Q
Beta strand	156–165	Beta strand	Evidence & references ECO:0007829 PDB:3D06	10/10 residues mapped to 9R2Q
Helix	166–168	Helix	Evidence & references ECO:0007829 PDB:3D06	3/3 residues mapped to 9R2Q
Helix	177–180	Helix	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Beta strand	181–183	Beta strand	Evidence & references ECO:0007829 PDB:4KVP	3/3 residues mapped to 9R2Q
Beta strand	187–189	Beta strand	Evidence & references ECO:0007829 PDB:6GGC	3/3 residues mapped to 9R2Q
Beta strand	194–199	Beta strand	Evidence & references ECO:0007829 PDB:3D06	6/6 residues mapped to 9R2Q
Beta strand	204–207	Beta strand	Evidence & references ECO:0007829 PDB:3D06	4/4 residues mapped to 9R2Q
Turn	209–211	Turn	Evidence & references ECO:0007829 PDB:3D06	3/3 residues mapped to 9R2Q
Beta strand	214–219	Beta strand	Evidence & references ECO:0007829 PDB:3D06	6/6 residues mapped to 9R2Q
Helix	221–224	Helix	Evidence & references ECO:0007829 PDB:6SHZ	4/4 residues mapped to 9R2Q
Turn	225–227	Turn	Evidence & references ECO:0007829 PDB:2FEJ	3/3 residues mapped to 9R2Q
Beta strand	228–236	Beta strand	Evidence & references ECO:0007829 PDB:3D06	9/9 residues mapped to 9R2Q
Helix	240–242	Helix	Evidence & references ECO:0007829 PDB:3D07	3/3 residues mapped to 9R2Q
Turn	243–248	Turn	Evidence & references ECO:0007829 PDB:3D06	6/6 residues mapped to 9R2Q
Beta strand	251–258	Beta strand	Evidence & references ECO:0007829 PDB:3D06	8/8 residues mapped to 9R2Q
Beta strand	260–262	Beta strand	Evidence & references ECO:0007829 PDB:2ADY	3/3 residues mapped to 9R2Q
Beta strand	264–274	Beta strand	Evidence & references ECO:0007829 PDB:3D06	11/11 residues mapped to 9R2Q
Helix	278–287	Helix	Evidence & references ECO:0007829 PDB:3D06	10/10 residues mapped to 9R2Q
Helix	288–290	Helix	Evidence & references ECO:0007829 PDB:4HJE	3/3 residues mapped to 9R2Q
Helix	322–324	Helix	Evidence & references ECO:0007829 PDB:3Q01	No verified residues in this structure
Beta strand	327–334	Beta strand	Evidence & references ECO:0007829 PDB:8UQR	No verified residues in this structure
Helix	335–349	Helix	Evidence & references ECO:0007829 PDB:8UQR	No verified residues in this structure
Turn	353–355	Turn	Evidence & references ECO:0007829 PDB:7BWN	No verified residues in this structure
Helix	375–380	Helix	Evidence & references ECO:0007829 PDB:1YC5	No verified residues in this structure
Helix	383–386	Helix	Evidence & references ECO:0007829 PDB:6RL3	No verified residues in this structure

Similar proteins · UniRef

These are sequence clusters. A cluster threshold is not a measured pairwise identity to this protein, and does not establish shared function.

UniRef100_P04637 5 members

Cluster: Cellular tumor antigen p53

Recorded preview: 5 members. See UniRef for the complete cluster.

Cellular tumor antigen p53 · Homo sapiens (Human)
P04637 ↗
Cellular tumor antigen p53 · Homo sapiens (Human)
K7PPA8 ↗
Cellular tumor antigen p53 · Pan paniscus (Pygmy chimpanzee) (Bonobo)
A0A2R9A5P4 ↗
Cellular tumor antigen p53 · Pan troglodytes (Chimpanzee)
H2QC53 ↗
Cellular tumor antigen p53 · Pan troglodytes (Chimpanzee)
K7B1Z3 ↗

Full cluster ↗

UniRef90_P04637 73 members

Cluster: Cellular tumor antigen p53

Recorded preview: 10 members. See UniRef for the complete cluster.

Cellular tumor antigen p53 · Homo sapiens (Human)
P04637 ↗
Cellular tumor antigen p53 · Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
P56423 ↗
Cellular tumor antigen p53 · Macaca fuscata fuscata (Japanese macaque)
P61260 ↗
Cellular tumor antigen p53 · Macaca mulatta (Rhesus macaque)
P56424 ↗
Cellular tumor antigen p53 · Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
P13481 ↗
Cellular tumor antigen p53 · Tupaia belangeri (Northern treeshrew) (Tupaia glis belangeri)
Q9TTA1 ↗
Cellular tumor antigen p53 · Homo sapiens (Human)
K7PPA8 ↗
Cellular tumor antigen p53 · Pan paniscus (Pygmy chimpanzee) (Bonobo)
A0A2R9A5P4 ↗
Cellular tumor antigen p53 · Pan troglodytes (Chimpanzee)
H2QC53 ↗
Cellular tumor antigen p53 · Pan troglodytes (Chimpanzee)
K7B1Z3 ↗

Full cluster ↗

UniRef50_P04637 259 members

Cluster: Cellular tumor antigen p53

Recorded preview: 10 members. See UniRef for the complete cluster.

Cellular tumor antigen p53 · Homo sapiens (Human)
P04637 ↗
Cellular tumor antigen p53 · Tupaia belangeri (Northern treeshrew) (Tupaia glis belangeri)
Q9TTA1 ↗
Cellular tumor antigen p53 · Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
P56423 ↗
Cellular tumor antigen p53 · Macaca fuscata fuscata (Japanese macaque)
P61260 ↗
Cellular tumor antigen p53 · Macaca mulatta (Rhesus macaque)
P56424 ↗
Cellular tumor antigen p53 · Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
P13481 ↗
Cellular tumor antigen p53 · Delphinapterus leucas (Beluga whale)
Q8SPZ3 ↗
Cellular tumor antigen p53 · Sus scrofa (Pig)
Q9TUB2 ↗
Cellular tumor antigen p53 · Ovis aries (Sheep)
P51664 ↗
Cellular tumor antigen p53 · Canis lupus familiaris (Dog) (Canis familiaris)
Q29537 ↗

Full cluster ↗

Homologs

OMA orthologs

Evolutionary relationships assigned by OMA, kept separate from sequence clusters. “1:1” describes an orthology relationship, not percentage identity.

Recorded preview of up to 12 orthologs; not an exhaustive list. Entries without a verified UniProt mapping open their OMA record.

Sources & References

Scientific descriptions and evidence come from the named sources. Atlas assembles the presentation and verifies residue mappings; it does not independently curate these claims.

UniProt ↗QuickGO ↗InterPro ↗PDB / PDBe ↗Complex Portal ↗UniRef ↗OMA ↗

Source dates & provenance

UniProt / The UniProt Consortium ↗ · 2026-11-09T11:39:45.604357+00:00
InterPro / EMBL-EBI and the member sources identified in the annotations ↗ · 2026-11-09T11:39:45.426686+00:00
AlphaFold DB / DeepMind Technologies Limited / EMBL-EBI ↗ · 2026-11-09T11:39:57.724641+00:00
UniProt / The UniProt Consortium ↗ · 2026-11-09T11:39:45.604357+00:00
InterPro / EMBL-EBI and the member sources identified in the annotations ↗ · 2026-11-09T11:39:45.426686+00:00
AlphaFold DB / DeepMind Technologies Limited / EMBL-EBI ↗ · 2026-11-09T11:39:57.724641+00:00
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Recorded 2026-11-10. Source dates and identifiers are retained below.

Publications in this UniProt entry

1 · Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.

1985 · EMBO J.

PubMed 4006916 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

Zakut-Houri R., Bienz-Tadmor B., Givol D., Oren M.

2 · Characterization of the human p53 gene.

1986 · Mol. Cell. Biol.

PubMed 2946935 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1); VARIANT GLY-76

Lamb P., Crawford L.

3 · Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 · Mol. Cell. Biol.

PubMed 3894933 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

Harlow E., Williamson N.M., Ralston R., Helfman D.M., Adams T.E.

4 · Molecular basis for heterogeneity of the human p53 protein.

1986 · Mol. Cell. Biol.

PubMed 3025664 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)

Harris N., Brill E., Shohat O., Prokocimer M., Wolf D., Arai N., Rotter V.

All source publications (238)

5 · A variation in the structure of the protein-coding region of the human p53 gene.

1988 · Gene

PubMed 2905688 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Buchman V.L., Chumakov P.M., Ninkina N.N., Samarina O.P., Georgiev G.P.

6 · p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 · EMBO J.

PubMed 1915267 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS SPORADIC CANCERS

Farrell P.J., Allan G., Shanahan F., Vousden K.H., Crook T.

7 · Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.

1993 · Radiat. Res.

PubMed 8316628 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LYS-286

Allalunis-Turner M.J., Barron G.M., Day R.S. III, Dobler K.D., Mirzayans R.

8 · Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.

2001 · J. Biol. Chem.

PubMed 11058590 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); INTERACTION WITH WWOX

Chang N.-S., Pratt N., Heath J., Schultz L., Sleve D., Carey G.B., Zevotek N.

9 · p53 isoforms can regulate p53 transcriptional activity.

2005 · Genes Dev.

PubMed 16131611 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 7; 8 AND 9); SUBCELLULAR LOCATION; TISSUE SPECIFICITY; ALTERNATIVE PROMOTER USAGE; ALTERNATIVE SPLICING; INDUCTION; VARIANT ARG-72

Bourdon J.C., Fernandes K., Murray-Zmijewski F., Liu G., Diot A., Xirodimas D.P., Saville M.K., Lane D.P.

· Reference

JUN-1991 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Chumakov P.M., Almazov V.P., Jenkins J.R.

· P53 genomic sequence. Corrections and polymorphism.

MAR-1997 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]

Rozemuller E.H., Tilanus M.G.J.

· Reference

NOV-2004 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-47; LYS-339 AND ALA-366

13 · Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.

2000 · Radiat. Res.

PubMed 11023613 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LYS-286

Anderson C.W., Allalunis-Turner M.J.

· Identification of a tumor-rejection antigen recognized by HLA-B46 restricted CTL.

MAR-2002 ·

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS HIS-273 AND SER-309

Azuma K., Shichijo S., Itoh K.

15 · Complete sequencing and characterization of 21,243 full-length human cDNAs.

2004 · Nat. Genet.

PubMed 14702039 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ARG-72

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.

16 · DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

2006 · Nature

PubMed 16625196 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.

· Reference

SEP-2005 ·

Scope & authors

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT ARG-72

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.

18 · The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

2004 · Genome Res.

PubMed 15489334 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ALA-278

19 · Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

2003 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 14660794 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [MRNA] OF 1-379 (ISOFORM 1); VARIANTS ASN-139 AND PRO-155

Kanashiro C.A., Schally A.V., Groot K., Armatis P., Bernardino A.L., Varga J.L.

20 · Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene.

1984 · EMBO J.

PubMed 6396087 ↗

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 101-393

Matlashewski G., Lamb P., Pim D., Peacock J., Crawford L., Benchimol S.

· Study on the effect of tumor suppressor gene p53 in arsenism patients.

SEP-2003 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-185

Pan X.L., Zhang A.H.

· Detection of P53 gene mutations and serum p53 antibodies associated with cigarette smoking.

AUG-2003 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 261-298; VARIANT GLN-282

Nimri L.F., Owais W., Momani E.

· Reference

JUL-1996 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 262-306; VARIANT VAL-262

Filippini G., Soldati G.

· Mutation detection utilizing a novel PCR approach for amplification of the p53 gene from microdissected tissue: application to archival tumor samples.

DEC-1999 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-260

Thompson-Hehir J., Davies M.P.A., Green J.A., Halliwell N., Joyce K.A., Salisbury J., Sibson D.R., Vergote I., Walker C.

· Bcl6 and P53 gene mutations in tonsillar B cells.

MAR-2000 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-260

Yavuz A.S., Farner N.L., Yavuz S., Grammer A.C., Girschick H.J., Lipsky P.E.

26 · Arginine methylation regulates the p53 response.

2008 · Nat. Cell Biol.

PubMed 19011621 ↗

Scope & authors

PROTEIN SEQUENCE OF 320-337; SUBUNIT; INTERACTION WITH PRMT5; SUBCELLULAR LOCATION; METHYLATION AT ARG-333; ARG-335 AND ARG-337 BY PRMT5; IDENTIFICATION BY MASS SPECTROMETRY; MUTAGENESIS OF 333-ARG--ARG-337

Jansson M., Durant S.T., Cho E.C., Sheahan S., Edelmann M., Kessler B., La Thangue N.B.

· Allelic variant in intron 9 of TP53 gene.

APR-2003 ·

Scope & authors

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 332-366

Pinto E.M., Mendonca B.B., Latronico A.C.

28 · The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.

1990 · Cell

PubMed 2175676 ↗

Scope & authors

INTERACTION WITH HUMAN PAPILLOMAVIRUS TYPE 6 AND 11 PROTEIN E6 (MICROBIAL INFECTION)

Scheffner M., Werness B.A., Huibregtse J.M., Levine A.J., Howley P.M.

29 · The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 · Oncogene

PubMed 2156209 ↗

Scope & authors

NUCLEAR LOCALIZATION SIGNAL; MUTAGENESIS OF LYS-319; LYS-320 AND LYS-321

Addison C., Jenkins J.R., Sturzbecher H.-W.

30 · Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 2141171 ↗

Scope & authors

PHOSPHORYLATION BY P60/CDC2 AND CYCLIN B/CDC2

Bischoff J.R., Friedman P.N., Marshak D.R., Prives C., Beach D.

31 · The tumor suppressor p53 is bound to RNA by a stable covalent linkage.

1991 · Mol. Cell. Biol.

PubMed 1705009 ↗

Scope & authors

PHOSPHORYLATION

Samad A., Carroll R.B.

32 · Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

1991 · Mol. Cell. Biol.

PubMed 1848668 ↗

Scope & authors

DEPHOSPHORYLATION BY PP2A

Scheidtmann K.H., Mumby M.C., Rundell K., Walter G.

33 · The human tumour suppressor gene p53 is alternatively spliced in normal cells.

1996 · Oncogene

PubMed 8632903 ↗

Scope & authors

ALTERNATIVE SPLICING

Flaman J.-M., Waridel F., Estreicher A., Vannier A., Limacher J.-M., Gilbert D., Iggo R., Frebourg T.

34 · Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 · Oncogene

PubMed 8632915 ↗

Scope & authors

GLYCOSYLATION

Shaw P., Freeman J., Bovey R., Iggo R.

35 · p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

1997 · Mol. Cell. Biol.

PubMed 9372954 ↗

Scope & authors

PHOSPHORYLATION AT SER-33

Ko L.J., Shieh S.-Y., Chen X., Jayaraman L., Tamai K., Taya Y., Prives C., Pan Z.-Q.

36 · Regulation of CAK kinase activity by p53.

1998 · Oncogene

PubMed 9840937 ↗

Scope & authors

FUNCTION; IDENTIFICATION IN COMPLEX WITH CAK

Schneider E., Montenarh M., Wagner P.

· Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

1999 · EMBO J.

Scope & authors

SUMOYLATION AT LYS-386; MUTAGENESIS OF LYS-386

Gostissa M., Hengstermann A., Fogal V., Sandy P., Schwarz S.E., Scheffner M., Del Sal G.

38 · Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

1999 · FEBS Lett.

PubMed 10606744 ↗

Scope & authors

PHOSPHORYLATION AT THR-18 BY CSNK1D/CK1

Dumaz N., Milne D.M., Meek D.W.

39 · A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain.

1999 · J. Biol. Chem.

PubMed 10551826 ↗

Scope & authors

BIPARTITE NUCLEAR LOCALIZATION SIGNAL; CHARACTERIZATION OF VARIANT ASN-305

Liang S.H., Clarke M.F.

40 · Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

1999 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 10570149 ↗

Scope & authors

PHOSPHORYLATION AT SER-15 AND SER-20; INDUCTION BY DNA DAMAGE; CHARACTERIZATION OF LFS VARIANT HIS-273; MUTAGENESIS OF THR-18; SER-20 AND 22-LEU-TRP-23; SUBCELLULAR LOCATION; INTERACTION WITH PML AND MDM2

Chehab N.H., Malikzay A., Stavridi E.S., Halazonetis T.D.

41 · Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.

2000 · J. Biol. Chem.

PubMed 10722742 ↗

Scope & authors

UBIQUITINATION

Fang S., Jensen J.P., Ludwig R.L., Vousden K.H., Weissman A.M.

42 · Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry.

2000 · J. Mol. Biol.

PubMed 10656795 ↗

Scope & authors

ACETYLATION AT LYS-373 AND LYS-382

Abraham J., Kelly J., Thibault P., Benchimol S.

43 · The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.

2000 · J. Mol. Biol.

PubMed 10884347 ↗

Scope & authors

PHOSPHORYLATION AT SER-315 AND SER-392 BY CDK2; MUTAGENESIS OF LYS-382; LEU-383 AND PHE-385

Luciani M.G., Hutchins J.R.A., Zheleva D., Hupp T.R.

44 · The function of PML in p53-dependent apoptosis.

2000 · Nat. Cell Biol.

PubMed 11025664 ↗

Scope & authors

FUNCTION; INTERACTION WITH PML; SUBCELLULAR LOCATION

Guo A., Salomoni P., Luo J., Shih A., Zhong S., Gu W., Pandolfi P.P.

45 · p53 is involved in the p120E4F-mediated growth arrest.

2000 · Oncogene

PubMed 10644996 ↗

Scope & authors

INTERACTION WITH E4F1

Sandy P., Gostissa M., Fogal V., Cecco L.D., Szalay K., Rooney R.J., Schneider C., Del Sal G.

46 · The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

2000 · Oncogene

PubMed 10951572 ↗

Scope & authors

PHOSPHORYLATION AT THR-18

Lopez-Borges S., Lazo P.A.

47 · Zinc binding and redox control of p53 structure and function.

2001 · Antioxid. Redox Signal.

PubMed 11554448 ↗

Scope & authors

REVIEW ON ZINC-BINDING PROPERTIES

Hainaut P., Mann K.

48 · Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.

2001 · Biochem. Biophys. Res. Commun.

PubMed 11554766 ↗

Scope & authors

PHOSPHORYLATION AT SER-15

Imamura K., Ogura T., Kishimoto A., Kaminishi M., Esumi H.

49 · hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.

2001 · Cell

PubMed 11672523 ↗

Scope & authors

DEACETYLATION AT LYS-382 BY SIRT1

Vaziri H., Dessain S.K., Ng Eaton E., Imai S., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A.

50 · p53 amino acids 339-346 represent the minimal p53 repression domain.

2001 · J. Biol. Chem.

PubMed 11007800 ↗

Scope & authors

MINIMAL REPRESSION DOMAIN

Hong T.M., Chen J.J., Peck K., Yang P.C., Wu C.W.

51 · Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

2001 · J. Biol. Chem.

PubMed 11447225 ↗

Scope & authors

PHOSPHORYLATION AT SER-20 BY PLK3

Xie S., Wang Q., Wu H., Cogswell J., Lu L., Jhanwar-Uniyal M., Dai W.

52 · Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

2001 · J. Biol. Chem.

PubMed 11551930 ↗

Scope & authors

PHOSPHORYLATION AT SER-20 BY PLK3

Xie S., Wu H., Wang Q., Cogswell J.P., Husain I., Conn C., Stambrook P., Jhanwar-Uniyal M., Dai W.

53 · SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.

2001 · J. Biol. Chem.

PubMed 11124955 ↗

Scope & authors

SUMOYLATION AT LYS-386; SUBCELLULAR LOCATION; MUTAGENESIS OF PHE-385; LYS-386; THR-387 AND GLU-388

Rodriguez M.S., Dargemont C., Hay R.T.

54 · Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.

2001 · J. Biol. Chem.

PubMed 11546806 ↗

Scope & authors

PHOSPHORYLATION BY PRPK

Abe Y., Matsumoto S., Wei S., Nezu K., Miyoshi A., Kito K., Ueda N., Shigemoto K., Hitsumoto Y., Nikawa J., Enomoto Y.

55 · A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

2001 · Mol. Cell

PubMed 11239457 ↗

Scope & authors

PHOSPHORYLATION AT SER-392

Keller D.M., Zeng X., Wang Y., Zhang Q.H., Kapoor M., Shu H., Goodman R., Lozano G., Zhao Y., Lu H.

56 · Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.

2002 · Cell

PubMed 12507430 ↗

Scope & authors

INTERACTION WITH USP7

Hu M., Li P., Li M., Li W., Yao T., Wu J.-W., Gu W., Cohen R.E., Shi Y.

57 · Differential effect of ik3-1/cables on p53- and p73-induced cell death.

2002 · J. Biol. Chem.

PubMed 11706030 ↗

Scope & authors

IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TP73

Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.

58 · Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

2002 · J. Biol. Chem.

PubMed 11925430 ↗

Scope & authors

INTERACTION WITH HIPK2

Kim E.-J., Park J.-S., Um S.-J.

59 · Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

2002 · Nat. Cell Biol.

PubMed 11740489 ↗

Scope & authors

INTERACTION WITH HIPK2; PHOSPHORYLATION AT SER-46; MUTAGENESIS OF SER-46 AND LYS-382

Hofmann T.G., Moeller A., Sirma H., Zentgraf H., Taya Y., Droege W., Will H., Schmitz M.L.

60 · Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

2002 · Nat. Cell Biol.

PubMed 11780126 ↗

Scope & authors

INTERACTION WITH HIPK2; PHOSPHORYLATION AT SER-46

D'Orazi G., Cecchinelli B., Bruno T., Manni I., Higashimoto Y., Saito S., Gostissa M., Coen S., Marchetti A., Del Sal G., Piaggio G., Fanciulli M., Appella E., Soddu S.

61 · p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

2003 · Cancer Res.

PubMed 12750254 ↗

Scope & authors

INTERACTION WITH ING4

Shiseki M., Nagashima M., Pedeux R.M., Kitahama-Shiseki M., Miura K., Okamura S., Onogi H., Higashimoto Y., Appella E., Yokota J., Harris C.C.

62 · Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

2003 · J. Biol. Chem.

PubMed 12724314 ↗

Scope & authors

ACETYLATION AT LYS-305

Wang Y.H., Tsay Y.G., Tan B.C., Lo W.Y., Lee S.C.

63 · The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.

2003 · J. Biol. Chem.

PubMed 12810724 ↗

Scope & authors

FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH CHEK2 AND PML; UBIQUITINATION BY MDM2; PHOSPHORYLATION AT SER-20

Louria-Hayon I., Grossman T., Sionov R.V., Alsheich O., Pandolfi P.P., Haupt Y.

64 · TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

2003 · J. Biol. Chem.

PubMed 12851404 ↗

Scope & authors

INTERACTION WITH TP53INP1

Tomasini R., Samir A.A., Carrier A., Isnardon D., Cecchinelli B., Soddu S., Malissen B., Dagorn J.-C., Iovanna J.L., Dusetti N.J.

65 · Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.

2003 · Mol. Cell. Biol.

PubMed 12944468 ↗

Scope & authors

NUCLEOCYTOPLASMIC SHUTTLING; NUCLEAR EXPORT SIGNAL

O'Keefe K., Li H., Zhang Y.

66 · iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

2003 · Nat. Genet.

PubMed 12524540 ↗

Scope & authors

FUNCTION; INTERACTION WITH PPP1R13L; PPP1R13B AND TP53BP2

Bergamaschi D., Samuels Y., O'Neil N.J., Trigiante G., Crook T., Hsieh J.-K., O'Connor D.J., Zhong S., Campargue I., Tomlinson M.L., Kuwabara P.E., Lu X.

67 · Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

2003 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 12702766 ↗

Scope & authors

INTERACTION WITH HIPK1

Kondo S., Lu Y., Debbas M., Lin A.W., Sarosi I., Itie A., Wakeham A., Tuan J., Saris C., Elliott G., Ma W., Benchimol S., Lowe S.W., Mak T.W., Thukral S.K.

68 · Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.

2004 · Biochem. J.

PubMed 15109303 ↗

Scope & authors

INTERACTION WITH CDKN2AIP

Hasan M.K., Yaguchi T., Minoda Y., Hirano T., Taira K., Wadhwa R., Kaul S.C.

69 · Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

2004 · Cell

PubMed 15186775 ↗

Scope & authors

INTERACTION WITH HRMT1L2; EP300 AND CARM1; FUNCTION

An W., Kim J., Roeder R.G.

70 · The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.

2004 · J. Mol. Biol.

PubMed 15136035 ↗

Scope & authors

INTERACTION WITH ANKRD2

Kojic S., Medeot E., Guccione E., Krmac H., Zara I., Martinelli V., Valle G., Faulkner G.

71 · Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.

2004 · Mol. Cell

PubMed 15053879 ↗

Scope & authors

PHOSPHORYLATION AT THR-55; MUTAGENESIS OF THR-55; INTERACTION WITH TAF1

Li H.-H., Li A.G., Sheppard H.M., Liu X.

72 · A dynamic role of HAUSP in the p53-Mdm2 pathway.

2004 · Mol. Cell

PubMed 15053880 ↗

Scope & authors

DEUBIQUITINATION BY USP7

Li M., Brooks C.L., Kon N., Gu W.

73 · Regulation of human p53 activity and cell localization by alternative splicing.

2004 · Mol. Cell. Biol.

PubMed 15340061 ↗

Scope & authors

ALTERNATIVE SPLICING (ISOFORM 4); FUNCTION; SUBCELLULAR LOCATION; UBIQUITINATION

Ghosh A., Stewart D., Matlashewski G.

74 · Regulation of p53 activity through lysine methylation.

2004 · Nature

PubMed 15525938 ↗

Scope & authors

METHYLATION AT LYS-372; MUTAGENESIS OF LYS-372

Chuikov S., Kurash J.K., Wilson J.R., Xiao B., Justin N., Ivanov G.S., McKinney K., Tempst P., Prives C., Gamblin S.J., Barlev N.A., Reinberg D.

75 · A new effector pathway links ATM kinase with the DNA damage response.

2004 · Nat. Cell Biol.

PubMed 15448695 ↗

Scope & authors

ACETYLATION AT LYS-382

Demonacos C., Krstic-Demonacos M., Smith L., Xu D., O'Connor D.P., Jansson M., La Thangue N.B.

76 · Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

2004 · Nat. Genet.

PubMed 14702041 ↗

Scope & authors

INTERACTION WITH AURKA; PHOSPHORYLATION AT SER-315

Katayama H., Sasai K., Kawai H., Yuan Z.M., Bondaruk J., Suzuki F., Fujii S., Arlinghaus R.B., Czerniak B.A., Sen S.

77 · A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.

2005 · Genes Dev.

PubMed 15687255 ↗

Scope & authors

INTERACTION WITH NQO1

Asher G., Tsvetkov P., Kahana C., Shaul Y.

78 · NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.

2005 · Genes Dev.

PubMed 16322561 ↗

Scope & authors

INTERACTION WITH NOC2L

Hublitz P., Kunowska N., Mayer U.P., Muller J.M., Heyne K., Yin N., Fritzsche C., Poli C., Miguet L., Schupp I.W., van Grunsven L.A., Potiers N., van Dorsselaer A., Metzger E., Roemer K., Schule R.

79 · Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.

2005 · J. Biol. Chem.

PubMed 15701641 ↗

Scope & authors

RETRACTED PAPER

Jalota-Badhwar A., Singh K., Pavithra L., Kaul-Ghanekar R., Jameel S., Chattopadhyay S.

80 · Reference

2020 · J. Biol. Chem.

PubMed 32144153 ↗

Scope & authors

RETRACTION NOTICE OF PUBMED:15701641

Jalota A., Singh K., Pavithra L., Kaul-Ghanekar R., Jameel S., Chattopadhyay S.

81 · Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

2005 · J. Biol. Chem.

PubMed 15855171 ↗

Scope & authors

INTERACTION WITH PTK2/FAK1

Golubovskaya V.M., Finch R., Cance W.G.

82 · WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

2005 · J. Biol. Chem.

PubMed 16219768 ↗

Scope & authors

INTERACTION WITH WWOX; MUTAGENESIS OF SER-46

Chang N.-S., Doherty J., Ensign A., Schultz L., Hsu L.-J., Hong Q.

83 · AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

2005 · Mol. Cell

PubMed 15866171 ↗

Scope & authors

PHOSPHORYLATION AT SER-15

Jones R.G., Plas D.R., Kubek S., Buzzai M., Mu J., Xu Y., Birnbaum M.J., Thompson C.B.

84 · LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

2006 · Cancer Res.

PubMed 17108107 ↗

Scope & authors

INTERACTION WITH STK11/LKB1; PHOSPHORYLATION AT SER-15 AND SER-392

Zeng P.Y., Berger S.L.

85 · The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.

2006 · FEBS J.

PubMed 16704422 ↗

Scope & authors

PHOSPHORYLATION AT THR-18

Blanco S., Klimcakova L., Vega F.M., Lazo P.A.

86 · Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.

2006 · FEBS Lett.

PubMed 16376338 ↗

Scope & authors

INTERACTION WITH YWHAZ

Gu Y.-M., Jin Y.-H., Choi J.-K., Baek K.-H., Yeo C.-Y., Lee K.-Y.

87 · Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.

2006 · J. Biol. Chem.

PubMed 16377624 ↗

Scope & authors

PHOSPHORYLATION AT SER-46; INTERACTION WITH PRKCG

Yoshida K., Liu H., Miki Y.

88 · Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

2006 · Mol. Cell

PubMed 17189187 ↗

Scope & authors

FUNCTION; ACETYLATION AT LYS-120; VARIANTS ARG-120; GLU-120 AND MET-120; CHARACTERIZATION OF VARIANTS ARG-120; GLU-120 AND MET-120

Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., McMahon S.B.

89 · Repression of p53 activity by Smyd2-mediated methylation.

2006 · Nature

PubMed 17108971 ↗

Scope & authors

METHYLATION AT LYS-370; MUTAGENESIS OF LYS-370

Huang J., Perez-Burgos L., Placek B.J., Sengupta R., Richter M., Dorsey J.A., Kubicek S., Opravil S., Jenuwein T., Berger S.L.

90 · Critical role for Daxx in regulating Mdm2.

2006 · Nat. Cell Biol.

PubMed 16845383 ↗

Scope & authors

INTERACTION WITH DAXX

Tang J., Qu L.K., Zhang J., Wang W., Michaelson J.S., Degenhardt Y.Y., El-Deiry W.S., Yang X.

91 · Structural basis for the methylation site specificity of SET7/9.

2006 · Nat. Struct. Mol. Biol.

PubMed 16415881 ↗

Scope & authors

MOTIF; METHYLATION AT LYS-372

Couture J.-F., Collazo E., Hauk G., Trievel R.C.

92 · Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.

2006 · Nucleic Acids Res.

PubMed 17145718 ↗

Scope & authors

INTERACTION WITH POU4F2

Budhram-Mahadeo V.S., Bowen S., Lee S., Perez-Sanchez C., Ensor E., Morris P.J., Latchman D.S.

93 · PRAK is essential for ras-induced senescence and tumor suppression.

2007 · Cell

PubMed 17254968 ↗

Scope & authors

PHOSPHORYLATION AT SER-37; MUTAGENESIS OF SER-37

Sun P., Yoshizuka N., New L., Moser B.A., Li Y., Liao R., Xie C., Chen J., Deng Q., Yamout M., Dong M.Q., Frangou C.G., Yates J.R. III, Wright P.E., Han J.

94 · Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.

2007 · Cell

PubMed 17719541 ↗

Scope & authors

INTERACTION WITH ZNF385A; CHARACTERIZATION OF VARIANTS ALA-143; HIS-175 AND PRO-175

Das S., Raj L., Zhao B., Kimura Y., Bernstein A., Aaronson S.A., Lee S.W.

95 · Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.

2007 · EMBO J.

PubMed 17170702 ↗

Scope & authors

UBIQUITINATION; INTERACTION WITH SYVN1; SUBCELLULAR LOCATION

Yamasaki S., Yagishita N., Sasaki T., Nakazawa M., Kato Y., Yamadera T., Bae E., Toriyama S., Ikeda R., Zhang L., Fujitani K., Yoo E., Tsuchimochi K., Ohta T., Araya N., Fujita H., Aratani S., Eguchi K., Komiya S., Maruyama I., Higashi N., Sato M., Senoo H., Ochi T., Yokoyama S., Amano T., Kim J., Gay S., Fukamizu A., Nishioka K., Tanaka K., Nakajima T.

96 · A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

2007 · EMBO J.

PubMed 17245430 ↗

Scope & authors

INTERACTION WITH PPP2CA; PPP2R1A; PPP2R2A AND PPP2R5C

Li H.H., Cai X., Shouse G.P., Piluso L.G., Liu X.

97 · SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.

2007 · FEBS Lett.

PubMed 17904127 ↗

Scope & authors

INTERACTION WITH ARMC10

Zhou X., Yang G., Huang R., Chen X., Hu G.

98 · Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.

2007 · FEBS Lett.

PubMed 18022393 ↗

Scope & authors

PHOSPHORYLATION AT SER-9

Arai S., Matsushita A., Du K., Yagi K., Okazaki Y., Kurokawa R.

99 · Nine-amino-acid transactivation domain: establishment and prediction utilities.

2007 · Genomics

PubMed 17467953 ↗

Scope & authors

DOMAIN

Piskacek S., Gregor M., Nemethova M., Grabner M., Kovarik P., Piskacek M.

100 · CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.

2007 · J. Biol. Chem.

PubMed 17121812 ↗

Scope & authors

INTERACTION WITH RFFL AND RNF34

Yang W., Rozan L.M., McDonald E.R. III, Navaraj A., Liu J.J., Matthew E.M., Wang W., Dicker D.T., El-Deiry W.S.

101 · The notch regulator MAML1 interacts with p53 and functions as a coactivator.

2007 · J. Biol. Chem.

PubMed 17317671 ↗

Scope & authors

FUNCTION; INTERACTION WITH MAML1

Zhao Y., Katzman R.B., Delmolino L.M., Bhat I., Zhang Y., Gurumurthy C.B., Germaniuk-Kurowska A., Reddi H.V., Solomon A., Zeng M.S., Kung A., Ma H., Gao Q., Dimri G., Stanculescu A., Miele L., Wu L., Griffin J.D., Wazer D.E., Band H., Band V.

102 · Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.

2007 · J. Cell Sci.

PubMed 17591690 ↗

Scope & authors

PHOSPHORYLATION AT SER-15; SER-33 AND SER-46; INTERACTION WITH CDK5; SUBCELLULAR LOCATION

Lee J.-H., Kim H.-S., Lee S.-J., Kim K.-T.

103 · Dynamic regulation of p53 subnuclear localization and senescence by MORC3.

2007 · Mol. Biol. Cell

PubMed 17332504 ↗

Scope & authors

INTERACTION WITH MORC3

Takahashi K., Yoshida N., Murakami N., Kawata K., Ishizaki H., Tanaka-Okamoto M., Miyoshi J., Zinn A.R., Shime H., Inoue N.

104 · DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.

2007 · Mol. Cell

PubMed 17349958 ↗

Scope & authors

FUNCTION; PHOSPHORYLATION AT SER-46; MUTAGENESIS OF SER-46

Taira N., Nihira K., Yamaguchi T., Miki Y., Yoshida K.

105 · p53 is regulated by the lysine demethylase LSD1.

2007 · Nature

PubMed 17805299 ↗

Scope & authors

DEMETHYLATION BY KDM1A

Huang J., Sengupta R., Espejo A.B., Lee M.G., Dorsey J.A., Richter M., Opravil S., Shiekhattar R., Bedford M.T., Jenuwein T., Berger S.L.

106 · Modulation of p53 function by SET8-mediated methylation at lysine 382.

2007 · Mol. Cell

PubMed 17707234 ↗

Scope & authors

METHYLATION AT LYS-382; MUTAGENESIS OF LYS-382

Shi X., Kachirskaia I., Yamaguchi H., West L.E., Wen H., Wang E.W., Dutta S., Appella E., Gozani O.

107 · ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

2007 · Science

PubMed 17525332 ↗

Scope & authors

IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.

108 · Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.

2008 · Biochem. Biophys. Res. Commun.

PubMed 18249187 ↗

Scope & authors

ACETYLATION; DEACETYLATION BY SIRT2

Jin Y.H., Kim Y.J., Kim D.W., Baek K.H., Kang B.Y., Yeo C.Y., Lee K.Y.

109 · Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes.

2008 · Cell. Signal.

PubMed 18585004 ↗

Scope & authors

INTERACTION WITH SETD2

Xie P., Tian C., An L., Nie J., Lu K., Xing G., Zhang L., He F.

110 · NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.

2008 · Curr. Cancer Drug Targets

PubMed 18690848 ↗

Scope & authors

INTERACTION WITH NUPR1

Clark D.W., Mitra A., Fillmore R.A., Jiang W.G., Samant R.S., Fodstad O., Shevde L.A.

111 · Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

2008 · Mol. Cell

PubMed 18206965 ↗

Scope & authors

UBIQUITINATION; SUBCELLULAR LOCATION

Lim S.T., Chen X.L., Lim Y., Hanson D.A., Vo T.T., Howerton K., Larocque N., Fisher S.J., Schlaepfer D.D., Ilic D.

112 · Hbo1 Links p53-dependent stress signaling to DNA replication licensing.

2008 · Mol. Cell. Biol.

PubMed 17954561 ↗

Scope & authors

INTERACTION WITH KAT7

Iizuka M., Sarmento O.F., Sekiya T., Scrable H., Allis C.D., Smith M.M.

113 · Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.

2008 · Mol. Cell. Biol.

PubMed 17967874 ↗

Scope & authors

INTERACTION WITH PPP2CA; PPP2R1A AND PPP2R5C; PHOSPHORYLATION AT SER-15 BY ATM; MUTAGENESIS OF SER-15

Shouse G.P., Cai X., Liu X.

114 · Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

2009 · Anal. Chem.

PubMed 19413330 ↗

Scope & authors

IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.

115 · Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.

2009 · EMBO J.

PubMed 19536131 ↗

Scope & authors

INTERACTION WITH MKRN1; MUTAGENESIS OF 291-LYS-LYS-292; UBIQUITINATION AT LYS-291 AND LYS-292 BY MKRN1

Lee E.-W., Lee M.-S., Camus S., Ghim J., Yang M.-R., Oh W., Ha N.-C., Lane D.P., Song J.

116 · Plk1-mediated phosphorylation of Topors regulates p53 stability.

2009 · J. Biol. Chem.

PubMed 19473992 ↗

Scope & authors

UBIQUITINATION BY TOPORS

Yang X., Li H., Zhou Z., Wang W.H., Deng A., Andrisani O., Liu X.

117 · MSL2 promotes Mdm2-independent cytoplasmic localization of p53.

2009 · J. Biol. Chem.

PubMed 19033443 ↗

Scope & authors

UBIQUITINATION AT LYS-351 AND LYS-357; SUBCELLULAR LOCATION

Kruse J.P., Gu W.

118 · MTA1 coregulator regulates p53 stability and function.

2009 · J. Biol. Chem.

PubMed 19837670 ↗

Scope & authors

INTERACTION WITH MTA1 AND COP1; UBIQUITINATION

Li D.Q., Divijendra Natha Reddy S., Pakala S.B., Wu X., Zhang Y., Rayala S.K., Kumar R.

119 · Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein.

2009 · J. Virol.

PubMed 19776115 ↗

Scope & authors

INTERACTION WITH HHV-5 PROTEIN UL123 (MICROBIAL INFECTION)

Hwang E.S., Zhang Z., Cai H., Huang D.Y., Huong S.M., Cha C.Y., Huang E.S.

120 · Two mammalian MOF complexes regulate transcription activation by distinct mechanisms.

2009 · Mol. Cell

PubMed 19854137 ↗

Scope & authors

ACETYLATION AT LYS-120

Li X., Wu L., Corsa C.A., Kunkel S., Dou Y.

121 · JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.

2009 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 19509332 ↗

Scope & authors

INTERACTION WITH FBXO42

Sun L., Shi L., Li W., Yu W., Liang J., Zhang H., Yang X., Wang Y., Li R., Yao X., Yi X., Shang Y.

122 · Trim24 targets endogenous p53 for degradation.

2009 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 19556538 ↗

Scope & authors

FUNCTION; UBIQUITINATION; INTERACTION WITH TRIM24

Allton K., Jain A.K., Herz H.M., Tsai W.W., Jung S.Y., Qin J., Bergmann A., Johnson R.L., Barton M.C.

123 · Lysine acetylation targets protein complexes and co-regulates major cellular functions.

2009 · Science

PubMed 19608861 ↗

Scope & authors

ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-381 AND LYS-382; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.

124 · TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.

2010 · BMC Mol. Biol.

PubMed 20096117 ↗

Scope & authors

INTERACTION WITH TAF6 ISOFORMS 1 AND 4

Wilhelm E., Kornete M., Targat B., Vigneault-Edwards J., Frontini M., Tora L., Benecke A., Bell B.

125 · USP10 regulates p53 localization and stability by deubiquitinating p53.

2010 · Cell

PubMed 20096447 ↗

Scope & authors

UBIQUITINATION; DEUBIQUITINATION BY USP10

Yuan J., Luo K., Zhang L., Cheville J.C., Lou Z.

126 · A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

2010 · Cell

PubMed 20673990 ↗

Scope & authors

FUNCTION

Huarte M., Guttman M., Feldser D., Garber M., Koziol M.J., Kenzelmann-Broz D., Khalil A.M., Zuk O., Amit I., Rabani M., Attardi L.D., Regev A., Lander E.S., Jacks T., Rinn J.L.

127 · Isoform specific phosphorylation of p53 by protein kinase CK1.

2010 · Cell. Mol. Life Sci.

PubMed 20041275 ↗

Scope & authors

PHOSPHORYLATION AT SER-20 BY CSNK1D/CK1

Venerando A., Marin O., Cozza G., Bustos V.H., Sarno S., Pinna L.A.

128 · p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.

2010 · FEBS Lett.

PubMed 20385133 ↗

Scope & authors

INTERACTION WITH SNAI1; CHARACTERIZATION OF VARIANTS LEU-110; PRO-155; HIS-175; SER-232; SER-249; HIS-273 AND TRP-282; MUTAGENESIS OF ARG-248

Lim S.O., Kim H., Jung G.

129 · Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.

2010 · J. Biol. Chem.

PubMed 19880522 ↗

Scope & authors

INTERACTION WITH PTK2B/PYK2 AND MDM2; UBIQUITINATION; SUBCELLULAR LOCATION

Lim S.T., Miller N.L., Nam J.O., Chen X.L., Lim Y., Schlaepfer D.D.

130 · G9a and Glp methylate lysine 373 in the tumor suppressor p53.

2010 · J. Biol. Chem.

PubMed 20118233 ↗

Scope & authors

METHYLATION AT LYS-373; MUTAGENESIS OF LYS-373

Huang J., Dorsey J., Chuikov S., Perez-Burgos L., Zhang X., Jenuwein T., Reinberg D., Berger S.L.

· Reference

2010 · J. Biol. Chem.

Scope & authors

ERRATUM OF PUBMED:20118233

Huang J., Dorsey J., Chuikov S., Perez-Burgos L., Zhang X., Jenuwein T., Reinberg D., Berger S.L.

132 · G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.

2010 · J. Biol. Chem.

PubMed 20124405 ↗

Scope & authors

PHOSPHORYLATION AT THR-55; INTERACTION WITH GRK5

Chen X., Zhu H., Yuan M., Fu J., Zhou Y., Ma L.

133 · BRD7 is a candidate tumour suppressor gene required for p53 function.

2010 · Nat. Cell Biol.

PubMed 20228809 ↗

Scope & authors

INTERACTION WITH BRD7; ACETYLATION AT LYS-382

Drost J., Mantovani F., Tocco F., Elkon R., Comel A., Holstege H., Kerkhoven R., Jonkers J., Voorhoeve P.M., Agami R., Del Sal G.

134 · RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.

2010 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 20173098 ↗

Scope & authors

UBIQUITINATION BY RFWD3

Fu X., Yucer N., Liu S., Li M., Yi P., Mu J.J., Yang T., Chu J., Jung S.Y., O'Malley B.W., Gu W., Qin J., Wang Y.

135 · Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.

2010 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 20660729 ↗

Scope & authors

INTERACTION WITH BRD7

Burrows A.E., Smogorzewska A., Elledge S.J.

136 · Initial characterization of the human central proteome.

2011 · BMC Syst. Biol.

PubMed 21269460 ↗

Scope & authors

IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.

137 · NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

2011 · Cell Cycle

PubMed 21952639 ↗

Scope & authors

INTERACTION WITH UHRF2

Mori T., Ikeda D.D., Fukushima T., Takenoshita S., Kochi H.

138 · E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.

2011 · Cell Death Differ.

PubMed 21597459 ↗

Scope & authors

INTERACTION WITH MUL1; SUBCELLULAR LOCATION; UBIQUITINATION AT LYS-24 BY MUL1; MUTAGENESIS OF LYS-24

Jung J.H., Bae S., Lee J.Y., Woo S.R., Cha H.J., Yoon Y., Suh K.S., Lee S.J., Park I.C., Jin Y.W., Lee K.H., An S., Lee J.H.

139 · Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.

2011 · J. Biol. Chem.

PubMed 20959462 ↗

Scope & authors

FUNCTION; INTERACTION WITH AURKB AND NOC2L; PHOSPHORYLATION AT SER-183; SER-269 AND THR-284; CHARACTERIZATION OF VARIANT ALA-284; MUTAGENESIS OF SER-183; SER-269 AND THR-284; IDENTIFICATION BY MASS SPECTROMETRY

Wu L., Ma C.A., Zhao Y., Jain A.

140 · PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway.

2012 · Apoptosis

PubMed 22914926 ↗

Scope & authors

INTERACTION WITH MDM2 AND PDCD5; SUBCELLULAR LOCATION

Xu L., Hu J., Zhao Y., Hu J., Xiao J., Wang Y., Ma D., Chen Y.

141 · Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.

2020 · Nat. Cancer

PubMed 35122041 ↗

Scope & authors

INTERACTION WITH ALDOB AND G6PD

Li M., He X., Guo W., Yu H., Zhang S., Wang N., Liu G., Sa R., Shen X., Jiang Y., Tang Y., Zhuo Y., Yin C., Tu Q., Li N., Nie X., Li Y., Hu Z., Zhu H., Ding J., Li Z., Liu T., Zhang F., Zhou H., Li S., Yue J., Yan Z., Cheng S., Tao Y., Yin H.

142 · A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

2011 · Nat. Genet.

PubMed 21946351 ↗

Scope & authors

INVOLVEMENT IN BCC7

Stacey S.N., Sulem P., Jonasdottir A., Masson G., Gudmundsson J., Gudbjartsson D.F., Magnusson O.T., Gudjonsson S.A., Sigurgeirsson B., Thorisdottir K., Ragnarsson R., Benediktsdottir K.R., Nexo B.A., Tjonneland A., Overvad K., Rudnai P., Gurzau E., Koppova K., Hemminki K., Corredera C., Fuentelsaz V., Grasa P., Navarrete S., Fuertes F., Garcia-Prats M.D., Sanambrosio E., Panadero A., De Juan A., Garcia A., Rivera F., Planelles D., Soriano V., Requena C., Aben K.K., van Rossum M.M., Cremers R.G., van Oort I.M., van Spronsen D.J., Schalken J.A., Peters W.H., Helfand B.T., Donovan J.L., Hamdy F.C., Badescu D., Codreanu O., Jinga M., Csiki I.E., Constantinescu V., Badea P., Mates I.N., Dinu D.E., Constantin A., Mates D., Kristjansdottir S., Agnarsson B.A., Jonsson E., Barkardottir R.B., Einarsson G.V., Sigurdsson F., Moller P.H., Stefansson T., Valdimarsson T., Johannsson O.T., Sigurdsson H., Jonsson T., Jonasson J.G., Tryggvadottir L., Rice T., Hansen H.M., Xiao Y., Lachance D.H., O'Neill B.P., Kosel M.L., Decker P.A., Thorleifsson G., Johannsdottir H., Helgadottir H.T., Sigurdsson A., Steinthorsdottir V., Lindblom A., Sandler R.S., Keku T.O., Banasik K., Jorgensen T., Witte D.R., Hansen T., Pedersen O., Jinga V., Neal D.E., Catalona W.J., Wrensch M., Wiencke J., Jenkins R.B., Nagore E., Vogel U., Kiemeney L.A., Kumar R., Mayordomo J.I., Olafsson J.H., Kong A., Thorsteinsdottir U., Rafnar T., Stefansson K.

143 · A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.

2011 · Oncogene

PubMed 21317932 ↗

Scope & authors

INTERACTION WITH NUAK1; PHOSPHORYLATION AT SER-15 AND SER-392

Hou X., Liu J.E., Liu W., Liu C.Y., Liu Z.Y., Sun Z.Y.

144 · p53 opens the mitochondrial permeability transition pore to trigger necrosis.

2012 · Cell

PubMed 22726440 ↗

Scope & authors

FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH PPIF

Vaseva A.V., Marchenko N.D., Ji K., Tsirka S.E., Holzmann S., Moll U.M.

145 · The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.

2012 · Cell Cycle

PubMed 22214662 ↗

Scope & authors

INTERACTION WITH UBC9; PHOSPHORYLATION AT SER-392; SUMOYLATION AT LYS-386

Bennett R.L., Pan Y., Christian J., Hui T., May W.S. Jr.

146 · Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.

2012 · Cell Death Differ.

PubMed 22522597 ↗

Scope & authors

INTERACTION WITH NOP53

Lee S., Kim J.Y., Kim Y.J., Seok K.O., Kim J.H., Chang Y.J., Kang H.Y., Park J.H.

147 · ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.

2012 · Eur. J. Immunol.

PubMed 22945289 ↗

Scope & authors

INTERACTION WITH ZNF385B

Iijima K., Yamada H., Miharu M., Imadome K., Miyagawa Y., Akimoto S., Kobayashi K., Okita H., Nakazawa A., Fujiwara S., Fujimoto J., Kiyokawa N.

148 · PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.

2012 · Nat. Struct. Mol. Biol.

PubMed 22864287 ↗

Scope & authors

METHYLATION AT LYS-370 AND LYS-382

Cui G., Park S., Badeaux A.I., Kim D., Lee J., Thompson J.R., Yan F., Kaneko S., Yuan Z., Botuyan M.V., Bedford M.T., Cheng J.Q., Mer G.

149 · p53 regulates Period2 expression and the circadian clock.

2013 · Nat. Commun.

PubMed 24051492 ↗

Scope & authors

FUNCTION

Miki T., Matsumoto T., Zhao Z., Lee C.C.

150 · MOZ increases p53 acetylation and premature senescence through its complex formation with PML.

2013 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 23431171 ↗

Scope & authors

ACETYLATION AT LYS-120 AND LYS-382

Rokudai S., Laptenko O., Arnal S.M., Taya Y., Kitabayashi I., Prives C.

151 · Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.

2014 · Cell Death Dis.

PubMed 24625977 ↗

Scope & authors

INTERACTION WITH HSPA9; SUBCELLULAR LOCATION

Sane S., Abdullah A., Boudreau D.A., Autenried R.K., Gupta B.K., Wang X., Wang H., Schlenker E.H., Zhang D., Telleria C., Huang L., Chauhan S.C., Rezvani K.

152 · S100A4 interacts with p53 in the nucleus and promotes p53 degradation.

2013 · Oncogene

PubMed 23752197 ↗

Scope & authors

INTERACTION WITH S100A4; SUBCELLULAR LOCATION

Orre L.M., Panizza E., Kaminskyy V.O., Vernet E., Graeslund T., Zhivotovsky B., Lehtioe J.

153 · DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].

2014 · J. Natl. Cancer Inst.

PubMed 24652652 ↗

Scope & authors

FUNCTION

Polato F., Rusconi P., Zangrossi S., Morelli F., Boeri M., Musi A., Marchini S., Castiglioni V., Scanziani E., Torri V., Broggini M.

154 · Disruption of FAT10-MAD2 binding inhibits tumor progression.

2014 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 25422469 ↗

Scope & authors

INTERACTION WITH UBD

Theng S.S., Wang W., Mah W.C., Chan C., Zhuo J., Gao Y., Qin H., Lim L., Chong S.S., Song J., Lee C.G.

155 · Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

2015 · Cell Death Differ.

PubMed 25168243 ↗

Scope & authors

INTERACTION WITH TTC5; SUBCELLULAR LOCATION

Maniam S., Coutts A.S., Stratford M.R., McGouran J., Kessler B., La Thangue N.B.

156 · Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.

2016 · Cell Stress Chaperones

PubMed 26634371 ↗

Scope & authors

SUBCELLULAR LOCATION

Sane S., Abdullah A., Nelson M.E., Wang H., Chauhan S.C., Newton S.S., Rezvani K.

157 · RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.

2015 · Cell. Physiol. Biochem.

PubMed 25591766 ↗

Scope & authors

UBIQUITINATION

Yang L., Zhou B., Li X., Lu Z., Li W., Huo X., Miao Z.

158 · PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

2016 · Oncogene

PubMed 25772236 ↗

Scope & authors

INTERACTION WITH HADV5 E1B-55K (MICROBIAL INFECTION)

Wimmer P., Berscheminski J., Blanchette P., Groitl P., Branton P.E., Hay R.T., Dobner T., Schreiner S.

159 · SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

2016 · Nat. Commun.

PubMed 26868148 ↗

Scope & authors

INTERACTION WITH FBXO22; UBIQUITINATION

Johmura Y., Sun J., Kitagawa K., Nakanishi K., Kuno T., Naiki-Ito A., Sawada Y., Miyamoto T., Okabe A., Aburatani H., Li S., Miyoshi I., Takahashi S., Kitagawa M., Nakanishi M.

160 · LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.

2016 · Oncotarget

PubMed 27323408 ↗

Scope & authors

INTERACTION WITH AFG1L; SUBCELLULAR LOCATION

Cesnekova J., Spacilova J., Hansikova H., Houstek J., Zeman J., Stiburek L.

161 · DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.

2017 · Sci. Rep.

PubMed 28842590 ↗

Scope & authors

INTERACTION WITH DDX3X AND GAMMA-TUBULIN; SUBCELLULAR LOCATION; PHOSPHORYLATION AT SER-15

Chen W.J., Wang W.T., Tsai T.Y., Li H.K., Lee Y.W.

162 · USP3 stabilizes p53 protein through its deubiquitinase activity.

2017 · Biochem. Biophys. Res. Commun.

PubMed 28807825 ↗

Scope & authors

DEUBIQUITINATION BY USP3

Fu S., Shao S., Wang L., Liu H., Hou H., Wang Y., Wang H., Huang X., Lv R.

163 · DAZAP2 acts as specifier of the p53 response to DNA damage.

2021 · Nucleic Acids Res.

PubMed 33591310 ↗

Scope & authors

INTERACTION WITH DAZAP2

Liebl M.C., Moehlenbrink J., Becker H., Raddatz G., Abdeen S.K., Aqeilan R.I., Lyko F., Hofmann T.G.

164 · De novo mutations activating germline TP53 in an inherited bone-marrow-failure syndrome.

2018 · Am. J. Hum. Genet.

PubMed 30146126 ↗

Scope & authors

INVOLVEMENT IN BMFS5

Toki T., Yoshida K., Wang R., Nakamura S., Maekawa T., Goi K., Katoh M.C., Mizuno S., Sugiyama F., Kanezaki R., Uechi T., Nakajima Y., Sato Y., Okuno Y., Sato-Otsubo A., Shiozawa Y., Kataoka K., Shiraishi Y., Sanada M., Chiba K., Tanaka H., Terui K., Sato T., Kamio T., Sakaguchi H., Ohga S., Kuramitsu M., Hamaguchi I., Ohara A., Kanno H., Miyano S., Kojima S., Ishiguro A., Sugita K., Kenmochi N., Takahashi S., Eto K., Ogawa S., Ito E.

165 · A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.

2018 · Cell Chem. Biol.

PubMed 29681526 ↗

Scope & authors

INTERACTION WITH MORN3; DEACETYLATION AT LYS-382; UBQIQUITINATION

Liang L., Wang H., Shi H., Li Z., Yao H., Bu Z., Song N., Li C., Xiang D., Zhang Y., Wang J., Hu Y., Xu Q., Ma Y., Cheng Z., Wang Y., Zhao S., Qian J., Chen Y., Fang J.Y., Xu J.

166 · Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.

2018 · Elife

PubMed 29474172 ↗

Scope & authors

ACETYLATION AT LYS-381; DEACETYLATION BY SIRT6; MUTAGENESIS OF LYS-381

Ghosh S., Wong S.K., Jiang Z., Liu B., Wang Y., Hao Q., Gorbunova V., Liu X., Zhou Z.

167 · VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.

2019 · Sci. Rep.

PubMed 31527692 ↗

Scope & authors

PHOSPHORYLATION AT THR-18 BY VRK1

Martin-Doncel E., Rojas A.M., Cantarero L., Lazo P.A.

168 · Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.

2020 · Sci. Rep.

PubMed 31953488 ↗

Scope & authors

DOMAIN; MUTAGENESIS OF SER-392

Kamagata K., Kanbayashi S., Honda M., Itoh Y., Takahashi H., Kameda T., Nagatsugi F., Takahashi S.

169 · The ORF45 protein of Kaposi Sarcoma-associated Herpesvirus (KSHV) is an inhibitor of p53 signaling during viral reactivation.

2021 · J. Virol.

PubMed 34523970 ↗

Scope & authors

INTERACTION WITH KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS/HHV-8 PROTEIN ORF45 (MICROBIAL INFECTION)

Alzhanova D., Meyo J.O., Juarez A., Dittmer D.P.

170 · ZNF768 links oncogenic RAS to cellular senescence.

2021 · Nat. Commun.

PubMed 34404770 ↗

Scope & authors

INTERACTION WITH ZNF768

Villot R., Poirier A., Bakan I., Boulay K., Fernandez E., Devillers R., Gama-Braga L., Tribouillard L., Gagne A., Duchesne E., Caron D., Berube J.S., Berube J.C., Coulombe Y., Orain M., Gelinas Y., Gobeil S., Bosse Y., Masson J.Y., Elowe S., Bilodeau S., Manem V., Joubert P., Mallette F.A., Laplante M.

171 · Ser392 phosphorylation modulated a switch between p53 and transcriptional condensates.

2022 · Biochim. Biophys. Acta

PubMed 35618207 ↗

Scope & authors

FUNCTION; DOMAIN; PHOSPHORYLATION AT SER-392; MUTAGENESIS OF SER-392

Dai Z., Li G., Chen Q., Yang X.

172 · Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain.

2022 · Int. J. Biol. Macromol.

PubMed 36108750 ↗

Scope & authors

DOMAIN; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANTS LFS CYS-337; HIS-337 AND PRO-344; CHARACTERIZATION OF VARIANT PRO-337

Chen C., Fu G., Guo Q., Xue S., Luo S.Z.

173 · Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.

2023 · Int. J. Biol. Macromol.

PubMed 36634798 ↗

Scope & authors

FUNCTION; DOMAIN

Chen Q., Wu Y., Dai Z., Zhang Z., Yang X.

174 · Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis.

2024 · Cell

PubMed 38653238 ↗

Scope & authors

FUNCTION; DOMAIN; LACTYLATION AT LYS-120 AND LYS-139; CHARACTERIZATION OF VARIANTS GLU-120; GLN-120; ASN-139; THR-139; GLN-139 AND GLU-139

Zong Z., Xie F., Wang S., Wu X., Zhang Z., Yang B., Zhou F.

175 · High-resolution structure of the oligomerization domain of p53 by multidimensional NMR.

1994 · Science

PubMed 8023159 ↗

Scope & authors

STRUCTURE BY NMR OF 319-360

Clore G.M., Omichinski J.G., Sakaguchi K., Zambrano N., Sakamoto H., Appella E., Gronenborn A.M.

176 · Solution structure of the tetrameric minimum transforming domain of p53.

1994 · Nat. Struct. Biol.

PubMed 7773777 ↗

Scope & authors

STRUCTURE BY NMR OF 325-355

Lee W., Harvey T.S., Yin Y., Yau P., Litchfield D., Arrowsmith C.H.

177 · Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.

1997 · EMBO J.

PubMed 9321402 ↗

Scope & authors

STRUCTURE BY NMR OF 326-354

McCoy M., Stavridi E.S., Waterman J.L., Wieczorek A.M., Opella S.J., Halazonetis T.D.

178 · Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.

1994 · Science

PubMed 8023157 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY

Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P.

179 · Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.

1995 · Science

PubMed 7878469 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY

Jeffrey P.D., Gorina S., Pavletich N.P.

180 · Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.

1996 · Science

PubMed 8875929 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH MDM2

Kussie P.H., Gorina S., Marechal V., Elenbaas B., Moreau J., Levine A.J., Pavletich N.P.

181 · Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.

1996 · Science

PubMed 8875926 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH 53BP2

Gorina S., Pavletich N.P.

182 · Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.

2004 · J. Biol. Chem.

PubMed 14534297 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ZINC IONS; SUBUNIT

Joerger A.C., Allen M.D., Fersht A.R.

183 · Structural basis of DNA recognition by p53 tetramers.

2006 · Mol. Cell

PubMed 16793544 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH DNA AND ZINC IONS; SUBUNIT

Kitayner M., Rozenberg H., Kessler N., Rabinovich D., Shaulov L., Haran T.E., Shakked Z.

184 · Molecular recognition of p53 and MDM2 by USP7/HAUSP.

2006 · Nat. Struct. Mol. Biol.

PubMed 16474402 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH USP7; INTERACTION WITH USP7

Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith C.H., Frappier L.

185 · Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

2006 · PLoS Biol.

PubMed 16402859 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH USP7; MUTAGENESIS OF PRO-359; GLY-361 AND SER-362; INTERACTION WITH USP7

Hu M., Gu L., Li M., Jeffrey P.D., Gu W., Shi Y.

186 · The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.

2010 · J. Biol. Chem.

PubMed 20870725 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY; METHYLATION AT LYS-382; MUTAGENESIS OF LYS-382; INTERACTION WITH L3MBTL1

West L.E., Roy S., Lachmi-Weiner K., Hayashi R., Shi X., Appella E., Kutateladze T.G., Gozani O.

187 · p53: at the crossroads of molecular carcinogenesis and risk assessment.

1993 · Science

PubMed 8266092 ↗

Scope & authors

REVIEW

Harris C.C.

188 · p53 mutations in human cancers.

1991 · Science

PubMed 1905840 ↗

Scope & authors

REVIEW ON VARIANTS

Hoolstein M., Sidransky D., Vogelstein B., Harris C.C.

189 · Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses.

1996 · Hum. Mutat.

PubMed 8829653 ↗

Scope & authors

REVIEW ON VARIANTS

de Vries E.M.G., Ricke D.O., de Vries T.N., Hartmann A., Blaszyk H., Liao D., Soussi T., Kovach J.S., Sommer S.S.

190 · Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.

2006 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 17015838 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ZINC IONS

Joerger A.C., Ang H.C., Fersht A.R.

191 · Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.

2008 · Acta Crystallogr. D

PubMed 18453682 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY OF VARIANT GLN-282

Tu C., Tan Y.H., Shaw G., Zhou Z., Bai Y., Luo R., Ji X.

192 · Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.

2008 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 18650397 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY OF VARIANT CYS-202 IN COMPLEX WITH ZINC IONS AND PHIKAN083

Boeckler F.M., Joerger A.C., Jaggi G., Rutherford T.J., Veprintsev D.B., Fersht A.R.

193 · Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.

2009 · J. Mol. Biol.

PubMed 18996393 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY OF VARIANT SER-249 IN COMPLEX WITH DNA

Suad O., Rozenberg H., Brosh R., Diskin-Posner Y., Kessler N., Shimon L.J., Frolow F., Liran A., Rotter V., Shakked Z.

194 · Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.

2009 · Protein Eng. Des. Sel.

PubMed 19515728 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH ZINC IONS

Khoo K.H., Joerger A.C., Freund S.M., Fersht A.R.

195 · Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.

2010 · Chem. Biol.

PubMed 20142040 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY OF VARIANT CYS-220 IN COMPLEX WITH ZINC IONS

Basse N., Kaar J.L., Settanni G., Joerger A.C., Rutherford T.J., Fersht A.R.

196 · Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.

2010 · Nat. Struct. Mol. Biol.

PubMed 20364130 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY IN COMPLEX WITH DNA AND ZINC IONS; SUBUNIT

Kitayner M., Rozenberg H., Rohs R., Suad O., Rabinovich D., Honig B., Shakked Z.

197 · Structure Determination of the Transactivation Domain of p53 in Complex with S100A4Using Annexin A2 as a Crystallization Chaperone.

2020 · Structure

PubMed 32442400 ↗

Scope & authors

X-RAY CRYSTALLOGRAPHY; INTERACTION WITH S100A4

Ecsedi P., Gogl G., Hof H., Kiss B., Harmat V., Nyitray L.

198 · Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.

1991 · Hum. Genet.

PubMed 1999338 ↗

Scope & authors

VARIANT ARG-72

Olschwang S., Laurent-Puig P., Vassal A., Salmon R.-J., Thomas G.

199 · A germ line mutation in exon 5 of the p53 gene in an extended cancer family.

1991 · Cancer Res.

PubMed 1933902 ↗

Scope & authors

VARIANT LFS THR-133

Law J.C., Strong L.C., Chidambaram A., Ferrell R.E.

200 · Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

1990 · Science

PubMed 1978757 ↗

Scope & authors

VARIANTS LFS CYS-245; TRP-248; PRO-252 AND LYS-258

Malkin D., Li F.P., Strong L.C., Fraumeni J.F. Jr., Nelson C.E., Kim D.H., Kassel J., Gryka M.A., Bischoff F.Z., Tainsky M.A., Friend S.H.

201 · Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.

1990 · Nature

PubMed 2259385 ↗

Scope & authors

VARIANT LFS ASP-245

Srivastava S., Zou Z., Pirollo K., Blattner W., Chang E.H.

202 · Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.

1992 · J. Clin. Invest.

PubMed 1737852 ↗

Scope & authors

VARIANT LFS LEU-272

Felix C.A., Nau M.M., Takahashi T., Mitsudomi T., Chiba I., Poplack D.G., Reaman G.H., Cole D.E., Letterio J.J., Whang-Peng J., Knutsen T., Minna J.D.

203 · Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.

1992 · N. Engl. J. Med.

PubMed 1565144 ↗

Scope & authors

VARIANTS LFS HIS-273 AND VAL-325

Malkin D., Jolly K.W., Barbier N., Look A.T., Friend S.H., Gebhardt M.C., Andersen T.I., Boerresen A.-L., Li F.P., Garber J., Strong L.C.

204 · Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 · Oncogene

PubMed 1694291 ↗

Scope & authors

VARIANTS SPORADIC CANCERS GLN-132; SER-249; LYS-280 AND LYS-285

Bartek J., Iggo R., Gannon J., Lane D.P.

205 · p53 mutations in colorectal cancer.

1990 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 1699228 ↗

Scope & authors

VARIANTS SPORADIC CANCERS PHE-241 AND HIS-273

Rodrigues N.R., Rowan A., Smith M.E.F., Kerr I.B., Bodmer W.F., Gannon J.V., Lane D.P.

206 · Frequent mutation of the p53 gene in human esophageal cancer.

1990 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 2263646 ↗

Scope & authors

VARIANTS SPORADIC CANCER VAL-154; VAL-245; GLN-248; LEU-278 AND SER-278

Hollstein M.C., Metcalf R.A., Welsh J.A., Montesano R., Harris C.C.

207 · Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.

1991 · Biochem. Biophys. Res. Commun.

PubMed 1647768 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Ishioka C., Sato T., Gamoh M., Suzuki T., Shibata H., Kanamaru R., Wakui A., Yamazaki T.

208 · p53 gene mutations in Barrett's epithelium and esophageal cancer.

1991 · Cancer Res.

PubMed 1868473 ↗

Scope & authors

VARIANTS SPORADIC CANCERS LEU-152; ALA-155; HIS-175; PHE-176 AND HIS-273

Casson A.G., Mukhopadhyay T., Cleary K.R., Ro J.Y., Levin B., Roth J.A.

209 · Mutational hotspot in the p53 gene in human hepatocellular carcinomas.

1991 · Nature

PubMed 1849234 ↗

Scope & authors

VARIANTS SPORADIC CANCERS IN CHINA

Hsu I.C., Metcalf R.A., Sun T., Welsh J.A., Wang N.J., Harris C.C.

210 · Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa.

1991 · Nature

PubMed 1672732 ↗

Scope & authors

VARIANTS SPORADIC CANCERS IN SOUTH AFRICA

Bressac B., Kew M., Wands J., Ozturk M.

211 · Frequent p53 mutations in head and neck cancer.

1992 · Cancer Res.

PubMed 1394225 ↗

Scope & authors

VARIANTS SPORADIC CANCERS PHE-176; PHE-242; CYS-245; LEU-248 AND HIS-273

Somers K.D., Merrick M.A., Lopez M.E., Incognito L.S., Schechter G.L., Casey G.

212 · Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.

1992 · EMBO J.

PubMed 1327751 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Crook T., Vousden K.H.

213 · The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.

1992 · Int. J. Cancer

PubMed 1459726 ↗

Scope & authors

VARIANTS SPORADIC CANCERS CYS-205; GLU-281 AND LYS-285

Sakai E., Rikimaru K., Ueda M., Matsumoto Y., Ishii N., Enomoto S., Yamamoto H., Tsuchida N.

214 · A novel mutation in the p53 gene in a Burkitt's lymphoma cell line.

1992 · Hum. Mol. Genet.

PubMed 1303181 ↗

Scope & authors

VARIANT PRO-HIS-PRO-178 INS

Bhatia K., Guiterrez M.I., Magrath I.T.

215 · p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas.

1992 · Oncogene

PubMed 1437144 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Duthu A., Debuire B., Romano J.W., Ehrhart J.C., Fiscella M., May E., Appella E., May P.

216 · An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.

1992 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 1631151 ↗

Scope & authors

VARIANT SPORADIC CANCER THR-280

Sun Y., Hegamyer G., Heng Y.-J., Hildesheim A., Chen J.-Y., Chen I.-H., Cao Y., Yao K.-T., Colburn N.H.

217 · p53 alterations in human squamous cell carcinomas and carcinoma cell lines.

1993 · Am. J. Pathol.

PubMed 7682763 ↗

Scope & authors

VARIANTS SPORADIC CANCERS SER-151; PRO-156; LYS-174; ARG-194; CYS-220; GLN-248; LEU-248 AND HIS-273

Caamano J., Zhang S.Y., Rosvold E.A., Bauer B., Klein-Szanto A.J.P.

218 · The incidence of p53 mutations increases with progression of head and neck cancer.

1993 · Cancer Res.

PubMed 8402617 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Boyle J.O., Hakim J., Koch W., van der Riet P., Hruban R.H., Roa R.A., Correo R., Eby Y.J., Ruppert J.M., Sidransky D.

219 · Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors.

1993 · Oncogene

PubMed 8336944 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Hamelin R., Jego N., Laurent-Puig P., Vidaud M., Thomas G.

220 · Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

1994 · Cancer Res.

PubMed 8118819 ↗

Scope & authors

VARIANTS; INVOLVEMENT IN LFL

Birch J.M., Hartley A.L., Tricker K.J., Prosser J., Condie A., Kelsey A.M., Harris M., Jones P.H., Binchy A., Crowther D., Craft A.W., Eden O.B., Evans D.G.R., Thompson E., Mann J.R., Martin J., Mitchell E.L.D., Santibanez-Koref M.F.

221 · A temperature-sensitive mutant of human p53.

1994 · EMBO J.

PubMed 8013454 ↗

Scope & authors

CHARACTERIZATION OF VARIANT ALA-143

Zhang W., Guo X.-Y., Hu G.-Y., Liu W.-B., Shay J.W., Deisseroth A.B.

222 · Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

1995 · Am. J. Hum. Genet.

PubMed 7887414 ↗

Scope & authors

VARIANTS LFS HIS-175; ARG-193; GLN-248; CYS-273 AND TYR-275

Frebourg T., Barbier N., Yan Y.-X., Garber J.E., Dreyfus M., Fraumeni J.F. Jr., Li F.P., Friend S.H.

223 · Germline mutations in the TP53 gene.

1995 · Cancer Surv.

PubMed 8718514 ↗

Scope & authors

VARIANTS; INVOLVEMENT IN LFL

Eeles R.A.

224 · An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

1995 · J. Med. Genet.

PubMed 8825920 ↗

Scope & authors

VARIANT LFS HIS-175

Varley J.M., McGrown G., Thorncroft M., Tricker K.J., Teare M.D., Santibanez-Koref M.F., Houlston R.S., Martin J., Birch J.M., Evans D.G.R.

225 · Molecular analysis of the TP53 gene in Barrett's adenocarcinoma.

1996 · Hum. Mutat.

PubMed 8829627 ↗

Scope & authors

VARIANTS SPORADIC CANCERS PHE-176; SER-245; TRP-248; TRP-282 AND GLN-286

Audrezet M.-P., Robaszkiewicz M., Mercier B., Nousbaum J.-B., Hardy E., Bail J.-P., Volant A., Lozac'H P., Gouerou H., Ferec C.

226 · Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer.

1997 · Hum. Mutat.

PubMed 9101296 ↗

Scope & authors

VARIANTS SPORADIC CANCERS

Guldberg P., Nedergaard T., Nielsen H.J., Olsen A.C., Ahrenkiel V., Zeuthen J.

227 · Drastic genetic instability of tumors and normal tissues in Turcot syndrome.

1997 · Oncogene

PubMed 9419979 ↗

Scope & authors

VARIANT SPORADIC CANCER ILE-157

Miyaki M., Nishio J., Konishi M., Kikuchi-Yanoshita R., Tanaka K., Muraoka M., Nagato M., Chong J.-M., Koike M., Terada T., Kawahara Y., Fukutome A., Tomiyama J., Chuganji Y., Momoi M., Utsunomiya J.

228 · Detection of p53 gene mutations in oral squamous cell carcinomas of a black African population sample.

1998 · Hum. Mutat.

PubMed 9450901 ↗

Scope & authors

VARIANTS SER-152; ILE-169; PHE-176; THR-195; CYS-220; ILE-230; CYS-273 AND SER-278

van Rensburg E.J., Engelbrecht S., van Heerden W.F.P., Kotze M.J., Raubenheimer E.J.

229 · A germline missense mutation R337C in exon 10 of the human p53 gene.

1998 · Hum. Mutat. Suppl.

PubMed 9452042 ↗

Scope & authors

VARIANT NON-CLASSICAL LFS CYS-337

Luca J.W., Strong L.C., Hansen M.F.

230 · Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.

1999 · Cancer Genet. Cytogenet.

PubMed 10484981 ↗

Scope & authors

VARIANT LFS ILE-292

Gueran S., Tunca Y., Imirzalioglu N.

231 · p53 and human cancer: the first ten thousand mutations.

2000 · Adv. Cancer Res.

PubMed 10549356 ↗

Scope & authors

VARIANTS

Hainaut P., Hollstein M.

232 · An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.

2001 · Proc. Natl. Acad. Sci. U.S.A.

PubMed 11481490 ↗

Scope & authors

VARIANT ADCC HIS-337

Ribeiro R.C., Sandrini F., Figueiredo B., Zambetti G.P., Michalkiewicz E., Lafferty A.R., DeLacerda L., Rabin M., Cadwell C., Sampaio G., Cat I., Stratakis C.A., Sandrini R.

233 · Investigations on a clinically and functionally unusual and novel germline p53 mutation.

2002 · Br. J. Cancer

PubMed 12085209 ↗

Scope & authors

INVOLVEMENT IN CPP

Rutherford J., Chu C.E., Duddy P.M., Charlton R.S., Chumas P., Taylor G.R., Lu X., Barnes D.M., Camplejohn R.S.

234 · The consensus coding sequences of human breast and colorectal cancers.

2006 · Science

PubMed 16959974 ↗

Scope & authors

VARIANTS [LARGE SCALE ANALYSIS] LEU-134; PHE-157; CYS-163; HIS-175; ARG-177; ARG-193; PRO-213; PHE-241; PHE-242; GLN-248; TRP-248; SER-249; TRP-267; LYS-271; CYS-273; HIS-273; LEU-273; SER-278; ILE-280 AND HIS-281

Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.

235 · Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

2007 · Breast Cancer Res.

PubMed 17224074 ↗

Scope & authors

VARIANTS PRO-110; VAL-113; VAL-138; CYS-163; HIS-163; THR-195; MET-216; ALA-241; MET-249; SER-251; TYR-259 AND CYS-273

Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.

236 · Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

2007 · Hum. Mutat.

PubMed 17311302 ↗

Scope & authors

VARIANTS

Petitjean A., Mathe E., Kato S., Ishioka C., Tavtigian S.V., Hainaut P., Olivier M.

237 · DBC1 functions as a tumor suppressor by regulating p53 stability.

2015 · Cell Rep.

PubMed 25732823 ↗

Scope & authors

CHARACTERIZATION OF VARIANT SPORADIC CANCER LYS-280; UBIQUITINATION; PROTEASOMAL DEGRADATION; INTERACTION WITH CCAR2

Qin B., Minter-Dykhouse K., Yu J., Zhang J., Liu T., Zhang H., Lee S., Kim J., Wang L., Lou Z.

238 · Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.

2016 · PLoS Biol.

PubMed 27657329 ↗

Scope & authors

VARIANTS VAL-138; HIS-175; ILE-237; TRP-248 AND PRO-273

Guan Y., Huang D., Chen F., Gao C., Tao T., Shi H., Zhao S., Liao Z., Lo L.J., Wang Y., Chen J., Peng J.

The TP53 Database ↗

Atlas of Genetics and Cytogenetics in Oncology and Haematology ↗

Wikipedia ↗

Protein Spotlight ↗

Annotation coverage audit

Every recorded UniProt comment and feature has a destination in this page. GO, Atlas annotations and interaction rows retain their separate source counts.

1569 source comments and features accounted for.

View annotation inventory

Source record	Type	Section
FUNCTION:0	FUNCTION	function
COFACTOR:0	COFACTOR	function
SUBUNIT:0	SUBUNIT	interactions
SUBUNIT:1	SUBUNIT	interactions
SUBUNIT:2	SUBUNIT	interactions
SUBUNIT:3	SUBUNIT	interactions
SUBUNIT:4	SUBUNIT	interactions
INTERACTION:0	INTERACTION	interactions
SUBCELLULAR LOCATION:0	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:1	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:2	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:3	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:4	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:5	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:6	SUBCELLULAR LOCATION	location
SUBCELLULAR LOCATION:7	SUBCELLULAR LOCATION	location
ALTERNATIVE PRODUCTS:0	ALTERNATIVE PRODUCTS	sequence
TISSUE SPECIFICITY:0	TISSUE SPECIFICITY	expression
INDUCTION:0	INDUCTION	expression
DOMAIN:0	DOMAIN	domains
DOMAIN:1	DOMAIN	domains
PTM:0	PTM	processing
PTM:1	PTM	processing
PTM:2	PTM	processing
PTM:3	PTM	processing
PTM:4	PTM	processing
PTM:5	PTM	processing
PTM:6	PTM	processing
PTM:7	PTM	processing
DISEASE:0	DISEASE	disease
DISEASE:1	DISEASE	disease
DISEASE:2	DISEASE	disease
DISEASE:3	DISEASE	disease
DISEASE:4	DISEASE	disease
DISEASE:5	DISEASE	disease
DISEASE:6	DISEASE	disease
DISEASE:7	DISEASE	disease
DISEASE:8	DISEASE	disease
MISCELLANEOUS:0	MISCELLANEOUS	function
MISCELLANEOUS:1	MISCELLANEOUS	function
MISCELLANEOUS:2	MISCELLANEOUS	function
MISCELLANEOUS:3	MISCELLANEOUS	function
MISCELLANEOUS:4	MISCELLANEOUS	function
SIMILARITY:0	SIMILARITY	domains
CAUTION:0	CAUTION	function
WEB RESOURCE:0	WEB RESOURCE	sources
WEB RESOURCE:1	WEB RESOURCE	sources
WEB RESOURCE:2	WEB RESOURCE	sources
WEB RESOURCE:3	WEB RESOURCE	sources
feature-0	Chain	processing
feature-1	DNA binding	domains
feature-2	Region	domains
feature-3	Region	domains
feature-4	Region	domains
feature-5	Region	domains
feature-6	Region	domains
feature-7	Region	domains
feature-8	Region	domains
feature-9	Region	domains
feature-10	Region	domains
feature-11	Region	domains
feature-12	Region	domains
feature-13	Region	domains
feature-14	Region	domains
feature-15	Region	domains
feature-16	Region	domains
feature-17	Region	domains
feature-18	Region	domains
feature-19	Region	domains
feature-20	Region	domains
feature-21	Region	domains
feature-22	Motif	domains
feature-23	Motif	domains
feature-24	Motif	domains
feature-25	Motif	domains
feature-26	Motif	domains
feature-27	Compositional bias	domains
feature-28	Compositional bias	domains
feature-29	Compositional bias	domains
feature-30	Binding site	domains
feature-31	Binding site	domains
feature-32	Binding site	domains
feature-33	Binding site	domains
feature-34	Site	domains
feature-35	Modified residue	processing
feature-36	Modified residue	processing
feature-37	Modified residue	processing
feature-38	Modified residue	processing
feature-39	Modified residue	processing
feature-40	Modified residue	processing
feature-41	Modified residue	processing
feature-42	Modified residue	processing
feature-43	Modified residue	processing
feature-44	Modified residue	processing
feature-45	Modified residue	processing
feature-46	Modified residue	processing
feature-47	Modified residue	processing
feature-48	Modified residue	processing
feature-49	Modified residue	processing
feature-50	Modified residue	processing
feature-51	Modified residue	processing
feature-52	Modified residue	processing
feature-53	Modified residue	processing
feature-54	Modified residue	processing
feature-55	Modified residue	processing
feature-56	Modified residue	processing
feature-57	Modified residue	processing
feature-58	Modified residue	processing
feature-59	Modified residue	processing
feature-60	Modified residue	processing
feature-61	Modified residue	processing
feature-62	Modified residue	processing
feature-63	Modified residue	processing
feature-64	Modified residue	processing
feature-65	Cross-link	processing
feature-66	Cross-link	processing
feature-67	Cross-link	processing
feature-68	Cross-link	processing
feature-69	Cross-link	processing
feature-70	Cross-link	processing
feature-71	Alternative sequence	sequence
feature-72	Alternative sequence	sequence
feature-73	Alternative sequence	sequence
feature-74	Alternative sequence	sequence
feature-75	Alternative sequence	sequence
feature-76	Alternative sequence	sequence
feature-77	Natural variant	disease
feature-78	Natural variant	disease
feature-79	Natural variant	disease
feature-80	Natural variant	disease
feature-81	Natural variant	disease
feature-82	Natural variant	disease
feature-83	Natural variant	disease
feature-84	Natural variant	disease
feature-85	Natural variant	disease
feature-86	Natural variant	disease
feature-87	Natural variant	disease
feature-88	Natural variant	disease
feature-89	Natural variant	disease
feature-90	Natural variant	disease
feature-91	Natural variant	disease
feature-92	Natural variant	disease
feature-93	Natural variant	disease
feature-94	Natural variant	disease
feature-95	Natural variant	disease
feature-96	Natural variant	disease
feature-97	Natural variant	disease
feature-98	Natural variant	disease
feature-99	Natural variant	disease
feature-100	Natural variant	disease
feature-101	Natural variant	disease
feature-102	Natural variant	disease
feature-103	Natural variant	disease
feature-104	Natural variant	disease
feature-105	Natural variant	disease
feature-106	Natural variant	disease
feature-107	Natural variant	disease
feature-108	Natural variant	disease
feature-109	Natural variant	disease
feature-110	Natural variant	disease
feature-111	Natural variant	disease
feature-112	Natural variant	disease
feature-113	Natural variant	disease
feature-114	Natural variant	disease
feature-115	Natural variant	disease
feature-116	Natural variant	disease
feature-117	Natural variant	disease
feature-118	Natural variant	disease
feature-119	Natural variant	disease
feature-120	Natural variant	disease
feature-121	Natural variant	disease
feature-122	Natural variant	disease
feature-123	Natural variant	disease
feature-124	Natural variant	disease
feature-125	Natural variant	disease
feature-126	Natural variant	disease
feature-127	Natural variant	disease
feature-128	Natural variant	disease
feature-129	Natural variant	disease
feature-130	Natural variant	disease
feature-131	Natural variant	disease
feature-132	Natural variant	disease
feature-133	Natural variant	disease
feature-134	Natural variant	disease
feature-135	Natural variant	disease
feature-136	Natural variant	disease
feature-137	Natural variant	disease
feature-138	Natural variant	disease
feature-139	Natural variant	disease
feature-140	Natural variant	disease
feature-141	Natural variant	disease
feature-142	Natural variant	disease
feature-143	Natural variant	disease
feature-144	Natural variant	disease
feature-145	Natural variant	disease
feature-146	Natural variant	disease
feature-147	Natural variant	disease
feature-148	Natural variant	disease
feature-149	Natural variant	disease
feature-150	Natural variant	disease
feature-151	Natural variant	disease
feature-152	Natural variant	disease
feature-153	Natural variant	disease
feature-154	Natural variant	disease
feature-155	Natural variant	disease
feature-156	Natural variant	disease
feature-157	Natural variant	disease
feature-158	Natural variant	disease
feature-159	Natural variant	disease
feature-160	Natural variant	disease
feature-161	Natural variant	disease
feature-162	Natural variant	disease
feature-163	Natural variant	disease
feature-164	Natural variant	disease
feature-165	Natural variant	disease
feature-166	Natural variant	disease
feature-167	Natural variant	disease
feature-168	Natural variant	disease
feature-169	Natural variant	disease
feature-170	Natural variant	disease
feature-171	Natural variant	disease
feature-172	Natural variant	disease
feature-173	Natural variant	disease
feature-174	Natural variant	disease
feature-175	Natural variant	disease
feature-176	Natural variant	disease
feature-177	Natural variant	disease
feature-178	Natural variant	disease
feature-179	Natural variant	disease
feature-180	Natural variant	disease
feature-181	Natural variant	disease
feature-182	Natural variant	disease
feature-183	Natural variant	disease
feature-184	Natural variant	disease
feature-185	Natural variant	disease
feature-186	Natural variant	disease
feature-187	Natural variant	disease
feature-188	Natural variant	disease
feature-189	Natural variant	disease
feature-190	Natural variant	disease
feature-191	Natural variant	disease
feature-192	Natural variant	disease
feature-193	Natural variant	disease
feature-194	Natural variant	disease
feature-195	Natural variant	disease
feature-196	Natural variant	disease
feature-197	Natural variant	disease
feature-198	Natural variant	disease
feature-199	Natural variant	disease
feature-200	Natural variant	disease
feature-201	Natural variant	disease
feature-202	Natural variant	disease
feature-203	Natural variant	disease
feature-204	Natural variant	disease
feature-205	Natural variant	disease
feature-206	Natural variant	disease
feature-207	Natural variant	disease
feature-208	Natural variant	disease
feature-209	Natural variant	disease
feature-210	Natural variant	disease
feature-211	Natural variant	disease
feature-212	Natural variant	disease
feature-213	Natural variant	disease
feature-214	Natural variant	disease
feature-215	Natural variant	disease
feature-216	Natural variant	disease
feature-217	Natural variant	disease
feature-218	Natural variant	disease
feature-219	Natural variant	disease
feature-220	Natural variant	disease
feature-221	Natural variant	disease
feature-222	Natural variant	disease
feature-223	Natural variant	disease
feature-224	Natural variant	disease
feature-225	Natural variant	disease
feature-226	Natural variant	disease
feature-227	Natural variant	disease
feature-228	Natural variant	disease
feature-229	Natural variant	disease
feature-230	Natural variant	disease
feature-231	Natural variant	disease
feature-232	Natural variant	disease
feature-233	Natural variant	disease
feature-234	Natural variant	disease
feature-235	Natural variant	disease
feature-236	Natural variant	disease
feature-237	Natural variant	disease
feature-238	Natural variant	disease
feature-239	Natural variant	disease
feature-240	Natural variant	disease
feature-241	Natural variant	disease
feature-242	Natural variant	disease
feature-243	Natural variant	disease
feature-244	Natural variant	disease
feature-245	Natural variant	disease
feature-246	Natural variant	disease
feature-247	Natural variant	disease
feature-248	Natural variant	disease
feature-249	Natural variant	disease
feature-250	Natural variant	disease
feature-251	Natural variant	disease
feature-252	Natural variant	disease
feature-253	Natural variant	disease
feature-254	Natural variant	disease
feature-255	Natural variant	disease
feature-256	Natural variant	disease
feature-257	Natural variant	disease
feature-258	Natural variant	disease
feature-259	Natural variant	disease
feature-260	Natural variant	disease
feature-261	Natural variant	disease
feature-262	Natural variant	disease
feature-263	Natural variant	disease
feature-264	Natural variant	disease
feature-265	Natural variant	disease
feature-266	Natural variant	disease
feature-267	Natural variant	disease
feature-268	Natural variant	disease
feature-269	Natural variant	disease
feature-270	Natural variant	disease
feature-271	Natural variant	disease
feature-272	Natural variant	disease
feature-273	Natural variant	disease
feature-274	Natural variant	disease
feature-275	Natural variant	disease
feature-276	Natural variant	disease
feature-277	Natural variant	disease
feature-278	Natural variant	disease
feature-279	Natural variant	disease
feature-280	Natural variant	disease
feature-281	Natural variant	disease
feature-282	Natural variant	disease
feature-283	Natural variant	disease
feature-284	Natural variant	disease
feature-285	Natural variant	disease
feature-286	Natural variant	disease
feature-287	Natural variant	disease
feature-288	Natural variant	disease
feature-289	Natural variant	disease
feature-290	Natural variant	disease
feature-291	Natural variant	disease
feature-292	Natural variant	disease
feature-293	Natural variant	disease
feature-294	Natural variant	disease
feature-295	Natural variant	disease
feature-296	Natural variant	disease
feature-297	Natural variant	disease
feature-298	Natural variant	disease
feature-299	Natural variant	disease
feature-300	Natural variant	disease
feature-301	Natural variant	disease
feature-302	Natural variant	disease
feature-303	Natural variant	disease
feature-304	Natural variant	disease
feature-305	Natural variant	disease
feature-306	Natural variant	disease
feature-307	Natural variant	disease
feature-308	Natural variant	disease
feature-309	Natural variant	disease
feature-310	Natural variant	disease
feature-311	Natural variant	disease
feature-312	Natural variant	disease
feature-313	Natural variant	disease
feature-314	Natural variant	disease
feature-315	Natural variant	disease
feature-316	Natural variant	disease
feature-317	Natural variant	disease
feature-318	Natural variant	disease
feature-319	Natural variant	disease
feature-320	Natural variant	disease
feature-321	Natural variant	disease
feature-322	Natural variant	disease
feature-323	Natural variant	disease
feature-324	Natural variant	disease
feature-325	Natural variant	disease
feature-326	Natural variant	disease
feature-327	Natural variant	disease
feature-328	Natural variant	disease
feature-329	Natural variant	disease
feature-330	Natural variant	disease
feature-331	Natural variant	disease
feature-332	Natural variant	disease
feature-333	Natural variant	disease
feature-334	Natural variant	disease
feature-335	Natural variant	disease
feature-336	Natural variant	disease
feature-337	Natural variant	disease
feature-338	Natural variant	disease
feature-339	Natural variant	disease
feature-340	Natural variant	disease
feature-341	Natural variant	disease
feature-342	Natural variant	disease
feature-343	Natural variant	disease
feature-344	Natural variant	disease
feature-345	Natural variant	disease
feature-346	Natural variant	disease
feature-347	Natural variant	disease
feature-348	Natural variant	disease
feature-349	Natural variant	disease
feature-350	Natural variant	disease
feature-351	Natural variant	disease
feature-352	Natural variant	disease
feature-353	Natural variant	disease
feature-354	Natural variant	disease
feature-355	Natural variant	disease
feature-356	Natural variant	disease
feature-357	Natural variant	disease
feature-358	Natural variant	disease
feature-359	Natural variant	disease
feature-360	Natural variant	disease
feature-361	Natural variant	disease
feature-362	Natural variant	disease
feature-363	Natural variant	disease
feature-364	Natural variant	disease
feature-365	Natural variant	disease
feature-366	Natural variant	disease
feature-367	Natural variant	disease
feature-368	Natural variant	disease
feature-369	Natural variant	disease
feature-370	Natural variant	disease
feature-371	Natural variant	disease
feature-372	Natural variant	disease
feature-373	Natural variant	disease
feature-374	Natural variant	disease
feature-375	Natural variant	disease
feature-376	Natural variant	disease
feature-377	Natural variant	disease
feature-378	Natural variant	disease
feature-379	Natural variant	disease
feature-380	Natural variant	disease
feature-381	Natural variant	disease
feature-382	Natural variant	disease
feature-383	Natural variant	disease
feature-384	Natural variant	disease
feature-385	Natural variant	disease
feature-386	Natural variant	disease
feature-387	Natural variant	disease
feature-388	Natural variant	disease
feature-389	Natural variant	disease
feature-390	Natural variant	disease
feature-391	Natural variant	disease
feature-392	Natural variant	disease
feature-393	Natural variant	disease
feature-394	Natural variant	disease
feature-395	Natural variant	disease
feature-396	Natural variant	disease
feature-397	Natural variant	disease
feature-398	Natural variant	disease
feature-399	Natural variant	disease
feature-400	Natural variant	disease
feature-401	Natural variant	disease
feature-402	Natural variant	disease
feature-403	Natural variant	disease
feature-404	Natural variant	disease
feature-405	Natural variant	disease
feature-406	Natural variant	disease
feature-407	Natural variant	disease
feature-408	Natural variant	disease
feature-409	Natural variant	disease
feature-410	Natural variant	disease
feature-411	Natural variant	disease
feature-412	Natural variant	disease
feature-413	Natural variant	disease
feature-414	Natural variant	disease
feature-415	Natural variant	disease
feature-416	Natural variant	disease
feature-417	Natural variant	disease
feature-418	Natural variant	disease
feature-419	Natural variant	disease
feature-420	Natural variant	disease
feature-421	Natural variant	disease
feature-422	Natural variant	disease
feature-423	Natural variant	disease
feature-424	Natural variant	disease
feature-425	Natural variant	disease
feature-426	Natural variant	disease
feature-427	Natural variant	disease
feature-428	Natural variant	disease
feature-429	Natural variant	disease
feature-430	Natural variant	disease
feature-431	Natural variant	disease
feature-432	Natural variant	disease
feature-433	Natural variant	disease
feature-434	Natural variant	disease
feature-435	Natural variant	disease
feature-436	Natural variant	disease
feature-437	Natural variant	disease
feature-438	Natural variant	disease
feature-439	Natural variant	disease
feature-440	Natural variant	disease
feature-441	Natural variant	disease
feature-442	Natural variant	disease
feature-443	Natural variant	disease
feature-444	Natural variant	disease
feature-445	Natural variant	disease
feature-446	Natural variant	disease
feature-447	Natural variant	disease
feature-448	Natural variant	disease
feature-449	Natural variant	disease
feature-450	Natural variant	disease
feature-451	Natural variant	disease
feature-452	Natural variant	disease
feature-453	Natural variant	disease
feature-454	Natural variant	disease
feature-455	Natural variant	disease
feature-456	Natural variant	disease
feature-457	Natural variant	disease
feature-458	Natural variant	disease
feature-459	Natural variant	disease
feature-460	Natural variant	disease
feature-461	Natural variant	disease
feature-462	Natural variant	disease
feature-463	Natural variant	disease
feature-464	Natural variant	disease
feature-465	Natural variant	disease
feature-466	Natural variant	disease
feature-467	Natural variant	disease
feature-468	Natural variant	disease
feature-469	Natural variant	disease
feature-470	Natural variant	disease
feature-471	Natural variant	disease
feature-472	Natural variant	disease
feature-473	Natural variant	disease
feature-474	Natural variant	disease
feature-475	Natural variant	disease
feature-476	Natural variant	disease
feature-477	Natural variant	disease
feature-478	Natural variant	disease
feature-479	Natural variant	disease
feature-480	Natural variant	disease
feature-481	Natural variant	disease
feature-482	Natural variant	disease
feature-483	Natural variant	disease
feature-484	Natural variant	disease
feature-485	Natural variant	disease
feature-486	Natural variant	disease
feature-487	Natural variant	disease
feature-488	Natural variant	disease
feature-489	Natural variant	disease
feature-490	Natural variant	disease
feature-491	Natural variant	disease
feature-492	Natural variant	disease
feature-493	Natural variant	disease
feature-494	Natural variant	disease
feature-495	Natural variant	disease
feature-496	Natural variant	disease
feature-497	Natural variant	disease
feature-498	Natural variant	disease
feature-499	Natural variant	disease
feature-500	Natural variant	disease
feature-501	Natural variant	disease
feature-502	Natural variant	disease
feature-503	Natural variant	disease
feature-504	Natural variant	disease
feature-505	Natural variant	disease
feature-506	Natural variant	disease
feature-507	Natural variant	disease
feature-508	Natural variant	disease
feature-509	Natural variant	disease
feature-510	Natural variant	disease
feature-511	Natural variant	disease
feature-512	Natural variant	disease
feature-513	Natural variant	disease
feature-514	Natural variant	disease
feature-515	Natural variant	disease
feature-516	Natural variant	disease
feature-517	Natural variant	disease
feature-518	Natural variant	disease
feature-519	Natural variant	disease
feature-520	Natural variant	disease
feature-521	Natural variant	disease
feature-522	Natural variant	disease
feature-523	Natural variant	disease
feature-524	Natural variant	disease
feature-525	Natural variant	disease
feature-526	Natural variant	disease
feature-527	Natural variant	disease
feature-528	Natural variant	disease
feature-529	Natural variant	disease
feature-530	Natural variant	disease
feature-531	Natural variant	disease
feature-532	Natural variant	disease
feature-533	Natural variant	disease
feature-534	Natural variant	disease
feature-535	Natural variant	disease
feature-536	Natural variant	disease
feature-537	Natural variant	disease
feature-538	Natural variant	disease
feature-539	Natural variant	disease
feature-540	Natural variant	disease
feature-541	Natural variant	disease
feature-542	Natural variant	disease
feature-543	Natural variant	disease
feature-544	Natural variant	disease
feature-545	Natural variant	disease
feature-546	Natural variant	disease
feature-547	Natural variant	disease
feature-548	Natural variant	disease
feature-549	Natural variant	disease
feature-550	Natural variant	disease
feature-551	Natural variant	disease
feature-552	Natural variant	disease
feature-553	Natural variant	disease
feature-554	Natural variant	disease
feature-555	Natural variant	disease
feature-556	Natural variant	disease
feature-557	Natural variant	disease
feature-558	Natural variant	disease
feature-559	Natural variant	disease
feature-560	Natural variant	disease
feature-561	Natural variant	disease
feature-562	Natural variant	disease
feature-563	Natural variant	disease
feature-564	Natural variant	disease
feature-565	Natural variant	disease
feature-566	Natural variant	disease
feature-567	Natural variant	disease
feature-568	Natural variant	disease
feature-569	Natural variant	disease
feature-570	Natural variant	disease
feature-571	Natural variant	disease
feature-572	Natural variant	disease
feature-573	Natural variant	disease
feature-574	Natural variant	disease
feature-575	Natural variant	disease
feature-576	Natural variant	disease
feature-577	Natural variant	disease
feature-578	Natural variant	disease
feature-579	Natural variant	disease
feature-580	Natural variant	disease
feature-581	Natural variant	disease
feature-582	Natural variant	disease
feature-583	Natural variant	disease
feature-584	Natural variant	disease
feature-585	Natural variant	disease
feature-586	Natural variant	disease
feature-587	Natural variant	disease
feature-588	Natural variant	disease
feature-589	Natural variant	disease
feature-590	Natural variant	disease
feature-591	Natural variant	disease
feature-592	Natural variant	disease
feature-593	Natural variant	disease
feature-594	Natural variant	disease
feature-595	Natural variant	disease
feature-596	Natural variant	disease
feature-597	Natural variant	disease
feature-598	Natural variant	disease
feature-599	Natural variant	disease
feature-600	Natural variant	disease
feature-601	Natural variant	disease
feature-602	Natural variant	disease
feature-603	Natural variant	disease
feature-604	Natural variant	disease
feature-605	Natural variant	disease
feature-606	Natural variant	disease
feature-607	Natural variant	disease
feature-608	Natural variant	disease
feature-609	Natural variant	disease
feature-610	Natural variant	disease
feature-611	Natural variant	disease
feature-612	Natural variant	disease
feature-613	Natural variant	disease
feature-614	Natural variant	disease
feature-615	Natural variant	disease
feature-616	Natural variant	disease
feature-617	Natural variant	disease
feature-618	Natural variant	disease
feature-619	Natural variant	disease
feature-620	Natural variant	disease
feature-621	Natural variant	disease
feature-622	Natural variant	disease
feature-623	Natural variant	disease
feature-624	Natural variant	disease
feature-625	Natural variant	disease
feature-626	Natural variant	disease
feature-627	Natural variant	disease
feature-628	Natural variant	disease
feature-629	Natural variant	disease
feature-630	Natural variant	disease
feature-631	Natural variant	disease
feature-632	Natural variant	disease
feature-633	Natural variant	disease
feature-634	Natural variant	disease
feature-635	Natural variant	disease
feature-636	Natural variant	disease
feature-637	Natural variant	disease
feature-638	Natural variant	disease
feature-639	Natural variant	disease
feature-640	Natural variant	disease
feature-641	Natural variant	disease
feature-642	Natural variant	disease
feature-643	Natural variant	disease
feature-644	Natural variant	disease
feature-645	Natural variant	disease
feature-646	Natural variant	disease
feature-647	Natural variant	disease
feature-648	Natural variant	disease
feature-649	Natural variant	disease
feature-650	Natural variant	disease
feature-651	Natural variant	disease
feature-652	Natural variant	disease
feature-653	Natural variant	disease
feature-654	Natural variant	disease
feature-655	Natural variant	disease
feature-656	Natural variant	disease
feature-657	Natural variant	disease
feature-658	Natural variant	disease
feature-659	Natural variant	disease
feature-660	Natural variant	disease
feature-661	Natural variant	disease
feature-662	Natural variant	disease
feature-663	Natural variant	disease
feature-664	Natural variant	disease
feature-665	Natural variant	disease
feature-666	Natural variant	disease
feature-667	Natural variant	disease
feature-668	Natural variant	disease
feature-669	Natural variant	disease
feature-670	Natural variant	disease
feature-671	Natural variant	disease
feature-672	Natural variant	disease
feature-673	Natural variant	disease
feature-674	Natural variant	disease
feature-675	Natural variant	disease
feature-676	Natural variant	disease
feature-677	Natural variant	disease
feature-678	Natural variant	disease
feature-679	Natural variant	disease
feature-680	Natural variant	disease
feature-681	Natural variant	disease
feature-682	Natural variant	disease
feature-683	Natural variant	disease
feature-684	Natural variant	disease
feature-685	Natural variant	disease
feature-686	Natural variant	disease
feature-687	Natural variant	disease
feature-688	Natural variant	disease
feature-689	Natural variant	disease
feature-690	Natural variant	disease
feature-691	Natural variant	disease
feature-692	Natural variant	disease
feature-693	Natural variant	disease
feature-694	Natural variant	disease
feature-695	Natural variant	disease
feature-696	Natural variant	disease
feature-697	Natural variant	disease
feature-698	Natural variant	disease
feature-699	Natural variant	disease
feature-700	Natural variant	disease
feature-701	Natural variant	disease
feature-702	Natural variant	disease
feature-703	Natural variant	disease
feature-704	Natural variant	disease
feature-705	Natural variant	disease
feature-706	Natural variant	disease
feature-707	Natural variant	disease
feature-708	Natural variant	disease
feature-709	Natural variant	disease
feature-710	Natural variant	disease
feature-711	Natural variant	disease
feature-712	Natural variant	disease
feature-713	Natural variant	disease
feature-714	Natural variant	disease
feature-715	Natural variant	disease
feature-716	Natural variant	disease
feature-717	Natural variant	disease
feature-718	Natural variant	disease
feature-719	Natural variant	disease
feature-720	Natural variant	disease
feature-721	Natural variant	disease
feature-722	Natural variant	disease
feature-723	Natural variant	disease
feature-724	Natural variant	disease
feature-725	Natural variant	disease
feature-726	Natural variant	disease
feature-727	Natural variant	disease
feature-728	Natural variant	disease
feature-729	Natural variant	disease
feature-730	Natural variant	disease
feature-731	Natural variant	disease
feature-732	Natural variant	disease
feature-733	Natural variant	disease
feature-734	Natural variant	disease
feature-735	Natural variant	disease
feature-736	Natural variant	disease
feature-737	Natural variant	disease
feature-738	Natural variant	disease
feature-739	Natural variant	disease
feature-740	Natural variant	disease
feature-741	Natural variant	disease
feature-742	Natural variant	disease
feature-743	Natural variant	disease
feature-744	Natural variant	disease
feature-745	Natural variant	disease
feature-746	Natural variant	disease
feature-747	Natural variant	disease
feature-748	Natural variant	disease
feature-749	Natural variant	disease
feature-750	Natural variant	disease
feature-751	Natural variant	disease
feature-752	Natural variant	disease
feature-753	Natural variant	disease
feature-754	Natural variant	disease
feature-755	Natural variant	disease
feature-756	Natural variant	disease
feature-757	Natural variant	disease
feature-758	Natural variant	disease
feature-759	Natural variant	disease
feature-760	Natural variant	disease
feature-761	Natural variant	disease
feature-762	Natural variant	disease
feature-763	Natural variant	disease
feature-764	Natural variant	disease
feature-765	Natural variant	disease
feature-766	Natural variant	disease
feature-767	Natural variant	disease
feature-768	Natural variant	disease
feature-769	Natural variant	disease
feature-770	Natural variant	disease
feature-771	Natural variant	disease
feature-772	Natural variant	disease
feature-773	Natural variant	disease
feature-774	Natural variant	disease
feature-775	Natural variant	disease
feature-776	Natural variant	disease
feature-777	Natural variant	disease
feature-778	Natural variant	disease
feature-779	Natural variant	disease
feature-780	Natural variant	disease
feature-781	Natural variant	disease
feature-782	Natural variant	disease
feature-783	Natural variant	disease
feature-784	Natural variant	disease
feature-785	Natural variant	disease
feature-786	Natural variant	disease
feature-787	Natural variant	disease
feature-788	Natural variant	disease
feature-789	Natural variant	disease
feature-790	Natural variant	disease
feature-791	Natural variant	disease
feature-792	Natural variant	disease
feature-793	Natural variant	disease
feature-794	Natural variant	disease
feature-795	Natural variant	disease
feature-796	Natural variant	disease
feature-797	Natural variant	disease
feature-798	Natural variant	disease
feature-799	Natural variant	disease
feature-800	Natural variant	disease
feature-801	Natural variant	disease
feature-802	Natural variant	disease
feature-803	Natural variant	disease
feature-804	Natural variant	disease
feature-805	Natural variant	disease
feature-806	Natural variant	disease
feature-807	Natural variant	disease
feature-808	Natural variant	disease
feature-809	Natural variant	disease
feature-810	Natural variant	disease
feature-811	Natural variant	disease
feature-812	Natural variant	disease
feature-813	Natural variant	disease
feature-814	Natural variant	disease
feature-815	Natural variant	disease
feature-816	Natural variant	disease
feature-817	Natural variant	disease
feature-818	Natural variant	disease
feature-819	Natural variant	disease
feature-820	Natural variant	disease
feature-821	Natural variant	disease
feature-822	Natural variant	disease
feature-823	Natural variant	disease
feature-824	Natural variant	disease
feature-825	Natural variant	disease
feature-826	Natural variant	disease
feature-827	Natural variant	disease
feature-828	Natural variant	disease
feature-829	Natural variant	disease
feature-830	Natural variant	disease
feature-831	Natural variant	disease
feature-832	Natural variant	disease
feature-833	Natural variant	disease
feature-834	Natural variant	disease
feature-835	Natural variant	disease
feature-836	Natural variant	disease
feature-837	Natural variant	disease
feature-838	Natural variant	disease
feature-839	Natural variant	disease
feature-840	Natural variant	disease
feature-841	Natural variant	disease
feature-842	Natural variant	disease
feature-843	Natural variant	disease
feature-844	Natural variant	disease
feature-845	Natural variant	disease
feature-846	Natural variant	disease
feature-847	Natural variant	disease
feature-848	Natural variant	disease
feature-849	Natural variant	disease
feature-850	Natural variant	disease
feature-851	Natural variant	disease
feature-852	Natural variant	disease
feature-853	Natural variant	disease
feature-854	Natural variant	disease
feature-855	Natural variant	disease
feature-856	Natural variant	disease
feature-857	Natural variant	disease
feature-858	Natural variant	disease
feature-859	Natural variant	disease
feature-860	Natural variant	disease
feature-861	Natural variant	disease
feature-862	Natural variant	disease
feature-863	Natural variant	disease
feature-864	Natural variant	disease
feature-865	Natural variant	disease
feature-866	Natural variant	disease
feature-867	Natural variant	disease
feature-868	Natural variant	disease
feature-869	Natural variant	disease
feature-870	Natural variant	disease
feature-871	Natural variant	disease
feature-872	Natural variant	disease
feature-873	Natural variant	disease
feature-874	Natural variant	disease
feature-875	Natural variant	disease
feature-876	Natural variant	disease
feature-877	Natural variant	disease
feature-878	Natural variant	disease
feature-879	Natural variant	disease
feature-880	Natural variant	disease
feature-881	Natural variant	disease
feature-882	Natural variant	disease
feature-883	Natural variant	disease
feature-884	Natural variant	disease
feature-885	Natural variant	disease
feature-886	Natural variant	disease
feature-887	Natural variant	disease
feature-888	Natural variant	disease
feature-889	Natural variant	disease
feature-890	Natural variant	disease
feature-891	Natural variant	disease
feature-892	Natural variant	disease
feature-893	Natural variant	disease
feature-894	Natural variant	disease
feature-895	Natural variant	disease
feature-896	Natural variant	disease
feature-897	Natural variant	disease
feature-898	Natural variant	disease
feature-899	Natural variant	disease
feature-900	Natural variant	disease
feature-901	Natural variant	disease
feature-902	Natural variant	disease
feature-903	Natural variant	disease
feature-904	Natural variant	disease
feature-905	Natural variant	disease
feature-906	Natural variant	disease
feature-907	Natural variant	disease
feature-908	Natural variant	disease
feature-909	Natural variant	disease
feature-910	Natural variant	disease
feature-911	Natural variant	disease
feature-912	Natural variant	disease
feature-913	Natural variant	disease
feature-914	Natural variant	disease
feature-915	Natural variant	disease
feature-916	Natural variant	disease
feature-917	Natural variant	disease
feature-918	Natural variant	disease
feature-919	Natural variant	disease
feature-920	Natural variant	disease
feature-921	Natural variant	disease
feature-922	Natural variant	disease
feature-923	Natural variant	disease
feature-924	Natural variant	disease
feature-925	Natural variant	disease
feature-926	Natural variant	disease
feature-927	Natural variant	disease
feature-928	Natural variant	disease
feature-929	Natural variant	disease
feature-930	Natural variant	disease
feature-931	Natural variant	disease
feature-932	Natural variant	disease
feature-933	Natural variant	disease
feature-934	Natural variant	disease
feature-935	Natural variant	disease
feature-936	Natural variant	disease
feature-937	Natural variant	disease
feature-938	Natural variant	disease
feature-939	Natural variant	disease
feature-940	Natural variant	disease
feature-941	Natural variant	disease
feature-942	Natural variant	disease
feature-943	Natural variant	disease
feature-944	Natural variant	disease
feature-945	Natural variant	disease
feature-946	Natural variant	disease
feature-947	Natural variant	disease
feature-948	Natural variant	disease
feature-949	Natural variant	disease
feature-950	Natural variant	disease
feature-951	Natural variant	disease
feature-952	Natural variant	disease
feature-953	Natural variant	disease
feature-954	Natural variant	disease
feature-955	Natural variant	disease
feature-956	Natural variant	disease
feature-957	Natural variant	disease
feature-958	Natural variant	disease
feature-959	Natural variant	disease
feature-960	Natural variant	disease
feature-961	Natural variant	disease
feature-962	Natural variant	disease
feature-963	Natural variant	disease
feature-964	Natural variant	disease
feature-965	Natural variant	disease
feature-966	Natural variant	disease
feature-967	Natural variant	disease
feature-968	Natural variant	disease
feature-969	Natural variant	disease
feature-970	Natural variant	disease
feature-971	Natural variant	disease
feature-972	Natural variant	disease
feature-973	Natural variant	disease
feature-974	Natural variant	disease
feature-975	Natural variant	disease
feature-976	Natural variant	disease
feature-977	Natural variant	disease
feature-978	Natural variant	disease
feature-979	Natural variant	disease
feature-980	Natural variant	disease
feature-981	Natural variant	disease
feature-982	Natural variant	disease
feature-983	Natural variant	disease
feature-984	Natural variant	disease
feature-985	Natural variant	disease
feature-986	Natural variant	disease
feature-987	Natural variant	disease
feature-988	Natural variant	disease
feature-989	Natural variant	disease
feature-990	Natural variant	disease
feature-991	Natural variant	disease
feature-992	Natural variant	disease
feature-993	Natural variant	disease
feature-994	Natural variant	disease
feature-995	Natural variant	disease
feature-996	Natural variant	disease
feature-997	Natural variant	disease
feature-998	Natural variant	disease
feature-999	Natural variant	disease
feature-1000	Natural variant	disease
feature-1001	Natural variant	disease
feature-1002	Natural variant	disease
feature-1003	Natural variant	disease
feature-1004	Natural variant	disease
feature-1005	Natural variant	disease
feature-1006	Natural variant	disease
feature-1007	Natural variant	disease
feature-1008	Natural variant	disease
feature-1009	Natural variant	disease
feature-1010	Natural variant	disease
feature-1011	Natural variant	disease
feature-1012	Natural variant	disease
feature-1013	Natural variant	disease
feature-1014	Natural variant	disease
feature-1015	Natural variant	disease
feature-1016	Natural variant	disease
feature-1017	Natural variant	disease
feature-1018	Natural variant	disease
feature-1019	Natural variant	disease
feature-1020	Natural variant	disease
feature-1021	Natural variant	disease
feature-1022	Natural variant	disease
feature-1023	Natural variant	disease
feature-1024	Natural variant	disease
feature-1025	Natural variant	disease
feature-1026	Natural variant	disease
feature-1027	Natural variant	disease
feature-1028	Natural variant	disease
feature-1029	Natural variant	disease
feature-1030	Natural variant	disease
feature-1031	Natural variant	disease
feature-1032	Natural variant	disease
feature-1033	Natural variant	disease
feature-1034	Natural variant	disease
feature-1035	Natural variant	disease
feature-1036	Natural variant	disease
feature-1037	Natural variant	disease
feature-1038	Natural variant	disease
feature-1039	Natural variant	disease
feature-1040	Natural variant	disease
feature-1041	Natural variant	disease
feature-1042	Natural variant	disease
feature-1043	Natural variant	disease
feature-1044	Natural variant	disease
feature-1045	Natural variant	disease
feature-1046	Natural variant	disease
feature-1047	Natural variant	disease
feature-1048	Natural variant	disease
feature-1049	Natural variant	disease
feature-1050	Natural variant	disease
feature-1051	Natural variant	disease
feature-1052	Natural variant	disease
feature-1053	Natural variant	disease
feature-1054	Natural variant	disease
feature-1055	Natural variant	disease
feature-1056	Natural variant	disease
feature-1057	Natural variant	disease
feature-1058	Natural variant	disease
feature-1059	Natural variant	disease
feature-1060	Natural variant	disease
feature-1061	Natural variant	disease
feature-1062	Natural variant	disease
feature-1063	Natural variant	disease
feature-1064	Natural variant	disease
feature-1065	Natural variant	disease
feature-1066	Natural variant	disease
feature-1067	Natural variant	disease
feature-1068	Natural variant	disease
feature-1069	Natural variant	disease
feature-1070	Natural variant	disease
feature-1071	Natural variant	disease
feature-1072	Natural variant	disease
feature-1073	Natural variant	disease
feature-1074	Natural variant	disease
feature-1075	Natural variant	disease
feature-1076	Natural variant	disease
feature-1077	Natural variant	disease
feature-1078	Natural variant	disease
feature-1079	Natural variant	disease
feature-1080	Natural variant	disease
feature-1081	Natural variant	disease
feature-1082	Natural variant	disease
feature-1083	Natural variant	disease
feature-1084	Natural variant	disease
feature-1085	Natural variant	disease
feature-1086	Natural variant	disease
feature-1087	Natural variant	disease
feature-1088	Natural variant	disease
feature-1089	Natural variant	disease
feature-1090	Natural variant	disease
feature-1091	Natural variant	disease
feature-1092	Natural variant	disease
feature-1093	Natural variant	disease
feature-1094	Natural variant	disease
feature-1095	Natural variant	disease
feature-1096	Natural variant	disease
feature-1097	Natural variant	disease
feature-1098	Natural variant	disease
feature-1099	Natural variant	disease
feature-1100	Natural variant	disease
feature-1101	Natural variant	disease
feature-1102	Natural variant	disease
feature-1103	Natural variant	disease
feature-1104	Natural variant	disease
feature-1105	Natural variant	disease
feature-1106	Natural variant	disease
feature-1107	Natural variant	disease
feature-1108	Natural variant	disease
feature-1109	Natural variant	disease
feature-1110	Natural variant	disease
feature-1111	Natural variant	disease
feature-1112	Natural variant	disease
feature-1113	Natural variant	disease
feature-1114	Natural variant	disease
feature-1115	Natural variant	disease
feature-1116	Natural variant	disease
feature-1117	Natural variant	disease
feature-1118	Natural variant	disease
feature-1119	Natural variant	disease
feature-1120	Natural variant	disease
feature-1121	Natural variant	disease
feature-1122	Natural variant	disease
feature-1123	Natural variant	disease
feature-1124	Natural variant	disease
feature-1125	Natural variant	disease
feature-1126	Natural variant	disease
feature-1127	Natural variant	disease
feature-1128	Natural variant	disease
feature-1129	Natural variant	disease
feature-1130	Natural variant	disease
feature-1131	Natural variant	disease
feature-1132	Natural variant	disease
feature-1133	Natural variant	disease
feature-1134	Natural variant	disease
feature-1135	Natural variant	disease
feature-1136	Natural variant	disease
feature-1137	Natural variant	disease
feature-1138	Natural variant	disease
feature-1139	Natural variant	disease
feature-1140	Natural variant	disease
feature-1141	Natural variant	disease
feature-1142	Natural variant	disease
feature-1143	Natural variant	disease
feature-1144	Natural variant	disease
feature-1145	Natural variant	disease
feature-1146	Natural variant	disease
feature-1147	Natural variant	disease
feature-1148	Natural variant	disease
feature-1149	Natural variant	disease
feature-1150	Natural variant	disease
feature-1151	Natural variant	disease
feature-1152	Natural variant	disease
feature-1153	Natural variant	disease
feature-1154	Natural variant	disease
feature-1155	Natural variant	disease
feature-1156	Natural variant	disease
feature-1157	Natural variant	disease
feature-1158	Natural variant	disease
feature-1159	Natural variant	disease
feature-1160	Natural variant	disease
feature-1161	Natural variant	disease
feature-1162	Natural variant	disease
feature-1163	Natural variant	disease
feature-1164	Natural variant	disease
feature-1165	Natural variant	disease
feature-1166	Natural variant	disease
feature-1167	Natural variant	disease
feature-1168	Natural variant	disease
feature-1169	Natural variant	disease
feature-1170	Natural variant	disease
feature-1171	Natural variant	disease
feature-1172	Natural variant	disease
feature-1173	Natural variant	disease
feature-1174	Natural variant	disease
feature-1175	Natural variant	disease
feature-1176	Natural variant	disease
feature-1177	Natural variant	disease
feature-1178	Natural variant	disease
feature-1179	Natural variant	disease
feature-1180	Natural variant	disease
feature-1181	Natural variant	disease
feature-1182	Natural variant	disease
feature-1183	Natural variant	disease
feature-1184	Natural variant	disease
feature-1185	Natural variant	disease
feature-1186	Natural variant	disease
feature-1187	Natural variant	disease
feature-1188	Natural variant	disease
feature-1189	Natural variant	disease
feature-1190	Natural variant	disease
feature-1191	Natural variant	disease
feature-1192	Natural variant	disease
feature-1193	Natural variant	disease
feature-1194	Natural variant	disease
feature-1195	Natural variant	disease
feature-1196	Natural variant	disease
feature-1197	Natural variant	disease
feature-1198	Natural variant	disease
feature-1199	Natural variant	disease
feature-1200	Natural variant	disease
feature-1201	Natural variant	disease
feature-1202	Natural variant	disease
feature-1203	Natural variant	disease
feature-1204	Natural variant	disease
feature-1205	Natural variant	disease
feature-1206	Natural variant	disease
feature-1207	Natural variant	disease
feature-1208	Natural variant	disease
feature-1209	Natural variant	disease
feature-1210	Natural variant	disease
feature-1211	Natural variant	disease
feature-1212	Natural variant	disease
feature-1213	Natural variant	disease
feature-1214	Natural variant	disease
feature-1215	Natural variant	disease
feature-1216	Natural variant	disease
feature-1217	Natural variant	disease
feature-1218	Natural variant	disease
feature-1219	Natural variant	disease
feature-1220	Natural variant	disease
feature-1221	Natural variant	disease
feature-1222	Natural variant	disease
feature-1223	Natural variant	disease
feature-1224	Natural variant	disease
feature-1225	Natural variant	disease
feature-1226	Natural variant	disease
feature-1227	Natural variant	disease
feature-1228	Natural variant	disease
feature-1229	Natural variant	disease
feature-1230	Natural variant	disease
feature-1231	Natural variant	disease
feature-1232	Natural variant	disease
feature-1233	Natural variant	disease
feature-1234	Natural variant	disease
feature-1235	Natural variant	disease
feature-1236	Natural variant	disease
feature-1237	Natural variant	disease
feature-1238	Natural variant	disease
feature-1239	Natural variant	disease
feature-1240	Natural variant	disease
feature-1241	Natural variant	disease
feature-1242	Natural variant	disease
feature-1243	Natural variant	disease
feature-1244	Natural variant	disease
feature-1245	Natural variant	disease
feature-1246	Natural variant	disease
feature-1247	Natural variant	disease
feature-1248	Natural variant	disease
feature-1249	Natural variant	disease
feature-1250	Natural variant	disease
feature-1251	Natural variant	disease
feature-1252	Natural variant	disease
feature-1253	Natural variant	disease
feature-1254	Natural variant	disease
feature-1255	Natural variant	disease
feature-1256	Natural variant	disease
feature-1257	Natural variant	disease
feature-1258	Natural variant	disease
feature-1259	Natural variant	disease
feature-1260	Natural variant	disease
feature-1261	Natural variant	disease
feature-1262	Natural variant	disease
feature-1263	Natural variant	disease
feature-1264	Natural variant	disease
feature-1265	Natural variant	disease
feature-1266	Natural variant	disease
feature-1267	Natural variant	disease
feature-1268	Natural variant	disease
feature-1269	Natural variant	disease
feature-1270	Natural variant	disease
feature-1271	Natural variant	disease
feature-1272	Natural variant	disease
feature-1273	Natural variant	disease
feature-1274	Natural variant	disease
feature-1275	Natural variant	disease
feature-1276	Natural variant	disease
feature-1277	Natural variant	disease
feature-1278	Natural variant	disease
feature-1279	Natural variant	disease
feature-1280	Natural variant	disease
feature-1281	Natural variant	disease
feature-1282	Natural variant	disease
feature-1283	Natural variant	disease
feature-1284	Natural variant	disease
feature-1285	Natural variant	disease
feature-1286	Natural variant	disease
feature-1287	Natural variant	disease
feature-1288	Natural variant	disease
feature-1289	Natural variant	disease
feature-1290	Natural variant	disease
feature-1291	Natural variant	disease
feature-1292	Natural variant	disease
feature-1293	Natural variant	disease
feature-1294	Natural variant	disease
feature-1295	Natural variant	disease
feature-1296	Natural variant	disease
feature-1297	Natural variant	disease
feature-1298	Natural variant	disease
feature-1299	Natural variant	disease
feature-1300	Natural variant	disease
feature-1301	Natural variant	disease
feature-1302	Natural variant	disease
feature-1303	Natural variant	disease
feature-1304	Natural variant	disease
feature-1305	Natural variant	disease
feature-1306	Natural variant	disease
feature-1307	Natural variant	disease
feature-1308	Natural variant	disease
feature-1309	Natural variant	disease
feature-1310	Natural variant	disease
feature-1311	Natural variant	disease
feature-1312	Natural variant	disease
feature-1313	Natural variant	disease
feature-1314	Natural variant	disease
feature-1315	Natural variant	disease
feature-1316	Natural variant	disease
feature-1317	Natural variant	disease
feature-1318	Natural variant	disease
feature-1319	Natural variant	disease
feature-1320	Natural variant	disease
feature-1321	Natural variant	disease
feature-1322	Natural variant	disease
feature-1323	Natural variant	disease
feature-1324	Natural variant	disease
feature-1325	Natural variant	disease
feature-1326	Natural variant	disease
feature-1327	Natural variant	disease
feature-1328	Natural variant	disease
feature-1329	Natural variant	disease
feature-1330	Natural variant	disease
feature-1331	Natural variant	disease
feature-1332	Natural variant	disease
feature-1333	Natural variant	disease
feature-1334	Natural variant	disease
feature-1335	Natural variant	disease
feature-1336	Natural variant	disease
feature-1337	Natural variant	disease
feature-1338	Natural variant	disease
feature-1339	Natural variant	disease
feature-1340	Natural variant	disease
feature-1341	Natural variant	disease
feature-1342	Natural variant	disease
feature-1343	Natural variant	disease
feature-1344	Natural variant	disease
feature-1345	Natural variant	disease
feature-1346	Natural variant	disease
feature-1347	Natural variant	disease
feature-1348	Natural variant	disease
feature-1349	Natural variant	disease
feature-1350	Natural variant	disease
feature-1351	Natural variant	disease
feature-1352	Natural variant	disease
feature-1353	Natural variant	disease
feature-1354	Natural variant	disease
feature-1355	Natural variant	disease
feature-1356	Natural variant	disease
feature-1357	Natural variant	disease
feature-1358	Natural variant	disease
feature-1359	Natural variant	disease
feature-1360	Natural variant	disease
feature-1361	Natural variant	disease
feature-1362	Natural variant	disease
feature-1363	Natural variant	disease
feature-1364	Natural variant	disease
feature-1365	Natural variant	disease
feature-1366	Natural variant	disease
feature-1367	Natural variant	disease
feature-1368	Natural variant	disease
feature-1369	Natural variant	disease
feature-1370	Natural variant	disease
feature-1371	Natural variant	disease
feature-1372	Natural variant	disease
feature-1373	Natural variant	disease
feature-1374	Natural variant	disease
feature-1375	Natural variant	disease
feature-1376	Natural variant	disease
feature-1377	Natural variant	disease
feature-1378	Natural variant	disease
feature-1379	Natural variant	disease
feature-1380	Natural variant	disease
feature-1381	Natural variant	disease
feature-1382	Natural variant	disease
feature-1383	Natural variant	disease
feature-1384	Natural variant	disease
feature-1385	Natural variant	disease
feature-1386	Natural variant	disease
feature-1387	Natural variant	disease
feature-1388	Natural variant	disease
feature-1389	Natural variant	disease
feature-1390	Natural variant	disease
feature-1391	Natural variant	disease
feature-1392	Natural variant	disease
feature-1393	Natural variant	disease
feature-1394	Natural variant	disease
feature-1395	Natural variant	disease
feature-1396	Natural variant	disease
feature-1397	Natural variant	disease
feature-1398	Natural variant	disease
feature-1399	Natural variant	disease
feature-1400	Natural variant	disease
feature-1401	Natural variant	disease
feature-1402	Natural variant	disease
feature-1403	Natural variant	disease
feature-1404	Natural variant	disease
feature-1405	Natural variant	disease
feature-1406	Natural variant	disease
feature-1407	Natural variant	disease
feature-1408	Natural variant	disease
feature-1409	Natural variant	disease
feature-1410	Natural variant	disease
feature-1411	Natural variant	disease
feature-1412	Natural variant	disease
feature-1413	Natural variant	disease
feature-1414	Natural variant	disease
feature-1415	Natural variant	disease
feature-1416	Natural variant	disease
feature-1417	Natural variant	disease
feature-1418	Natural variant	disease
feature-1419	Natural variant	disease
feature-1420	Natural variant	disease
feature-1421	Natural variant	disease
feature-1422	Natural variant	disease
feature-1423	Natural variant	disease
feature-1424	Natural variant	disease
feature-1425	Natural variant	disease
feature-1426	Natural variant	disease
feature-1427	Natural variant	disease
feature-1428	Natural variant	disease
feature-1429	Natural variant	disease
feature-1430	Natural variant	disease
feature-1431	Natural variant	disease
feature-1432	Natural variant	disease
feature-1433	Natural variant	disease
feature-1434	Natural variant	disease
feature-1435	Natural variant	disease
feature-1436	Natural variant	disease
feature-1437	Natural variant	disease
feature-1438	Natural variant	disease
feature-1439	Natural variant	disease
feature-1440	Mutagenesis	disease
feature-1441	Mutagenesis	disease
feature-1442	Mutagenesis	disease
feature-1443	Mutagenesis	disease
feature-1444	Mutagenesis	disease
feature-1445	Mutagenesis	disease
feature-1446	Mutagenesis	disease
feature-1447	Mutagenesis	disease
feature-1448	Mutagenesis	disease
feature-1449	Mutagenesis	disease
feature-1450	Mutagenesis	disease
feature-1451	Mutagenesis	disease
feature-1452	Mutagenesis	disease
feature-1453	Mutagenesis	disease
feature-1454	Mutagenesis	disease
feature-1455	Mutagenesis	disease
feature-1456	Mutagenesis	disease
feature-1457	Mutagenesis	disease
feature-1458	Mutagenesis	disease
feature-1459	Mutagenesis	disease
feature-1460	Mutagenesis	disease
feature-1461	Mutagenesis	disease
feature-1462	Mutagenesis	disease
feature-1463	Mutagenesis	disease
feature-1464	Mutagenesis	disease
feature-1465	Mutagenesis	disease
feature-1466	Mutagenesis	disease
feature-1467	Mutagenesis	disease
feature-1468	Mutagenesis	disease
feature-1469	Mutagenesis	disease
feature-1470	Mutagenesis	disease
feature-1471	Mutagenesis	disease
feature-1472	Mutagenesis	disease
feature-1473	Mutagenesis	disease
feature-1474	Mutagenesis	disease
feature-1475	Mutagenesis	disease
feature-1476	Mutagenesis	disease
feature-1477	Mutagenesis	disease
feature-1478	Helix	sequence
feature-1479	Turn	sequence
feature-1480	Helix	sequence
feature-1481	Helix	sequence
feature-1482	Beta strand	sequence
feature-1483	Helix	sequence
feature-1484	Helix	sequence
feature-1485	Helix	sequence
feature-1486	Helix	sequence
feature-1487	Turn	sequence
feature-1488	Beta strand	sequence
feature-1489	Beta strand	sequence
feature-1490	Beta strand	sequence
feature-1491	Turn	sequence
feature-1492	Beta strand	sequence
feature-1493	Beta strand	sequence
feature-1494	Beta strand	sequence
feature-1495	Beta strand	sequence
feature-1496	Helix	sequence
feature-1497	Helix	sequence
feature-1498	Beta strand	sequence
feature-1499	Beta strand	sequence
feature-1500	Beta strand	sequence
feature-1501	Beta strand	sequence
feature-1502	Turn	sequence
feature-1503	Beta strand	sequence
feature-1504	Helix	sequence
feature-1505	Turn	sequence
feature-1506	Beta strand	sequence
feature-1507	Helix	sequence
feature-1508	Turn	sequence
feature-1509	Beta strand	sequence
feature-1510	Beta strand	sequence
feature-1511	Beta strand	sequence
feature-1512	Helix	sequence
feature-1513	Helix	sequence
feature-1514	Helix	sequence
feature-1515	Beta strand	sequence
feature-1516	Helix	sequence
feature-1517	Turn	sequence
feature-1518	Helix	sequence
feature-1519	Helix	sequence

TP53Cellular tumor antigen p53

Function

Additional functional context

Cofactors

GO functions & biological processes

Names & Taxonomy

Subcellular Location

Membrane topology 0

Disease & Variants

Esophageal cancer ESCR

Li-Fraumeni syndrome LFS

Squamous cell carcinoma of the head and neck HNSCC

Lung cancer LNCR

Papilloma of choroid plexus CPP

Adrenocortical carcinoma ADCC

Basal cell carcinoma 7 BCC7

Bone marrow failure syndrome 5 BMFS5

Natural variants 1,363

Laboratory mutagenesis 38

PTM/Processing

Processed chains & precursor regions 1

Modifications 36

Expression

Induction

Interaction

Documented interaction partners

Complex membership & assembly descriptions

UniProt subunit description

Other association resources

Structure

9R2Q · p53 bound to nucleosome at position SHL-5.7 (non-crosslinked sample)

Components & chains

Structure validation

Publication

Available structures 319

Family & Domains

Domain architecture

Atlas domains, motifs & repeats 4

UniProt domains, repeats & motifs 5

Functional sites 6

Sequence regions 23

Sequence & Isoforms

Sequence & isoforms

Isoform sequence differences 6

Sequence conflicts & cautions 0

Recorded secondary structure 42

Similar Proteins

Similar proteins · UniRef

Homologs

OMA orthologs

Sources & References

Publications in this UniProt entry

Annotation coverage audit